Genetic selection of peptide inhibitors of biological pathways

Science

Volumn 285, Issue 5427, 1999, Pages 591-595

  Norman, Thea C ^a,b   Smith, Dana L ^a   Sorger, Peter K ^a,c   Drees, Becky L ^d   O'Rourke, Sean M ^e   Hughes, Timothy R ^f   Roberts, Christopher J ^f   Friend, Stephen H ^f   Fields, Stan ^d   Murray, Andrew W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Microbia PE Inc   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f ROSETTA INPHARMATICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; NUCLEASE;

ARTICLE; GENETIC SELECTION; HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS; TRANSCRIPTION REGULATION; YEAST;

AMINO ACID SEQUENCE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; FUNGAL PROTEINS; G1 PHASE; GALACTOSE; LIPOPROTEINS; MICROCOCCAL NUCLEASE; MITOSIS; MITOTIC SPINDLE APPARATUS; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDES; PHEROMONES; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SELECTION (GENETICS); SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS); SACCHAROMYCETALES; STAPHYLOCOCCUS;

EID: 0033597939     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.285.5427.591     Document Type: Article

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43. Supported by grants from NIH, Human Frontier Science Program, and Chiron (A.W.M.); an NIH senior fellowship (T.C.N.); an NIH grant and the Herbert W. Boyer Fund (S.M.O.); and NIH grant P41-RR11823 (B.L.D. and S.F.). S.F. is an Investigator of the Howard Hughes Medical Institute. We thank L. Hartwell, I. Herskowitz, L. Huang, and J. Rine for yeast strains and plasmids; T. Geyer, Alejandro Colman-Lerner, and R. Brent for communicating unpublished results; and D. Gottschling, I. Herskowitz, L. Pillus, J. Simon, and members of the Seattle Project and the Murray laboratory for valuable discussions.