Probing the active site of cytochrome P450 2B1: Metabolism of 7- alkoxycoumarins by the wild type and five site-directed mutants

Biochemistry

Volumn 37, Issue 19, 1998, Pages 6679-6688

  Kobayashi, Yasuna ^a,b   Fang, Xiaojun ^a,c   Szklarz, Grazyna D ^a   Halpert, James R ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b SHOWA UNIVERSITY   (Japan)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHOXYCOUMARIN; CYTOCHROME P450;

ARTICLE; DEALKYLATION; ENZYME ACTIVE SITE; ENZYME METABOLISM; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION;

7-ALKOXYCOUMARIN O-DEALKYLASE; ALANINE; ANIMALS; BENZOFLAVONES; BINDING SITES; COUMARINS; CYTOCHROME P-450 CYP2B1; DEALKYLATION; ESCHERICHIA COLI; LEUCINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OXAZINES; OXIDATION-REDUCTION; RATS; VALINE;

ESCHERICHIA COLI;

EID: 0032510766     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9731450     Document Type: Article

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