The alloimmune response and effector mechanisms of allograft rejection

Seminars in Nephrology

Volumn 20, Issue 2, 2000, Pages 95-102

  Arakelov, Alexandr ^a   Lakkis, Fadi G ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; PERFORIN;

ALLOIMMUNITY; ANTIGEN PRESENTATION; CYTOTOXIC T LYMPHOCYTE; HUMAN; IMMUNE RESPONSE; KIDNEY ALLOGRAFT REJECTION; MACROPHAGE; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE ACTIVATION;

ANTIGEN-PRESENTING CELLS; CYTOKINES; GRAFT REJECTION; HUMANS; ISOANTIBODIES; ISOANTIGENS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 0034100568     PISSN: 02709295     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (67)

1. Campbell RD, Trowsdale J: Map or the human MHC. Immunol Today 14:349-352, 1993
2. Watts C: Capture and processing of exogenous antigens for presentation on MHC molecules. Annu Rev Immunol 15: 821-850, 1997
3. Goulmy E: Human minor histocompatibility antigens. Curr Opin Immunol 8:75-81, 1996
4. Simpson E, Roopenian D: Minor histocompatibility antigens. Curr Opin Immunol 9:655-661, 1997
5. Benichou G, Tam RC, Soares LR, et al: Indirect T-cell allorecognition: Perspectives for peptide-based therapy in transplantation. Immunol Today 18:67-71, 1997
6. Magee CC, Sayegh MH: Peptide-mediated immunosuppression. Curr Opin Immunol 9:669-675, 1997
7. Benichou G, Valujskikh A, Heeger PS: Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice. J Immunol 162:352-358, 1999
8. Cantrell D: T cell antigen receptor signal transduction pathways. Annu Rev Immunol 14:259-274, 1996
9. Sayegh MH, Turka LA: The role of T-cell costimulatory activation pathways in transplant rejection. N Engl J Med 338:1813-1821, 1998
10. Grakoui A, Bromley SK, Sumen C, et al: The immunological synapse: A molecular machine controlling T cell activation. Science 285:221-227, 1999
11. Lenschow DJ, Walunas TL, Bluestone JA: CD28/B7 system of T cell costimulation. Annu Rev Immunol 14:233-258, 1996
12. Viola A, Schroeder S, Sakakibara Y, et al: T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283:680-682, 1999
13. Foy TM, Aruffo A, Bajorath J, et al: Immune regulation by CD40 and its ligand gp39. Annu Rev Immunol 14:591-617, 1996
14. Ridge JP, Di Rosa F, Matzinger P: A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and T-killer cell. Nature 393:474-478, 1998
15. Bennett SRM, Carbone FR, Karamalis F, et al: Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393:478-480, 1998
16. Schoenberger SP, Toes REM, van der Voort EIH, et al: T-cell help for cytotoxic T lymphocytes is mediated by CD40LCD40 interactions. Nature 393:480-483, 1998
17. Grewal IS, Flavell RA: CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 16:111-135, 1998
18. Larsen CP, Pearson TC: The CD40 pathway in allograft rejection, acceptance, and tolerance. Curr Opin Immunol 9:641-647, 1997
19. Kirk AD, Burkly LC, Batty DS, et al: Humanized anti-CD 154 monoclonal antibody treatment prevents acute renal allograft rejection in non-human primates. Nature Med 5:686-693, 1999
20. Matsuda A, Motoya S, Kimura S, et al: Disruption of lymphocyte function and signaling in CD45-associated proteinnull mice. J Exp Med 187:1863-1870, 1998
21. DeBenedette MA, Shahinian A, Mak TW, et al: Costimulation of CD28- T lymphocytes by 4-1BB ligand. J Immunol 158:551-559, 1997
22. Wu Y, Shou Q, Zheng P, et al: CD28-independent induction of T helper cells and immunoglobulin class switching requires costimulation by heat-stable antigen. J Exp Med 187: 1151-1156, 1998
23. Shuford WW, Klussman K, Tritchler DD, et al: 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med 186:47-55, 1997
24. Hutloff A, Dittrich AM, Beier KC, et al: ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397:263-266, 1999
25. Lakkis FG: Role of cytokines in transplantation tolerance: Lessons learned from gene-knockout mice. J Am Soc Nephrol 9:2361-2367. 1998
26. Steiger B, Nickerson PW, Steurer W, et al: IL-2 knock-out recipient mice reject islet cell allografts. J Immunol 155: 489-498, 1995
27. Dai Z, Konieczny BT, Baddoura FK, et al: Impaired alloantigen-mediated T cell apoptosis and failure to induce long term allograft survival in interleukin-2-deficient mice. J Immunol 161:1659-1663, 1998
28. Nickerson P, Zheng X, Steiger J, et al: Prolonged islet allograft acceptance in the absence of interleukin 4 expression. Transplant Immunology 4:81-85, 1996
29. Lakkis FG, Konieczny BT, Saleem S, et al: Blocking the CD28-B7 T cell costimulation pathway induces long-term cardiac allograft acceptance in the absence of interleukin-4. J Immunol 158:2443-2448, 1997
30. Li XC, Roy-Chaudhury P, Hancock WW, et al: IL-2 and IL-4 double knockout mice reject islet allografts: A role for novel T cell growth factors in allograft rejection. J Immunol 160:890-896, 1998
31. Saleem S, Konieczny BT, Lowry RP, et al: Acute rejection of vascularized heart allografts in the absence of IFNγ. Transplantation 62:1908-1911, 1996
32. Steiger JU, Nickerson PW, Hermle M, et al: IFNg receptor signaling is not required in the effector phase of the alloimmune response. Transplantation 65:1649-1652, 1998
33. Ring GH, Saleem S, Dai Z, et al: Interferon-γ is necessary for initiating the acute rejection of major histocompatibility complex class II-disparate skin allografts. Transplantation 67: 1362-1365, 1999
34. Rosenberg AS, Finbloom DS, Maniera TG, et al: Specific prolongation of MHC class 2 disparate skin allografts by in vivo administration of anti-IFN-γ monoclonal antibody. J Immunol 144:4648-4650, 1990
35. Goes N, Sims T, Urmson J, et al: Disturbed MHC regulation in interferon-γ knockout mouse. J Immunol 155: 4559-4566, 1995
36. Goes N, Urmson J, Hobart M, et al: The unique role of interferon-γ in the regulation of MHC expression on arterial endothelium. Transplantation 62:1889-1894, 1996
37. Lenardo M, Chan FK-M, Hornung F, et al: Mature T lymphocyte apoptosis-Immune regulation in a dynamic and unpredictable antigenic environment. Annu Rev Immunol 17: 221-253, 1999
38. Liu C-C, Young LHY, Young JD-E: Lymphocyte-mediated cytolysis and disease. N Engl J Med 335:1651-1659, 1996
39. Kagi D, Ledermann B, Burkt K, et al: Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol 14:207-232, 1996
40. Nagata S, Golstein P: The Fas death factor. Science 267:1449-1456, 1995
41. Schultz M, Schuurman HJ, Joergensen J, et al: Acute rejection of vascular heart allografts by perforin-deficient mice. Eur J Immunol 25:474-480, 1995
42. Larsen CP, Alexander DZ, Hendrix R, et al: Fas-mediated cytotoxicity. Transplantation 60:221-224, 1995
43. Beutler B: TNF, immunity and inflammatory disease: Lessons of the past decade. J Invest Med 43:227-235, 1995
44. Dinarello CA: Biological basis of interleukin-1 in disease. Blood 87:2095-2147, 1995
45. Abbas AK, Lichtman AH, Pober JS: Cytokines, in Abbas AK, Lichtman AH, Pober JS (eds): Cellular and Molecular Immunology. Philadelphia, PA, Saunders, 1997, pp 249-277
46. Trinchieri G: Interleukin 12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 13:251-276, 1995
47. Waldmann TA, Tagaya Y: The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol 17:19-49, 1999
48. Abbas AK, Lichtman AH, Pober JS: Effector mechanisms of T cell mediated immune responses, in Abbas AK, Lichtman AH, Pober JS (eds): Cellular and Molecular Immunology. Philadelphia, PA, Saunders, 1997, pp 278-296
49. Moretta A, Bottino C, Vitale M, et al: Receptors for HLA class-I molecules in human natural killer cells. Annu Rev Immunol 14:619-648, 1996
50. Karre K: How to recognize a foreign submarine. Immunol Rev 155:5-9, 1997
51. Bradley JA, Mason DW, Morris PJ: Evidence that rat renal allografts are rejected by cytotoxic T cells and not by non-specific effectors. Transplantation 39:169-175, 1985
52. Williams GM, Hume DM, Hudson RP, et al: "Hyperacute" renal homograft rejection in man. N Engl J Med 279: 611-618, 1968
53. Russell PS, Chase CM, Colvin RB: Alloantibody- and T cell-mediated immunity in the pathogenesis of transplant arteriosclerosis. Transplantation 64:1531-1536, 1997
54. Van Parijs L, Abbas AK: Homeostasis and self-tolerance in the immune system: Turning lymphocytes off. Science 280: 243-248, 1998
55. Waterhouse P, Penninger JM, Timms E, et al: Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270:985-988, 1995
56. Krummel MF, Allison JP: CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med 183:2533-2540, 1996
57. Walunas TL, Bakker CY, Bluestone JA: CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med 183:2541-2550, 1996
58. Perez VL, Van Parijs L, Biuckians A, et al: Induction of peripheral tolerance in vivo requires CTLA-4 engagement. Immunity 6:411-417, 1997
59. Lin H, Rathmell JC, Gray GS, et al: Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. J Exp Med 188:199-204, 1998
60. Zheng XX, Markees TG, Hancock WW, et al: CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment. J Immunol 162:4983-4990, 1999
61. van Parijs L, Abbas AK: Role of Fas-mediated cell death in the regulation of immune responses. Cun Opin Immunol 8:355-361, 1996
62. Abbas AK, Lichtman AH, Pober JS: Regulation of immune responses, in Abbas AK, Lichtman AH, Pober JS (eds): Cellular and Molecular Immunology. Philadelphia, PA, Saunders, 1998, pp 213-230
63. Van Parijs L, Ibraghimov A, Abbas AK: The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity 4:321-328, 1996
64. Refaeli Y, Van Parijs L, London CA, et al: Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 8:615-623, 1998
65. Dai Z, Arakelov A, Wagener M, et al: The role of the common cytokine receptor y chain (yc) in regulating IL-2dependent, activation-induced CD8+ T cell death. J Immunol 163:3131-3137, 1999
66. Konieczny BT, Dai Z, Elwood ET, et al: IFNγ is critical for long term allograft survival induced by blocking the CD28 and CD40L T cell costimulation pathways. J Immunol 160: 2059-2064, 1998
67. Hassan AT, Dai Z, Konieczny BT, et al: Regulation of alloantigen-mediated T-cell proliferation by endogenous interferon-γ. Implications for long-term allograft acceptance. Transplantation 68:124-129, 1999