Distribution and kinetics of ethanol metabolism in rat brain

Alcoholism: Clinical and Experimental Research

Volumn 22, Issue 8, 1998, Pages 1623-1627

  Zimatkin, Sergey M ^a,b   Liopo, Anton V ^a   Deitrich, Richard A ^b,c  

^a INSTITUTE OF BIOCHEMISTRY   (Belarus)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Acetaldehyde; Brain Regions; Ethanol Metabolism

Indexed keywords

ACETALDEHYDE; ALCOHOL; AMITROLE; CATALASE;

ALCOHOL METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN METABOLISM; BRAIN STEM; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVITY; HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

EID: 0031789210     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1998.tb03958.x     Document Type: Article

References (33)

1. Hunt WA: Role of acetaldehyde in the actions of ethanol on the brain - A review. Alcohol 13:147-151, 1996
2. Smith BR, Aragon CM, Amit Z: Catalase and the production of brain acetaldehyde: A possible mediator or the psychopharmacological effects of ethanol. Addict Biol 2:277-289, 1997
3. Sippel HW: The acetaldehyde content in rat brain during ethanol metabolism. J Neurochem 23:451-452, 1974
4. Westcott JY, Weiner H, Schultz J, Myers RD: In vivo acetaldehyde in the brain of the rat treated with ethanol. Biochem Pharmacol 29:411-417, 1980
5. Zimatkin SM: Histochemical study of aldehyde dehydrogenase in the rat CNS. J Neurochem 56:1-11, 1991
6. Zimatkin SM, Pronko PS: Levels of ethanol and acetaldehyde and morphological disturbances in brain following administration of alcohol and ALDH inhibitors, in Jacob B, Bonte W (eds): International Association of Forensic Science. Berlin, Verlag, 1995, pp 1-4
7. Eriksson CJP, Fukunaga T: Human blood acetaldehyde (update 1992). Alcohol Alcohol 2(Suppl.):9-25, 1993
8. Zimatkin SM, Deitrich RA: Ethanol metabolism in the brain. Addict Biol 2:387-392, 1997
9. Mukherji B, Kashiki Y, Ohyanagi H, Sloviter HA: Metabolism of ethanol and acetaldehyde by the isolated perfused rat brain. J Neurochem 24:841-843, 1975
10. Cohen G, Sinet PM, Heikkila R: Ethanol oxidation by rat brain in vivo. Alcohol Clin Exp Res 4:366-370, 1980
11. Gill K, Menez JF, Lucas D, Deitrich RA: Enzymatic production of acetaldehyde from ethanol in rat brain tissue. Alcohol Clin Exp Res 16:910-915, 1992
12. 2 system. Biochem Pharmacol 44:93-98, 1992
13. Hamby-Mason R, Chen JJ, Schenker S, Perez A, Henderson GI: Catalase mediates acetaldehyde formation from ethanol in fetal and neonatal rat brain. Alcohol Clin Exp Res 21:1063-1072, 1997
14. Eysseric H, Gonthier B, Soubeyran A, Bessard G, Saxod R, Barret L: Characterization of the production of acetaldehyde by astrocytes in culture after ethanol exposure. Alcohol Clin Exp Res 21:1018-1023, 1997
15. Aebi H: Catalase in vitro. Methods Enzymol 105:121-126, 1984
16. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275, 1951
17. m mitochondrial aldehyde dehydrogenase in the rat central nervous system. Alcohol Clin Exp Res 16:1162-1167, 1992
18. He X, Nebert DW, Vasiliou V, Zhu H, Shertzer HG: Genetic differences in alcohol drinking preference between inbred strains of mice. Pharmacogenetics 7:223-233, 1997
19. Gill K, France C, Amit Z: Voluntary ethanol consumption in rats: An examination of blood/brain ethanol levels and behavior. Alcohol Clin Exp Res 10:457-462, 1986
20. Bergamaschi S, Govoni S, Rius RA, Trabucchi M: Acute ethanol and acetaldehyde administration produce similar effects on L-type calcium channels in rat brain. Alcohol 5:337-340, 1988
21. Ward RJ, Colantuoni C, Dahchour A, Quertemont E, De Witte P: Acetaldehyde-induced changes in the monoamine and amino acid extracellular microdialysate content of the nucleus accumbens. Neuropharmacology 36:225-232, 1997
22. Pardo CA, Xu Z, Borchelt DR, Price DL, Sisodia SS, Cleveland DW: Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. Proc Natl Acad Sci USA 92:954-958, 1995
23. Cross AR, Jones OTG: Enzymic mechanisms of superoxide production. Biochim Biophys Acta 1057:281-298, 1991
24. Simonson SG, Zhang J, Canada AT Jr, Su Y-F, Benveniste H, Piantadosi CA: Hydrogen peroxide production by monoamine oxidase during ischemia-reperfusion in the rat brain. J Cereb Blood Flow Metab 13:125-134, 1993
25. Prat AG, Turrens JF: Ascorbate- and hemoglobin-dependent brain chemiluminescence. Free Radic Biol Med 8:319-325, 1990
26. Tynes RE, Sabourin PJ, Hodgson E, Philpot RM: Formation of hydrogen peroxide and n-hydroxylated amines catalyzed by pulmonary flavin-containing monooxygenases in the presence of primary alkylamines. Arch Biochem Biophys 251:654-664, 1986
27. Bhamre S, Bhagwat SV, Shankar SK, Williams DE, Ravindranath V: Cerebral flavin-containing monooxygenase-mediated metabolism of antidepressants in brain: Immunochemical properties and immunocytochemical localization. J Pharmacol Exp Ther 267:555-566, 1993
28. 2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase. Biochem J 281:627-630, 1992
29. 2 concentration in rat brain after hyperoxic convulsions. J Appl Physiol 69:1761-1766, 1990
30. Brannan TS, Maker HS, Raes IP: Regional distribution of catalase in the adult rat brain. J Neurochem 36:307-309, 1981
31. Hafer G, Agarwal DP, Goedde HW: Human brain aldehyde dehydrogenase: Activity with DOPAL and isozyme distribution. Alcohol 4:413-418, 1987
32. Pietruszko R, Meier J, Major LF, Saini N, Manz H, Hawley RJ: Human brain aldehyde dehydrogenase activity and isozyme distribution in different areas. Alcohol 1:363-367, 1984
33. Zimatkin SM, Deitrich RA: Aldehyde dehydrogenase activities in the brains of rats and mice genetically selected for different sensitivity to alcohol. Alcohol Clin Exp Res 19:1300-1306, 1995