Spontaneous and radiation-induced apoptosis in lung carcinoma cells with different intrinsic radiosensitivities

Anticancer Research

Volumn 18, Issue 2 A, 1998, Pages 695-699

  Sirzén, Florin ^a   Zhivotovsky, Boris ^b   Nilsson, Anders ^b   Bergh, Jonas ^c   Lewensohn, Rolf ^a,b,d  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^d Swedish Radiation Protection Authority   (Sweden)

Author keywords

Aptoptosis; Bcl 2; c Myc; Lung carcinoma cell lines; p53; PARP; Radiosensitivity; RB

Indexed keywords

MYC PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; RETINOBLASTOMA PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; IRRADIATION; LUNG CARCINOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; RADIOSENSITIVITY; STAINING; TUMOR SUPPRESSOR GENE;

EID: 0031839519     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Hopwood LE and Tolmach LJ: Manifestations of damage from ionizing radiation in mammalian cells in the postirradiation generations. Adv Radial Res 8: 317-362, 1979.
2. Dewey WC, Ling CC and Meyn RE: Radiation-induced apoptosis: relevance to radiotherapy. Int J Radiat Oncol Biol Phys 33: 781-796, 1995.
3. Meyn RE, Stephens LC and Milas L: Programmed cell death and radioresistance. Cancer Met Rev 15: 119-131, 1996.
4. Shinohara K and Nakano H: Interphase death and reproductive death in x-irradiated MOLT-4 cells. Radiat Res 135: 197-205, 1993.
5. Vidair C, Chen CH, Ling CC and Dewey WC: Apoptosis induced by x-irradiation of rec-myc cells is postmitotic and not predicted by the time after irradiation or behaviour of sister cells. Cancer Res 56: 4116-4118, 1996.
6. McConkey DJ, Zhivotovsky B and Orrenius S: Apoptosis-molecular mechanisms and biomedical implications. Molec Aspects Med 17: 1-110, 1996.
7. Zhivotovsky B, Burgess DH and Orrenius S: Proteases in apoptosis. Experientia 52: 968-978, 1996.
8. Liebermann DA, Hoffman B and Steinman RA: Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways. Oncogene 11: 199-210, 1995.
9. Meritt AJ, Potten CS, Kemp J, Hickman JA, Balmain A, Lane DP and Hall PA: The role of p53 in spontaneous and radiation induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res. 54: 614-617, 1994.
10. Haupt Y, Rowan S and Oren M: p53-mediated apoptosis in HeLa cells can be overcome by excess of pRb. Oncogene 10: 1563-1571, 1995.
11. Bracey TS, Miller JC, Preece A and Paraskeva C: γ-radiation-induced apoptosis in human colorectal adenoma and carcinoma cell lines can occur in the absence of wild type p53. Oncogene 10: 2391-2396, 1995.
12. Ryan KM and Birnie GD: Myc oncogenes: the enigmatic family. Biochem J 314: 713-721, 1996.
13. Bisonnette RP, Echeverri F, Mahboubi A and Green DR: Apoptotic cell death induced by c-myc is inhibited by Bcl-2. Nature 359: 552-554, 1992.
14. McDonell TJ, Beham A, Sarkiss M, Andersen MM and Lo P: Importance of the Bcl-2 family in cell death regulation. Experientia 52: 1008-1017, 1996.
15. Bergh J, Larsson E, Zech L and Nilsson K: Establishment and characterization of two neoplastic cell lines (U-1285 and U-1568) derived from small cell carcinoma of the lung. Acta Path Microbiol Immunol Scand (SecA) 90: 149-158, 1982.
16. Bergh J, Nilsson K, Ekman R and Giovanella B: Establishment and characterization of cell lines from human small cell and large cell carcinomas of the lung. Acta Path Microbiol Immunol Scand (SecA) 93: 133-147, 1985.
17. Brodin O, Lennartsson L and Nilsson S: Single-dose and fractionated irradiation of four human lung cancer cell lines in vitro. Acta Oncol 30: 967-974, 1991.
18. Ben-Ezra JM, Kornstein MJ, Grimes MM and Krystal G: Small cell carcinomas of the lung express Bcl-2 protein. Am J Pathol 145: 1036-1040, 1994.
19. Sorenson CM, Barry MA and Eastman A: Analysis of events associated with cell cycle arrest at G2 phase and cell death induced by cisplatin. J Natl Cancer Inst 82: 749-755, 1990.
20. Sjogren S, Inganas M, Norberg T, Lindgren A, Nordgren H, Holmberg L and Bergh J: The p53 gene in breast cancer: prognostic value of complementary DNA sequencing versus immunohistochemistry. J Natl Cancer Inst 88: 173-182, 1996.
21. Lagerkvist A, Stewart J, Lagerstrom-Fermér M and Landegren U: Manifold sequencing: efficient processing of large sets of sequencing reactions. Proc Natl Acad Sci USA 91: 2245-2249, 1994.
22. Sirzén F, Heiden T, Nilsson A, Skog S, Bergh J and Lewensohn R: Characterisation of the G1/S cell cycle checkpoint defect in lung carcinoma cells with different intrinsic radiosensitivities. Anticancer Res in press, 1997.
23. Meyn RE, Stephens LC, Ang KK, Hunter NR, Milas L and Peters LJ: Heterogeneity in apoptosis development in irradiated murine tumors, Int J Radiat Biol 64: 583-591, 1993.
24. Wheeler JS, Stephens L, Eifel P, Ang K, Milas L, Allen P and Meyn RE: Apoptosis as a predictor of tumor response to radiation in stage 1B cervical adenocarcinoma. Int J Radiat Oncol Biol Phys 32: 1487-1493, 1995.
25. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML and Wyllie AH: Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362: 849-852, 1993.
26. Haas-Kogan DA, Kogan SC, Levi D, Dazin P, T Ang A, Fung YK and Israel MA: Inhibition of apoptosis by the retinoblastoma gene product. EMBO J 14: 461-472, 1995.
27. Hensel CH, Hsieh CL, Gazdar AF, Johnsarl BE, Sakaguchi AY, Naylor SL, Lee W-H and Lee EY-H: Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer. Cancer Res 50: 3067-3072, 1990.
28. Almasan A, Yin Y, Kelly RE, Lee EY-HP, Bradley A, Li W, Bertino J and Wahl GM: Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes and apoptosis. Proc Natl Acad Sci USA 92: 5436-5440, 1995.
29. Little CD, Nau MM, Carney DN, Gazdar AF and Minna JD: Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature 306: 194-196, 1983.
30. Hermeking H and Eick D: Mediation of c-myc induced apoptosis by p53. Science 265: 2091-2093, 1994.
31. Saksela K, Bergh J, Lehto V-P, Nilsson K and Alitalo K: Amplification of the c-myc oncogene in a subpopulation of human small cell lung cancer. Cancer Res 45: 1823-1827, 1985.
32. Campos L, Rovalult JP, Sabido O, Oriol P, Roubi N, Vasselon C, Archimbaud E, Magaud JP and Guyotat D: High expression of Bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy. Blood 18: 3091-3096, 1993.
33. Reeve JG, Xiong J, Morgan J and Bleehen NM: Expression of apoptosis-regulatory genes in lung tumour cell lines: relationship to p53 expression and relevance to acquired drug resistance. Br J Cancer 73: 1193-1200, 1996.
34. D' Amico D, Carbone D, Mitsudomi T, Nau M, Fedorko J, Russell E, Johnson B, Buchhagen D, Bodner S, Phelps R, Gazdar A and Minna JD: High frequency of somatically acquired p53 mutations in small cell lung cancer cell lines and tumors. Oncogene 7: 339-346, 1992.