Rescue of ischemic brain injury by adenoviral gene transfer of glial cell line-derived neurotrophic factor after transient global ischemia in gerbils

Brain Research

Volumn 885, Issue 2, 2000, Pages 273-282

  Yagi, Takashi ^a   Jikihara, Ikuyo ^a   Fukumura, Masayuki ^b   Watabe, Kazuhiko ^c   Ohashi, Toya ^d   Eto, Yoshikatsu ^d   Hara, Mitsuhiro ^a   Maeda, Mitsuyo ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b DNAVEC Research Inc   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^d JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adenoviral vector; Delayed neuronal death; GDNF; Transient global ischemia

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; GENE TRANSFER; GERBIL; NONHUMAN; PRIORITY JOURNAL;

ADENOVIRIDAE; ANIMALS; BRAIN ISCHEMIA; CELL DEATH; CELL SURVIVAL; CEREBRAL CORTEX; DNA, COMPLEMENTARY; EPENDYMA; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GERBILLINAE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HIPPOCAMPUS; HUMANS; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS;

EID: 0034624290     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02956-5     Document Type: Article

References (66)

1. Amelioration of brain edema by topical application of glial cell line-derived neurotrophic factor in reperfused rat brain
2. Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors [see comments]
3. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret
4. Neuroprotection of spinal motoneurons following targeted transduction with an adenoviral vector carrying the gene for glial cell line-derived neurotrophic factor
5. Targeted transduction of CNS neurons with adenoviral vectors carrying neurotrophic factor genes confers neuroprotection that exceeds the transduced population
6. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain [see comments]
7. Intrastriatal injection of an adenoviral vector expressing glial cell line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease
8. A commentary on glial cell line-derived neurotrophic factor (GDNF). From a glial secreted molecule to gene therapy
9. A rapid colorimetric in situ mRNA hybridization technique using hyperbiotinylated oligonucleotide probes for analysis of mdr1 in mouse colon carcinoma cells
10. Glial cell line-derived neurotrophic growth factor inhibits apoptotic death of postnatal substantia nigra dopamine neurons in primary culture
11. Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination
12. Dopaminergic neurons protected from degeneration by GDNF gene therapy [see comments]
13. Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor
14. GDNF improves survival and reduces apoptosis in human embryonic dopaminergic neurons in vitro
15. Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons
16. GDNF signalling through the Ret receptor tyrosine kinase [see comments]
17. Prevention of motoneuron death by adenovirus-mediated neurotrophic factors
18. GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle
19. Regulation of spinal motoneuron survival by GDNF during development and following injury
20. Colorimetric detection of herpes simplex virus by DNA in situ sandwich hybridization: a rapid, formamide-free, random oligomer-enhanced method
21. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF
22. Conditioned medium from aged monkey fibroblasts stably expressing GDNF and BDNF improves survival of embryonic dopamine neurons in vitro
23. A simple and efficient method for purification of infectious recombinant adenovirus
24. Suppression of c-Myc-induced apoptosis by Ras signalling through PI (3)K and PKB
25. Ameliorative effect of glial cell line-derived neurotrophic factor on brain edema formation after permanent middle cerebral artery occlusion in rats
26. Reduction of ischemic brain injury by topical application of glial cell line-derived neurotrophic factor after permanent middle cerebral artery occlusion in rats
27. In vivo neurotrophic effects of GDNF on axotomized retinal ganglion cells
28. Effects of GDNF on retinal ganglion cell survival following axotomy
29. Adenovirus-mediated transduction with human glial cell line-derived neurotrophic factor gene prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopamine depletion in striatum of mouse brain
30. GDNF family ligands and receptors are differentially regulated after brain insults in the rat
31. Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease
32. Pharmacological characterization of glial cell line-derived neurotrophic factor (GDNF): implications for GDNF as a therapeutic molecule for treating neurodegenerative diseases
33. An adenovirus vector for gene transfer into neurons and glia in the brain
34. Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor
35. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons [see comments]
36. Intracerebral distribution of albumin after transient cerebral ischemia: light and electron microscopic immunocytochemical investigation
37. Single stranded DNA as an immunocytochemical marker for apoptotic change of ischemia in the gerbil hippocampus
38. Glial cell line-derived neurotrophic factor: the lateral cerebral ventricle as a site of administration for stimulation of the substantia nigra dopamine system in rats
39. Potent inhibitory effects of glial derived neurotrophic factor against kainic acid mediated seizures in the rat
40. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome
41. In situ hybridization protocol for overall preservation of mRNA in fixed tissues with a poly d (T) oligonucleotide probe
42. Cellular and developmental patterns of expression of Ret and glial cell line-derived neurotrophic factor receptor alpha mRNAs
43. Calcium-dependent Ret activation by GDNF and neurturin
44. Adenovirus-mediated gene transfer and expression of human beta-glucuronidase gene in the liver, spleen, and central nervous system in mucopolysaccharidosis type VII mice
45. Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF [see comments]
46. Functional regeneration of sensory axon into the adult spinal cord
47. Phosphatidylinositol-3-OH kinase as a direct target of Ras [see comments]
48. Adenoviral vector-mediated GDNF gene transfer prevents death of adult facial motoneurons
49. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins
50. Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats
51. Expression of GDNF mRNA in rat and human nervous tissue
52. An improved staining method for rat microglial cells using the lectin from Griffonia simplicifolia (GSA I-B4)
53. Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo
54. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo [see comments]
55. Characterization of a multicomponent receptor for GDNF [see comments]
56. Functional receptor for GDNF encoded by the c-ret proto-oncogene [see comments]
57. Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation
58. Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survival
59. A rapid simple in situ hybridization method for herpes simplex virus employing a synthetic biotin-labeled oligonucleotide probe: a comparison with immunohistochemical methods for HSV detection
60. Glial cell line-derived neurotrophic factor protects against ischemia-induced injury in the cerebral cortex
61. Rescue of lesioned adult rat spinal motoneurons by adenoviral gene transfer of glial cell line-derived neurotrophic factor
62. Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs
63. Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase
64. In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons [see comments]
65. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
66. Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones