Effect of a new immunosuppressive agent, FTY720, on survival of islet allografts

Cell Transplantation

Volumn 7, Issue 4, 1998, Pages 403-406

  Yamasaki, Toru ^a   Inoue, Kazutomo ^b   Hayashi, Hiroyuki ^a   Gu, Yuanjun ^b   Setoyama, Hiroshi ^a   Ida, Jun ^a   Cui, Wanxing ^a   Kawakami, Yoshiyuki ^a   Kogire, Masafumi ^a   Imamura, Masayuki ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

FTY720; Immumosuppressant; Islet transplantation; T cell

Indexed keywords

FINGOLIMOD; GLUCOSE; IMMUNOSUPPRESSIVE AGENT; STREPTOZOCIN;

ALLOGRAFT; ALLOTRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GRAFT SURVIVAL; HYPERGLYCEMIA; IMMUNOSUPPRESSIVE TREATMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PANCREAS ISLET TRANSPLANTATION; PORTAL VEIN; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD GLUCOSE; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE AGENTS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; PROPYLENE GLYCOLS; RATS; RATS, INBRED LEW; SPHINGOSINE;

EID: 13144279335     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0963-6897(98)00021-9     Document Type: Article

References (23)

1. Adachi, K.; Kohara, T.; Nakao, N.; Arita, M.; Chiba, K.; Mishima, T.; Sasaki, S.; Fujita, T. Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720. Bioorg. Med. Chem. 5:853-856; 1995.
2. Benhamou, P.Y.; Watt, P.C.; Mullen, Y.; Ingles, S.; Watanabe, Y.; Nomura, Y.; Hober, C.; Miyamoto, M.; Kenmochi, T.; Passaro, E.P.; Zinner, M.J.; Brunicardi, F.C. Human islet isolation in 104 consecutive cases. Transplantation 57:1804-1810; 1994.
3. Calne, R.Y.; White, D.J. The use of cyclosporin A in clinical organ grafting. Ann. Surg. 196:330-337; 1982.
4. Chiba, K.; Hoshino, Y.; Suzuki, C.; Masubuchi, Y.; Yanagawa, Y.; Ohtsuki, M.; Sasaki, S.; Fujita, T. FTY720, a novel immunosuppressant possessing unique mechanisms. I. Prolongation of skin allograft survival and synergistic effect in combination with cyclosporine in rats. Transplant. Proc. 28:1056-1059; 1996.
5. Enosawa, S.; Suzuki, S.; Kakefuda, T.; Li, X.; Amemiya, H. Induction of selective cell death targeting on mature T-lymphocytes in rats by a novel immunosuppressant, FTY720. Immunopharmacology 34:171-179; 1996.
6. Federlin, K.F.; Hering, B.; Bretzel, R.G. Islet transplantation: Clinical and experimental. Horm. Metab. Res. Suppl. 26:148-151; 1992.
7. Federlin, K.F. Islet transplantation. Exp. Clin. Endocrinol. 101:334-345; 1993.
8. Fujita, T.; Yoneta, M.; Hirose, R.; Inoue, K.; Kiuchi, M.; Hirase, S.; Adachi, K.; Arita, M.; Chiba, K. Simple compounds, 2-alkyl-2-amino-1,3-propanediols, have potent immunosuppressive activity. Bioorg. Med. Chem. 5:847-852; 1995.
9. Hoshino, Y.; Suzuki, C.; Ohtsuki, M.; Masubuchi, Y.; Amano, Y.; Chiba, K. FTY720, a novel immunosuppressant possessing unique mechanisms. II. Long-term graft survival induction in rat heterotopic cardiac allografts and synergistic effect in combination with cyclosporine A. Transplant. Proc. 28:1060-1061; 1996.
10. Islet Transplant Registry 4; 1994.
11. Islet Transplant Registry 5; 1995.
12. Islet Transplant Registry 6; 1996.
13. Jaeger, C.; Hering, B.J. Islet cell antibodies and glutamic acid decarboxylase antibodies in patients with insulin dependent diabetes mellitus undergoing kidney and islet-after-kidney transplantation. Transplantation 62:424-426; 1996.
14. Lennard, L.; Murphy, M.F.; Maddocks, J.L. Severe megaloblastic anaemia with abnormal azathioprine metabolism. Br. J. Clin. Pharmacol. 17:171-172; 1984.
15. Min, D.I.; Monaco, A.P. Complications associated with immunosuppressive therapy and their management. Pharmacotherapy 11:119S-125S; 1991.
16. Ochiai, T.; Nakajima, K.; Nagata, M.; Hori, S.; Asano, T.; Isono, K. Studies of the induction and maintenance of long term graft acceptance by treatment with FK506 in heterotopic cardiac allotransplantation in rats. Transplantation 44:734-738; 1987.
17. Ricordi, C.; Tzakis, A.G.; Carroll, P.B.; Zeng, Y.; Rilo, H.L.R.; Alejandro, R.; Shapiro, R.; Fung, J.J.; Demetris, A.J.; Mintz, D.H.; Starzl, T.E. Human islet isolation and allotransplantation in 22 consecutive cases. Transplantation 53:407-414; 1992.
18. Sutherland, D.E.R.; Gruessner, A. Pancreas transplantation in the United States as reported to the United Network for Organ Sharing and analyzed by the International Pancreas Transplant Registry. Clin. Transplant. 9:49-67; 1995.
19. Suzuki, S.; Enosawa, S.; Kakefuda, T.; Shinomiya, T.; Amari, M.; Naoe, S.; Hoshino, Y.; Chiba, K. A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation. Transplantation 61:200-205; 1996.
20. Suzuki, S.; Enosawa, S.; Kakefuda, T.; Amemiya, H.; Hoshino, Y.; Chiba, K. Long-term graft acceptance in allografted rats and dogs by treatment with a novel immunosuppressant, FTY720. Transplant. Proc. 28:1375-1376; 1996.
21. Suzuki, S.; Enosawa, S.; Kakefuda, T.; Li, X.; Mitsusada, M.; Takahara, S.; Amemiya, H. Immunosuppressive effect of a new drug, FTY720, on lymphocyte responses in vitro and cardiac allograft survival in rats. Transpl. Immunol. 4:252-255; 1996.
22. Todo, S.; Ueda, Y.; Demetris, J.A.; Imventarza, O.; Nalesnik, M.; Venkataramanan, R.; Makowka, L.; Starzl, T.E. Immunosuppression of canine, monkey, and baboon allografts by FK506. Surgery 104:239-249; 1988.
23. Vargas, F.; Vives-Pi, M.; Somoza, N.; Alcalde, L.; Armengol, P.; Marti, M.; Serradell, L.; Costa, M.; Fernandez-Llamazares, J.; Sanmarti, A.; Pujol-Borrell, R.; Advantages of using a cell separator and metrizamide gradients for human islet purification. Transplantation 61:1562-1566; 1996.