The mutation rate and cancer

Genetics

Volumn 148, Issue 4, 1998, Pages 1483-1490

  Jackson, Aimee L ^a   Loeb, Lawrence A ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b University of Seattle   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER RISK; CARCINOGENESIS; DNA SEQUENCE; GENETIC SUSCEPTIBILITY; HUMAN; MOLECULAR STABILITY; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; SOMATIC MUTATION;

ANIMALS; HUMANS; MICROSATELLITE REPEATS; MUTATION; NEOPLASMS; PHENOTYPE; SELECTION (GENETICS);

EUKARYOTA; RNA VIRUSES;

EID: 0031953260     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (83)

1. AALTONEN, L. A., P. PELTOMAKI, F. S. LEACH, P. SISTONEN, L. PYLKKANEN et al., 1993 Clues to the pathogenesis of familial colorectal cancer. Science 260: 812-816.
2. ARMITAGE, P., and R. DOLL, 1954 The age distribution of cancer and a multi-stage theory of carcinogenesis. Br. J. Cancer 8: 1-12.
3. BALABAN, G. B., M. HERLYN, W. H. CLARK, JR. and P. C. NOWELL, 1986 Karyotypic evolution in human malignant melanoma. Cancer Geriet. Cytogenet. 19: 113-122.
4. BHATTACHARYYA, N. P., A. SKANDALIS, A. GANESH, J. GRODEN and M. MEUTH, 1994 Mutatorphenotypes in human colorectal carcinoma cell lines. Proc. Natl. Acad. Sci. USA 91: 6319-6323.
5. BOYER, J. C., A. UMAR, J. I. RISINGER, J. R. LIPFORD, M. KANE et al., 1995 Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res. 55: 6063-6070.
6. BRENTNALL, T. A., R. CHEN, J. G. LEE, M. B. KIMMEY, M. P. BRONNER et al., 1995 Microsatellite instability and K-ras mutations associated with pancreatic adenocarcinoma and pancreatitis. Cancer Res. 55: 4264-4267.
7. BRENTNALL, T. A., D. A. CRISPIN, M. P. BRONNER, S. P. CHERIAN, M. HUEFFED et al., 1996 Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res. 56: 1237-1240.
8. BRONNER, C. E., S. M. BAKER, P. T. MORRISON, G. WARREN, L. G. SMITH et al., 1994 Mutation in the DNA mismatch repair homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368: 258-261.
9. CHEN, X. Q., M. STROUN, J. L. MAGNENAT, L. P. NICOD, A. M. KURT et al, 1996 Microsatellite alterations in plasma DNA of small cell lung cancer patients. Nat. Med. 2: 972-974.
10. CHU, E. H. Y., M. BOEHNKE, S. M. HANASH, R. D. KUICK, B. J. LAMB et al, 1988 Estimation of mutation rates based on the analysis of polypeptide constituents of cultured human lymphblastoid cells. Genetics 119: 693-703.
11. CORY, S., 1995 Regulation of lymphocyte survival by the bcl-2 gene family. Annu. Rev. Immunol. 13: 513-543.
12. DAMS, E., E. J. Z. VAN DE KELFT, J.-J. MARTIN, J. VERLOOV and P. J. WILLEMS, 1995 Instability of microsatellites in human gliomas. Cancer Res. 55: 1547-1549.
13. DEMARS, R., and K. R. HELD, 1972 The spontaneous azaguanine-resistant mutants of diploid human fibroblasts. Humangenetik 16: 87-110.
14. Dos SANTOS, N. R., R. SERUCA, M. COSTANCIA, M. SEIXAS and M. SoBRINHO-SIMOES, 1996 Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis. Gastroenterology 110: 38-44.
15. DRAKE, J. W., 1991 A constant rate of mutation in DNA-based microbes. Proc. Natl. Acad. Sci. USA 88: 7160-7164.
16. DRAKE, J. W., 1993 Rates of spontaneous mutation among RNA viruses. Proc. Natl. Acad. Sci. USA 90: 4171-4175.
17. EGAWA, S., T. UCHIDA, K, SUYAMA, C. WANG, M. OHORI et al, 1994 Genomic instability of microsatellite repeats in prostate cancer: relationship to clinicopathological variables. Cancer Res. 55: 2418-2421.
18. EIGEN, M., 1993 Viral quasispecies. Sci. Amer. 269: 42-49.
19. EIGEN, M., and P. SCHUSTER, 1977 The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle. Naturwissenschaften 64: 541-565.
20. ESHLEMAN, J. R., and S. D. MARKOWITZ, 1995 Microsatellite instability in inherited and sporadic neoplasms. Curr. Opin. Oncol. 7: 83-89.
21. FEARON, E. R., and B. VOGELSTEIN, 1990 A genetic model for colorectal tumorigenesis. Cell 61: 759-767.
22. GLAAB, W. E., and K. R. TINDALL, 1997 Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects. Carcinogenesis 18: 1-8.
23. HARRIS, H., 1988 The analysis of malignancy by cell fusion: the position in 1988. Cancer Res. 48: 3302-3306.
24. HEINEN, C. D., N. SHIVAPURKAR, Z. TANG, J. GRODEN and O. ALABASTER, 1996 Microsatellite instability in aberrant crypt foci from human colons. Cancer Res. 56: 5339-5341.
25. HOLLAND, J., K, SPINDLER, F. HORODYSKI, E. GRABAU, S. NICHOL. et al., 1982 Rapid evolution of RNA genomes. Science 215: 1577-1585.
26. HOLMES, J., S. J. CLARK and P. MODRICH, 1990 Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. Proc. Natl. Acad. Sci. USA 87: 5837-5841.
27. HUANG, J., N. PAPADOPOULOS, A. J. MCKINLEY, S. M. FARRINGTON, L. J. CURTIS et al., 1996 APC mutations in colorectal tumors with mismatch repair deficiency. Proc. Natl. Acad. Sci. USA 93: 9049-9054.
28. ICHII, S., S. TAKEDA, A. HORII, S. NAKATSURU, Y. MIYOSHI et al., 1993 Detailed analysis of genetic alterations in colorectal tumors from patients without familial adenomatous polyposis (FAP). Oncogene 8: 2399-2405.
29. IONOV, Y., M. A. PEINADO, S. MALKHOSYAN, D. SHIBATA and M. PERUCHO, 1993 Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363: 558-561.
30. IWABUCHI, H., M. SAKAMOTO, H. SAKUNAGA, Y-Y. MA, M. L. CARCANGIU et al., 1995 Genetic analysis of benign, low grade, and high grade ovarian tumors. Cancer Res. 55: 6172-6180.
31. JEN, J., S. M. POWELL, N. PAPADOPOULOS, K. J. SMITH, S. R. HAMILTON et al., 1994 Molecular determinants of dysplasia in colorectal lesions. Cancer Res. 54: 5523-5526.
32. KALLIONIEMI, A., O.-P. KALLIONIEMI, J. PIPER, M. TANNER, T. STOKE et al., 1994 Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc. Natl. Acad. Sci. 91: 2156-2160.
33. KOI, M., A. UMAR, D. CHAUHAN, S. CHERIAN, J. M. CARETHERS et al., 1994 Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitroguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res. 54: 4308-4312.
34. KORSMEYER, S. J., 1995 Regulators of cell death. Trends Genet. 11: 101-105.
35. LARSON, A. A., S. KERN, R. L. SOMMERS, J. YOKOTA, W. K. CAVENEE et al., 1996 Analysis of replication error (RER+) phenotypes in cervical carcinoma. Cancer Res. 56: 1426-1431.
36. LEACH, F. S., N. C. NICOLAIDES, N. PAPADOPOULOS, B. LIU, J. JEN et al., 1993 Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75: 1215-1225.
37. LEVY, D. B., K. J. SMITH, Y. BEAZER-BARCLAY, S. R. HAMILTON, B. VOGELSTEIN et al., 1994 Inactivation of both APC alleles in human and mouse tumors. Cancer Res. 54: 5953-5958.
38. LI, G.-M., and P. MODRICH, 1995 Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. Proc. Natl. Acad. Sci. USA 92: 1950-1954.
39. LOEB, L. A., 1991 Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 51: 3075-3079.
40. LOEB, L. A., 1994 Microsatellite instability: marker of a mutator phenotype in cancer. Cancer Res. 54: 5059-5063.
41. LOEB, L. A., 1998 Cancer cells manifest a mutator phenotype. Adv. Cancer Res. (in press).
42. LOEB, L. A., C. F. SPRINGOATE and N. BATTULA, 1974 Errors in DNA replication as a basis of malignant change. Cancer Res. 34: 2311-2321.
43. LUONGO, C., A. R. MOSER, S. GLEDHILL and W. F. DOVE, 1994 Loss of Apc+ in intestinal adenomas from Min mice. Cancer Res. 54: 5947-5952.
44. MACPHEE, D. G., 1995 Mismatch repair, somatic mutations, and the origins of cancer. Cancer Res. 55: 5489-5492.
45. MAO, E. F., L. LANE, J. LEE and J. H. MILLER, 1997 Proliferation of mutators in a cell population. J. Bacteriol. 179: 417-422.
46. MAO, L., D. J. LEE, M. S. TOCKMAN, Y. S. EROZAN, F. ASKIN et al., 1994 Microsatellite alterations as clonal markers for the detection of human cancer. Proc. Natl. Acad. Sci. USA 91: 9871-9875.
47. MAO, L., M. P. SCHOENBERG, M. SCICCHITANO, Y. S. EROZAN, A. MERLO et al., 1996 Molecular detection of primary bladder cancer by microsatellite analysis. Science 271: 659-662.
48. MARKOWITZ, S. J., J. WANG, L. MYEROFF, R. PARSONS, L. SUN et al., 1995 Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 268: 1336-1338.
49. McNIEVE, I. K., F. M. STEWART, D. M. DEACON, D. S. TEMELES, K. M. ZSEBO et al., 1989 Detection of a human CFC with a high proliferative potential. Blood 74: 609-612.
50. MIRONOV, N. M., A.-M. AGUELON, E. HOLLAMS, J.-C. LOZANO and H. YAMASAKI, 1995 Microsatellite alterations in human and rat esophageal tumors at selective loci. Mol. Carcinog. 13: 1-5.
51. NAYLOR, S. L., B. E. JOHNSON, J. D. MINNA and A. Y. SAKAGUCHI, 1987 Loss of heterozygosity of chromsome 3p markers in small-cell lung cancer. Nature 329: 451-454.
52. NEEL, J. V., C. SATOH, K. GORIKI, M. FUJITA, N. TAKAHASHI et al., 1986 The rate with which spontaneous mutation alters the electrophorctic mobility of polypeptides. Proc. Natl. Acad. Sci. USA 83: 389-393.
53. NINIO, J., 1991 Transient mutators: a semiquantitative analysis of the influence of translation and transcription errors on mutation rates. Genetics 129: 957-962.
54. NOWELL, P. C., 1976 The clonal evolution of tumor cell populations. Science 194: 23-28.
55. OGASAWARA, S., C. MAESAWA, G. TAMURA and R. SATODATE, 1995 Frequent microsatellite alterations on chromosome 3p in esophageal squamous cell carcinoma. Cancer Res. 55: 891-894.
56. OLLER, A. R., P. RASTOGI, S. MORGENTHALER and W. G. THILLY, 1989 A statistical model to estimate variance in long term low dose mutation assays: testing of the model in a human lymphoblastoid mutation assay. Mutat. Res. 216: 149-161.
57. OLTVAI, Z. N., C. L. MILLIMAN and S. J. KORSMEYER, 1993 Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619.
58. PAPADOPOULOS, N., N. C. NICOLAIDES, Y.-F. WEI, S. M. RUBEN, K. C. CARTER et al., 1994 Mutation of a mutL homolog in hereditary colon cancer. Science 263: 1625-1629.
59. PAPADOPOULOS, N., N. C. NICOLAIDES, B. LIU, R. E. PARSONS, C. LENGAUER et al., 1995 Mutations of GTBP in genetically unstable cells. Science 268: 1915-1917.
60. PARSONS, R., L. L. MYEROFF, B. Liu, J. K, V. WILLSON, S. D. MARKOWITZ et al., 1995 Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer. Cancer Res. 55: 5548-5550.
61. PATEL, U., S. GRIMDFEST-BRONIATOWSKI, M. GUPTA and S. BANERJEE, 1994 Microsatellite instabilities at five chromosomes in primary breast tumors. Oncogene 9: 3695-3700.
62. PEINADO, M. A., S. MALKHOSYAN, A. VELAZQUEZ and M. PERUCHO, 1992 Isolation and characterization of allelic loss and gains in colorectal tumors by arbitrarily primed polymerase chain reaction. Proc. Natl. Acad. Sci. USA 89: 10065-10069.
63. PELTOMAKI, P., L. A. AALTONEN, P. SISTONEN, L. PYLKKANEN, J.-P. MECKLIN et al., 1993 Genetic mapping of a locus predisposing to human colorectal cancer. Science 260: 810-812.
64. POWELL, S. M., N. ZILZ, Y. BLAZER-BARCLAY, T. M. BRYAN, S. R. HAMILTON et al., 1992 APC mutations occur early during colorectal tumorigenesis. Nature 359: 235-237.
65. RAMPINO, N., H. YAMAMOTO, Y. IONOV, Y. LI, H. SAWAI et al., 1997 Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275: 967-969.
66. RICHARDS, B., H. ZHANG, G. PHEAR and M. MEUTH, 1997 Conditional mutator phenotypes in hMSH2 deficient tumor cell lines. Science (in press).
67. RISINGER, J. L., A. BERCHUCK, M. F. KOHLER, P. WATSON, H. T. LYNCH et al., 1993 Genetic instability of microsatellites in endometrial carcinoma. Cancer Res. 53: 5100-5103.
68. RYBERG, D., B. A. LINDSTEDT, S. ZIENOLDDINY and A. HAUGEN, 1995 A hereditary genetic marker closely associated with microsatellite instability in lung cancer. Cancer Res. 55: 3996-3999.
69. SHIRATA, D., W. NAVIDI, R. SALOVAARA, Z.-H. LI and L. A. AALTONEN, 1996 Somatic microsatellite mutations as molecular tumor clocks. Nature Med. 2: 676-681.
70. SHIBATA, D., M. A. PEINADO, Y. IONOV, S. MALKHOSYAN and M. PERUCHO, 1994 Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nat. Genet. 6: 273-281.
71. SHINMURA, K., H. SUGIMURA, Y. NAITO, P. G. SHIELDS and I. KINO, 1995 Frequent co-occurrence of mutator phenotype in synchronous, independent multiple cancers of the stomach. Carcinogenesis 16: 2989-2993.
72. SMITH, A. J., H. S. STERN, M. PENNER, M. HAY, A. MITRI et al., 1994a Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons. Cancer Res. 54: 5527-5530.
73. SMITH, R. J., K. PACK, S. HODGSON, S. K. TAY, R. PHILLIPS et al., 1994b APC mutation associated with late onset of familial adenomatous polyposis. J. Med. Genet. 31: 888-890.
74. STRAUSS, B. S., 1992 The origin of point mutations in human tumor cells. Cancer Res. 52: 249-253.
75. TADDEI, F., M. RADMAN, J. MAYNARD-SMITH, B. TOUPANCE, P. H. GOUYON et al., 1997 Role of mutator alleles in adaptive evolution. Nature 387: 700-702.
76. THIBODEAU, S. N., G. BREN and D. SCHAID, 1993 Microsatellite instability in cancer of the proximal colon. Science 260: 816-819.
77. TOGO, G., N. TODA, F. KANAI, N. KATO, Y. SHIRATORI et al., 1996 A transforming growth factor β type II receptor gene mutation common in sporadic cecum cancer with microsatellite instability. Cancer Res. 56: 5620-5623.
78. UMAR, A., J. C. BOYER, D. C. THOMAS, D. C. NGUYEN, J. I. RISINGER et al., 1994 Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J. Biol. Chem. 269: 14367-14370.
79. UMAR, A., and T. A. KUNKEL, 1996 DNA-replication fidelity, mismatch repair and genomic instability in cancer cells. Eur. J. Biochem. 238: 297-307.
80. VOGELSTEIN, B., E. R. FEARON, S. E. KERN, S. R. HAMILTON, A. C. PREISINGER et al., 1988 Genetic alterations during colorectal-tumor development. N. Engl. J. Med. 319: 525-532.
81. WEINBERG, R. A., 1995 The molecular basis of oncogenes and tumor suppresser genes. Ann. NY Acad. Sci. 758: 331-338.
82. WHITE, E., 1996 Life, death, and the pursuit of apoptosis. Genes Dev. 10: 1-15.
83. WRANA, J. L., L. ATTISANO, R. WEISER, F. VENTURA and J. MASSAGUÉ, 1994 Mechanism of activation of the TGF-β receptor. Nature 370: 341-347.