The role of Cdc25 phosphatases in cell cycle checkpoints

Protoplasma

Volumn 211, Issue 1-2, 2000, Pages 8-11

  Hoffmann, Ingrid ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Cdc25 phosphatase; Cell cycle; Checkpoint; Cyclin dependent kinase; DNA damage; Phosphorylation

Indexed keywords

CDC25 PHOSPHATASE; CDC25A PHOSPHATASE; CDC25B PHOSPHATASE; CDC25C PHOSPHATASE; CDS1 PROTEIN; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CHK1 PROTEIN; CYCLIN DEPENDENT KINASE; DEPHOSPHORYLATION; DNA DAMAGE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EUKARYOTIC CELL; MITOSIS;

EID: 0034112516     PISSN: 0033183X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01279894     Document Type: Article

References (37)

1. Amon A, Surana U, Muroff I, Nasmyth K (1992) Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae. Nature 355: 368-371
2. Blasina A, Van de Weyer I, Laus M, Luyten WAP, McGowan C (1999) A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr Biol 9: 1-10
3. 1/S transition and leads to premature activation of cyclin E-and cyclin A-dependent kinases. Mol Cell Biol 19: 6183-6194
4. Boddy M, Funari B, Mondesert O, Russell P (1998) Replication checkpoint enforced by kinases Cds1 and Chk1. Science 280: 909-912
5. Enoch T, Nurse P (1991) Coupling M phase and S phase: controls maintaining the dependence of mitosis on chromosome replication. Cell 65: 921-923
6. Fauman E, Cogswell J, Lovejoy B, Rocque W, Holmes W, Montana V, Piwnica-Worms H, Rink M, Saper M (1998) Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. Cell 93: 617-625
7. Funari B, Rhind N, Russell P (1997) Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase. Science 277: 1495-1497
8. Gabrielli B, DeSouza C, Tonks I, Clark J, Hayward N, Ellem K (1996) Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells. J Cell Sci 109: 1081-1093
9. Galaktionov K, Beach D (1991) Specific activation of cdc25 tyrosine phosphatase by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell 67: 1181-1194
10. -Lee A, Eckstein J, Draetta G, Meckler J, Loda M, Beach D (1995) Cdc25 phosphatases as potential human oncogenes. Science 269: 1575-1577
11. Gasparotto D, Maestro R, Piccinin S, Vukosavljevic T, Barzan L, Sulfaro S, Boiocchi M (1997) Overexpression of Cdc25A and Cdc25B in head and neck cancers. Cancer Res 57: 2366-2368
12. Harper W, Elledge S (1998) The role of Cdk7 in CAK function, a retro-retrospective. Genes Dev 12: 285-289
13. Hernandez S, Hernandez I, Bea S, Cazorla M, Fernandez P, Nadal A, Muntane J, Mallofre C, Montserrat E, Cardesa A, Campo E (1998) Cdc25 cell cycle-activating phosphatases and c-myc expression in human non-Hodgkin's lymphomas. Cancer Res 58: 1762-1767
14. Hoffmann I, Clarke PR, Marcote MJ, Karsenti E, Draetta G (1993) Phosphorylation and activation of human cdc25C by Cdc2/cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J 12: 53-63
15. -Draetta G, Karsenti E (1994) The tyrosine phosphatase activity of human cdc25A is activated by cyclin E/cdk2 during the G1/S transition. EMBO J 13: 4302-4310
16. Izumi T, Maller J (1993) Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase. Mol Biol Cell 4: 1337-1350
17. Jinno S, Suto K, Nagata A, Igarashi M, Kanaoka Y, Nojima H, Okayama H (1994) Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J 13: 1549-1556
18. Kumagai A, Dunphy WG (1992) Regulation of the cdc25 protein during the cell cycle in Xenopus extracts. Cell 70: 139-151
19. -(1996) Purification and molecular cloning of Plx1, a cdc25-stimulatory kinase from Xenopus egg extracts. Science 273: 1377-1380
20. -Guo Z, Emami K, Wang S, Dunphy W (1998) The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint controls in cell-free extracts. J Cell Biol 142: 1559-1569
21. Lammer C, Wagerer S, Saffrich R, Mertens D, Ansorge W, Hoffmann I (1998) The cdc25B phosphatase is essential for the G2/M phase transition in human cells. J Cell Sci 111: 2445-2453
22. Lew D, Kornbluth S (1996) Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control. Curr Opin Cell Biol 8: 795-804
23. -Reed S (1995) A cell cycle checkpoint monitors cell morphogenesis in budding yeast. J Cell Biol 129: 739-749
24. Lopez-Girona A, Funari B, Mondesert O, Russell P (1999) Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature 397: 172-175
25. Matsuoka S, Huang M, Elledge S (1998) Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282: 1893-1896
26. cdc25 is a nuclear protein required for initiation of mitosis in human cells. Proc Natl Acad Sci USA 88: 10500-10504
27. Morgan D (1995) Principles of cdk regulation. Nature 374: 131-134
28. Nagata A, Igarashi M, Jinno S, Suto K, Okayama H (1991) An additional homolog of the fission yeast cdc25 gene occurs in humans and is highly expressed in some cancer cells. New Biol 3: 959-967
29. Nishijima H, Nishitani H, Seki T, Nishimoto T (1997) A dual-specificity phosphatase cdc25B is an unstable protein and triggers p34cdc2/cyclinB activation in hamster BHK21 cells arrested with hydroxyurea. J Cell Biol 138: 1105-1116
30. Peng C, Graves P, Thoma R, Wu R, Shaw A, Piwnica-Worms H (1997) Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of cdc25C on serine-216. Science 277: 1501-1505
31. Rhind N, Russell P (1998) Tyrosine phosphorylation of Cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe. Mol Cell Biol 18: 3782-3787
32. -Furnari B, Russell P (1997) Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast. Genes Dev 11: 504-511
33. Sadhu K, Reed SI, Richardson H, Russell P (1990) Human homolog of fission yeast cdc25 is predominantly expressed in G1. Proc Natl Acad Sci USA 87: 5139-5143
34. Sanchez Y, Wong C, Thoma R, Richman R, Wu Z, Piwnica-Worms H, Elledge S (1997) Conservation of the chk1 checkpoint pathway in mammals: linkage of DNA damage to cdk regulation through cdc25. Science 277: 1497-1501
35. Sorger P, Murray A (1992) S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34cdc28. Nature 355: 365-368
36. Walworth N, Davey S, Beach D (1993) Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature 363: 368-371
37. Wu W, Fan Y, Kemp B, Walsh G, Mao L (1998) Overexpression of Cdc25A and Cdc25B is frequent in primary non-small cell lung cancer but is not associated with overexpression of c-myc. Cancer Res 58: 4082-4085