bcl-2 rearrangement detected by pulsed-field gel electrophoresis (PFGE) in B-chronic lymphocytic leukemia (CLL) cells

International Journal of Cancer

Volumn 76, Issue 6, 1998, Pages 909-912

  Laytragoon Lewin, Nongnit ^a,c   Kashuba, Vladimir ^b   Mellstept, Håkan ^a,c   Klein, George ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; B CELL LEUKEMIA; B LYMPHOCYTE; CHROMOSOME TRANSLOCATION; CHRONIC LYMPHATIC LEUKEMIA; GENE REARRANGEMENT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

B-LYMPHOCYTES; ELECTROPHORESIS, GEL, PULSED-FIELD; GENE REARRANGEMENT; GENES, BCL-2; HUMANS; LEUKEMIA, B-CELL, CHRONIC; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0032503557     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980610)76:6<909::AID-IJC23>3.0.CO;2-W     Document Type: Article

References (23)

1. ADACHI, M., TEFFERI, A., GREIPP, P., KIPPS, T. and TSUJIMOTO, Y., Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia. J. exp. Med., 171, 559-564 (1990).
2. AGUILAR-SANTELISES, M., ROTTENBERG, M., LEWIN, N., MELLSTEDT, H. and JONDAL, M., Bcl-2. Bax and P53 expression in B-CLL in relation to in vitro survival and clinical progression. Int. J. Cancer, 69, 114-119 (1996).
3. AOKI, H., TAKISHITA, M., KOSAKA, M. and SAITO, S., Frequent somatic mutations in D and /or JH segments of Ig gene in Waldenström's maeroglobulinemia and chronic lymphocytic leukemia (CLL) with Richter's syndrome but not in common CLL. Blood, 85, 1913-1920 (1995).
4. DÖHNER, H., PILZ, T., FISCHER, K., CABOT, G., DIEHL., D., FINK, T., STILGENBAUER, S., BENTZ, M., and LICHTER, P., Molecular cytogenetic analysis of RB-1 in chronic B cell leukemias. Leukemia Lymphoma. 16, 97-103 (1994).
5. DYER, M., ZANI, V., LU, W., O'BYRNE, A., MOULD, S., CHAPMAN, R., HEWARD, J., KAYANO, H., JADAYEL, D., MATUTES, E., CATOVSKY, D. and OSCIER, D., Bcl-2 translocations in leukemias of mature B cells. Blood, 83, 3682-3688 (1994).
6. GAIDANO, G., BALLERINI, P., GONG, J., INGHIRAMI, G., NERI, A., NEWCOMB, E., MAGRATH, I., KNOWLES, D. and DALLA-FAVERA, R., p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc. natl Aaid. Sci. (Wash.), 88, 5413-5417 (1991).
7. GAIDANO, G., NEWCOMB, E., GONG, J., TASSI, V., NERI, A.,CORTELEZZI, A., CALORI, R., BALDINI, L. and DALLA-FAVERA, R., Analysis of alterations of oncogenes and tumor suppressor genes in chronic lymphocytic leukemia. Amer. J. Pathol., 144, 1312-1319 (1994).
8. KARENDE, A., FIALKOW, P., NILSON, K., POVEY, S., KLEIN, G., NAJFELD, V. and PENFOLD, G., Establishment of a lymphoid cell line from leukemic cells of a patient with chronic lymphocytic leukemia. Int. J. Cancer, 26, 551-556 (1980).
9. KNOX, K. and GORDON, J., Protein tyrosine phosphorylation is mandatory for CD40-mediated rescue of germinal center B cells from apoptosis. Europ. J. Immunol., 23, 2578-2584 (1993).
10. LEWIN, N., AVILA-CARINO, J., MINAROVITS, J., MELLSTEDT, H., LENETTE, E., BRAUTBAR, C., KLEIN, G. and KLEIN, E., Detection of two Epstein Barr virus (EBV) carrying leukemic cell clones in a patient with chronic lymphocytic leukemia (CLL). Int. J. Cancer, 61, 159-164 (1995).
11. LIPFORD, E., WRIGHT. J., URBA, W., WHANG-PENG, J., KIRSCH, I., RAFFELD, M., COSSMAN, J., LONGO, D., BAKHSHI, A. and KORSMEYER, S., Refinement of lymphoma cytogenetics hy the chromosome 18q21 major breakpoint region. Blood, 70, 1816-1823 (1987).
12. MCDONNELL, T., DEANE, N., PLATT, F., NUÑEZ, G., JAEGER, U., MCKEARN, J. and KORSMEYER, S., bcl-2 -immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell, 57, 79-88 (1989).
13. MONTSERRAT, E., BENNET, J., CATOVSKY, D., DIGHIERO, G., GALE., R., RAI, K. and ROZMAN, C., Meeting report: 5th international workshop on chronic lymphocytic leukemia. Leukocyte Res., 16, 717-720 (1992).
14. NAJFELD, V. FIALKOW, P., KARANDE, A., NILSSON, K., KLEIN, G. and PENFOLD, G., Chromosome analysis of lymphoid cell lines derived from patients with chronic lymphocytic leukemia. Int. J. Cancer, 26, 543-549 (1980).
15. NUÑEZ, G., LONDON, L., HOCKENBERY, D., ALEXANDER, M., MCKEARN, J. and KORSMEYER, S., Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J. Imimnol., 144, 3602-3610 (1990).
16. PEHTERSSON, M., JERNBERG-WIKLUND, L., LARSSON, L., SUNDSTROM, C., GIVOL, L. TSUJIMOTO, Y. and NILSSON, K., Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells. Blood, 79, 495-502 (1992).
17. PEZZELLA, F., TSE, A., CORDELL, J., PULFORD, K., GATTER, K. and MASON, D., Expression of the Bcl-2 oncogene protein is not specific for the 14:18 chromosomal translocation. Amer. J. Pathol., 137, 225-232 (1990).
18. SCHENA, M., LARSSON, L., GOTTARDI, D., GAIDANO, G., CARLSSON, M., NILSSON, K. and CALIGARIS-CAPPIO, F., Expression of bcl-2 is down-regulated during mitogenic stimulation of B-chronic lymphocytic leukemia cells. Blood, 79, 291-298 (1992).
19. SOUTHERN, S. Detection of specific sequence among DNA fragments separated by gel electrophoresis. J. mol. Biol., 98, 503-517 (1975).
20. STRASSER, A., HARRIS, A., BATH, M. and CORY, S., Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature (Lond.), 348, 331-333 (1990).
21. STRASSER, A., HARRIS, A. and CORY, S., Eμ-bcl-2-transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells. Oncogene, 8, 1-9 (1993).
22. TSUJIMOTO, Y., BASHIR, M., GIVOL, I. COSSMAN, J., JAFFE, E. and CROCK, C., DNA rearrangements in human follicular lymphoma can involve the 5′or the 3′ region of the bcl-2 gene. Proc. natl. Acad. Sci. (Wash.), 84, 1327-1331 (1987).
23. VAUX, D., CORY, S. and ADAMS, J., bcl-2 gene promotes haemotopoietic cell survival and cooperates with c-myc to immortalized pre-B cells. Nature (Lond.), 335, 440-442 (1988).