Autoradiographic studies indicate regional variations in the characteristics of L-glutamate transporters in the rat brain

Neuroscience Letters

Volumn 216, Issue 2, 1996, Pages 101-104

  Killinger, Suzanne ^a   Blume, Gail L ^a   Bohart, Lotte ^c   Bested, Annette ^c   Dias, Leonora S ^a   Cooper, Benedict ^a   Allan, Robin D ^b   Balcar, Vladimir J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b University of Sydney   (Australia)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Excitatory amino acids; GLAST; GLT 1; Glutamate transport inhibitors; Na+ dependent glutamate transporters; Neurotoxicity

Indexed keywords

GLUTAMIC ACID;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN REGION; CONTROLLED STUDY; FEMALE; MALE; NEUROTOXICITY; NEUROTRANSMITTER UPTAKE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030604018     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)13015-9     Document Type: Article

References (20)

1. 3H]aspartate binding sites, Life Sci., 52 (1993) 863-868.
2. [2] Balcar, V.J. and Li, Y., Heterogeneity of high affinity uptake of L-glutamate and L-aspartate in the mammalian central nervous system,. Life Sci., 51 (1992) 1467-1478.
3. 3H]kainate studied by autoradiography in rat forebrain, Neurochem. Int., 26 (1995) 155-163.
4. [4] Bridges, R.J., Stanley, M.S., Anderson, M.W., Cotman, C.W. and Chamberlin, A.R., Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereoisomer, J. Med. Chem., 34 (1991) 717-725.
5. [5] Christensen, H.N., Greene, A.A., Kakuda, D.K. and MacLeod, C.L., Special transport and neurological significance of two amino acids in a configuration conventionally designated as D. J. Exp. Biol., 196(1994) 297-305.
6. +-dependent glutamate uptake in rat hippocampal astrocyte cultures, J. Neurochem., 67 (1996) 277-286.
7. [7] Johnston, G.A.R., Kennedy, S.M.E. and Twitchin, B., Action of the neurotoxin kainic acid on high affinity uptake of L-glutamic acid in rat brain slices, J. Neurochem., 32 (1979) 121-127.
8. [8] Kanai, Y., Bhide, P.G., DiFiglia, M. and Hediger, M.A., Neuronal high affinity glutamate transport in the rat central nervous system, NeuroReport. 6 (1995) 2357-2362.
9. [9] Killinger, S., Li, Y. and Balcar, V.J., Sensitivity of the binding sites on glutamate transporters to neurotoxic agents, NeuroReport, 6 (1995) 1290-1292.
10. 3H]L-aspartate in thaw-mounted sections of rat forebrain, Exp. Brain Res., 97 (1994) 415-422.
11. [11] McBean, G.J. and Roberts, P.J., Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum, J. Neurochem., 44 (1985) 247-254.
12. [12] Mitrovic, A.D. and Johnston, G.A.R., Regional differences in the inhibition of L-glutamate and L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylate, threo-3-hydroxy-D-aspartate and D-aspartate, Neurochem. Int., 24 (1994) 583-588.
13. [13] Pines, G., Danbolt, N.C., Bjørås, M., Zhang, Y., Bendahan, A., Eide, L., Koeppsel, H., Storm-Mathisen, J., Seeberg, E. and Kanner, B.I., Cloning and expression of a rat brain L-glutamate transporter, Nature, 360 (1992) 464-467.
14. 3H]glutamate transport activity: pharmacologie specificity and regulation by potassium and sodium, J. Neurochem., 60 (1993) 167-179.
15. [15] Rothstein, J.D., Martin, L., Levey, A.I., Dykes-Hoberg, M., Jin, L., Wu, D., Nash, N. and Kuncl, R.W., Localization of neuronal and glial glutamate transporters, Neuron, 13 (1994) 713-725.
16. [16] Rothstein, J.D., Van Kammen, M., Levey, A.I., Martin, L.J. and Kuncl, R.W., Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis, Ann. Neurol., 38 (1995) 73-84.
17. [17] Rothstein, J.D., Dykes-Hoberg, M., Pardo, C.A., Bristol, L.A., Jin, L., Kanai, Y., Hediger, M.A,. Wang, Y., Schielke, J. and Welty, D.F., Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron, 16 (1996) 675-685.
18. [18] Scott, H.L., Tannenberg, A.E.G. and Dodd, P.R., Variant forms of neuronal glutamate transporter sites in Alzheimer disease cerebral cortex. J. Neurochem., 64 (1995) 2193-2202.
19. +-dependent glutamate/aspartate transporter from rat brain, Proc. Natl. Acad. Sci. USA, 89 (1992) 10955-10959.
20. [20] Tanaka, K., Expression-cloning of a rat glutamate transporter, Neurosci. Res., 16 (1993) 149-153.