Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes

EMBO Journal

Volumn 17, Issue 9, 1998, Pages 2554-2565

  Okada, Shuichi ^a   Matsuda, Michiyuki ^b   Anafi, Mordechai ^c   Pawson, Tony ^c   Pessin, Jeffrey E ^a  

^a UNIVERSITY OF IOWA   (United States)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

C3G; CrkII; Insulin; Rap1; Ras

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; HUMAN INSULIN; HYBRID PROTEIN; INSULIN; PHOSPHOTRANSFERASE; RAS PROTEIN; RHEUMATOID ARTHRITIS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; COMPLEX FORMATION; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CHO CELLS; CRICETINAE; GLUTATHIONE TRANSFERASE; GRB2 ADAPTOR PROTEIN; GTP-BINDING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE TRIPHOSPHATE; HUMANS; INSULIN; KINETICS; PROTEIN KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CRK; PROTO-ONCOGENE PROTEINS C-RAF; RAP GTP-BINDING PROTEINS; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; RAS PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, INSULIN; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TRANSFECTION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0032080085     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.9.2554     Document Type: Article

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