Radiosensitivity of tumor cells: Oncogenes and apoptosis

Quarterly Journal of Nuclear Medicine

Volumn 44, Issue 4, 2000, Pages 355-364

  Peltenburg, L T C ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apoptosis; Caspases; Cell survival; Cytochrome c; Genes, myc; Genes, p53; Genes, ras; Mitochondria; Neoplasms; Oncogenes; p53 protein; Proto oncogene proteins; Proto oncogene proteins c bcl 2; Proto oncogene proteins c myc; Proto oncogene proteins c raf; Radiation tolerance; Radiation, ionizing; Ras proteins

Indexed keywords

CASPASE 9; CYTOCHROME C; GROWTH FACTOR; INHIBITOR OF APOPTOSIS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; PROTEIN BAD; PROTEIN BCL 2; PROTEIN P53; RAF PROTEIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR;

APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; CYTOSOL; GENE ACTIVATION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; IONIZING RADIATION; MITOCHONDRIAL RESPIRATION; MOLECULAR INTERACTION; NONHUMAN; ONCOGENE; ONCOGENE C MYC; ONCOGENE RAF; ONCOGENE RAS; PROGNOSIS; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RADIATION DOSE; RADIOSENSITIVITY; REGULATORY MECHANISM; RESPIRATORY CHAIN; REVIEW; TUMOR CELL; TUMOR SUPPRESSOR GENE;

APOPTOSIS; GENES, TUMOR SUPPRESSOR; HUMANS; NEOPLASMS; PROTO-ONCOGENES; RADIATION TOLERANCE;

EID: 0034478115     PISSN: 11243937     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (89)

1. The radiobiology of tumours
2. Tumor radiosensitivity and apoptosis
3. Apoptosis
4. Caspases: Enemies within
5. Mitochondria and apoptosis
6. The mitochondrial permeability transition in cell death: A common mechanism in necrosis, apoptosis and autophagy
7. The effect of lethal doses of x-irradiation on the enzymatic activity of mitochondrial cytochrome c
8. Differential requirement for caspase 9 in apoptotic pathways in vivo
9. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
10. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
11. p53, the cellular gatekeeper for growth and division
12. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
13. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
14. A model for p53-induced apoptosis
15. A matter of life and cell death
16. p53 status affects the rate of the onset but not the overall extent of doxorubicin-induced cell death in rat-1 fibroblasts constitutively expressing c-Myc
17. Role of p53 mutations in the radiosensitivity status of tumor cells
18. Ras oncogenes in human cancer: A review
19. Ras signalling and apoptosis
20. Studies on the influence of the presence of an activated ras oncogene on the in vitro radiosensitivity of human mammary epithelial cells
21. The influence of ras oncogene expression on radiation response in the Rat-1 cell
22. Sensitivity to ionising radiation of transformed human cells containing mutant ras genes
23. The radio-sensitivity of human keratinocytes: Influence of activated c-H-ras oncogene expression and tumorigenicity
24. The effect of transfection with the oncogenes H-ras and c-myc on the radiosensitivity of a mink epithelial cell line
25. Transformation and radiosensitivity of human diploid skin fibroblasts transfected with activated RAS oncogene and SV40 T- antigen
26. Activated human N-ras oncogene enhances X-irradiation repair of mammalian cells in vitro less effectively at low dose rate. Implications for increased therapeutic ratio of low dose rate irradiation
27. The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation
28. Mutant p53 increases radioresistance in rat embryo fibroblasts simultaneously transfected with HPV16-E7 and/or activated H-ras
29. Influence of the H-ras oncogene on radiation responses of a rat rhabdomyosarcoma cell line
30. Synergistic effect of the v-myc oncogene with H-ras on radioresistance
31. Increased radio-resistance of EJ ras-transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p21 ras isoprenylation
32. Increased radiation resistance in transformed and nontransformed cells with elevated ras proto-oncogene expression
33. The influence of oncogenes N-ras and c-myc on the radiation sensitivity of cells of a human melanoma cell line
34. Radiosensitization of human tumor cell lines induced by the adenovirus-mediated expression of an anti-ras single-chain antibody fragment
35. The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts
36. Raf involvement in the simultaneous genetic transfer of the radioresistant and transforming phenotypes
37. Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells
38. Effect of antisense c-raf-1 on tumorigenicity and radiation sensitivity of a human squamous carcinoma
39. Effects of c-raf-1 and c-myc expression on radiation response in an in vitro model of human small-cell-lung carcinoma
40. Oncogene-transformed NIH 3T3 cells display radiation resistance levels indicative of a signal transduction pathway leading to the radiation-resistant phenotype
41. C-raf-1 proto-oncogene expression relates to radiosensitivity rather than radioresistance
42. The influence of the oncogene N-ras on cell cycle delay in a human melanoma cell line with reduced radio-resistance
43. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
44. Increased G2 delay in radiation-resistant cells obtained by transformation of primary rat embryo cells with the oncogenes H-ras and v-myc
45. No association between radiosensitivity and TP53 status, G1 arrest or protein levels of p53, myc, ras or raf in human melanoma lines
46. Radiosensitivity of small-cell lung cancer xenografts compared with activity of c-myc, N-MYC, L-MYC, c-raf-1 and K-ras proto-oncogenes
47. Response to radiotherapy of human uterine cervix carcinoma is not correlated with rearrangements of the Ha-ras-1 and/or c-myc genes
48. The MYC oncogene: Its role in transformation and differentiation
49. Mechanisms of apoptosis by c-Myc
50. Hamcack EKf. Induction of apoptosis in fibroblasts by c-myc protein
51. Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy
52. Transfected c-myc and c-Ha-ras modulate radiation-induced apoptosis in rat embryo cells
53. Potential indicators of radiosensitivity in squamous cell carcinoma of the head and neck
54. N-myc gene copy number in neuroblastoma cell lines and resistance to experimental treatment
55. c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release
56. Cooperative interaction between c-myc and bcl-2 proto-oncogenes
57. Escaping cell death: Survival proteins in cancer
58. The Bcl-2 protein family: Arbiters of cell survival
59. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
60. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
61. Bcl-2 protects murine erythroleukemia cells from p53-dependent and -independent radiation-induced cell death
62. Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols
63. Spontaneous and radiation-induced apoptosis in lung carcinoma cells with different intrinsic radiosensitivities
64. Bcl-2 protein expression correlates with recurrence and survival in early stage head and neck cancer treated by radiotherapy
65. Bax and Bcl-2 expressions predict response to radiotherapy in human cervical cancer
66. p53 and bcl-2 immunohistochemical alterations in prostate cancer treated with radiation therapy
67. Bcl-2/bax ratio as a predictive marker for therapeutic response to radiotherapy in patients with prostate cancer
68. Bcl-2 and proliferating cell nuclear antigen (PCNA) expression correlates with subsequent local recurrence in nasopharyngeal carcinomas
69. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
70. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-idependent mechanisms inhibitable by Bcl-2
71. L and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death
72. Bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells
73. Differential effects of BCL-2 on survival and proliferation of human B-lymphoma cells following gamma-irradiation
74. Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis
75. L in inhibiting radiation-induced cytosolic accumulation of cytochrome c (cyt c), caspase-3 activity, and apoptosis
76. The mitochondrial permeability transition pore and its role in cell death
77. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
78. Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator
79. L
80. L
81. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
82. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.
83. Expression and location of pro-apoptotic Bcl-2 family protein BAD in normal human tissues and tumor cell lines
84. IAP family proteins suppressors of apoptosis
85. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
86. Control of apoptosis and mitotic spindle checkpoint by survivin
87. Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer
88. Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas
89. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs