Association of restriction fragment-length polymorphisms in the alcohol dehydrogenase 2 gene with alcoholic brain atrophy

Alcoholism: Clinical and Experimental Research

Volumn 20, Issue 1 SUPPL., 1996, Pages

  Maezawa, Yoshihiko ^a   Yamauchi, Masayoshi ^a   Searashi, Yasuyuki ^a   Takeda, Kunihiko ^a   Mizuhara, Yuuji ^a   Kimura, Taketo ^b   Toda, Gotaro ^a   Suzuki, Hitoshi ^a   Sakurai, Susumu ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b National Hospital Organization   (Japan)

Author keywords

Alcohol Dehydrogenase; Alcoholic Brain Atrophy; Aldehyde Dehydrogenase

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; DNA;

ALCOHOLISM; ARTICLE; BRAIN ATROPHY; COMPUTER ASSISTED TOMOGRAPHY; GENE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; AGED; ALCOHOL DEHYDROGENASE; ALCOHOLISM; ALDEHYDE DEHYDROGENASE; ATROPHY; BRAIN; BRAIN DAMAGE, CHRONIC; CEREBRAL CORTEX; CEREBRAL VENTRICLES; GENE FREQUENCY; GENOTYPE; HUMANS; ISOENZYMES; JAPAN; LIVER CIRRHOSIS, ALCOHOLIC; MALE; MIDDLE AGED; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0029878394     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1996.tb01723.x     Document Type: Article

References (14)

1. Bosron WF, Li T-K: Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology 6:502-510, 1986
2. Lieber CS, Jones DP, DeCarli LM: Effect of prolonged ethanol intake: Production of fatty liver despite adequate diets. J Clin Invest 44:1009-1021, 1965
3. Best CH, Hartroft WS, Lucas CC, Ridout JH: Liver damage produced by feeding alcohol or sugar and its prevention by choline. Br Med J 2:1001-1006, 1949
4. Harada S, Misawa S, Agarwal DP, Goedde HW: Liver alcohol dehydrogenase and aldehyde dehydrogenase in Japanese: Isoenzyme variation and its possible role in alcohol intoxication. Am J Hum Genet 32:8-15, 1980
5. Smith M: Genetics of human alcohol and aldehyde dehydrogenase. Adv Hum Genet 15:249-290, 1986
6. Yoshida A, Hsu LC, Yasunami M: Genetics of human alcohol-metabolizing enzymes. Prog Nucleic Acid Res Mol Biol 40:255-287, 1991
7. Goedde HW, Agarwal DP, Fritze G, Meier-Tackmann D, Singh S, Beckmann G, Bhatia K, Chen LZ, Fang B, Lisker R, Paik YK, Rothhammer F, Saha N, Segal B, Srivastava LM, Czeizel A: Distribution of ADH2 and ALDH2 genotypes in different populations. Hum Genet 88:344-346, 1992
8. Bosron WF, Lumeng L, Li T-K: Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcoholic liver disease. Mol Aspects Med 10:147-158, 1988
9. Couzigou P, Fleury B, Groppi A, Cassaigne A, Begueret J, Iron A: The French group for research on alcohol and liver: Genotyping study of alcohol dehydrogenase class I polymorphism in French patients with alcoholic cirrhosis. Alcohol Alcohol 25:623-626, 1990
10. Sherman DIN, Ward RJ, Warren-Perry M, Williams R, Peters TJ: Association of restriction fragment length polymorphism in alcohol dehydrogenase 2 gene with alcohol induced liver damage. Br Med J 307:1388-1390, 1993
11. Chao Y-C, Liou S-R, Chung Y-Y, Tang H-S, Hsu C-T, Li T-K, Yin S-J: Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients. Hepatology 19:360-366, 1994
12. Yamauchi M, Maezawa Y, Toda G: Genetic factors for alcoholic liver diseases. Biol Clin 10:34-37, 1995
13. 2 allele is dominant. J Clin Invest 83:314-316, 1989
14. Singh S, Fritze G, Fang B, Harada S, Paik YK, Eckey R, Agarwal DP, Doedde HW: Inheritance of mitochondrial aldehyde dehydrogenase: Genotyping in Chinese, Japanese and South Korean families reveals dominance of the mutant allele. Hum Genet 83:119-121, 1989