The role of inflammation after acute stroke: Utility of pursuing anti- adhesion molecule therapy

Neurology

Volumn 51, Issue 3 SUPPL., 1998, Pages

  DeGraba, Thomas J ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ENCEPHALITIS; HUMAN; LEUKOCYTE MIGRATION; MEDIATOR RELEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REPERFUSION INJURY; STROKE; VASOMOTOR REFLEX;

EID: 0031685143     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/wnl.51.3_suppl_3.s62     Document Type: Article

References (63)

1. Benveniste EN. Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action. Am J Physiol 1992;263:C1-16.
2. Hallenbeck JM. Inflammatory reactions at the blood-endothelial interface in acute stroke. Adv Neurol 1996;71:281-297.
3. Rothwell NJ, Loddick SA, Stroemer P. Interleukins and cerebral ischaemia. Int Rev Neurobiol 1997;40:281-298.
4. Dinarello CA, Gelfand JA, Wolff SM. Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. JAMA 1993;269:1829-1835.
5. Choi DW. Cerebral hypoxia: some new approaches and unanswered questions. J Neurosci 1990;10:2493-2501.
6. Kristián T, Siesjö BK. Calcium-related damage in ischemia. Life Sci 1996;59:357-367.
7. Nawroth PP, Stern DM. Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J Exp Med 1986;163:740-745.
8. Lui T, Clark RK, McDonnell PC, et al. Tumor necrosis factor-alpha expression in ischemic neurons. Stroke 1994;25:1481-1488.
9. Bevilacqua MP, Pober JS, Majeau GR, Cotran R, Gimbrone MA Jr. Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J Exp Med 1984;160:618-623.
10. Nawroth PP, Handley DA, Esmon CT, Stern DM. Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity. Proc Natl Acad Sci USA 1986;83:3460-3464.
11. Bevilacqua MP. Endothelial-leukocyte adhesion molecules. Annu Rev Immunol 1993;11:767-804.
12. Bevilacqua MP, Nelson RM. Selectins. J Clin Invest 1993;91:379-387.
13. Adams DH, Shaw S. Leukocyte endothelial interactions and regulation of leukocyte migration. Lancet 1994;343:831-836.
14. Bruce AJ, Boling W, Kindy MS, et al. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 1996;2:788-794.
15. Mattson MP, Barger SW, Furukawa K, et al. Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease. Brain Res Brain Res Rev 1997;23:47-61.
16. Wang X, Yue TL, Barone FC, White RF, Gagnon RC, Feuerstein GZ. Concomitant cortical expression of TNF-alpha and IL-1beta mRNAs follows early response gene expression in transient focal ischemia. Mol Chem Neuropathol 1994;23:103-114.
17. Betz AL, Schielke GP, Yang GY. Interleukin-1 in cerebral ischemia. Keio J Med 1996;45:230-237.
18. Garcia JH, Liu KF, Relton JK. Interleukin-1 receptor antagonist decreases the number of necrotic neurons in rats with middle cerebral artery occlusion. Am J Pathol 1995;147:1477-1486.
19. Barone FC, Arvin B, White RF, et al. Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury. Stroke 1997;28:1233-1244.
20. Dawson D, Martin D, Hallenbeck JM. Inhibition of tumor necrosis factor-alpha reduces focal cerebral ischemic injury in the spontaneously hypertensive rat. Neurosci Lett 1996;218:41-44.
21. Yamasaki Y, Matsuura N, Shozuhara H, Onodera H, Itoyama Y, Kogure K. Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats. Stroke 1995;26:676-680.
22. Relton JK, Rothwell NJ. Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Res Bull 1992;29:243-246.
23. Relton JK, Martin D, Thompson RC, Russell DA. Peripheral administration of interleukin-1 receptor antagonist inhibits brain damage after focal cerebral ischemia in the rat. Exp Neurol 1996;138:206-213.
24. Gauldie J, Northemann W, Fey GH. IL-6 functions as an exocrine hormone in inflammation. Hepatocytes undergoing acute phase responses require exogenous IL-6. J Immunol 1990;144:3804-3808.
25. Rothwell NJ, Busbridge NJ, Lefeuvre RA, Hardwick AJ, Gauldie J, Hopkins SJ. Interleukin-6 is a centrally acting endogenous pyrogen in the rat. Can J Physiol Pharmacol 1991;69:1465-1469.
26. Xing Z, Gauldie J, Cox G, et al. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 1998;101:311-320.
27. Tarkowski E, Rosengren L, Blomstrand C, et al. Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke. Stroke 1995;26:1393-1398.
28. Fassbender K, Rossol S, Kammer T, et al. Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease. J Neurol Sci 1994;122:135-139.
29. Baggiolini M, Loetscher P, Moser B. Interleukin-8 and the chemokine family. Int J Immunopharmacol 1995;17:103-108.
30. Kostulas N, Kivisakk P, Huang Y, Matusevicius D, Kostulas V, Link H. Ischemic stroke is associated with a systemic increase of blood mononuclear cells expressing interleukin-8 mRNA. Stroke 1998;29:462-466.
31. Matsumoto T, Ikeda K, Mukaida N, et al. Prevention of cerebral edema and infarct in cerebral reperfusion injury by an antibody to interleukin-8. Lab Invest 1997;77:119-125.
32. Smith CW. Endothelial adhesion molecules and their role in inflammation. Can J Physiol Pharmacol 1993;71:76-87.
33. Bevilacqua MP, Nelson RM, Mannori G, Cecconi O. Endothelial-leukocyte adhesion molecules in human disease. Annu Rev Med 1994;45:361-378.
34. Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 1991;67:1033-1036.
35. Springer TA. Adhesion receptors of the immune system. Nature 1990;346:425-434.
36. Clark WM, Lauten JD, Lessov N, Woodward W, Coull BM. Time course of ICAM-1 expression and leukocyte subset infiltration in rat forebrain ischemia. Mol Chem Neuropathol 1995;26:213-230.
37. Okada Y, Copeland BR, Mori E, Tung MM, Thomas WS, del Zoppo GJ. P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion. Stroke 1994;25:202-211.
38. Lindsberg PJ, Carpen O, Paetau A, Karjalainen-Lmdsberg ML, Kaste M. Endothelial ICAM-1 expression associated with inflammatory cell response in human ischemic stroke. Circulation 1996;94:939-945.
39. Hess DC, Zhao W, Carroll J, McEachin M, Buchanan K. Increased expression of ICAM-1 during reoxygenation in brain endothelial cells. Stroke 1994;25:1463-1467.
40. Garcia JH, Liu KF, Yoshida Y, Lian J, Chen S, del Zoppo GJ. Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat). Am J Pathol 1994;144:188-199.
41. Hallenbeck JM, Dutka AJ, Tanishima T, et al. Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period. Stroke 1986;17:246-253.
42. del Zoppo GJ, Schmid-Schonbein GW, Mori E, Copeland BR, Chang CM. Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 1991;22:1276-1283.
43. Pozzilli C, Lenzi GL, Argentino C, et al. Imaging of leukocytic infiltration in human cerebral infarcts. Stroke 1985;16:251-255.
44. Murota S, Fujita H, Wakabayashi Y, Morita I. Cell adhesion molecule mediates endothelial cell injury caused by activated neutrophils. Keio J Med 1996;45:207-211.
45. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 1989;320:365-376.
46. Akopov S, Sercombe R, Seylaz J. Cerebrovascular reactivity: role of endothelium/platelet/leukocyte interactions. Cerebrovasc Brain Metab Rev 1996;8:11-94.
47. Bjork J, Hedqvist P, Arfors KE. Increase in vascular permeability induced by leukotriene B4 and the role of polymorphonuclear leukocytes. Inflammation 1982;6:189-200.
48. Hamann GF, Okada Y, Fitridge R, del Zoppo GJ. Microvascular basal lamina antigens disappear during cerebral ischemia and reperfusion. Stroke 1995;26:2120-2126.
49. Abbas AK, Lichtman AH, Pober JS. Cytokines. In: Cellular and molecular immunology. 3rd ed. Philadelphia: WB Saunders, 1997:249-277.
50. Dutka AJ, Kochanek PM, Hallenbeck JM. Influence of granulocytopenia on canine cerebral ischemia induced by air embolism. Stroke 1989;20:390-395.
51. Soriano SG, Lipton SA, Wang YF, et al. Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury. Ann Neurol 1996;39:618-624.
52. Chen H, Chopp M, Zhang RL, et al. Anti-CD11b monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia in rat. Ann Neurol 1994;35:458-463.
53. Clark WM, Madden KP, Rothlein R, Zivin JA. Reduction of central nervous system ischemic injury by monoclonal antibody to intercellular adhesion molecule. J Neurosurg 1991;75:623-627.
54. Zhang RL, Chopp M, Li Y, et al. Anti-ICAM-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat. Neurology 1994;44:1747-1751.
55. Zhang RL, Chopp M, Jiang N, et al. Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat. Stroke 1995;26:1438-1442.
56. del Zoppo GJ. Why do all drugs work in animals but none in stroke patients? 1: Drugs promoting cerebral blood flow. J Intern Med 1995;237:79-88.
57. Grotta J. Why do all drugs work in animals but none in stroke patients? 2: Neuroprotective therapy. J Intern Med 1995;237:89-94.
58. Abbas AK, Lichtman AH, Pober JS. Antibodies and antigens. In: Cellular and molecular immunology. 3rd ed. Philadelphia: WB Saunders, 1997:37-65.
59. Rothlein R, Kishimoto TK, Mainolfi E. Cross-linking of ICAM-1 induces co-signaling of an oxidative burst from mononuclear leukocytes. J Immunol 1994;152:2488-2495.
60. Zhang R, Powers C, Zhang Z, Chopp M. Infusion of intercellular adhesion molecule 1 antibody (18h) upregulates E- and P-selectin expression during focal embolic cerebral ischemia in rats [abstract]. Stroke 1998;29:282.
61. Ohtsuki T, Ruetzler CA, Tasaki K, Hallenbeck JM. Interleukin-1 mediates induction of tolerance to global ischemia in gerbil hippocampal CA1 neurons. J Cereb Blood Flow Metab 1996;16:1137-1142.
62. Beamer NB, Coull BM, Clark WM, Hazel JS, Silberger JR. Interleukin-6 and interleukin-1 receptor antagonist in acute stroke. Ann Neurol 1995;37:800-805.
63. Loddick SA, Wong ML, Bongiorno PB, Gold PW, Licinio J, Rothwell NJ. Endogenous interleukin-1 receptor antagonist is neuroprotective. Biochem Biophys Res Commun 1997;234:211-215.