Activation of protein kinase C inhibits uptake, currents and binding associated with the human dopamine transporter expressed in Xenopus oocytes

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 3, 1997, Pages 1358-1365

  Zhu, Si Jia ^a   Kavanaugh, Michael P ^b   Sonders, Mark S ^b   Amara, Susan G ^b   Zahniser, Nancy R ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4ALPHA PHORBOL DIDECANOATE; BISINDOLYLMALEIMIDE; DOPAMINE TRANSPORTER; MAZINDOL; PROTEIN KINASE C;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CELL SURFACE; DOPAMINE BRAIN LEVEL; DOPAMINE UPTAKE; ENZYME BINDING; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION; XENOPUS;

ALANINE; ANIMALS; CARRIER PROTEINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; MAZINDOL; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; OOCYTES; PROTEIN KINASE C; RECOMBINANT PROTEINS; TETRADECANOYLPHORBOL ACETATE; XENOPUS LAEVIS;

EID: 0030922926     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. AMARA, S. G. AND KUHAR, M. J.: Neurotransmitter transporters: Recent progress. Annu. Rev. Neurosci. 16: 73-93, 1993.
2. ANDERSON, G. M. AND HORNE, W. C.: Activators of protein kinase C decrease serotonin transport in human platelets. Biochim. Biophys. Acta 1137: 331-337, 1992.
3. BARISH, M. E.: A transient calcium-dependent chloride current in the immature Xenopus oocyte. J. Physiol. 342: 309-325, 1983.
4. BOURINET, E., FOURNIER, F., LORY, P., CHARNET, P. AND NARGEOT, J.: Protein kinase C regulation of cardiac calcium channels expressed in Xenopus oocytes. Pflugers Arch. Eur. J. Physiol. 421: 247-255, 1992.
5. COPELAND, B. J., VOGELSBERG, V., NEFF, N. H. AND HADJICONSTANTINOU, M.: Protein kinase C activators decrease dopamine uptake into striatal synaptosomes. J. Pharmacol. Exp. Ther. 277: 1527-1532, 1996.
6. COREY, J. L., DAVIDSON, N., LESTER, H. A., BRECHA, N. AND QUICK, M. W.: Protein kinase C modulates the activity of a cloned γ-aminobutyric acid transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporter. J. Biol. Chem. 269: 14759-14767, 1994.
7. DEFELICE, L. J. AND BLAKELY, R. D.: Pore models for transporters? Biophys. J. 70: 579-580, 1996.
8. ESHLEMAN, A. J., NEVE, R. L., JANOWSKY, A. AND NEVE, K. A.: Characterization of a recombinant human dopamine transporter in multiple cell lines. J. Pharmacol. Exp. Ther. 274: 276-283, 1995.
9. GIROS, B., EL MESTIKAWY, S., GODINOT, N., ZHENG, K., HAN, H., YANG-FENG, T. AND CARON, M. G.: Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Mol. Pharmacol. 42: 383-390, 1992.
10. GIROS, B., JABER, M., JONES, S. R., WIGHTMAN, R. M. AND CARON, M. G.: Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379: 606-612, 1996.
11. GOMEZA, J. CASADO, M., GIMENEZ, C. AND ARAGON, C.: Inhibition of high-affinity γ-aminobutyric acid uptake in primary astrocytes by phorbol esters and phospholipase C. Biochem. J. 275: 435-439, 1991.
12. GU, H., WALL, S. C. AND RUDNICK, G.: Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence. J. Biol. Chem. 269: 7124-7130, 1994.
13. +/glucose cotransporter expression by protein kinases in Xenopus laevis oocytes. J. Biol. Chem. 271: 14740-14746, 1996.
14. max. J. Neurochem. 68: 225-232, 1997.
15. 3H]Mazindol binding associated with neuronal dopamine and norepinephrine uptake sites. Mol. Pharmacol. 26: 35-44, 1984.
16. JAVITCH, J. A., D'AMATO, R. J., STRITTMATTER, S. M. AND SNYDER, S. H.: Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc. Natl. Acad. Sci. U.S.A. 82: 2173-2177, 1985.
17. JUNG, D. AND RICHTER, H. P.: Changes of alanine-sodium co-transport during maturation of Xenopus laevis oocytes. Cell Biol. Int. Rep. 7: 697-707, 1983.
18. KADOWAKI, K., HIROTA, K., KOIKE, K., OHMICHI, M., KIYAMA, H., MIYAKE, A. AND TANIZAWA, O.: Adenosine 3′,5′-cyclic monophosphate enhances dopamine accumulation in rat hypothalamic cell culture containing dopaminergic neurons. Neuroedocrinology 52: 256-261, 1990.
19. KILTY, J. E., LORANG, D. AND AMARA, S. G.: Cloning and expression of a cocaine-sensitive rat dopamine transporter. Science 54: 578-579, 1991.
20. KITAYAMA, S., DOHI, T. AND UHL, G. R.: Phorbol esters alter functions of the expressed dopamine transporter. Eur. J. Pharmacol. 268: 115-119, 1994.
21. KRUEGER, B. K.: Kinetics and block of dopamine uptake in synaptosomes from rat caudate nucleus. J. Neurochem. 55: 260-267, 1990.
22. LESTER, H. A., MAGER, S., QUICK, M. W. AND COREY, J. L.: Permeation properties of neurotransmitter transporters. Ann. Rev. Pharmacol. Toxicol. 34: 219-249, 1994.
23. LOO, D. D. F., HIRSCH, J. R., SARKAR, H. K. AND WRIGHT, E. M.: Regulation of the mouse retinal taurine transporter (TAUT) by protein kinases in Xenopus oocytes. FEBS Lett. 392: 250-254, 1996.
24. MCELVAIN, J. S. AND SCHENK, J. O.: A multisubstrate mechanism of striatal dopamine uptake and its inhibition by cocaine. Biochem. Pharmacol. 43: 2189-2199, 1992.
25. MELAMED, E., ROSENTHAL, J., COHEN, O., GLOBUS AND UZZAN, A.: Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP. Eur. J. Pharmacol. 116: 179-181, 1985.
26. NESTLER, E. J., HOPE, B. T. AND WIDNELL, K. L.: Drug addiction: A model for the molecular basis of neural plasticity. Neuron 11: 995-1006, 1993.
27. OSAWA, I., SAITO, N., KOGA, T. AND TANAKA, C.: Phorbol ester-induced inhibition of GABA uptake by synaptosomes and by Xenopus oocytes expressing GABA transporter (GAT1). Neurosci. Res. 19: 287-293, 1994.
28. PULVIRENTI, L. AND KOOB, G. F.: Dopamine receptor agonists, partial agonists and psychostimulant addiction. Trends Pharmacol. Sci. 15: 374-379, 1994.
29. QIAN, Y., GALLI, A., RAMAMOORTHY, S., RISSO, S., DEFLICE, L. J AND BLAKELY, R. D.: Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression. J. Neurosci. 17: 45-57, 1997.
30. RITZ, M. C., LAMB, R. J., GOLDBERG, S. R. AND KUHAR, M. J.: Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237: 1219-1223, 1987.
31. SATO, K., ADAMS, R., BETZ, H. AND SCHLOSS, P.: Modulation of a recombinant glycine transporter (GLYT1b) by activation of protein kinase C. J. Neurochem. 65: 1967-1973, 1995a.
32. SATO, K., BETZ, H. AND SCHLOSS, P.: The recombinant GABA transporter GAT1 is downregulated upon activation of protein kinase C. FEBS Lett. 375: 99-102, 1995B.
33. SHIMADA, S., KITAYAMA, S., LIN, C.-L., PATEL, A., NANTHAKUMAR, E., GREGOR, P., KUHAR, M. AND UHL, G.: Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA. Science 254: 576-578, 1991.
34. SONDERS, M. S. AND AMARA, S. G.: Channels in transporters. Curr. Opin. Neurobiol. 6: 294-302, 1996.
35. SONDERS, M. S., ZHU, S.-J., ZAHNISER, N. R., KAVANAUGH, M. P. AND AMARA, S. G.: Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants. J. Neurosci. 17: 960-974, 1997.
36. TIAN, Y., KAPATOS, G., GRANNEMAN, J. G. AND BANNON, M. J.: Dopamine and γ-aminobutyric acid transporters: Differential regulation by agents that promote phosphorylation. Neurosci. Lett. 173: 143-146, 1994.
37. TOULLEC, D., PIANETTI, P., COSTE, H., BELLEVERGUE, P., GRAND-PERRET, T., AJAKANE, M., BAUDET, V., BOISSIN, P., BOURSIER, E., LORIOLLE, F., DUHAME, L., CHARON, D. AND KIRILOVSKY, J.: The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266: 15771-15781, 1991.
38. USDIN, T. B., MEZEY E., CHEN, C., BROWNSTEIN, M. J. AND HOFFMAN, B. J.: Cloning of the cocaine-sensitive bovine dopamine transporter. Proc. Natl. Acad. Sci. U.S.A. 88: 11168-11171, 1991.
39. VANDENBERGH, D. J., PERSICO, A. M. AND UHL, G. R.: A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs. Mol. Brain Res. 15: 161-166, 1992.
40. +-ATPase in oocytes of Xenopus laevis. J. Membr. Biol. 118: 131-142, 1990.
41. WISE, R. A.: Addictive drugs and brain stimulation reward. Annu. Rev. Neurosci. 19: 319-340, 1996.
42. ZAMPIGHI, G., KREMAN, M., BOORER, K. J., LOO, D. D. F., BEZANILLA, F., CHANDY, G., HALL, J. E. AND WRIGHT, E. M.: A method for determining the unitary functional capacity of cloned channels and transporters expressed in Xenopus laevis oocytes. J. Membr. Biol. 148: 65-78, 1995.
43. ZHANG, L., COFFEY, L. L. AND REITH, M. E. A.: Regulation of the functional activity of the human dopamine transporter by protein kinase C. Biochem. Pharmacol. 53: 677-688, 1997.