메뉴 건너뛰기




Volumn 286, Issue 2, 1996, Pages 179-189

Pharmacological characterization of glial cell line-derived neurotrophic factor (GDNF): Implications for GDNF as a therapeutic molecule for treating neurodegenerative diseases

Author keywords

Amytrophic lateral sclerosis; Cholinergic and noradrenergic neurons; Dementia; GDNF; Motorneurons; Neurotrophic factor; Parkinson's disease; Primate; Rodent

Indexed keywords

NEURITE PROMOTING FACTOR;

EID: 0029804160     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410050687     Document Type: Review
Times cited : (53)

References (90)
  • 2
    • 0027296947 scopus 로고
    • Effects of chronic basic fibroblast growth factor administration to rats with partial fimbrial transections on presynaptic cholinergic parameters and muscarinic receptors in the hippocampus: Comparison with nerve growth factor
    • Araujo DM, Lapchak PA, Hefti F (1993) Effects of chronic basic fibroblast growth factor administration to rats with partial fimbrial transections on presynaptic cholinergic parameters and muscarinic receptors in the hippocampus: comparison with nerve growth factor. J Neurochem 61:899-910
    • (1993) J Neurochem , vol.61 , pp. 899-910
    • Araujo, D.M.1    Lapchak, P.A.2    Hefti, F.3
  • 3
    • 0029584686 scopus 로고
    • GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo
    • Arenas E, Trupp M, Akerud P, Ibanez, CF (1995) GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo. Neuron 15:1465-1473
    • (1995) Neuron , vol.15 , pp. 1465-1473
    • Arenas, E.1    Trupp, M.2    Akerud, P.3    Ibanez, C.F.4
  • 4
    • 0024332481 scopus 로고
    • Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: Response to fimbria-fornix transection
    • Batchelor PE, Armstrong DM, Blaker SN, Gage FH (1989) Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: response to fimbria-fornix transection. J Comp Neurol 284:187-204
    • (1989) J Comp Neurol , vol.284 , pp. 187-204
    • Batchelor, P.E.1    Armstrong, D.M.2    Blaker, S.N.3    Gage, F.H.4
  • 5
    • 0029620781 scopus 로고
    • GDNF mRNA expression in normal postnatal development, aging and in weaver mutant mice
    • Blum M, Weickert CS (1995) GDNF mRNA expression in normal postnatal development, aging and in weaver mutant mice. Neurobiol Aging 16:925-929
    • (1995) Neurobiol Aging , vol.16 , pp. 925-929
    • Blum, M.1    Weickert, C.S.2
  • 8
    • 10544235584 scopus 로고
    • Morphological and functional effects of GDNF in rodents and primates
    • Collins F, Lapchak PA (1995) Morphological and functional effects of GDNF in rodents and primates. Soc Neurosci 21:493
    • (1995) Soc Neurosci , vol.21 , pp. 493
    • Collins, F.1    Lapchak, P.A.2
  • 9
    • 0344855846 scopus 로고
    • GDNF provides potent neuroprotection of motor neurons against chronic glutamate toxicity
    • Corse AM, Coccia CF, Rothstein JD, Kuncl RW (1995) GDNF provides potent neuroprotection of motor neurons against chronic glutamate toxicity. Soc Neurosci Abstr 21:544
    • (1995) Soc Neurosci Abstr , vol.21 , pp. 544
    • Corse, A.M.1    Coccia, C.F.2    Rothstein, J.D.3    Kuncl, R.W.4
  • 12
    • 0027383681 scopus 로고
    • Evidence that neuropeptide Y and dopamine in the perifornical hypothalamus interact antagonistically in the control of food intake
    • Gillard ER, Dang DQ, Stanley BG (1993) Evidence that neuropeptide Y and dopamine in the perifornical hypothalamus interact antagonistically in the control of food intake. Brain Res 628:128-136
    • (1993) Brain Res , vol.628 , pp. 128-136
    • Gillard, E.R.1    Dang, D.Q.2    Stanley, B.G.3
  • 13
    • 0023731344 scopus 로고
    • Delayed treatment with nerve growth factor reverses the apparent loss of cholinergic neurons after acute brain damage
    • Hagg T, Manthorpe M, Vahlsing HL, Varon S (1988) Delayed treatment with nerve growth factor reverses the apparent loss of cholinergic neurons after acute brain damage. Exp Neurol 101:303-312
    • (1988) Exp Neurol , vol.101 , pp. 303-312
    • Hagg, T.1    Manthorpe, M.2    Vahlsing, H.L.3    Varon, S.4
  • 14
    • 0022486717 scopus 로고
    • Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
    • Hefti F (1986) Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. J Neurosci 6:2155-2162
    • (1986) J Neurosci , vol.6 , pp. 2155-2162
    • Hefti, F.1
  • 15
    • 0021359024 scopus 로고
    • Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions
    • Hefti F, Dravid A, Hartikka J (1984) Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions. Brain Res 293:305-311
    • (1984) Brain Res , vol.293 , pp. 305-311
    • Hefti, F.1    Dravid, A.2    Hartikka, J.3
  • 19
    • 0030031116 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factors exerts neurotrophic effects on dopaminergic neurons in vitro and promotes their survival and regrowth after damage by 1-methyl-4-phenylpyridinium
    • Hou JGG, Lin LFH, Mytilineou C (1996) Glial cell line-derived neurotrophic factors exerts neurotrophic effects on dopaminergic neurons in vitro and promotes their survival and regrowth after damage by 1-methyl-4-phenylpyridinium. J Neurochem 66:74-82
    • (1996) J Neurochem , vol.66 , pp. 74-82
    • Hou, J.G.G.1    Lin, L.F.H.2    Mytilineou, C.3
  • 21
    • 0028302831 scopus 로고
    • Neurons of the hippocampal formation express glial cell line-derived neurotrophic factor messenger RNA in response to kainate-induced excitation
    • Humpel C, Hoffer B, Stromberg I, Bektesh S, Collins F, Olson L (1994) Neurons of the hippocampal formation express glial cell line-derived neurotrophic factor messenger RNA in response to kainate-induced excitation. Neuroscience 59:791-795
    • (1994) Neuroscience , vol.59 , pp. 791-795
    • Humpel, C.1    Hoffer, B.2    Stromberg, I.3    Bektesh, S.4    Collins, F.5    Olson, L.6
  • 22
    • 0029269229 scopus 로고
    • The rationale for the use of dopamine agonists in Parkinson's disease
    • Jenner P (1995) The rationale for the use of dopamine agonists in Parkinson's disease. Neurology 45:S6-S12
    • (1995) Neurology , vol.45
    • Jenner, P.1
  • 23
    • 0025751604 scopus 로고
    • Dopamine transmission in the initiation and expression of drug- And stress-induced sensitization of motor activity
    • Kalivas PW, Stewart J (1991) Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res Rev 16:223-244
    • (1991) Brain Res Rev , vol.16 , pp. 223-244
    • Kalivas, P.W.1    Stewart, J.2
  • 24
    • 0028874203 scopus 로고
    • GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo
    • Kearns CM, Gash DM (1995) GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo. Brain Res 672:101-111
    • (1995) Brain Res , vol.672 , pp. 101-111
    • Kearns, C.M.1    Gash, D.M.2
  • 25
    • 0026574673 scopus 로고
    • Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain
    • Knüsel B, Beck KD, Winslow JW, Rosenthal A, Burton LE, Widmer HR, Nikolics K, Hefti F (1992) Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain. J Neurosci 12:4391-4402
    • (1992) J Neurosci , vol.12 , pp. 4391-4402
    • Knüsel, B.1    Beck, K.D.2    Winslow, J.W.3    Rosenthal, A.4    Burton, L.E.5    Widmer, H.R.6    Nikolics, K.7    Hefti, F.8
  • 27
    • 0028334932 scopus 로고
    • Highly selective effects of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 on intact and injured basal forebrain magnocellular neurons
    • Koliatsos VE, Price DL, Gouras GK, Cayouette MH, Burton LE, Winslow JW (1994a) Highly selective effects of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 on intact and injured basal forebrain magnocellular neurons. J Comp Neurol 343:247-262
    • (1994) J Comp Neurol , vol.343 , pp. 247-262
    • Koliatsos, V.E.1    Price, D.L.2    Gouras, G.K.3    Cayouette, M.H.4    Burton, L.E.5    Winslow, J.W.6
  • 28
    • 0028269017 scopus 로고
    • Ventral root avulsion: An experimental model of death of adult motor neurons
    • Koliatsos VE, Price WL, Pardo DA, Price DL (1994b) Ventral root avulsion: an experimental model of death of adult motor neurons. J Comp Neurol 342:35-44
    • (1994) J Comp Neurol , vol.342 , pp. 35-44
    • Koliatsos, V.E.1    Price, W.L.2    Pardo, D.A.3    Price, D.L.4
  • 29
    • 0024246783 scopus 로고
    • Loss of transmitterassociated enzyme staining following axotomy does not indicate death of brainstem cholinersic neurons
    • Lams BE, Isacson O, Sofroniew MV (1988) Loss of transmitterassociated enzyme staining following axotomy does not indicate death of brainstem cholinersic neurons. Brain Res 475:401-406
    • (1988) Brain Res , vol.475 , pp. 401-406
    • Lams, B.E.1    Isacson, O.2    Sofroniew, M.V.3
  • 30
    • 0026722830 scopus 로고
    • Therapeutic potential for nerve growth factor in Alzheimer's disease: Insights from pharmacological studies using lesioned central cholinergic neurons
    • Lapchak PA (1992) Therapeutic potential for nerve growth factor in Alzheimer's disease: insights from pharmacological studies using lesioned central cholinergic neurons. Rev Neurosci 3:109-119
    • (1992) Rev Neurosci , vol.3 , pp. 109-119
    • Lapchak, P.A.1
  • 31
    • 0027771726 scopus 로고
    • Nerve growth factor pharmacology: Application to the treatment of cholinergic neurodegeneration in Alzheimer's disease
    • Lapchak PA (1993) Nerve growth factor pharmacology: application to the treatment of cholinergic neurodegeneration in Alzheimer's disease. Exp Neurol 124:16-20
    • (1993) Exp Neurol , vol.124 , pp. 16-20
    • Lapchak, P.A.1
  • 32
    • 0025732221 scopus 로고
    • 3H|acetylcholine release and choline acetyltransferase activity
    • 3H|acetylcholine release and choline acetyltransferase activity. Neuroscience 42:639-649
    • (1991) Neuroscience , vol.42 , pp. 639-649
    • Lapchak, P.A.1    Hefti, F.2
  • 34
    • 0026808629 scopus 로고
    • Pharmacological stimulation reveals NGF-induced increases of in vivo hippocampal cholinergic function measured in rats with partial fimbrial transections
    • Lapchak PA, Jenden DJ, Hefti F (1992b) Pharmacological stimulation reveals NGF-induced increases of in vivo hippocampal cholinergic function measured in rats with partial fimbrial transections. Neuroscience 50:847-856
    • (1992) Neuroscience , vol.50 , pp. 847-856
    • Lapchak, P.A.1    Jenden, D.J.2    Hefti, F.3
  • 36
    • 0025695511 scopus 로고
    • The nigrostriatal dopaminergic system assessed in vivo by positron emission tomography in healthy volunteers and in patients with Parkinson's disease
    • Leenders KL, Salmon EP, Tyrrell P, Perani D, Brooks DJ, Sager H, Jones T, Marsden D, Franchowiak RSJ (1990) The nigrostriatal dopaminergic system assessed in vivo by positron emission tomography in healthy volunteers and in patients with Parkinson's disease. Arch Neurol 47:1290-1298
    • (1990) Arch Neurol , vol.47 , pp. 1290-1298
    • Leenders, K.L.1    Salmon, E.P.2    Tyrrell, P.3    Perani, D.4    Brooks, D.J.5    Sager, H.6    Jones, T.7    Marsden, D.8    Franchowiak, R.S.J.9
  • 38
    • 0027285510 scopus 로고
    • GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin L-F, Doherty DH, Lile JD, Bektesh S, Collins F (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130-1132
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.-F.1    Doherty, D.H.2    Lile, J.D.3    Bektesh, S.4    Collins, F.5
  • 39
  • 40
    • 0001925175 scopus 로고
    • Fluctuations of disability in Parkinson's disease - Clinical aspects
    • Marsden CD, Fahn S (eds) Butterworths, London
    • Marsden CD, Parkes JD, Quinn N (1982) Fluctuations of disability in Parkinson's disease - clinical aspects. In: Marsden CD, Fahn S (eds) Movement disorders. Butterworths, London, pp 96-122
    • (1982) Movement Disorders , pp. 96-122
    • Marsden, C.D.1    Parkes, J.D.2    Quinn, N.3
  • 41
    • 0029068923 scopus 로고
    • Potent inhibitory effects of GDNF against kainic acid mediated scizures in rats
    • Martin D, Miller G, Rosendahl M, Russell DA (1995) Potent inhibitory effects of GDNF against kainic acid mediated scizures in rats. Brain Res 683:172-178
    • (1995) Brain Res , vol.683 , pp. 172-178
    • Martin, D.1    Miller, G.2    Rosendahl, M.3    Russell, D.A.4
  • 42
    • 10544231597 scopus 로고    scopus 로고
    • Glial derived neurotrophic factor: The lateral cerebral ventricle is an effective site of administration for stimulation of the nigrostriatal system
    • in press
    • Martin D, Miller G, Fischer N, Dix D, Cullen T (1996) Glial derived neurotrophic factor: the lateral cerebral ventricle is an effective site of administration for stimulation of the nigrostriatal system. Eur J Neurosci (in press)
    • (1996) Eur J Neurosci
    • Martin, D.1    Miller, G.2    Fischer, N.3    Dix, D.4    Cullen, T.5
  • 44
    • 0026770233 scopus 로고
    • Fine structure of rat septohippocampal neurons. II. A time course analysis following axotomy
    • Naumann T, Peterson GM, Frotscher M (1992) Fine structure of rat septohippocampal neurons. II. A time course analysis following axotomy. J Comp Neurol 325:219-242
    • (1992) J Comp Neurol , vol.325 , pp. 219-242
    • Naumann, T.1    Peterson, G.M.2    Frotscher, M.3
  • 45
    • 0028152623 scopus 로고
    • Fine structure of rat septohippocampal neurons. III. Recovery of choline acetyl-transferase immunoreactivity after fimbria-fornix transection
    • Naumann T, Kenmer P, Frotscher M (1994) Fine structure of rat septohippocampal neurons. III. Recovery of choline acetyl-transferase immunoreactivity after fimbria-fornix transection. J Comp Neurol 350:161-170
    • (1994) J Comp Neurol , vol.350 , pp. 161-170
    • Naumann, T.1    Kenmer, P.2    Frotscher, M.3
  • 46
    • 0027527205 scopus 로고
    • Insulin-like growth factors: Putative muscle-derived trophic agents that promote motoneuron survival
    • Neff NT, Prevette D, Houenou LJ (1993) Insulin-like growth factors: putative muscle-derived trophic agents that promote motoneuron survival. J Neurobiol 24:1578-1588
    • (1993) J Neurobiol , vol.24 , pp. 1578-1588
    • Neff, N.T.1    Prevette, D.2    Houenou, L.J.3
  • 47
    • 0028240195 scopus 로고
    • Neurotrophins in neurodegenerative disease: Theoretical issues and clinical trials
    • Olson L (1994) Neurotrophins in neurodegenerative disease: theoretical issues and clinical trials. Neurochemistry 25:1-3
    • (1994) Neurochemistry , vol.25 , pp. 1-3
    • Olson, L.1
  • 49
    • 0025811297 scopus 로고
    • Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor
    • Oppenheim RW, Prevette D, Yin QW, Collins F, MacDonald J (1991) Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor. Science 251:1616-1618
    • (1991) Science , vol.251 , pp. 1616-1618
    • Oppenheim, R.W.1    Prevette, D.2    Yin, Q.W.3    Collins, F.4    MacDonald, J.5
  • 50
    • 0027094145 scopus 로고
    • Brain-derived neurotrophic factor rescues developing avian motorneurons from cell death
    • Oppenheim RW, Yin QW, Prevette D, Yan Q (1992) Brain-derived neurotrophic factor rescues developing avian motorneurons from cell death. Nature 360:755-757
    • (1992) Nature , vol.360 , pp. 755-757
    • Oppenheim, R.W.1    Yin, Q.W.2    Prevette, D.3    Yan, Q.4
  • 51
    • 0027254498 scopus 로고
    • Biological studies of a putative avian muscle-derived neurotrophic factor that prevents naturally occurring motoneuron death in vivo
    • Oppenheim RW, Prevette D, Haverkamp LJ, Houenou L, Yin QW, McManaman J (1993) Biological studies of a putative avian muscle-derived neurotrophic factor that prevents naturally occurring motoneuron death in vivo. J Neurobiol 24:1065-1079
    • (1993) J Neurobiol , vol.24 , pp. 1065-1079
    • Oppenheim, R.W.1    Prevette, D.2    Haverkamp, L.J.3    Houenou, L.4    Yin, Q.W.5    McManaman, J.6
  • 54
    • 0021059767 scopus 로고
    • Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase
    • Pearson RCA, Sofroniew MV, Cuello AC, Powell TPS, Eckenstein F, Esiri MM, Wilcock GK (1983) Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase. Brain Res 289:375-379
    • (1983) Brain Res , vol.289 , pp. 375-379
    • Pearson, R.C.A.1    Sofroniew, M.V.2    Cuello, A.C.3    Powell, T.P.S.4    Eckenstein, F.5    Esiri, M.M.6    Wilcock, G.K.7
  • 55
    • 10544237058 scopus 로고    scopus 로고
    • Neurotrophic factors: Potential for therapeutic intervention in Alzheimer's disease
    • Brioni J, Decker M (eds) Wiley, New York (in press)
    • Pelleymounter MA, Williams LR (1996) Neurotrophic factors: potential for therapeutic intervention in Alzheimer's disease. In: Brioni J, Decker M (eds) Animal models of Alzheimer's disease. Wiley, New York (in press)
    • (1996) Animal Models of Alzheimer's Disease
    • Pelleymounter, M.A.1    Williams, L.R.2
  • 56
    • 0026509389 scopus 로고
    • Identified septohippocampal neurons survive axotomy: A fine-structural analysis in the rat
    • Peterson GM, Naumann T, Frotscher M (1992) Identified septohippocampal neurons survive axotomy: a fine-structural analysis in the rat. Neurosci Lett 138:81-85
    • (1992) Neurosci Lett , vol.138 , pp. 81-85
    • Peterson, G.M.1    Naumann, T.2    Frotscher, M.3
  • 59
    • 0023896463 scopus 로고
    • Evidence that the substantia nigra is a site of action for L-DOPA
    • Robertson GS. Robertson HA (1988) Evidence that the substantia nigra is a site of action for L-DOPA. Neurosci Lett 89:204-208
    • (1988) Neurosci Lett , vol.89 , pp. 204-208
    • Robertson, G.S.1    Robertson, H.A.2
  • 60
    • 0024458006 scopus 로고
    • Evidence that L-DOPA-induced rotational behavior is dependent on both striatal and nigral mechanisms
    • Robertson GS, Robertson HA (1989) Evidence that L-DOPA-induced rotational behavior is dependent on both striatal and nigral mechanisms. J Neurosci 9:3326-3331
    • (1989) J Neurosci , vol.9 , pp. 3326-3331
    • Robertson, G.S.1    Robertson, H.A.2
  • 61
    • 0025299819 scopus 로고
    • Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis
    • Rothstein JD, Tsai G, Kuncl RW (1990) Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann Neurol 28:18-25
    • (1990) Ann Neurol , vol.28 , pp. 18-25
    • Rothstein, J.D.1    Tsai, G.2    Kuncl, R.W.3
  • 62
    • 0026597010 scopus 로고
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    • Rothstein JD, Martin LJ, Kuncl RW (1992) Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N Engl J Med 326:1464-1468
    • (1992) N Engl J Med , vol.326 , pp. 1464-1468
    • Rothstein, J.D.1    Martin, L.J.2    Kuncl, R.W.3
  • 63
    • 0028019154 scopus 로고
    • Role of neurotrophins in cholinergic-neuron function in the adult and aged CNS
    • Rylett RJ, Williams LR (1994) Role of neurotrophins in cholinergic-neuron function in the adult and aged CNS. Trends Neurosci 17:486-490
    • (1994) Trends Neurosci , vol.17 , pp. 486-490
    • Rylett, R.J.1    Williams, L.R.2
  • 64
    • 0027178807 scopus 로고
    • Acetylcholinc synthesis and release following continuous intracerebral administration of NGF in adult and aged Fischer-344 rats
    • Rylett RJ, Goddard S, Schmidt BM, Williams LR (1993) Acetylcholinc synthesis and release following continuous intracerebral administration of NGF in adult and aged Fischer-344 rats. J Neurosci 13:3956-3963
    • (1993) J Neurosci , vol.13 , pp. 3956-3963
    • Rylett, R.J.1    Goddard, S.2    Schmidt, B.M.3    Williams, L.R.4
  • 65
    • 0029047329 scopus 로고
    • Glial cell line-derived neurotrophic factor but not transforming growth factor β3 prevents delayed degeneration of nigral neurons following striatal 6-hydroxydopamine lesions
    • Saner H, Rosenblad C, Bjorklund A (1995) Glial cell line-derived neurotrophic factor but not transforming growth factor β3 prevents delayed degeneration of nigral neurons following striatal 6-hydroxydopamine lesions. Proc Natl Acad Sci USA 92:8935-8939
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8935-8939
    • Saner, H.1    Rosenblad, C.2    Bjorklund, A.3
  • 66
    • 0027730253 scopus 로고
    • Regional and cell-specific expression of GDNF in rat brain
    • Scharr DG, Sieber BA, Dreyfus CF, Black I (1993) Regional and cell-specific expression of GDNF in rat brain. Exp Neurol 124:368-371
    • (1993) Exp Neurol , vol.124 , pp. 368-371
    • Scharr, D.G.1    Sieber, B.A.2    Dreyfus, C.F.3    Black, I.4
  • 67
    • 0028096652 scopus 로고
    • Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats
    • Schmidt-Kastner R, Tomac A, Hoffer B, Bektesh S, Rosenzweig B, Olson L (1994) Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats. Mol Brain Res 26:325-330
    • (1994) Mol Brain Res , vol.26 , pp. 325-330
    • Schmidt-Kastner, R.1    Tomac, A.2    Hoffer, B.3    Bektesh, S.4    Rosenzweig, B.5    Olson, L.6
  • 68
    • 0025325548 scopus 로고
    • Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy
    • Sendtner M, Kreutzberg GW, Thoenen H (1990) Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature 345:440-441
    • (1990) Nature , vol.345 , pp. 440-441
    • Sendtner, M.1    Kreutzberg, G.W.2    Thoenen, H.3
  • 69
    • 0027070473 scopus 로고
    • Brain-derived neurotrophic factor prevents the death of motorneurons in newborn rats after nerve section
    • Sendtner M, Holtmann B, Kolbeck R, Thoenen H, Barde YA (1992a) Brain-derived neurotrophic factor prevents the death of motorneurons in newborn rats after nerve section. Nature 360:757-759
    • (1992) Nature , vol.360 , pp. 757-759
    • Sendtner, M.1    Holtmann, B.2    Kolbeck, R.3    Thoenen, H.4    Barde, Y.A.5
  • 70
    • 0026749255 scopus 로고
    • Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy
    • Sendtner M, Schmalbruch H, Stockli KA, Carroll P, Kreutzberg GW, Thoenen H (1992b) Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature 358:502-504
    • (1992) Nature , vol.358 , pp. 502-504
    • Sendtner, M.1    Schmalbruch, H.2    Stockli, K.A.3    Carroll, P.4    Kreutzberg, G.W.5    Thoenen, H.6
  • 71
    • 0011484137 scopus 로고    scopus 로고
    • Hffects of intrastriatal injections of glial cell line-derived neurotrophic factor (GDNF) in rats
    • in press
    • Shults CW, Shin C, Ernesto C, Martin D (1996) Hffects of intrastriatal injections of glial cell line-derived neurotrophic factor (GDNF) in rats. Exp Neurol (in press)
    • (1996) Exp Neurol
    • Shults, C.W.1    Shin, C.2    Ernesto, C.3    Martin, D.4
  • 72
    • 0027134807 scopus 로고
    • Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3
    • Sofroniew M, Cooper JD, Svendsen CN, Crossman P, Ip NY, Lindsay RM, Zafra F, Lindholm D (1993) Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3. J Neurosci 13:5263-5276
    • (1993) J Neurosci , vol.13 , pp. 5263-5276
    • Sofroniew, M.1    Cooper, J.D.2    Svendsen, C.N.3    Crossman, P.4    Ip, N.Y.5    Lindsay, R.M.6    Zafra, F.7    Lindholm, D.8
  • 73
    • 0023099778 scopus 로고
    • Basal forebrain magnocellular neurons stain for nerve growth factor receptor: Correlation with cholinergic cell bodies and effects of axotomy
    • Springer JE, Koh S, Tayrien MW, Loy R (1987) Basal forebrain magnocellular neurons stain for nerve growth factor receptor: correlation with cholinergic cell bodies and effects of axotomy. J Neurosci Res 17:111-118
    • (1987) J Neurosci Res , vol.17 , pp. 111-118
    • Springer, J.E.1    Koh, S.2    Tayrien, M.W.3    Loy, R.4
  • 74
    • 0028901367 scopus 로고
    • cDNA sequence and differential mRNA regulation of two forms of glial cell line-derived neurotrophic factor in Schwann cells and rat skeletal muscle
    • Springer JE, Seeburger JL, He J, Gabrea A, Blankenhorn EP, Bergman LW (1995) cDNA sequence and differential mRNA regulation of two forms of glial cell line-derived neurotrophic factor in Schwann cells and rat skeletal muscle. Exp Neurol 131:47-52
    • (1995) Exp Neurol , vol.131 , pp. 47-52
    • Springer, J.E.1    Seeburger, J.L.2    He, J.3    Gabrea, A.4    Blankenhorn, E.P.5    Bergman, L.W.6
  • 75
    • 0027731592 scopus 로고
    • Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo
    • Stromberg I, Bjorklund L, Johansson M, Tomac A, Collins F, Olson L, Hoffer BJ, Humpel C (1993) Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo, Exp Neurol 124:401-412
    • (1993) Exp Neurol , vol.124 , pp. 401-412
    • Stromberg, I.1    Bjorklund, L.2    Johansson, M.3    Tomac, A.4    Collins, F.5    Olson, L.6    Hoffer, B.J.7    Humpel, C.8
  • 76
    • 0028604499 scopus 로고
    • GDNF is expressed in two forms in many tissues outside the CNS
    • Suter-Crazzolara C, Unsicker K (1994) GDNF is expressed in two forms in many tissues outside the CNS. Neuroreport 5:2486-2488
    • (1994) Neuroreport , vol.5 , pp. 2486-2488
    • Suter-Crazzolara, C.1    Unsicker, K.2
  • 77
    • 0027756168 scopus 로고
    • Trophic support of motorneurons: Physiological, pathophysiological, and therapeutic implications
    • Thoenen H, Hughes RA, Sendtner M (1993) Trophic support of motorneurons: physiological, pathophysiological, and therapeutic implications. Exp Neurol 124:47-55
    • (1993) Exp Neurol , vol.124 , pp. 47-55
    • Thoenen, H.1    Hughes, R.A.2    Sendtner, M.3
  • 79
    • 0029007011 scopus 로고
    • Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons
    • Trupp M, Ryden M, Jornvall H, Funakoshi H, Timmusk T, Arenas E, Ibanez CF (1995) Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J Cell Biol 130:137-148
    • (1995) J Cell Biol , vol.130 , pp. 137-148
    • Trupp, M.1    Ryden, M.2    Jornvall, H.3    Funakoshi, H.4    Timmusk, T.5    Arenas, E.6    Ibanez, C.F.7
  • 80
    • 0025061139 scopus 로고
    • Basal forebrain cell loss following fimbria/fornix transection
    • Tuszynski MH, Armstrong DM, Gage FH (1990) Basal forebrain cell loss following fimbria/fornix transection. Brain Res 508:241-248
    • (1990) Brain Res , vol.508 , pp. 241-248
    • Tuszynski, M.H.1    Armstrong, D.M.2    Gage, F.H.3
  • 81
    • 0029804409 scopus 로고    scopus 로고
    • GDNF triggers fiber outgrowth of fetal ventral mesenencephalic grafts from nigra to striatum in 6-OHDA lesioned rats
    • in press
    • Wang X, Tien LT, Lapchak PA, Hoffer BJ (1996) GDNF triggers fiber outgrowth of fetal ventral mesenencephalic grafts from nigra to striatum in 6-OHDA lesioned rats. Cell Tissue Res (in press)
    • (1996) Cell Tissue Res
    • Wang, X.1    Tien, L.T.2    Lapchak, P.A.3    Hoffer, B.J.4
  • 83
    • 0024446673 scopus 로고
    • Axotomy-dependent stimulation of choline acetyltransferase by exogenous mouse nerve growth factor in rat basal forebrain
    • Williams LR, Jodelis KS, Donald MR (1989) Axotomy-dependent stimulation of choline acetyltransferase by exogenous mouse nerve growth factor in rat basal forebrain. Brain Res 498:243-256
    • (1989) Brain Res , vol.498 , pp. 243-256
    • Williams, L.R.1    Jodelis, K.S.2    Donald, M.R.3
  • 84
    • 0030437247 scopus 로고    scopus 로고
    • GDNF sustains axotomized basal forebrain cholinergic neurons in vivo: Dose-response comparison to NGF and BDNF
    • Williams LR, Inouye G, Cummins V, Pelleymounter MA (1996) GDNF sustains axotomized basal forebrain cholinergic neurons in vivo: dose-response comparison to NGF and BDNF. J Pharmacol Exp Ther 277:1140-1151
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1140-1151
    • Williams, L.R.1    Inouye, G.2    Cummins, V.3    Pelleymounter, M.A.4
  • 85
    • 0027154946 scopus 로고
    • Expression of nitric-oxide synthase (NOS) in injured CNS neurons as shown by NADPH diaphorase histochemistry
    • Wu W (1993) Expression of nitric-oxide synthase (NOS) in injured CNS neurons as shown by NADPH diaphorase histochemistry. Exp Neurol 120:153-159
    • (1993) Exp Neurol , vol.120 , pp. 153-159
    • Wu, W.1
  • 86
    • 0343391471 scopus 로고
    • Retrograde transport study of glial cell line-derived neurotrophic factor (GDNF) in adult rat nervous system
    • Van Q, Matheson CR (1995) Retrograde transport study of glial cell line-derived neurotrophic factor (GDNF) in adult rat nervous system. Soc Neurosci Abstr 21:1301
    • (1995) Soc Neurosci Abstr , vol.21 , pp. 1301
    • Van, Q.1    Matheson, C.R.2
  • 87
    • 0027067035 scopus 로고
    • Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death
    • Van Q, Elliott J, Snider WD (1992) Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death. Nature 360:753-755
    • (1992) Nature , vol.360 , pp. 753-755
    • Van, Q.1    Elliott, J.2    Snider, W.D.3
  • 89
    • 0027969192 scopus 로고
    • The biological responses of axotomized adult motorneurons to brain-derived neurotrophic factor
    • Van Q, Matheson C, Lopez OT, Miller JA (1994) The biological responses of axotomized adult motorneurons to brain-derived neurotrophic factor. J Neurosci 14:5281-5291
    • (1994) J Neurosci , vol.14 , pp. 5281-5291
    • Van, Q.1    Matheson, C.2    Lopez, O.T.3    Miller, J.A.4
  • 90
    • 0028854836 scopus 로고
    • In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons
    • Van Q, Matheson C, Lopez OT (1995) In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons. Nature 373:341-344
    • (1995) Nature , vol.373 , pp. 341-344
    • Van, Q.1    Matheson, C.2    Lopez, O.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.