Induction of c-Jun immunoreactivity in spinal cord and brainstem neurons in a transgenic mouse model for amyotrophic lateral sclerosis

Neuroscience Letters

Volumn 219, Issue 3, 1996, Pages 179-182

  Jaarsma, Dick ^a   Holstege, Jan C ^a   Troost, Dirk ^b   Davis, Maria ^a   Kennis, Josette ^a   Haasdijk, Elize D ^a   De Jong, Vianney J M B ^b  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Immediate early genes; Motoneuron disease; Reticular formation; Spinal interneurons

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CONTROLLED STUDY; IMMEDIATE EARLY GENE; IMMUNOCYTOCHEMISTRY; MOTOR NEURON DISEASE; MOUSE; NONHUMAN; ONCOGENE C JUN; PRIORITY JOURNAL; RETICULAR FORMATION; SPINAL CORD; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BRAIN STEM; IMMUNOLOGIC TECHNIQUES; ISOENZYMES; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; NEURONS; PROTO-ONCOGENE PROTEINS C-JUN; SPINAL CORD; SUPEROXIDE DISMUTASE; TISSUE DISTRIBUTION;

EID: 0030606316     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)13202-X     Document Type: Article

References (16)

1. [1] Cozzari, C., Howard, J. and Hartman, B., Analysis of epitopes on choline acetyltransferase (ChAT) using monoclonal antibodies, Soc. Neurosci. Abstr., 16 (1990) 91.6.
2. [2] Dal Canto, C. and Gurney, M.E., Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis, Am. J. Pathol., 145 (1994) 1271-1280.
3. [3] Dragunow, M. and Preston, K., The role of inducible transcription factors in apoptotic nerve cell death, Brain Res. Brain Res. Rev., 21 (1995) 1-28.
4. [4] Estus, S., Zaks, W.J., Freeman, R.S., Gruda, M., Bravo, R. and Johnson, E. Jr., Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis, J. Cell Biol., 127 (1994) 1717-1727.
5. [5] Gurney, M.E., Pu, H., Chui, A.Y. et al., Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation, Science, 264 (1994) 1772-1775.
6. [6] Herdegen, T., Kovary, K., Buhl, A., Bravo, R., Zimmermann, M. and Gass, P., Basal expression of the inducible transcription factors c-Jun, JunB, JunD, c-Fos, FosB, and Krox-24 in the adult rat brain, J. Comp. Neurol., 354 (1995) 39-56.
7. [7] Herdegen, T. and Zimmermann, M., Expression of c-Jun and JunD transcription factors represent specific changes in neuronal gene expression following axotomy, Prog. Brain Res., 103 (1994) 153-171.
8. [8] Holstege, G. and Kuypers, H.G.J.M., The anatomy of brain stem pathways to the spinal cord in cat. A labeled amino acid tracing study. In H.G.J.M. Kuypers and G.F. Martin (Eds.), The Anatomy of Brain Stem Pathways to the Spinal Cord in Cat. A Labeled Amino Acid Tracing Study, Elsevier, Amsterdam, 1982, pp. 145-175.
9. [9] Holstege, J.C. and Kuypers, H.G.J.M., Brainstem projections to spinal motoneurons: an update, Neuroscience, 23 (1987) 809-821.
10. [10] Jaarsma, D., Kennis, J., Troost, D., De Jong, J.M.B.V. and Holstege, J.C., Degeneration of spinal interneurons in addition to motoneurons in a trangenic mouse model for ALS, Soc. Neurosci. Abstr., 22 (1996) 94.5.
11. [11] Jankowska, E., Interneuronal relay in spinal pathways from proprioceptors, Prog. Neurobiol., 38 (1992) 335-378.
12. [12] Leah, J.D., Herdegen, T., Murashov, A., Dragunow, M. and Bravo, R., Expression of immediate early gene proteins following axotomy and inhibition of axonal transport in the rat central nervous system, Neuroscience, 57 (1993) 53-66.
13. [13] Ripps, M.E., Huntley, G.W., Hof, P.R., Morrison, J.H. and Gordon, J.W., Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis, Proc. Natl. Acad. Sci. USA, 92 (1995) 689-693.
14. [14] Rosen, D.R., Siddique, T., Patterson, D. et al., Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis, Nature, 362 (1993) 59-62.
15. [15] Virgo, L. and de Belleroche, J., Induction of the immediate early gene c-jun in human spinal cord in amyotrophic lateral sclerosis with concomitant loss of NMDA receptor NR-1 and glycine transporter mRNA, Brain Res., 676 (1995) 196-204.
16. [16] Wong, P.C., Pardo, C.O., Borchelt, D.R. et al., An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria, Neuron, 14 (1995) 1105-1116.