Glutamate induces rapid upregulation of astrocyte glutamate transport and cell-surface expression of GLAST

Journal of Neuroscience

Volumn 19, Issue 23, 1999, Pages 10193-10200

  Duan, Shumin ^a   Anderson, Christopher M ^a   Stein, Becky A ^a   Swanson, Raymond A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VAMC   (United States)

Author keywords

Actin; Cytochalasin; EAAT1; EAAT2; GLAST; GLT 1; Glutamate uptake; Trafficking

Indexed keywords

ACTIN; GLUTAMATE TRANSPORTER; GLUTAMIC ACID;

ANIMAL CELL; ARTICLE; ASTROCYTE; BINDING AFFINITY; BIOTINYLATION; CELL SURFACE; CELL TRANSPORT; CONTROLLED STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 0033501641     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-23-10193.1999     Document Type: Article

References (53)

1. Arriza JL, Fairman WA, Wadiche JI, Murdoch GH, Kavanaugh MP, Amara SG (1994) Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci 14:5559-5569.
2. Bernstein EM, Quick MW (1999) Regulation of gamma-aminobutyric acid (GABA) transporters by extracellular GABA. J Biol Chem 274:889-895.
3. Blitzblau R, Gupta S, Djali S, Robinson MB, Rosenberg PA (1996) The glutamate transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical cultures. Eur J Neurosci 8:1840-1852.
4. Casado M, Bendahan A, Zafra F, Danbolt NC, Aragon C, Gimenez C, Kanner BI (1993) Phosphorylation and modulation of brain glutamate transporters by protein kinase C. J Biol Chem 268:27313-27317.
5. Clarke JF, Young PW, Yonezawa K, Kasuga M, Holman GD (1994) Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin. Biochem J 300:631-635.
6. Conradt M, Stoffel W (1997) Inhibition of the high-affinity brain glutamate transporter GLAST-1 via direct phosphorylation. J Neurochem 68:1244-1251.
7. Correale DM, Kalandadze A, Zelenaia O, Robinson MB (1998) Comparison of the regulation of cell surface expression of the GLT-1, GLAST, and EAAC1 subtypes of glutamate transporters. Soc Neurosci Abstr 24:2071.
8. Davis KE, Straff DJ, Weinstein EA, Bannerman PG, Correale DM, Rothstein JD, Robinson MB (1998) Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma. J Neurosci 18:2475-2485.
9. Diamond JS, Jahr CE (1997) Transporters buffer synaptically released glutamate on a submillisecond time scale. J Neurosci 17:4672-4687.
10. Dowd LA, Robinson MB (1996) Rapid stimulation of EAAC1-mediated Na+-dependent L-glutamate transport activity in C6 glioma cells by phorbol ester. J Neurochem 67:508-516.
11. Drejer J, Larsson OM, Schousboe A (1982) Characterization of L-glutamate uptake into and release from astrocytes and neurons cultured from different brain regions. Exp Brain Res 47:259-269.
12. Duan S, Farrell K, Guenza JK, Stein BA, Swanson RA (1998) Glutamate induces a rapid increase in glutamate uptake activity in mouse astrocyte cultures. Soc Neurosci Abstr 24:775.
13. Fonnum F (1984) Glutamate: a neurotransmitter in mammalian brain. J Neurochem 42:1-11.
14. Ganel R, Crosson CE (1998) Modulation of human glutamate transporter activity by phorbol ester. J Neurochem 70:993-1000.
15. Gegelashvili G, Civenni G, Racagni G, Danbolt NC, Schousboe I, Schousboe A (1996) Glutamate receptor agonists up-regulate glutamate transporter GLAST in astrocytes. NeuroReport 8:261-265.
16. Gegelashvili G, Schousboe A (1998) Cellular distribution and kinetic properties of high-affinity glutamate transporters. Brain Res Bull 45:233-238.
17. Grady EF, Bohm SK, Bunnett NW (1997) Turning off the signal: mechanisms that attenuate signaling by G protein-coupled receptors. Am J Physiol 273:G586-G601.
18. Hall A (1998) Rho GTPases and the actin cytoskeleton. Science 279:509-514.
19. Haugeto O, Ullensvang K, Levy LM, Chaudhry FA, Honore T, Nielsen M, Lehre KP, Danbolt NC (1996) Brain glutamate transporter proteins form homomultimers. J Biol Chem 271:27715-27722.
20. Harris EW, Stevens DR, Cotman CW (1987) Hippocampal cells primed with quisqualate are depolarized by AP4 and AP6, ligands for a putative glutamate uptake site. Brain Res 418:361-365.
21. Jordan MA, Wilson L (1998) Use of drugs to study role of microtubule assembly dynamics in living cells. Methods Enzymol 298:252-276.
22. Lagord C, Carpentier G, Moraczewski J, Pons G, Climent F, Martelly I (1993) Satellite cell myogenesis is highly stimulated by the kinase inhibitor iso-H7: comparison with HA1004 and staurosporine effects. Biochem Biophys Res Commun 191:928-936.
23. Lamaze C, Fujimoto LM, Yin HL, Schmid SL (1997) The actin cytoskeleton is required for receptor-mediated endocytosis in mammalian cells. J Biol Chem 272:20332-20335.
24. Lissin DV, Carroll RC, Nicoll RA, Malenka RC, Zastrow M (1999) Rapid, activation-induced redistribution of ionotropic glutamate receptors in cultured hippocampal neurons. J Neurosci 19:1263-1272.
25. MacLean-Fletcher S, Pollard TD (1980) Mechanism of action of cytochalasin B on actin. Cell 20:329-341.
26. McLennan H (1976) The autoradiographic localization of L-[3H]glutamate in rat brain tissue. Brain Res 115:139-144.
27. Mills JW, Mandel LJ (1994) Cytoskeletal regulation of membrane transport events. FASEB J 8:1161-1165.
28. Munir M, Correale DM, Lu L, Robinson MB (1998) Protein kinase C activation increases and N-methyl-D-aspartate (MNDA) receptor activation decreases cell surface expression of EAAC1 in neuron-enriched cultures. Soc Neurosci Abstr 24:2071.
29. Ohmori H, Toyama S, Toyama S (1992) Direct proof that the primary site of action of cytochalasin on cell motility processes is actin. J Cell Biol 16:933-941.
30. Otis TS, Wu YC, Trussell LO (1996) Delayed clearance of transmitter and the role of glutamate transporters at synapses with multiple release sites. J Neurosci 16:1634-1644.
31. Qian Y, Galli A, Ramamoorthy S, Risso S, DeFelice LJ, Blakely RD (1997) Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression. J Neurosci 17:45-57.
32. Quick MW, Corey JL, Davidson N, Lester HA (1997) Second messengers, trafficking-related proteins, and amino acid residues that contribute to the functional regulation of the rat brain GABA transporter GAT1. J Neurosci 17:2967-2979.
33. Ramamoorthy S, Blakely RD (1999) Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science 285:763-766.
34. Rampal AL, Pinkofsky HB, Jung CY (1980) Structure of cytochalasins and cytochalasin B binding sites in human erythrocyte membranes. Biochemistry 19:679-683.
35. Robinson MB, Dowd LA (1997) Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in the mammalian central nervous system. Adv Pharmacol 37:69-115.
36. Rothstein JD, Martin L, Levey AI, Dykes-Hoberg M, Jin L, Wu D, Nash N, Kuncl RW (1994) Localization of neuronal and glial glutamate transporters. Neuron 13:1-20.
37. Rothstein JD, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, Kuncl RW, Kanai Y, Hediger MA, Wang Y, Schielke JP, Welty DF (1996) Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16:675-686.
38. Sasaki T, Takai Y (1998) The Rho small G protein family-Rho GDI system as a temporal and spatial determinant for cytoskeletal control. Biochem Biophys Res Commun 245:641-645.
39. Schlag BD, Vondrasek JR, Munir M, Kalandadze A, Zelenaia OA, Rothstein JD, Robinson MB (1998) Regulation of the glial Na+-dependent glutamate transporters by cyclic AMP analogs and neurons. Mol Pharmacol 53:355-369.
40. Sensenbrenner M, Labourdette G, Delaunoy JP, Pettmann B, Devilliers G, Moonen G, Bock E (1980) Morphological and biochemical differentiation of glial cells in primary culture. In: Tissue culture in neurobiology (Giacobini E, ed), pp 385-395. New York: Raven.
41. Swanson RA, Seid LL (1998) Barbiturates impair astrocyte glutamate uptake. Glia 24:365-371.
42. Swanson RA, Liu J, Miller JW, Rothstein JD, Farrell K, Stein BA, Longuemare MC (1997) Neuronal regulation of glutamate transporter subtype expression in astrocytes. J Neurosci 17:932-940.
43. Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, Iwama H, Nishikawa T, Ichihara N, Kikuchi T, Okuyama S, Kawashima N, Hori S, Takimoto M, Wada K (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276:1699-1702.
44. Tong G, Jahr CE (1994) Block of glutamate transporters potentiates postsynaptic excitation. Neuron 13:1195-1203.
45. Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F (1991) The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266:15771-15781.
46. Trotti D, Rizzini BL, Rossi D, Haugeto O, Racagni G, Danbolt NC, Volterra A (1997) Neuronal and glial glutamate transporters possess an SH-based redox regulatory mechanism. Eur J Neurosci 9:1236-1243.
47. Tsakiridis T, Vranic M, Klip A (1994) Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane. J Biol Chem 269:29934-29942.
48. Vandenberg RJ, Mitrovic AD, Johnston GA (1998) Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions. Mol Pharmacol 54:189-196.
49. Wang Q, Bilan PJ, Tsakiridis T, Hinek A, Klip A (1998) Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes. Biochem J 331:917-928.
50. Watase K, Hashimoto K, Kano M, Yamada K, Watanabe M, Inoue Y, Okuyama S, Sakagawa T, Ogawa S, Kawashima N, Hori S, Takimoto M, Wada K, Tanaka K (1998) Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur J Neurosci 10:976-988.
51. Ye ZC, Sontheimer H (1998) Stereospecific transport of trans-ACPD and its impact on intracellular glutamate levels in astrocytes. Soc Neurosci Abstr 24:2070.
52. Ye ZC, Sontheimer H (1999) Metabotropic glutamate receptor agonists reduce glutamate release from cultured astrocytes. Glia 25:270-281.
53. Zerangue N, Arriza JL, Amara SG, Kavanaugh MP (1995) Differential modulation of human glutamate transporter subtypes by arachidonic acid. J Biol Chem 270:6433-6435.