Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A

Journal of Neuroscience

Volumn 20, Issue 20, 2000, Pages 7571-7578

  Bauman, A L ^a   Apparsundaram, S ^a   Ramamoorthy, S ^a   Wadzinski, B E ^a   Vaughan, R A ^a   Blakely, R D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dopamine; Norepinephrine; Phosphorylation; Protein kinase C; Protein phosphatase 2A; Serotonin; Transporter

Indexed keywords

CALYCULIN A; CARRIER PROTEIN; COCAINE; DOPAMINE TRANSPORTER; NORADRENALIN; NORADRENALIN TRANSPORTER; OKADAIC ACID; PHORBOL ESTER; PHOSPHOPROTEIN PHOSPHATASE 2A; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ENZYME SUBUNIT; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

EID: 0034667557     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-20-07571.2000     Document Type: Article

References (68)

1. Acute regulation of norepinephrine transport: I. Protein kinase C-linked muscarinic receptors influence transport capacity and transporter density in SK-N-SH cells
2. Acute regulation of norepinephrine transport: II. PKC-modulated surface expression of human norepinephrine transporter proteins
3. Norepinephrine and serotonin transporters: Molecular targets of antidepressant drugs
4. Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A
5. Multiple G-protein-coupled receptors initiate protein kinase C redistribution of GABA transporters in hippocampal neurons
6. Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder
7. Cellular localization and expression of the serotonin transporter in mouse brain
8. Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxyme-thamphetamine ('Ecstasy') in serotonin transporter-deficient mice
9. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level
10. Regulation of gamma-aminobutyric acid (GABA) transporters by extracellular GABA
11. Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins
12. Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium
13. In vivo assessment of dopamine uptake in rat medial prefrontal cortex: Comparison with dorsal striatum and nucleus accumbens
14. The structure and regulation of protein phosphatases
15. Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters
16. Neurotransmitters
17. Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum
18. Glutamate induces rapid upregulation of astrocyte glutamate transport and cell-surface expression of GLAST
19. Is platelet imipramine binding reduced in depression?
20. Differential inhibition and posttranslational modification of protein phosphatasc 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin
21. Affective disorders
22. Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors
23. Recovery of dopamine transporter binding and function after intrastriatal administration of the irreversible inhibitor RTI-76 [3 beta-(3p-chlorophenyl) tropan-2 beta-carboxylic acid p-isothiocyanatophenylethyl ester hydrochloride]
24. Cloning and chromosomal mapping of the murine norepinephrine transporter
25. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
26. A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A
27. Regulation of protein phosphatase 2A by direct interaction with casein kinase 2α
28. Dopamine transporter activity in the substantia nigra and striatum assessed by high-speed chronoamperometric recordings in brain slices
29. Identification of a domain of axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain
30. Phorbol esters increase dopamine transporter phosphorylation and decrease transport Vmax
31. Activation of histamine H3-receptors inhibits carrier-mediated norepinephrine release during protracted myocardial ischemia. Comparison with adenosine A1-receptors and alpha2-adrenoceptors
32. Histone H1 phosphorylated by protein kinase C is a selective substrate for the assay of protein phosphatase 2A in the presence of phosphatase 1
33. Oligomerization of serotonin transporter and its functional consequences
34. Reduced levels of norepinephrine transporters in the locus coerulcus in major depression
35. The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta 2-adrenergic receptor dephosphorylation by vesicular acidification
36. Imaging transporters for dopamine and other neurotransmitters in brain
37. Adrenergic receptors: Recent insights into their mechanism of activation and desensitization
38. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
39. Effects of ethanol and nomifensine on NE clearance in the cerebellum of young and aged Fischer 344 rats
40. Differential regulation of single CFTR channels by PP2C, PP2A, and other phosphatases
41. Membrane trafficking regulates the activity of the human dopamine transporter
42. Inability to N-glycosylate the human norepinephrine transporter reduces protein stability, surface trafficking, and transport activity but not ligand recognition
43. Adenosine A3 receptors regulate scrotonin transport via nitric oxide and cGMP
44. Regulation of endosome sorting by a specific PP2A isoform
45. - neurotransmitter transporters
46. Role of serotonin in the pathophysiology of depression: Focus on the serotonin transporter
47. The structure and function of norepinephrine, dopamine, and serotonin transporters
48. Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter
49. Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression
50. Phosphorylation of serotonin transporter domains and their role of phosphorylation in acute transporter regulation
51. Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies
52. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants
53. Phosphorylation and regulation of antidepressant-sensitive serotonin transporters
54. Biosynthesis, N-glycosylation, and surface trafficking of biogenic amine transporter proteins
55. A sodium channel signaling complex: Modulation by associated receptor protein tyrosine phosphatase beta
56. Examination of glutamate transporter heterogeneity using synaptosomal preparations
57. Modulation of serotonin transporter activity by a protein kinase C activator and an inhibitor Of type 1 and 2A serine/threonine phosphatases
58. Immunolocalization of the cocaine- and antidepressant-sensitive 1-norepinephrine transporter
59. Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency
60. Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin
61. Protein kinase C-mediated phosphorylation and functional regulation of dopamine transporters in striatal synaptosomes
62. 2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A
63. Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex
64. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants
65. Regulation of the functional activity of the human dopamine transporter by protein kinase C
66. Expression and regulation of the human dopamine transporter in a neuronal cell line
67. Downregulation of the human norepinephrine transporter in intact 293-hNET cells exposed to desipramine
68. Activation of protein kinase C inhibits uptake, currents and binding associated with the human dopamine transporter expressed in Xenopus oocytes