Targeted transduction of CNS neurons with adenoviral vectors carrying neurotrophic factor genes confers neuroprotection that exceeds the transduced population

Journal of Neuroscience

Volumn 17, Issue 17, 1997, Pages 6504-6511

  Baumgartner, Brian J ^a   Shine, H David ^a,b  

^a Department of Neurosurgery ^*  (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Adenoviral vector; Facial nerve; Facial nucleus; Nervous system trauma; Neuroprotection; Neurotrophic factors; Retrograde transport

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIC FACTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FACIAL NERVE; FACIAL NERVE NUCLEUS; GENE TARGETING; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; NERVE CELL LESION; NERVE INJURY; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RETROGRADE NERVE FIBER TRANSPORT;

EID: 0030763998     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-17-06504.1997     Document Type: Article

References (14)

1. Akli S, Caillaud C, Vigne E, Stratford-Perricaudet LD, Poenaru L, Perricaudet M, Kahn A, Peschanski MR (1993) Transfer of a foreign gene into the brain using adenovirus vectors. Nat Genet 3:224-228.
2. Baumgartner BJ, Barnes Jr EM (1994) Analysis of neuronal mRNA levels by quantitative reverse transcriptase-polymerase chain reaction. In: Neuroscience protocols, Module 4, Sec 20 (Wouterlood FG, ed), pp 1-13. Amsterdam: Elsevier Science.
3. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
4. Davidson BL, Allen ED, Kozarsky KF, Wilson JM, Roessler BJ (1993) A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat Genet 3:219-223.
5. Davies AM (1989) Neurotrophic factor bioassay using dissociated neurons. In: Nerve growth factors (Rush RA, ed), pp 95-109. New York: Wiley.
6. Eaton MJ, Whittemore SR (1996) Autocrine BDNF secretion enhances the survival and serotonergic differentiation of raphe neuronal precursor cells grafted into the adult rat CNS. Exp Neurol 140:105-114.
7. Fang B, Eisensmith RC, Li XHC, Finegold MJ, Shedlovsky A, Dove W, Woo SLC (1994) Gene therapy for phenylketonuria: phenotypic correction in a genetically deficient mouse model by adenovirus-mediated hepatic gene transfer. Gene Ther 1:247-254.
8. Finiels F, Gimenez y Ribotta M, Barkats M, Samolyk M, Robert J, Privat A, Revah F, Mallet J (1995) Specific and efficient gene transfer strategy offers new potentialities for the treatment of motor neurone disease. NeuroReport 7:373-378.
9. Friedman B, Kleinfeld D, Ip NY, Verge VMK, Moulton R, Boland P, Zlotchenko E, Lindsay RM, Liu L (1995) BDNF and NT-4/5 exert neurotrophic influences on injured adult spinal motor neurons. J Neurosci 15:1044-1056.
10. Geschwind MD, Kessler JA, Geller AI, Federoff HJ (1994) Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective herpes simplex virus vector. Transfer of NGF gene into cells by a HSV-1 vector. Mol Brain Res 24:327-335.
11. Ghadge GD, Roos RP, Kang UJ, Wollmann R, Fishman PS, Kalynych AM, Barr E, Leiden JM (1995) CNS gene delivery by retrograde transport of recombinant replication-defective adcnoviruses. Gene Ther 2:132-137.
12. Graham F, Prevec L (1991) Manipulation of adenovirus vectors. In: Methods in molecular biology: gene transfer and expression protocols (Murray EJ, ed), pp 109-128. Clifton, NJ: Humana.
13. Henderson CE, Phillips HS, Pollock RA, Davies AM, Lemeulle C, Armanini M, Simmons L, Moffet B, Vandlen RA, Koliatsos VE, Rosenthal A (1994) GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266:1062-1064.
14. Kato AC, Lindsay RM (1994) Overlapping and additive effects of neurotrophins and CNTF on cultured human spinal cord neurons. Exp Neurol 130:196-201.