Inhibition of TNF-α-induced neutrophil apoptosis by crystals of calcium pyrophosphate dihydrate is mediated by the extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways up-stream of caspase 3

Journal of Immunology

Volumn 165, Issue 10, 2000, Pages 5798-5806

  Tudan, C ^a   Jackson, J K ^a   Blanis, L ^a   Pelech, S L ^a   Burt, H M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CALCIUM PYROPHOSPHATE; CASPASE 3; DNA FRAGMENT; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE C INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WORTMANNIN;

APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NEUTROPHIL; PATHOGENESIS; PRIORITY JOURNAL; PSEUDOGOUT;

EID: 0034670006     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.10.5798     Document Type: Article

References (53)

1. Pathagenesis and treatment of crystal induced inflamation
2. Crystal induced protein tyrosine phosphorylation in neutrophils and the effect of a tyrosine kinase inhibitor on neutrophil responses
3. Polymorphonuclear leukocyte responses to monosodium urate crystals: Modification of absorbed serum proteins
4. Immunoglobulin G coating of crystals and ceramics enhances polymorphonuclear cell superoxide production: Correlation with immunogloblin G absorbed
5. Macrophage phagocytosis of aging neutrophils in inflammation: Programmed cell death in the neutrophil leads to its recognition by macrophages
6. Neutrophil priming: The cellular signals that say 'amber' not 'green'
7. Neutrophil apoptosis is modulated by endothelial transmigration and adhesion molecule engagement
8. Modulation of human neutrophil apoptosis by immune complexes
9. Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products
10. Caspases mediate tumor necrosis factor-α-induced neutrophil apoptosis and downregulation of reactive oxygen production
11. Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-α
12. In vivo regulation of neutrophil apoptosis occuring spontaneously or induced with TNF-α or cycloheximide
13. Wortmannin enhances tumour necrosis factor α-stimulated neutrophil apoptosis
14. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control
15. Inhibition of TNF-induced apoptosis by NF-κB
16. Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor?
17. The activation of p38 and apoptosis by the inhibition of Erk is antagonized by phosphoinositide 3-kinase/Akt pathway
18. MEKKs, GCKs, MLKs, PAKs, TAK, and tpls: Upstream regulators of c-Jun-terminal kinases?
19. Mitogen-activated protein kinases signal inhibition of apoptosis in lipopolysaccharide-stimulated neutrophils
20. Akt Signaling: Linking membrane events to life and death decisions
21. PKB/Akt: Connecting phosphinositol 3-kinase to cell survival and beyond
22. PI3K: Downstream AKTion blocks apoptosis
23. Regulation of neuronal survival by the serine-threonine protein kinase Akt
24. Inhibition of TNF-α and spontaneous apoptosis by crystals of calcium pyrophosphate dihydrate in neutrophils
25. Prevention of neutrophil apoptosis by monosodium urate crystals
26. Sequential changes in human polymorphonuclear leukocytes after urate crystal phagocytosis: An electron microscopic study
27. Calcium pyrophosphate and monosodium urate crystal interactions with neutrophils: Effect of crystal size and lipoprotein binding to crystals
28. Neutrophil apoptosis during the development of oleic acid-induced acute lung injury in the rat
29. Calcium pyrophosphate dihydrate crystals activate MAP kinase in human neutrophils: Inhibition of MAP kinase, oxidase activation and degranulation responses of neutrophils by taxol
30. Requirement of caspase-3(-like) protease-mediated hydrogen peroxide production for apoptosis induced by various anticancer drugs
31. Selective inhibition of protein kinase C, mitogen-activated kinase, and neutrophil activation in response to calcium pyrophosphate dihydrate crystals, formyl-methionylleucyl-phenylalanine, and phorbol ester by O-(chloroacetyl-carbamoyl) fumagillol (AGM-1470; TNP-470)
32. VEGF provents apoptosis of human microvascular endothelial cells via opposing effects on MAP/ERK and SAPK/JNK signaling
33. Apoptosis of ovarian graulosa cells: Correlation with the reduced activity of ERK-signaling module
34. Signalling through lipid products of phosphoinositide-3-OH kinase
35. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphotidylinositol 3-kinase
36. Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation
37. Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor
38. Activation of S6 kinase in human neutrophils by calcium pyrophosphate dihydrate crystals: Protein kinase C-dependent and phosphatidylinositol-3-kinase-independent pathways
39. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5,-trisphosphate in neutrophil responses
40. Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase
41. FMLP activates Ras and Raf in human neutrophils: Potential role in activation of MAP kinase
42. Angiogenesis inhibition supresses collagen arthritis
43. Suppression of collagen-induced arthritis using an angiogenesis inhibitor, AGM-1470, and a microtubule stabilizer, taxol
44. A novel angiogenesis inhibitor suppresses rat adjuvant arthritis
45. A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf
46. The involvement of phosphatidylinositol 3-kinase in crystal induced neutrophil activation
47. Oxidative stress as a mediator of apoptosis
48. 2 integrin CD11b/CD18 in neutrophil apoptosis: A homeostasis mechanism in inflammation
49. 1- and Bax-α-mediated regulation of apoptosis of human neutrophils via caspase-3
50. Molecular thanatopsis: A discourse on the BCL2 family and cell death
51. Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis
52. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery