CD3ζ and CD28 down-modulation on CD8 T cells during viral infection

Blood

Volumn 96, Issue 3, 2000, Pages 1021-1029

  Trimble, Linda A ^a   Kam, Lawrence W ^a   Friedman, Rachel S ^a   Xu, Zhan ^a   Lieberman, Judy ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CENTER FOR BLOOD RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD57 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 2; PERFORIN; T LYMPHOCYTE RECEPTOR;

ACUTE GASTROENTERITIS; ANTIGEN EXPRESSION; ARTICLE; CASE REPORT; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; CYTOTOXIC T LYMPHOCYTE; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; INFECTIOUS MONONUCLEOSIS; INTERFERON PRODUCTION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VIRUS INFECTION; CD8+ T LYMPHOCYTE; CYTOTOXICITY; DOWN REGULATION; IMMUNOLOGY; VIROLOGY;

ANTIGENS, CD28; ANTIGENS, CD3; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; DOWN-REGULATION; HUMANS; VIRUS DISEASES;

EID: 0034238107     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.3.1021.015k37_1021_1029     Document Type: Article

References (43)

1. Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice
2. Loss of T-cell receptor zeta chain and p56lck in T-cells infiltrating human renal cell carcinoma
3. Correlation between disease activity and T-cell CD3 zeta chain expression in a B-cell lymphoma
4. HIV infection-induced posttranslational modification of T cell signaling molecules associated with disease progression
5. Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 zeta, the signaling chain of the T-cell receptor complex
6. Decreased expression of signal-transducing CD3 zeta chains in T cells from the joints and peripheral blood of rheumatoid arthritis patients
7. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosis
8. Expression and activity of signaling molecules in T lymphocytes obtained from patients with metastatic melanoma before and after interleukin 2 therapy
9. Transfer of the interleukin-2 gene into human cancer cells induces specific antitumor recognition and restores the expression of CD3/T-cell receptor associated signal transduction molecules
10. Interleukin 2 restores CD3-zeta chain expression but fails to generate tumour-specific lytic activity in tumour-infiltrating lymphocytes derived from human colorectal hepatic metastases
11. A transgenic mouse model to analyze CD8+ effector T cell differentiation in vivo
12. Down-modulation of CD3ζ, the signaling chain of the T cell receptor complex, is associated with CD8 T cell dysfunction in HIV infection [thesis]
13. Cytotoxic T lymphocytes from HIV-1 seropositive individuals recognize immunodominant epitopes in Gp160 and reverse transcriptase
14. Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum
15. Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: Evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency
16. T cells from patients with Hodgkin's disease have a defective T-cell receptor zeta chain expression that is reversible by T-cell stimulation with CD3 and CD28
17. Expansion of CD57 and CD62L-CD45RA+ CD8 T lymphocytes correlates with reduced viral plasma RNA after primary HIV infection
18. Lymphocyte-mediated cytotoxicity in vitro and in vivo: Mechanisms and significance
19. CD2/LFA-3 or LFA-1/ICAM-1 but not CD28/B7 interactions can augment cytotoxicity by virus-specific CD8+ cytotoxic T lymphocytes
20. Signal transduction by lymphocyte antigen receptors
21. Regulation of T cell activation by CD28 and CTLA4
22. The complexity of the B7-CD28/CTLA-4 costimulatory pathway
23. Direct visualization of antigen-specific CD8+ T Cells during the primary immune response to Epstein-Barr virus in vivo
24. Requirements for CD28-dependent T cell-mediated cytotoxicity
25. Phenotypic and functional separation of memory and effector human CD8+ T cells
26. Differentiation of human CD8 T cells: Implications for in vivo persistence of CD8+ CD28- cytotoxic effector clones
27. Large clonal expansions of CD8+ T cells in acute infectious mononucleosis
28. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
29. Induction and exhaustion of lymphocytic choriomeningitis virus- specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes
30. Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections
31. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T celt response
32. CD28 costimulation prevents cell death during primary T cell activation
33. CD28 co-stimulation inhibits TCR-induced apoptosis during a primary T cell response
34. Major expansions of select CD8+ subsets in acute Epstein-Barr virus infection: Comparison with chronic human immunodeficiency virus disease
35. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
36. On immunological memory
37. Rapid effector function in CD8+ memory T cells
38. Immunological memory
39. T cell memory
40. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
41. Phenotypic analysis of antigen-specific T lymphocytes
42. Modeling T-cell memory by genetic marking of memory T cells in vivo
43. HIV-specific circulating CD8 T lymphocytes have down-modulated CD3 and CD28, key signaling molecules for T cell activation