Hypersensitivity to DNA damage leads to increased apoptosis during early mouse development

Genes and Development

Volumn 14, Issue 16, 2000, Pages 2072-2084

  Heyer, B S ^a   Macauley, A ^a   Behrendtsen, O ^a   Werb, Z ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Atm; DNA damage; Embryo; Gastrulation; Irradiation; p53; Primordial germ cells

Indexed keywords

PROTEIN P53;

APOPTOSIS; ARTICLE; BLASTOCYST; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; FEMALE; GASTRULATION; GENOTOXICITY; IONIZING RADIATION; MOUSE; NONHUMAN; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION RESPONSE;

ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINEAGE; DNA DAMAGE; DNA PRIMERS; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; GASTRULA; MICE; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0034663872     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage
2. High-frequency developmental abnormalities in p53-deficient mice
3. Enhanced phosphorylation of p53 by ATM in response to DNA damage
4. Atm-deficient mice: A paradigm of ataxia telangiectasia
5. Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways
6. Metalloproteinases regulate parietal endoderm differentiating and migrating in cultured mouse embryos
7. The SCID mouse mutant: Definition, characterization, and potential uses
8. Developmental effects of X-irradiation of early Drosophila embryos
9. p53-Dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells
10. Signals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo
11. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
12. Analysis of mouse Evx genes: Evx-1 displays graded expression in the primitive streak
13. A matter of life and cell death
14. Amphibian micronucleus test(s): A simple and reliable method for evaluating in vivo genotoxic effects of freshwater pollutants and radiations
15. The complexity of p53 modulation: Emerging patterns from divergent signals
16. Primordial germ cells in the mouse embryo during gastrulation
17. Transgenic mouse model for studying the transcriptional activity of the p53 protein: Age- and tissue-dependent changes in radiation-induced activation dur ing embryogenesis
18. The tumor suppressor gene Brcal is required for embryonic cellular proliferation in the mouse
19. Expression of the fibroblast growth factor-5 gene in the mouse embryo
20. mRNA localization studies suggest that routine FGF-5 plays a role in gastrulation
21. Expression pattern of Brachyury gene in whole-mount Twis/Twis mutant embryos
22. Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
23. X-ray inactivation of Caenorhabditis elegans embryos or larvae
24. Tumor spectrum analysis in p53-mutant mice
25. Splitting the ATM: Distinct repair and checkpoint defects in ataxia-telangiectasia
26. DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage
27. A mammalian checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
28. p53: Puzzle and paradigm
29. Clonal analysis of the origin of primordial germ cells in the mouse
30. p53, The cellular gatekeeper for growth and division
31. A mutation in mouse rad51 resuits in an early embryonic lethal that is suppressed by a mutation in p53
32. Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
33. A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity
34. Characterization of the unusually rapid cell cycles during rat gastrulation
35. Apoptosis in mouse embryos: Elevated levels in pregastrulae and in the distal anterior region of gastrulae of normal and mutant mice
36. Signaling for germ cells
37. Signaling to p53: Breaking the MDM2-p53 circuit
38. The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo
39. An analysis of the changing radiation response of the developing mouse embryo
40. Regulation of ES cell differentiation by functional and conformational modulation of p53
41. Patterns of cell death during gastrulation in chick and mouse embryos
42. Role of the INK4a locus in tumor suppression and cell mortality
43. Tumor surveillance via the ARF-p53 pathway
44. The Drosophila Atm homologue Mei-41 has an essential checkpoint function at midblastula transition
45. The DNA-dependent protein kinase
46. Gastrulation in the mouse: Growth and regionalisation of the epiblast
47. Cell cycle analysis in the mouse egg-cylinder
48. Biological effects of prenatal irradiation
49. Brca2 is required for embryonic cellular proliferation in the mouse
50. Cellular responses to DNA damage
51. DNA damage produced by ionizing radiation in mammalian cells: Identities, mechanisms of formation, and reparability
52. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
53. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma