A peptidomimetic antagonist of TNF-α-mediated cytotoxicity identified from a phage-displayed random peptide library

Journal of Immunology

Volumn 161, Issue 10, 1998, Pages 5621-5626

  Chirinos Rojas, Carlos L ^a   Steward, Michael W ^a   Partidos, Charalambos D ^b  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE LIBRARY; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; CYTOTOXICITY; HOST RESISTANCE; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

EID: 0032533467     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Balkwill, F. R., and F. Burke. 1989. The cytokine network, Immunol. Today 10:299.
2. Larrick, J. W., and S. L. Kunkel. 1988. The role of tumor necrosis factor and interleukin 1 in the immunoinflammatory response. Pharm. Research 3:129.
3. Brockhaus, M., H. J. Schoenfeld, E. J. Schlaeger, W. Hunziker, W. Lesslauer, and H. Loetscher. 1990. Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies. Proc. Natl. Acad. Sci. USA 87: 3127.
4. Foxwell, B., K. Barret, and M. Feldmann. 1990. Cytokine receptors: structure and signal transduction. Clin. Exp. Immunol. 90:161.
5. Banner, D. W., A. D'Arcy, W. James, R. Gentz, H. J. Schoenfeld. C. Broger, H. Loetscher, and W. Lesslauer. 1993. Crystal structure of the soluble human 55-kDa TNF receptor-human TNF-β complex: implications for TNF receptor activation. Cell 73:431.
6. Tracey, K., and A. Cerami. 1993. Tumor necrosis factor, other cytokines and disease. Annu. Rev. Cell Biol. 9:317.
7. Evans, T. J., D. Moyes, A. Carpenter, R. Martin, H. Loetscher, W. Lesslauer, and J. Cohen. 1994. Protective effect of 55-but not 75-kDa soluble tumor necrosis factor receptor-immunoglobulin G fusion proteins in an animal model of gramnegative sepsis. J. Exp. Med. 180:2173.
8. Komer, H., A. L. Goodsall, F. Lemckert, B. J. Scallon, J. Ghrayeb, A. L. Ford, and D. Sedgwick. 1995. Unimpaired autoreactive T-cell traffic within the central nervous system during tumor necrosis factor receptor-mediated inhibition of experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 92:11066.
9. Dick, A. D., P. G. McMenamin, H. Korner, B. J. Scallon, J. Ghrayeb, J. V. Forrester, and J. D. Sedgwick. 1996. Inhibition of tumor necrosis factor activity minimizes target organ damage in experimental autoimmune uveoretinitis despite quantitatively normal activated T cell traffic to the retina. Eur. J. Immunol. 26:1018.
10. Suffredini, A. F., D. Reda, S. M. Banks, M. Tropea, J. M. Agosti, and R. Miller. 1995. Effect of recombinant dimeric TNF receptor on human inflammatory responses following intravenous endotoxin administration. J. Immunol. 155:5038.
11. Lesslauer, W., H. Tabuchi, R. Gentz, M. Brockhaus, E. J. Schlaeger, G. Grau, P. F. Piguet, P. Pointaire, P. Vassalli, and H. Loetscher. 1991. Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide-induced lethality. Eur. J. Immunol. 21:2883.
12. Mohler, K. M., D. S. Torrance, C. A. Smith, R. G. Goodwin, K. E. Stremler, V. P. Fung, H. Madani, and M. B. Widmer. 1993. Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists. J. Immunol. 151: 1548.
13. Lam, K., K. Salmon, E. Hersh, V. Hruby, W. Kazmierski, and R. Knapp. 1991. A new type of synthetic peptide library for identifying ligand binding activity. Nature 354:82.
14. Scott, J. K., and G. P Smith. 1990. Searching for peptide ligands with an epitope library. Science 249:386.
15. D'Mello, F., C. D. Partidos, M. W. Steward, and C. R. Howard. 1997. Definition of the primary structure of hepatitis B virus (HBV) pre-S hepatocyte binding domain using random peptide libraries. Virology 237:319.
16. Yanofsky, S. D., D. N. Baldwin, J. H. Butler, F. R. Holden, J. W. Jacobs, P. Balasubramanian, J. P. Chinn, S. E. Cwirla, E. Peters-Bhatt, E. A. Whitehorn, E. H. Tate, A. Akeson, T. L. Bowlin, W. J. Dower, and R. W. Barren. 1996. High affinity type I interleukin 1 receptor antagonists discovered by screening recombinant peptide libraries. Proc. Natl. Acad. Sci. USA 93:7381.
17. Lofas, S., and B. Johnsson. 1990. A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors for fast and efficient covalent immobilization of ligands. J. Chem. Soc. Chem. Commun. 21:1526.
18. Karlsson, R., and A. Fall. 1997. Experimental design for kinetic analysis of protein-protein interactions with surface plasmon resonance biosensors. J. Immunol. Methods 200:121.
19. Padlan, E. A. 1977. Structural implications of sequence variability in immunoglobulins. Proc. Natl. Acad. Sci. USA 74:2551.
20. Sneath, P. H. 1966. Relations between chemical structure and biological activity in peptides. J. Theor. Biol. 12:157.
21. Corti, A., C. Poiesi, S. Merli, and G. Cassani. 1994. Tumor necrosis factor (TNF-α) quantification by ELISA and bioassay: effects of TNF-α-soluble TNF receptor (p55) complex dissociation during assay incubations. J. Immunol. Methods 177:191.
22. Engelman, H., D. Novick, and D. Wallach. 1990. Two tumor necrosis factor binding proteins purified from human urine: evidence from immunological crossreactivity with cell surface tumor necrosis factor receptors. J. Biol. Chem. 265-1531.
23. Lantz, M., S. Malik, M. L. Slevin, and I. Olsson. 1990. Infusion of tumor necrosis factor (TNF) causes an increase in circulating TNF binding protein in humans. Cytokine 2:402.
24. Hwang, C., M. Gatanaga, E. K. Innis, R. S. Yamamoto, G. A. Granger, and T. Gatanaga. 1991. A 20 amino acid synthetic peptide of a region from 55-kDa human tumor necrosis factor receptor inhibits cytolytic and binding activities of a recombinant human TNF in vitro. Proc. R. Soc. Lond. B. 245:115.
25. Lie, B.-L., D. Tunemoto, H. Hemmi, Y. Mizukami, H. Fukuda, H. Kikuchi, S. Kato, and N. Numamo. 1992. Identification of the binding site of 55-kDa tumor necrosis factor receptor by synthetic peptides. Biochem. Biophys. Res. Commun. 188:503.
26. Wrighton, N. C., F. X. Farrell, R. Chang, A. K. Kashyap, F. P. Barbone, L. S. Mulcahy, D. L. Johnson, R. W. Barren, L. K. Jolliffe, and W. J. Dower. 1996. Small peptides as potent mimetics of the protein hormone erythropoietin. Science 273:458.
27. Chirinos-Rojas, C. L., M. W. Steward, and C. D. Partidos. 1997. Use of a solid-phase random peptide library to identify inhibitors of TNF-α-mediated cytotoxicity in vitro. Cytokine 9:226.
28. Eck, M. J., and S. R. Sprang. 1989. The structure of tumor necrosis factor-α at 2.6 Å resolution. J. Biol. Chem. 264:17595.
29. Butler, D., B. Scallon, A. Meager, M. Kissonerghis, A. Corcoran, Y. Chernajovsky, M. Feldmann, J. Ghrayeb, and F. Brennan. 1994. TNF receptor fusion proteins are effective inhibitors of TNF mediated cytotoxicity on human KYM-1D4 rhabdomyosarcoma cells. Cytokine 6:616.
30. Lewis, M., L. A. Tartaglia, A. Lee, G. L. Bennett, G. C. Rice, G. H. W. Wong, E. Y. Chen, and D. V. Goeddel. 1991. Cloning and expression and cross-linking analysis of the murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc. Natl. Acad. Sci. USA 88:2830.
31. Dembic, Z., H. Loetscher, U. Gubler, Y.-C. E. Pan, H. W. Lahm, R. Gentz, M. Brockhaus, and W. Lesslauer. 1990. Two human TNF receptors have similar extracellular but distinct intracellular domain sequences. Cytokine 2:231.
32. Takasaki, W., Y. Kajino, K. Kajino, R. Murali, and M. I. Greene. 1997. Structure-based design and characterization of exocyclic peptidomimetics that inhibit TNF-α binding to its receptor. Nat. Biotechnol. 15:1266.