Transgenic expression of Ly-49A in thymocytes alters repertoire selection

Journal of Immunology

Volumn 164, Issue 2, 2000, Pages 884-892

  Pauza, Mary ^a   Smith, Kathleen M ^b   Neal, Heather ^a   Reilly, Christina ^a   Lanier, Lewis L ^b   Lo, David ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; MEMBRANE PROTEIN LY49A; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SELECTION; CONTROLLED STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMOCYTE; TRANSGENIC MOUSE;

EID: 0034650693     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.2.884     Document Type: Article

References (47)

1. + T cells. Immunity 3:79.
2. + T cell responses to isolated antigenic class II proteins by fibronectin and intercellular adhesion molecule-1. J. Immunol. 159:1676.
3. Hampl, J., Y. H. Chien, and M. M. Davis. 1997. CD4 augments the response of a T cell to agonist but not to antagonist ligands. Immunity 7:379.
4. O'Rourke, A. M., and M. F. Mescher. 1994. Signals for activation of CD8-dependent adhesion and costimulation in CTLs. J. Immunol. 152:4358.
5. Heath, W. R., J. Allison, M. W. Hoffmann, G. Schonrich, G. Hammerling, B. Arnold, J. F. Miller. 1992. Autoimmune diabetes as a consequence of locally produced interleukin-2. Nature 359:547.
6. Lee, K. M., E. Chuang, M. Griffin, R. Khattri, D. K. Hong, W. Zhang, D. Straus, L. E. Samelson, C. B. Thompson, and J. A. Bluestone. 1998. Molecular basis of T cell inactivation by CTLA-4. Science 282:2263.
7. Long, E. O. 1999. Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 17:875.
8. Yokoyama, W.M., P.J. Kehn, D.I. Cohen, and E. M. Shevach. 1990. Chromosomal location of the Ly-49 (AI. YEI/48) multigene family: genetic association with the NKI.1 antigen. J. Immunol. 145:2353.
9. Yokoyama, W.M. 1995. Natural killer cell receptors. Curr. Opin. Immunol. 7:110.
10. Wong, S., J. D. Freeman, C. Kelleher, D. Mager, and F. Takei. 1991. Ly-49 multigene family: new members of a superfamily of type II membrane proteins with lectin-like domains. J. Immunol. 147:1417.
11. Mason, L. M., P. Gosselin, S. K. Anderson, W. E. Folger, J. R. Ortaldo, and D. W. McVicar. 1997. Differential tyrosine phosphorylation of inhibitory versus activating Ly-49A receptor proteins and their recruitment of SHP-1 phosphatase. J. Immunol. 159:4187.
12. Olcese, L., P. Lang, F. Vely, A. Campiaggi, D. Marguet, M. Blery, K. L. Hippen, R. Biassoni, L. Moretta, J. C. Cambier, and E. Vivier. 1996. Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases. J. Immunol 156:4531.
13. Nakamura, M. C., E. C. Niemi, M. J. Fisher, L. D. Schultz, W. E. Seaman, and J. C. Ryan. 1997. Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 phosphatase. J. Exp. Med. 185:673.
14. D'Andrea, A., C. Chang, J. H. Phillips, and L. L. Lanier. 1996. Regulation of T cell lymphokine production by killer inhibitory receptor recognition of self HLA class I alleles. J. Exp. Med. 184:789.
15. Mingari, M. C., A. Morretta, and L. Morretta. 1998. Regulation of KIR expression in human T cells: a safety mechanism that may impair protective T-cell responses. Immunol. Today 19:153.
16. + T cells. J. Immunol 160:1158.
17. Phillips, J. H., J. E. Gumperz, P. Parham, and L. L. Lanier. 1995. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes. Science 268:403.
18. + T cells. J. Exp. Med. 187:2109.
19. Sawada, S., J. D. Scarborough, N. Killeen, and D. R. Littman 1994. A lineage specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77:917.
20. Yokoyama, W. M., L. B. Jacobs, O. Kanagawa, E. M. Shevach, and D. I. Cohen. 1989. A murine T lymphocyte antigen belongs to a supergene family of type II integral membrane proteins. J. Immunol. 143:1379.
21. + single positive cells with a class II major histocompatibilily complex-restricted receptor. J. Exp. Med. 180:25.
22. Degermann, S., C. Reilly, B. Scott, L. Ogata, H. von Boehmer, and D. Lo. 1994. On the various manifestations of spontaneous autoimmune diabetes in rodent models. Eur. J. Immunol. 24:3155.
23. Held, W., and D. H. Raulet. 1997. Ly49A transgenic mice provide evidence for a major histocompatibility complex-dependent education process in natural killer cell development. J. Exp. Med. 185:2079.
24. Fahlen, L., N. K. Khoo, M. R. Daws, and C. L. Sentman. 1997. Location-specific regulation of transgenic Ly49A receptors by major histocompatibility complex class 1 molecules. Eur. J. Immunol. 27:2057.
25. Held, W., D. Cado, and D. H. Raulel. 1996. Transgenic expression of the Ly49A natural killer cell receptor confers class I major histocompatibility complex (MHC)-specific inhibition and prevents bone marrow allograft rejection. J. Exp. Med. 184:2037.
26. Blackman, M., J. Yague, R. Kubo, D. Gay, C. Coleclough, E. Palmer, J. Kappler, and P. Marrack. 1986. The T cell repertoire may be biased in favor of MHC recognition. Cell 47:349.
27. Zerrahn, J., W. Held, and D. H. Raulet. 1997. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 88:627.
28. Davey, G. M., S. L. Schober, B. T. Endrizzi, A. K. Dutcher, S. C. Jameson, and K. A. Hogquist, 1998. Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells. J. Exp. Med. 188:1867.
29. + T lymphocytes. Proc. Natl. Acad. Sci. USA 89:5138.
30. Cooke, K. R., W. Krenger, G. Hill, T. R. Martin, L. Kobzik, J. Brewer, R. Simmons, J. M. Crawford, M. R. van den Brink, and J. L. Ferrara. 1998. Host reactive donor T cells are associated with lung injury after experimental allogeneic bone marrow transplantation. Blood 92:2571.
31. Burakoff, S. J., H. J. Deeg, J. Ferrara, and K. Atkinson, K., eds. 1990. Graft-vs.-Host Disease: Immunology, Pathophysiology, and Treatment. Marcel Dekker. New York.
32. Workman, D. L., and J. Clancy, Jr. 1995. Phenotypic analysis of pulmonary perivascular mononuclear infiltrates that occur as a direct result of acute lethal graft-versus-host disease describes the onset of interstitial pneumonitis. Am. J. Pathol. 147:1350.
33. Plas, D. R., R. Johnson, J. T. Pingel, R. J. Matthews, M. Dalton, G. Roy, A. C. Chan, and M. L. Thomas. 1996. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science 272:1173.
34. Van Oers, N. S. C., N. Killeen, and A. Weiss. 1994. ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells. Immunity 1:675.
35. Burshtyn, D. N., A. S. Lam, M. Weston, N. Gupta, P. A. M. Warmerdam, and E. O. Long. 1999. Conserved residues amino-terminal of cytoplasmic tyrosines contribute to the SHP-1-mediated inhibitory function of killer cell Ig-like receptors. J. Immunol. 162:897.
36. Monks, C. R., B. A. Freiberg, H. Kupfer, N. Sciaky, and A. Kupfer. 1998. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395:82.
37. Viola, A., S. Schroeder, Y. Sakakibara, and A. Lanzavecchia. 1999. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283:680.
38. Haque S.J., P. Harbor, M. Tabrizi, T. Yi, and B. R. G. Williams. 1998. Protein-tyrosine phosphatase shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction. J. Biol. Chem. 273:33893.
39. Kim C. H., C-K. Qu, G. Hangoc, S. Cooper, N. Anzai, G-S. Feng, and H. E. Broxmeyer. 1999. Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses. J. Exp. Med. 190:681.
40. Pani, G., K. D. Fisher, I. Mlinaric-Rascan, and K. A. Siminovitch. 1996. Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J. Exp. Med. 184:839.
41. Lorenz, U., K. S. Ravichandran, S. J. Burakoff, and B. G. Neel. 1996. Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness. Proc. Natl. Acad. Sci USA 93:9624.
42. Su, X., T. Zhou, P. A. Yang, Z. Wang, and J. D. Mountz. 1996. Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect. J. Immunol. 156:4198.
43. Cyster, J. G., and C. C. Goodnow. 1995. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity 2:13.
44. Zhang J., A.-K. Somani, D. Yuen, Y. Yang, P. E. Love, and K. A. Siminovitch. 1999. Involvement of the shp-1 typrosine phosphatase in regulation of T cell selection. J. Immunol. 163:3012.
45. Lo, D., C. R. Reilly, L. C. Burkly, J. DeKoning, T. M. Laufer, and L. H. Glimcher. 1997. Thymic stromal cell specialization and the T-cell receptor repertoire. Immunol. Res. 16:3.
46. Laufer, T. M., J. DeKoning, J. S. Markowitz, D. Lo, and L. H. Glimcher. 1996. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 382:81.
47. Benoist, C., and D. Mathis. 1989. Positive selection of the T cell repertoire: where and when does it occur? Cell 58:1027.