A T helper cell 2 (Th2) immune response against non-self antigens modifies the cytokine profile of autoimmune T cells and protects against experimental allergic encephalomyelitis

Journal of Experimental Medicine

Volumn 185, Issue 5, 1997, Pages 901-907

  Falcone, Marika ^a,b   Bloom, Barry R ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; INTERLEUKIN 12; INTERLEUKIN 4; MYELIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; CELL CLONE; CONTROLLED STUDY; DIAGNOSIS; ETIOLOGY; FEMALE; HELPER CELL; IMMUNOCOMPETENT CELL; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; ANTIGENS; AUTOIMMUNITY; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; HEMOCYANIN; INTERFERON TYPE II; INTERLEUKIN-4; MICE; MICE, INBRED STRAINS; T-LYMPHOCYTES; TH2 CELLS;

EID: 0030941082     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.5.901     Document Type: Article

References (41)

1. Ben-Nun, A., H. Wekerle, and I.R. Cohen. 1981. The rapid isolation of clonable antigen-specific T lymphocytes lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol. 11:195-199.
2. Pettinelli, C.B., R.B. Fritz, C.H.J. Chau, and D.E. McFarlin. 1982. Encephalitogenic activity of guinea pig myelin basic protein in the SJL/J mouse. J. Immunol. 129:1209-1211.
3. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today. 1:34-38.
4. Miller, S.D., and W.J. Karpus. 1994. The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases. Immunol. Today, 8:356-361.
5. Chen, Y., V.K. Kuchroo, J. Inobe, D.A. Hafler, and H.L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science (Wash. DC). 265:1237-1240.
6. Racke, M.K., A. Bonomo, D.E. Scott, B. Cannella, A. Levine, C.S. Raine, E.M. Shevach, and M. Rocken. 1994. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 180:1961-1966.
7. Van der Veen, R.C., and S.A. Stohlman. 1993. Encephalitogenic Th1 cells are inhibited by Th2 cells with related peptide specificity: relative roles of interleukin (IL)-4 and IL-10. J. Neuroimmunol. 48:213-220.
8. Miller, A., A. Al-Sabbagh, L.M.B. Santos, M. Prabhu-Das, and H.L. Weiner. 1993. Epitopes of myelin basic protein that trigger TGF-b release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven by-stander suppression. J. Immunol. 151:7307-7315.
9. Lafaille, J.J., K. Nagashima, M. Katsuki, and S. Tonegawa. 1994. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell. 78:399-408.
10. Governman, J., A. Woods, L. Larson, L.P. Weiner, L. Hood, and D.M. Zaller. 1993. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell. 72:551-560.
11. Oldstone, M.B.A. 1989. Overview: Infectious agents as etiologic triggers of autoimmune disease. Curr. Top. Microbiol. Immunol. 145:1-3.
12. Yang, X.-D., and U. Feige. 1992. Heat shock proteins in autoimmune diseases. From causative antigen to specific therapy? Experientia (Basel). 48:650-656.
13. van den Broek, M.F., E.J.M. Hogervorst, M.C.J. van Bruggen, W. van Eden, R. van der Zee, and W.B. van den Berg. 1989. Protection against streptococcal cell wall-induced arthritis by pretreatment with the 65-kD mycobacterial heat shock proteins. J. Exp. Med. 170:449-466.
14. Billingham, M.E.J., S. Carney, R. Butler, and M.J. Colston. 1990. A mycobacterial heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic. J. Exp. Med. 171:339-344.
15. Elias, D., D. Markovits, T. Reshef, R. van der Zee, and I.R. Cohen. 1990. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc. Natl. Acad. Sci. USA. 87:1576-1580.
16. Elias, D., T. Reshef, O.S. Birk, R. van der Zee, M.D. Walker, and I.R. Cohen. 1991. Vaccination against autoimmune mouse diabetes with a T cell epitope of the human 65-kDa heat-shock protein. Proc. Natl. Acad. Sci. USA. 88:3088-3091.
17. Hempel, K., A. Freitag, B. Freitag, B. Endres, B. Mai, and G. Liebaldt. 1985. Unresponsiveness to experimental allergic encephalomyelitis in Lewis rats pretreated with complete Freund's adjuvant. Int. Arch. Allerg. Appl. Immunol. 76:193-199.
18. Lehmann, D., and A. Ben-Nun. 1992. Bacterial agents pro tect against autoimmune disease. I. Mice pre-exposed to Bordetella pertussis or Mycobacterium tuberculosis are highly refractory to induction of experimental autoimmune encephalomyelitis. J. Autoimmun, 5:675-690.
19. Fiori, P., G. Ristori, C. Buttinelli, M. Falcone, A. Cacciani, S. Di Giovanni, C. Pozzilli, and M. Salvetti. 1996. Down-regulation of cell-surface CD4 coreceptor expression and modulation of experimental allergic encephalomyelitis. Int. Immunol In press.
20. Ben-Nun, A., S. Yossefi, and D. Lehmann. 1993. Protection against autoimmune disease by bacterial agents. II. PPD and pertussis toxin as proteins active in protecting mice against experimental autoimmune encephalomyelitis. Eur. J. Immunol. 23:689-696.
21. Ben-Nun, A., I. Mendel, G. Sappier, and N. Kerlero de Rosbo. 1995. A 12-kDa protein of Mycobacterium tuberculosis protects mice against experimental autoimmune encephalomyelitis. J. Immunol. 154:2939-2948.
22. Norton, W.T., and S.E. Poduslo. 1973. Myelin in rat brain: method of myelin isolation. J. Neurochem. 21:749-757.
23. Merrill, J.E., D.H. Kono, J. Clayton, D.G. Ando, D.R. Hinton, and F.M. Hofman. 1992. Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice. Proc. Natl. Acad. Sci. USA. 89:574-578.
24. Leonard, J.P., K.E. Waldburger, and S.J. Goldman. 1995. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin-12. J. Exp. Med. 181:381-386.
25. Taguchi, T., J.R. McGhee, R.L. Coffman, K.W. Beagley, J.H. Eldridge, K. Takatsu, and H. Kiyono. 1990. Detection of individual mouse splenic T cells producing IFN-γ and IL-5 using the enzyme-linked immunospot (ELISPOT) assay. J. Immunol. Methods. 128:65-73.
26. Reiner, S.L., S. Zheng, D.B. Corry, and R.M. Locksley. 1993. Constructing polycompetitor cDNA for quantitative. PCR. J. Immunol. Methods. 165:37-46.
27. deKruyff, R.H., Y. Fang, S.F. Wolf, and D.T. Umetsu. 1995. IL-12 inhibits IL-4 synthesis in keyhole limpet heniocyaninprimed CD4+ T cells through an effect on antigen-presenting cells. J. Immunol. 154:2578-2587.
28. Kurtzke, J.F. 1983. Epidemiology of MS. In Multiple Sclerosis. J.F. Hallpike, C.W.M. Adams, and W.E. Tourtellote, editors. Williams and Wilkins, Baltimore, MD. 49-95.
29. Ebers, G.C., D.E. Bulman, A.D. Sadovnick, D.W. Paty, S. Warren, W. Hader, T.J. Murray, T.P. Seland, P. Duquette, T. Grey et al. 1986. A population based study of MS in twins. N. Engl. Med. 315:1638-1642.
30. Oldstone, M.B.A. 1987. Molecular mimicry and autoim mune disease. Cell. 50:819-820.
31. Wucherpfennig, K.W., and J.L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 80:695-705.
32. Brocke, S., T. Veromaa, I. Weissman, K. Gijbels, and L. Steinman, 1994. Infections and multiple sclerosis: A possible role for superantigens? Trends Microbiol. 2:250-254.
33. Miller, A., O. Lider, and H.L. Weiner. 1991. Antigen-driven bystander suppression after oral administration of antigens. J. Exp. Med. 174:791-798.
34. Saoudi, A., S. Simmonds, I. Huitinga, and D. Mason. 1995. Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells. J. Exp. Med. 182:335-344.
35. Windhagen, A., C. Scholz, P. Hollsberg, H. Fukaura, A. Sette, and D.A. Hafler. 1995. Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity. 2:373-380.
36. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091-1098.
37. Pearlman, E., J.W. Kazura, F.E. Hazlett, and W.H. Boom. 1993. Modulation of murine cytokine responses to mycobacterial antigens by helminth-induced T helper 2 cell responses. J. Immunol. 151:4857-4864.
38. Kullberg, M.C., E.J. Pearce, S.E. Hieny, A. Sher, and J.A. Berzofsky. 1992. Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen. J. Immunol. 148:3264-3270.
39. + cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance. Proc. Natl. Acad. Sci. USA. 90:948-952.
40. Curry, A.J., K.J. Else, F. Jones, A. Bancroft, R.K. Grencis, and D.W. Dunne. 1995. Evidence that cytokine-mediated immune interactions induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris. J. Exp. Med. 181:769-774.
41. Forsthuber, T., H.C. Yip, and P.V. Lehmann. 1996. Induction of Th1 and Th2 immunity in neonatal mice. Science (Wash. DC). 271:1728-1730.