Mutant T cell lines as model systems for the dissection of T cell antigen receptor signaling pathways

Immunologic Research

Volumn 22, Issue 2-3, 2000, Pages 95-117

  Abraham, R T ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Phospholipase C 1; Signal transduction; T cell antigen receptor; ZAP 70

Indexed keywords

ADAPTOR PROTEIN; CYTOKINE; ENZYME; PHOSPHOLIPASE C; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; CELL DIFFERENTIATION; CELL SURFACE; CONFERENCE PAPER; CYTOPLASM; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SOMATIC MUTATION; T LYMPHOCYTE ACTIVATION;

ANIMALS; HUMANS; ISOENZYMES; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MUTATION; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0034446569     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:22:2-3:95     Document Type: Conference Paper

References (74)

1. Differential signaling by lymphocyte antigen receptors
2. The tyrosine activation motif as a target of protein tyrosine kinases and SH2 domains
3. ITAM multiplicity and thymocyte selection: How low can you go?
4. The immunological synapse: A molecular machine controlling T cell activation
5. The ups and downs oft cell costimulation
6. Models of T cell anergy: Is there a common molecular mechanism?
7. Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy
8. A protein tyrosine kinase in the interferon alpha/beta signaling pathway
9. Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons
10. Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway
11. Use of somatic cell mutants to study the signal transduction function of the T cell antigen receptor
12. Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor
13. Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production
14. LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway
15. Uncoupling of nonreceptor tyroseine kinases from PLC-gamma-1 in an SLP-76-deficient T cell
16. Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events
17. Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: Reconstitution studies in a ZAP-70-deficient Jurkat T-cell line
18. Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes
19. Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase
20. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency
21. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
22. Syk mutation in Jurkat E6-derived clones results in lack of p72 syk expression
23. Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling
24. Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases
25. Reconstitution of T cell antigen receptor-induced Erk2 kinase activation in Lck-negative JCaMl cells by Syk
26. The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling
27. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
28. The Syk family of protein tyrosine kinases in T-cell activation and development
29. Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding
30. Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor
31. Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70
32. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
33. RING for destruction?
34. Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation
35. Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck
36. Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling
37. Antiproliferative action of interferon-alpha requires components of T-cell-receptor signalling
38. Calcium and T lymphocyte activation
39. Calcium oscillations increase the efficiency and specificity of gene expression
40. Signal transmission between the plasma membrane and nucleus of T lymphocytes
41. The role of protein kinase C in the regulation of extracellular signal-regulated kinase by the T cell antigen receptor
42. Analysis of the role of protein kinase C-alpha, -epsilon, and -zeta in T cell activation
43. Stimulation of p21 ras upon T-cell activation
44. Role of protein kinase C in T-cell antigen receptor regulation of p21ras: Evidence that two p21ras regulatory pathways coexist in T cells
45. Three-dimensional segregation of supra-molecular activation clusters in T cells
46. Selective modulation of protein kinase C-theta during T-cell activation
47. NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta
48. Protein kinase Ctheta, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells
49. Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes
50. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes
51. A novel functional interaction between Vav and PKC-theta is required for TCR-induced T cell activation
52. RasGRP links T-cell receptor signaling to Ras
53. The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters
54. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs
55. Phospholipase C-gamma1: Regulation of enzyme function and role in growth factor-dependent signal transduction
56. Phosphoinositide-specific phospholipase C and mitogenic signaling
57. Phospholipase C gamma 2 is essential in the functions of B cell and several Fc receptors
58. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254
59. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
60. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells
61. Tec family kinases in lymphocyte signaling and function
62. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity
63. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
64. Association of grb2, gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues: Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling
65. Differential effects of Cb1 and 70Z/3 Cb1 on T cell receptor-induced phospholipase Cgamma-1 activity
66. Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cb1
67. Cb1: Complex formation and functional implications
68. The amino-terminal Src homology 2 domain of phospholipase C gamma 1 is essential for TCR-induced tyrosine phosphorylation of phospholipase C gamma 1
69. Functional independence and interdependence of the Src homology domains of phospholipase C-gamma 1 in B-cell receptor signal transduction
70. Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: Requirement for CD28 up-regulation of RE/AP
71. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites
72. Gene targeting and somatic cell genetics - A rebirth or a coming of age?
73. Requirement for p53 and p21 to sustain G2 arrest after DNA damage
74. Gene targeting in human cells without isogenic DNA