Expression and activity of signaling molecules in T lymphocytes obtained from patients with metastatic melanoma before and after interleukin 2 therapy

Clinical Cancer Research

Volumn 2, Issue 8, 1996, Pages 1263-1274

  Rabinowich, Hannah ^a,b   Banks, Michael ^a,b   Reichert, Torsten E ^a,b   Logan, Theodore F ^a,b   Kirkwood, John M ^a,b   Whiteside, Theresa L ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2;

ANTIGEN PRESENTATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVITY; FLOW CYTOMETRY; FROZEN SECTION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; KILLER CELL; MELANOMA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY;

HUMANS; INTERLEUKIN-2; LYMPH NODES; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MELANOMA; MEMBRANE PROTEINS; PHOSPHOLIPASE C; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 0029737843     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Whiteside, T. L. Tumor-Infiltrating Lymphocytes in Human Malignancies. Austin. TX: R. G Landes Company, 1994.
2. Weidmann, E , Elder, E. M., Trucco, M., Lotze, M. T., and Whiteside, T. L. Usage of T-cell receptor V beta chain genes in fresh and cultured tumor-infiltrating lymphocytes from human melanoma. Int. J. Cancer, 54: 383-390, 1993.
3. Shilyansky, J., Nishimura, M. I., Yannelli, J. R., Kawakami, Y., Jacknin, L. S., Charmley, P., and Rosenberg, S. A. T-cell receptor usage by melanoma-specific clonal and highly oligoclonal tumor-infiltrating lymphocyte lines. Proc. Natl. Acad. Sci. USA, 91: 2829-2833, 1994.
4. Sensi, M., Salvi, S., Castelli, C., Maccalli, C., Mazzocchi, A., Mortarini, R., Nicolini, G., Herlyn, M., Parmiani, G., and Anichini, A. T cell receptor (TCR) structure of autologous melanoma-reactive cytotoxic T lymphocyte (CTL) clones: tumor-infiltrating lymphocytes overexpress in vivo the TCR beta chain sequence used by an HLA-A2-restricted and melanocyte-lineage-specific CTL clone. J. Exp. Med., 178: 1231-1246, 1993.
5. Boon, T., Cerottim, J. C. Van den Eynde, B., van der Bruggen, P., and Van Pel, A. Tumor antigens recognized by T lymphocytes Annu. Rev. Immunol., 12: 337-365, 1994.
6. Alexander, J. P., Kudoh, S., Melsop, K. A., Hamilton, T. A., Edinger, M. G., Tubbs, R. R., Sica, D., Tuason, L., Klein, E., Bukowski, R. M., and Finke, J. H. T-cells infiltrating renal cell carcinoma display a poor proliferative response even though they can produce interleukin 2 and express interleukin 2 receptors. Cancer Res., 53: 1380-1387, 1993.
7. Miescher, S., Whiteside, T. L., Carrel, S., and Von Fhedner, V. Functional properties of tumor infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes. J. Immunol., 136: 1899-1907, 1986.
8. Miescher, S., Stoeck, M., Qiao, L., Barras, C., Barrelet, L., and Von Fliedner, V. Preferential clonogenic deficit of CD8-positive T lymphocytes infiltrating human solid tumors. Cancer Res., 48, 6992-6998, 1988.
9. Applegate, K. G., Balch, C. M., and Pellis, N. R. In vitro migration of lymphocytes through collagen matrix: arrested locomotion in tumor-infiltrating lymphocytes. Cancer Res., 50: 7153-7158, 1990.
10. Vitolo, D., Zerbe, T , Kanbour, A., Dahl, C., Herberman, R. B , and Whiteside, T. L. Expression of mRNA for cytokines in tumor-infiltrating mononuclear cells in ovarian adenocarcinoma and invasive breast cancer. Int. J. Cancer, 57: 573-580, 1992.
11. Rivoltini, L., Kawakami, Y., Sakaguchi, K., Southwood, S., Sette, A., Robbins, P F., Marincola, F. M., Salgaller, M. L., Yannelli, J. R., Appella, E., and Rosenberg, S. A. Induction of tumor-reactive CTL from peripheral blood and tumor-infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MART-1. J. Immunol., 154: 2257-2265, 1995.
12. Hom, S. S., Schwartzentruber, D. J., Rosenberg, S. A., and Topalian, S. L. Specific release of cytokines by lymphocytes infiltrating human melanomas in response to shared melanoma antigens. J. Immunother., 13: 18-30, 1993.
13. Webb, S., Morris, C., and Sprent, J. Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell, 63: 1249-1256, 1990.
14. Fujimoto, S., Greene, M. I., and Sehon, A. H. Regulation of the immune response to tumor antigens. II. The nature of immunosuppressor cells in tumor-bearing hosts. J. Immunol., 116: 791-799, 1976.
15. Townsend, S. E., and Allison, J. P. Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science (Washington DC), 259: 368-370, 1993.
16. Watson, G. A., and Lopez, D. M. Aberrant antigen presentation by macrophages from tumor-bearing mice is involved in the down-regulation of their T cell responses. J. Immunol., 155: 3124-3134, 1995.
17. Browning, M. J., and Bodmer, W. F. MHC antigens and cancer: implications for T-cell surveillance Curr. Opin. Immunol., 4: 613-618, 1992.
18. lck in T-cell infiltrating human renal cell carcinoma. Cancer Res., 53: 5613-5616, 1993.
19. Tartour, E., Latour, S., Mathiot, C , Thiounn, N., Mosser, V., Joyeux, I., Dubois D'Enghien, C., Lee, R., Debre, B , and Herman Fridman, W. Variable expression of CD3-ζ chain in tumor-infiltrating lymphocytes (TIL) derived from renal cell carcinoma: relationship with TIL phenotype and function. Int. J. Cancer, 63: 205-212, 1995.
20. Nakagomi, H., Petersson, M., Magnusson, I., Julilin, C., Matsuda, M., Mellstedt, H., Taupin, J-L., Vivier, E., Anderson, P., and Kiessling, R. Decreased expression of the signal-transducing ζ chains in tumor-infiltrating T-cell and NK cells of patients with colorectal carcinoma. Cancer Res., 53: 5610-5612, 1993.
21. Matsuda, M , Petersson, M., Lenkei, R., Raupin. J-L., Magnusson, I., Mellstedt, H., Anderson, P., and Kiessling, R. Alterations in the signal-transducing molecules of T cells and NK cells in colorectal tumor-infiltrating gut mucosal and peripheral lymphocytes: correlation with the stage of the disease. Int. J. Cancer, 61: 765-772, 1995.
22. Lai, P., Rabinowich, H., Crowley-Nowick, P. A., Bell, M. C., Mantovani, G., and Whiteside, T. L. Alteration in expression and function of signal transducing proteins in tumor-associated T and NK cells in patients with ovarian carcinoma. Clin. Cancer Res., 2: 161-173, 1996.
23. Zea, A. H., Cutri, B. D., Longo, D. L., Alvord, W. G., Strobl, S. L., Mizoguchi, H., Creekmore, S. P., O'Shea, J. J., Powers, G. C., Urba, W. J., and Ochoa, A. C Alterations in T cell receptor and signal transduction molecules in melanoma patients. Clin. Cancer Res., 1: 1327-1335, 1995.
24. Farace, F., Angevin, E., Vanderplancke, J., Escudier, B., and Triebel, F. The decreased expression of CD3 ζ chains in cancer patients is not reversed by IL-2 administration. Int. J. Cancer, 59: 752-755, 1994.
25. Gunji, Y., Hori, S., Aoe, T., Asano, T., Ochiai, T., Isono, K., and Saito, T. High frequency of patients with abnormal assembly of T cell receptor-CD3 complex in peripheral blood T lymphocytes. Jpn. J. Cancer Res., 85: 1189-1192, 1994.
26. Franco, J. L., Ghosh, P., Wiltrout, R. H., Carter, C. R. D., Zea, A. H., Momozaki, N., Ochoa, A C., Longo, D. L., Sayers, T. J., and Komschlies, K. L. Partial degradation of T-cell signal transduction molecules by contaminating granulocytes during protein extraction of splenic T cells from tumor-bearing mice. Cancer Res., 55: 3840-3846, 1995.
27. Levey, D. L., and Srivastava, P. K. T cells from late tumor-bearing mice express normal levels pf p56lck, p59lyn, ZAP-70, and CD3ζ despite suppressed cytolytic activity. J. Exp. Med., 182: 1029-1036, 1995.
28. Mizoguchi, H., O'Shea, J. J., Longo, D. L., Loeffler, C. M., McVicar, D. W., and Ochoa, A. C. Alteration in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science (Washington DC), 258: 1795-1798, 1992.
29. Salvadori, S., Gansbacher, B., Pizzimenti, A. M., and Zier, K. S. Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL2-secreting tumors. J. Immunol., 153: 5176-5183, 1994.
30. Salvadori, S., Gansbacher, B., and Zier, K Functional defects are associated with abnormal signal transduction in T cells of mice inoculated with parental but not IL-2 secreting tumor cells. Cancer Gene Ther., 1: 165-170, 1994.
31. Kirkwood, J. M., Ernstoff, M. S., Vlock, D. R., Herberman, R. B., and Whiteside, T L. New approaches to the use of IL-2 in melanoma: adoptive cellular therapy utilizing purified populations of A-LAK effectors. In. P. Hershey (ed.) Biological Agents in the Treatment of Cancer, pp. 40-46. Newcastle, NSW: Government Printing, 1990.
32. Julius, M. H., Simpson, E., and Herzenberg, L. A. A rapid method for the isolation of functional thymus derived murine lymphocytes. Eur. J. Immunol., 3: 645-649, 1973.
33. Manciulea, M., Rabinowich, H., Sulica, A., Lin, W-c., Whiteside, T. L., DeLeo, A., Herberman, R. B., and Corey, S. J Divergent phosphotyrosine signaling via FcγRIIIA on human NK cells. Cell Immunol., 167: 63-71, 1996.
34. Weidmann, E., Sacchi, M., Plaisance, S., Heo, D. S., Yasumura, S., Lin, W. C., Johnson, J. T., Herberman, R. B., Azzarone, B., and Whiteside, T. L Receptors for interleukin 2 on human squamous cell carcinoma cell lines and tumor in situ. Cancer Res., 52: 5963-5970, 1992.
35. Vivier, E., Rochet, N., Kochan, J. P., Presky, D. H., Schlossman, S. F., and Anderson, P. Structural similarity between Fc receptors and T cell receptors: expression of the gamma-subunit of Fc epsilon RI in human T cells, natural killer cells and thymocytes. J. Immunol., 147: 4263-4270, 1991.
36. Straus, D. B., and Weiss, A. Genetic evidence for the involvement of the Lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell. 70: 585-593, 1992.
37. Mule, J. J., Schwarz, S. L., Roberts, A. B., Sporn, M B., and Rosenberg, S. A. Transforming growth factor β inhibits the generation of lymphokine-activated cells and cytotoxic cells. Cancer Immunol. Immunother., 26: 95-103, 1988.
38. Arteaga, C. L , Hurd, S. D., Winnier, A. R., Johnson, M. D., Fendley, B. M., and Forbes, J T. Anti-transforming growth factor (TGF)-β antibodies inhibit breast cancer cells tumorigenicity and increase mouse spleen natural killer cell activity. Implication for a possible role of tumor cell/host TGF-β interactions in human breast cancer progression. J. Clin. Invest., 92: 2569-2576, 1993.
39. Becker, J. C., Czerny, C., and Brocker, E-B. Maintenance of clonal anergy by endogenously produced IL10. Int. Immunol., 6: 1605-1612, 1994.
40. Rosenberg, S. A., Packard, B. S., Aebersold, P. M., Solomon, D., Topalian, S. L., Toy, S. T , Simon, P., Lotze, M. T., Yang, J. C., Seipp, C. A., Simpson, C., Carter, C., Bock, S., Schwartzentruber, D., Wei, J. P., and White, D. E. Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma: a preliminary report. N. Engl. J. Med., 319: 1676-1680, 1988.
41. Whiteside, T. L , Heo, D. S., Takagi, S., Johnson, J. T., Iwatsuki, S., and Herberman, R. B. Cytolytic antitumor effector cells in long-term cultures of human tumor-infiltrating lymphocytes in recombinant interleukin 2. Cancer Immunol Immunother., 26: 1-10, 1988.
42. Takagi, S., Chen, K., Schwarz, R., Iwatsuki, S., Herberman, R. B., and Whiteside, T. L. Functional and phenotypic analysis of tumor-infiltrating lymphocytes isolated from human primary and metastatic liver tumors and cultured in recombinant interleukin-2. Cancer (Phila.), 63: 102-111, 1989.
43. Aebersold, P., Hyatt, C., Johnson, S., Hines, K., Korcak, L., Sanders, M., Lotze, M., Topalian, S., Yang, J , and Rosenberg, S. A. Lysis of autologous melanoma cells by tumor-infiltrating lymphocytes: association with clinical response. J. Natl. Cancer Inst., 83: 932-937, 1991.