Persistence of physiological self antigen is required for the regulation of self tolerance

Journal of Immunology

Volumn 164, Issue 8, 2000, Pages 3982-3989

  Garza, Kristine M ^a,c   Agersborg, Sally S ^a   Baker, Elizabeth ^b   Tung, Kenneth S K ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN ZP3; AUTOANTIGEN; UNCLASSIFIED DRUG;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; FEMALE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; MALE; NONHUMAN; ONTOGENY; OVARIECTOMY; PRENATAL EXPOSURE; PRIORITY JOURNAL; SEX DIFFERENCE;

EID: 0034655277     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.8.3982     Document Type: Article

References (59)

1. Lopez-Guerrero, J. A., J. P. Lopez-Bote, M. A. Ortiz, R. S. Gupta, E. Paez, and C. Bernaheu. 1993. Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein, Infect. Immun. 61:.4225.
2. Ohashi, P. S., S. Gehen, K. Buerki, H. Pircher, C. T. Ohashi, B. Odermatt, B. Malissen, R. M. Zinkemagel, and H. Hengartner. 1991. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65:305.
3. Morahan, G., J. Allison, and J. F. A. P. Miller. 1989. Tolerance of class I histocompatibility antigens expressed extrathymically. Nature 339:622.
4. Burkly, L. C., D. Lo, and R. A. Flavell. 1990. Tolerance in transgenic mice expressing major histocompatibility molecules extrathymically on pancreatic cells. Science 248:1364.
5. Schonrich, G., U. Kalinke, F. Momburg, M. Malissen, A.-M. Schmitt-Verhulst, B. Malissen, G. J. Hammerling, and B. Arnold. 1991. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 65:293.
6. Lafaille, J. J., H. Van de Keere, A. L. Hsu, J. L. Baron, W. Haas, C. S. Raine, and S. Tonegawa. 1997. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from disease. J. Exp. Med. 186:307.
7. Goverman, J., A. Woods, W. Larson, L. Hood, and D. M. Zaller. 1993. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72:551.
8. + T cell-mediated spontaneous diabetes in neonatal mice. J. Immunol. 157:978.
9. Billingham, R. E., L. Brent, and P. B. Medawar. 1953. Actively acquired tolerance of foreign cells. Nature 172:603.
10. Barnett, L. A., J. L. Whitton, Y. Wada, and R. S. Fujinami. 1993. Enhancement of autoimmune disease using recombinant vaccinia virus encoding myelin proleolipid protein. J. Neuroimm. 44:15.
11. Qin, Y., D. Sun, M. Goto, R. Meyermann, and H. Wekerle. 1989. Resistance to experimental autoimmune encephalomyelitis induced by neonatal tolerization to myelin basic protein: clonal elimination vs. regulation of autoaggressive lymphocytes. Eur. J. Immunol. 19:373.
12. Clayton, J. P., C. Gammon, D. G. Ando, D. H. Kono, L. Hood, and E. E. Sercarz. 1989. Peptide-specific prevention of experimental allergic encephalomyelitis: neonatal tolerance induced to the dominant T cell determinant of myelin basic protein. J. Exp. Med. 169:1681.
13. Forsthuber, T., H. C. Yip, and P. V. Lehmann. 1996, Induction of Th1 and Th2 immunity in neonatal mice. Science 271:1728.
14. Singh, R. R., B. H. Hahn, and E. E. Sercarz. 1996. Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs T cell-mediated autoimmunity. J. Exp. Med. 183:1613.
15. Garza, K. M., N. D. Griggs, and K. S. K. Tung. 1997. Neonatal injection of an ovarian peptide induces autoimmune ovarian disease in female mice: requirement of endogenous neonatal ovaries. Immunity 6:89.
16. Rhim, S. H., S. E. Millar, F. Robey, J. Dean, P. M. Allen, T. Yule, A.-M. Luo, Y.-H. Lou, and K. S. K. Tung. 1992. Autoimmune disease of the ovary induced by a ZP3 peptide from the murine zona pellucida. J. Clin. Invest. 89:28.
17. Bagavant, H., S. Adams, P. Terranova, A. Chang, F. W. Kraemer, Y.-H. Lou, K. Kasai, A.-M. Luo, and K. S. K. Tung. 1999. Autoimmune ovarian inflammation triggered by proinflammaiory (Th1) T cells is compatible with normal ovarian function. Biol. Reprod. 61:635.
18. 2 production as a sensitive and rapid assay for the quantitation of murine IFN-γ. J. Immunol. Methods 139:107.
19. Ringuette, M. J., D. A. Sobieski, S. M. Charow, and J. Dean. 1986. Oocyte-specific gene expression: molecular characterization of a cDNA coding for ZP-3, the sperm receptor of mouse zona pellucida. Proc. Natl. Acad. Sci. USA 83:4341.
20. Lira, S. A., R. A. Kinlock, S. Mortillo, and P. M. Wassarman. 1990. An upstream region of the mouse ZP3 gene directs expression of firefly luciferase specifically to growing oocytes in transgenic mice. Proc. Natl. Acad. Sci. USA 87:7215.
21. Siteri, P. K., L. A. Jones, J. Boubinian, and N. Talal. 1980. Sex steroids and the immune system. I. Sex differences in autoimmune disease in NZB/NZW hybrid mice. J. Steroid Biochem. 12:425.
22. Lahita, R. G. 1985. Sex steroids and the rheumatoid diseases. Arthritis Rheum. 28:121.
23. Grossman, C. 1989. Possible underlying mechanisms of sexual dimorphism in the immune response: fact and hypothesis. J. Steroid Biochem. 34:241.
24. Smith, E. M., and M. J. Ebaugh. 1996. Neuroimmunoendocrinology and sexual dimorphism of the immune response. In Reproductive Immunology. R. A. Bronson, N. J. Alexander, D. J. Anderson, D. W. Branch, and W. H. Kutteh, eds. Blackwell. Cambridge, p 103.
25. Ishimaru, N., K. Saegusa, K. Yanagi, N. Haneji, I. Saito, and Y. Hayashi. 1999. Estrogen deficiency accelerates autoimmune exocrinopathy in murine Sjogren's syndrome through Fas-mediated apoptosis. Am. J. Pathol. 155:173.
26. Harrington, C. J., A. Paez, T. Hunkapiller, V. Mannikko, T. Brabb, M. Ahearn, C. Beeson, and J. Goverman. 1998. Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein. Immunity 5:571.
27. Medawar, P. B., and S. Woodruf. 1958. The induction of tolerance by skin homografts on newborn rats. Immunology 1:27.
28. Billingham, R. E., and T. Silvers. 1960. Studies on tolerance of the Y chromosome antigen in mice. J. Immunol. 85:14.
29. + T cells. J. Exp. Med 177:1587.
30. Hamano, K., M. A. Rawsthorne, A. R. Bushell, P. J. Morris, and K. J. Wood. 1996. Evidence that the continued presence of the organ graft and not peripheral donor microchimerism is essential for maintenance of tolerance to alloantigen in vivo in anti-CD4 treated recipients. Transplantation 62:380.
31. 1 donor cells. Transplant. Proc. 27:188.
32. Waters, C. A., L. Pilarski, T. G. Wegmann, and E. Diener. 1979. Tolerance induction during ontogeny. I. Presence of active suppression in mice rendered tolerant to human gamma-globulin in utero correlates with the breakdown of the tolerant state. J. Exp. Med. 149:1134.
33. Rocha, S., P. Tanchot, and H. von Boehmer. 1993. Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J. Exp. Med. 177:1517.
34. Aichele, P., K. Brduscha-Hiem, R. M. Zinkernagel, H. Hengartner, and H. Pircher. 1995. T cell priming versus T cell tolerance induced by synthetic peptides. J. Exp. Med. 182:261.
35. Jamieson, B. D., and R. Ahmed. 1988. T-cell tolerance: exposure to virus in utero does not cause a permanent deletion of specific T cells. Proc. Natl Acad. Sci. USA 85:2265.
36. Morecki, S., B. Leshem, A. Eid, and S. Slavin. 1987. Alloantigen persistence in induction and maintenance of transplantation tolerance. J. Exp. Med. 165:1468.
37. Ramsdell, F., and B. J. Fowlkes. 1992. Maintenance of in vivo tolerance by persistence of antigen. Science 257:1130.
38. Alferink, J., B. Schittek, G. Schonrich, G. J. Hammerling, and B. Arnold. 1994. Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance. Int. Immunol. 7:331.
39. Triplett, E. L. 1962. On the mechanism of immunological self recognition. J. Immunol. 89:505.
40. Eishi, Y., and P. McCullagh. 1988. Acquisition of immunological self-recognition by the fetal rat. Immunology 64:319.
41. McCullagh, P. 1989. Interception of the development of self tolerance in fetal lambs. Eur. J. Immunol. 19:1387.
42. Adams, T. E., S. Alpert, and D. Hanahan. 1987. Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells. Nature 325:223.
43. Soldevila, G., T. Geiger, and R. A. Flavell. 1995. Breaking immunological ignorance to an antigenic peptide of simian virus 40 large T antigen. J. Immunol. 155:5590.
44. Geiger, T., L. R. Gooding, and R. A. Flavell. 1992. T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice. Proc. Natl. Acad. Sci. USA 89:2985.
45. Ridge, J. P., E. J. Fuchs, and P. Matzinger. 1996, Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science 271:1723.
46. Sarzotti, M., D. S. Robbins, and M. P. Huffman. 1996. Induction of protective CTL responses in newborn mice by a murine retrovirus. Science 271:1726.
47. Kearney, E. R., K. A. Paper, D. Y. Loh, and M. K. Jenkins. 1994. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1:327.
48. + T cells. J. Exp. Med. 186:239.
49. Taguchi, O., K. Kontani, H. Ikeda, M. Takeuchi, M. Takahashi, and H. Takahashi. 1994. Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens. Immunology 82:365.
50. Seddon, B., and D. Mason. 1999. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J. Exp. Med 189:877.
51. Tung, K. S. K., Y.-H. Lou, K. M. Garza, and C. Teuscher. 1997. Autoimmune ovarian disease: mechanism of disease induction and prevention. Curr. Opin. Immunol. 9:839.
52. Sakaguchi, S., K. Fukuma, K. Kuribayashi, and T. Masuda. 1985. Organ-specific autoimmune disease induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance: deficit of a T cell subset as a possible cause of autoimmune disease. J. Exp. Med. 161:72.
53. Smith, H., Y. Sakamoto, K. Kasai, and K. S. K. Tung. 1991. Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy. J. Immunol. 147:2928.
54. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cell expressing IL-2 receptor α-chain [CD25]: breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151.
55. + cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160: 1212.
56. Sakaguchi, S., H. Takahashi, and Y. Nishizuka. 1982. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal mice for the prevention of oophoritis. J. Exp. Med. 156:1577.
57. Smith, H., Y.-H. Lou, P. Lacy, and K. S. K. Tung. 1992. Tolerance mechanism in ovarian and gastric autoimmune disease. J. Immunol. 149:2212.
58. Taguchi, O., and Y. Nishizuka. 1987. Self tolerance and localized autoimmunity: mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance. J. Exp. Med. 165:146.
59. Garza, K. M., and K. S. K. Tung 1995. Frequency of molecular mimicry among T cell peptides as the basis for autoimmune disease and autoantibody induction. J. Immunol. 155:5444.