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Volumn 9, Issue 12, 1998, Pages 2361-2367

Role of cytokines in transplantation tolerance: Lessons learned from gene-knockout mice

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4;

EID: 0031755722     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (25)

References (83)
  • 2
    • 0029888844 scopus 로고    scopus 로고
    • Mechanisms underlying T-cell tolerance
    • Kruisbeek AK, Amsen D: Mechanisms underlying T-cell tolerance. Curr Opin Immunol 8: 233-244, 1996
    • (1996) Curr Opin Immunol , vol.8 , pp. 233-244
    • Kruisbeek, A.K.1    Amsen, D.2
  • 3
    • 0030722507 scopus 로고    scopus 로고
    • Transplantation tolerance: Putting the pieces together
    • Lechler R, Bluestone JA: Transplantation tolerance: Putting the pieces together. Curr Opin Immunol 9: 631-633, 1997
    • (1997) Curr Opin Immunol , vol.9 , pp. 631-633
    • Lechler, R.1    Bluestone, J.A.2
  • 4
    • 0030658863 scopus 로고    scopus 로고
    • T cell inactivation and cytokine deviation promoted by anti-CD3 antibodies
    • Smith JA, Bluestone JA: T cell inactivation and cytokine deviation promoted by anti-CD3 antibodies. Curr Opin Immunol 9: 648-654, 1997
    • (1997) Curr Opin Immunol , vol.9 , pp. 648-654
    • Smith, J.A.1    Bluestone, J.A.2
  • 5
    • 85013318797 scopus 로고
    • CD4: A potential target molecule for immunosuppressive therapy and tolerance induction
    • Wood KJ, Pearson TS, Darby C, Morris PJ: CD4: A potential target molecule for immunosuppressive therapy and tolerance induction. Transplantation 55: 150-156, 1991
    • (1991) Transplantation , vol.55 , pp. 150-156
    • Wood, K.J.1    Pearson, T.S.2    Darby, C.3    Morris, P.J.4
  • 6
    • 0030711051 scopus 로고    scopus 로고
    • Peptide-mediated immunosuppression
    • Magee CC, Sayegh MH: Peptide-mediated immunosuppression. Curr Opin Immunol 9: 669-675, 1997
    • (1997) Curr Opin Immunol , vol.9 , pp. 669-675
    • Magee, C.C.1    Sayegh, M.H.2
  • 7
    • 0027451441 scopus 로고
    • Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion
    • Lin H, Boiling SF, Linsley PS, Wei R-Q, Gordon D, Thompson CB, Turka LA: Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. J Exp Med 178: 1801-1806, 1993
    • (1993) J Exp Med , vol.178 , pp. 1801-1806
    • Lin, H.1    Boiling, S.F.2    Linsley, P.S.3    Wei, R.-Q.4    Gordon, D.5    Thompson, C.B.6    Turka, L.A.7
  • 8
    • 0030656278 scopus 로고    scopus 로고
    • Bone marrow chimerism and transplantation tolerance
    • Nikolic B, Sykes M: Bone marrow chimerism and transplantation tolerance. Curr Opin Immunol 9: 634-640, 1997
    • (1997) Curr Opin Immunol , vol.9 , pp. 634-640
    • Nikolic, B.1    Sykes, M.2
  • 9
    • 0028886953 scopus 로고
    • T cell costimulatory pathways: Promising novel targets for immunosuppression and tolerance induction
    • Sayegh MH, Turka LA: T cell costimulatory pathways: Promising novel targets for immunosuppression and tolerance induction. J Am Soc Nephrol 6: 1143-1150, 1995
    • (1995) J Am Soc Nephrol , vol.6 , pp. 1143-1150
    • Sayegh, M.H.1    Turka, L.A.2
  • 10
    • 0030659503 scopus 로고    scopus 로고
    • The CD40 pathway in allograft rejection, acceptance, and tolerance
    • Larsen CP, Pearson TC: The CD40 pathway in allograft rejection, acceptance, and tolerance. Curr Opin Immunol 9: 641-647, 1997
    • (1997) Curr Opin Immunol , vol.9 , pp. 641-647
    • Larsen, C.P.1    Pearson, T.C.2
  • 12
    • 0027438831 scopus 로고
    • Cytokines as mediators of organ graft rejection and tolerance
    • Dallman MJ: Cytokines as mediators of organ graft rejection and tolerance. Curr Opin Immunol 5: 788-793, 1993
    • (1993) Curr Opin Immunol , vol.5 , pp. 788-793
    • Dallman, M.J.1
  • 13
    • 0028876520 scopus 로고
    • Cytokines and transplantation: Th1/Th2 regulation of the immune response to solid organ transplants in the adult
    • Dallman MJ: Cytokines and transplantation: Th1/Th2 regulation of the immune response to solid organ transplants in the adult. Curr Opin Immunol 7: 632-638, 1995
    • (1995) Curr Opin Immunol , vol.7 , pp. 632-638
    • Dallman, M.J.1
  • 14
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature 383: 787-793, 1996
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 15
    • 0029928417 scopus 로고    scopus 로고
    • The expanding universe of T-cell subsets: Th1, Th2 and more
    • Mosmann TR, Sad S: The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 17: 138-146, 1996
    • (1996) Immunol Today , vol.17 , pp. 138-146
    • Mosmann, T.R.1    Sad, S.2
  • 16
    • 0032033419 scopus 로고    scopus 로고
    • Cytokines induce the development of functionally heterogeneous T helper cell subsets
    • O'Garra A: Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8: 275-283, 1998
    • (1998) Immunity , vol.8 , pp. 275-283
    • O'Garra, A.1
  • 19
    • 0027153195 scopus 로고
    • Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts
    • O'Connell PJ, Pacheco-Silva A, Nickerson PW, Muggia RA, Bastos M, Rubin-Kelley V, Strom TB: Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts. J Immunol 150: 1093-1104, 1993
    • (1993) J Immunol , vol.150 , pp. 1093-1104
    • O'Connell, P.J.1    Pacheco-Silva, A.2    Nickerson, P.W.3    Muggia, R.A.4    Bastos, M.5    Rubin-Kelley, V.6    Strom, T.B.7
  • 20
    • 0027332312 scopus 로고
    • CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines
    • Kupiec-Weglinski JW, Wasowska B, Papp I, Schmidbauer G, Sayegh MH, Baldwin WM III, Wieder KJ, Hancock WW: CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines. J Immunol 151: 5053-5061, 1993
    • (1993) J Immunol , vol.151 , pp. 5053-5061
    • Kupiec-Weglinski, J.W.1    Wasowska, B.2    Papp, I.3    Schmidbauer, G.4    Sayegh, M.H.5    Baldwin W.M. III6    Wieder, K.J.7    Hancock, W.W.8
  • 22
    • 0030849309 scopus 로고    scopus 로고
    • Balancing the immune system for tolerance: A case for regulatory CD4 cells
    • Field EH, Gao Q, Chen NX, Rouse TM: Balancing the immune system for tolerance: A case for regulatory CD4 cells. Transplantation 64: 1-7, 1997
    • (1997) Transplantation , vol.64 , pp. 1-7
    • Field, E.H.1    Gao, Q.2    Chen, N.X.3    Rouse, T.M.4
  • 23
    • 0030951832 scopus 로고    scopus 로고
    • Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival?
    • Picotti JR, Chan SY, VanBuskirk AM, Eichwald EJ, Bishop DK: Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival? Transplantation 63: 619-624, 1997
    • (1997) Transplantation , vol.63 , pp. 619-624
    • Picotti, J.R.1    Chan, S.Y.2    VanBuskirk, A.M.3    Eichwald, E.J.4    Bishop, D.K.5
  • 24
    • 0028150823 scopus 로고
    • Cytokine antagonists and their potential therapeutic use
    • Debets R, Savelkoul HF: Cytokine antagonists and their potential therapeutic use. Immunol Today 15: 455-458, 1994
    • (1994) Immunol Today , vol.15 , pp. 455-458
    • Debets, R.1    Savelkoul, H.F.2
  • 25
    • 0024328536 scopus 로고
    • Altering the genome by homologous recombination
    • Capecchi MR: Altering the genome by homologous recombination. Science 244: 1288-1292, 1989
    • (1989) Science , vol.244 , pp. 1288-1292
    • Capecchi, M.R.1
  • 26
    • 0028288925 scopus 로고
    • Lymphocyte ontogeny and activation in gene targeted mutant mice
    • Pfeffer K, Mak TW: Lymphocyte ontogeny and activation in gene targeted mutant mice. Annu Rev Immunol 12: 367-411, 1994
    • (1994) Annu Rev Immunol , vol.12 , pp. 367-411
    • Pfeffer, K.1    Mak, T.W.2
  • 27
    • 0030905895 scopus 로고    scopus 로고
    • Some misconceptions about understanding autoimmunity through experiments with knockouts
    • Steinman L: Some misconceptions about understanding autoimmunity through experiments with knockouts. J Exp Med 185: 2039-2041, 1997
    • (1997) J Exp Med , vol.185 , pp. 2039-2041
    • Steinman, L.1
  • 28
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • Schorle H, Holtschke T, Hunig T, Schimpl A, Horak I: Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352: 621-624, 1991
    • (1991) Nature , vol.352 , pp. 621-624
    • Schorle, H.1    Holtschke, T.2    Hunig, T.3    Schimpl, A.4    Horak, I.5
  • 29
    • 0026328818 scopus 로고
    • Generation and analysis of interleukin-4 deficient mice
    • Kuhn R, Rajewsky K, Muller W: Generation and analysis of interleukin-4 deficient mice. Science 254: 707-710, 1991
    • (1991) Science , vol.254 , pp. 707-710
    • Kuhn, R.1    Rajewsky, K.2    Muller, W.3
  • 31
    • 0027400726 scopus 로고
    • Multiple defects of immune cell function in mice with disrupted interferon-γ genes
    • Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart T: Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259: 1739-1742, 1993
    • (1993) Science , vol.259 , pp. 1739-1742
    • Dalton, D.K.1    Pitts-Meek, S.2    Keshav, S.3    Figari, I.S.4    Bradley, A.5    Stewart, T.6
  • 33
    • 0032529195 scopus 로고    scopus 로고
    • Impaired alloantigen-mediated T cell apoptosis and failure to induce long term allograft survival in IL-2-deficient mice
    • Dai Z, Konieczny BT, Baddoura FK, Lakkis FG: Impaired alloantigen-mediated T cell apoptosis and failure to induce long term allograft survival in IL-2-deficient mice. J Immunol 161: 1659-1663, 1998
    • (1998) J Immunol , vol.161 , pp. 1659-1663
    • Dai, Z.1    Konieczny, B.T.2    Baddoura, F.K.3    Lakkis, F.G.4
  • 34
    • 0001701591 scopus 로고
    • Therapy with monoclonal antibody to interleukin 2 receptor spares suppressor T cells and prevents or reverses acute allograft rejection in rats
    • Kupiec-Weglinski JW, Diamantstein T, Tilney NL, Strom TB: Therapy with monoclonal antibody to interleukin 2 receptor spares suppressor T cells and prevents or reverses acute allograft rejection in rats. Proc Natl Acad Sci USA 83: 2624-2627, 1986
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 2624-2627
    • Kupiec-Weglinski, J.W.1    Diamantstein, T.2    Tilney, N.L.3    Strom, T.B.4
  • 41
    • 0027394657 scopus 로고
    • The IL-2/IL-2 receptor system: A current overview
    • Taniguchi T, Minami Y: The IL-2/IL-2 receptor system: A current overview. Cell 73: 5-8, 1993
    • (1993) Cell , vol.73 , pp. 5-8
    • Taniguchi, T.1    Minami, Y.2
  • 42
    • 0029414787 scopus 로고
    • c)- Dependent cytokines: Understanding in vivo functions by gene targeting
    • c)- dependent cytokines: Understanding in vivo functions by gene targeting. Immunol Rev 148: 19-34, 1995
    • (1995) Immunol Rev , vol.148 , pp. 19-34
    • Di Santo, J.P.1    Kuhn, R.2    Muller, W.3
  • 43
    • 0029994319 scopus 로고    scopus 로고
    • Interferon-γ: Biology and role in pathogenesis
    • Billiau A: Interferon-γ: Biology and role in pathogenesis. Adv Immunol 62: 61-130, 1996
    • (1996) Adv Immunol , vol.62 , pp. 61-130
    • Billiau, A.1
  • 46
    • 0032572278 scopus 로고    scopus 로고
    • Interferon-gamma receptor signaling is not required in the effector phase of the alloimmune response
    • Steiger JU, Nickerson PW, Hermle M, Thiel G, Heim MH: Interferon-gamma receptor signaling is not required in the effector phase of the alloimmune response. Transplantation 65: 1649-1652, 1998
    • (1998) Transplantation , vol.65 , pp. 1649-1652
    • Steiger, J.U.1    Nickerson, P.W.2    Hermle, M.3    Thiel, G.4    Heim, M.H.5
  • 48
    • 0025341649 scopus 로고
    • Specific prolongation of MHC class 2 disparate skin allografts by in vivo administration of anti-IFN-γ monoclonal antibody
    • Rosenberg AS, Finbloom DS, Maniero TG, Van der Meide PH, Singer A: Specific prolongation of MHC class 2 disparate skin allografts by in vivo administration of anti-IFN-γ monoclonal antibody. J Immunol 144: 4648-4650, 1990
    • (1990) J Immunol , vol.144 , pp. 4648-4650
    • Rosenberg, A.S.1    Finbloom, D.S.2    Maniero, T.G.3    Van Der Meide, P.H.4    Singer, A.5
  • 49
    • 85190674574 scopus 로고    scopus 로고
    • Interferon-gamma (IFNγ) is necessary for acute rejection of MHC class II-disparate skin allografts but is not required for MHC class I rejection
    • Saleem S, Konieczny BT, Baddoura FK, Lakkis FG: Interferon-gamma (IFNγ) is necessary for acute rejection of MHC class II-disparate skin allografts but is not required for MHC class I rejection [Abstract]. J Am Soc Nephrol 8: 664A, 1997
    • (1997) J Am Soc Nephrol , vol.8
    • Saleem, S.1    Konieczny, B.T.2    Baddoura, F.K.3    Lakkis, F.G.4
  • 51
    • 0030240965 scopus 로고    scopus 로고
    • Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients
    • Onodera K, Lehmann M, Akalin E, Volk H-D, Sayegh MH, Kupiec-Weglinski JW: Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients. J Immunol 157: 1944-1950, 1996
    • (1996) J Immunol , vol.157 , pp. 1944-1950
    • Onodera, K.1    Lehmann, M.2    Akalin, E.3    Volk, H.-D.4    Sayegh, M.H.5    Kupiec-Weglinski, J.W.6
  • 53
    • 0030470416 scopus 로고    scopus 로고
    • The role of IL-4 in the induction phase of allogeneic neonatal tolerance
    • Gao Q, Chen N, Rouse TM, Field EH: The role of IL-4 in the induction phase of allogeneic neonatal tolerance. Transplantation 62: 1847-1852, 1996
    • (1996) Transplantation , vol.62 , pp. 1847-1852
    • Gao, Q.1    Chen, N.2    Rouse, T.M.3    Field, E.H.4
  • 54
    • 0029664599 scopus 로고    scopus 로고
    • Prevention of TH1 responses is critical for tolerance
    • Chen N, Gao Q, Field EH: Prevention of TH1 responses is critical for tolerance. Transplantation 61: 1076-1083, 1996
    • (1996) Transplantation , vol.61 , pp. 1076-1083
    • Chen, N.1    Gao, Q.2    Field, E.H.3
  • 55
    • 0031571310 scopus 로고    scopus 로고
    • IL-4 expression by grafts from transgenic mice fails to prevent allograft rejection
    • Mueller R, Davies JD, Krahl T, Sarvetnick N: IL-4 expression by grafts from transgenic mice fails to prevent allograft rejection. J Immunol 159: 1599-1603, 1997
    • (1997) J Immunol , vol.159 , pp. 1599-1603
    • Mueller, R.1    Davies, J.D.2    Krahl, T.3    Sarvetnick, N.4
  • 57
    • 0029020011 scopus 로고
    • Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation
    • Zheng XX, Steele AW, Nickerson PW, Steurer W, Steiger J, Strom TB: Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation. J Immunol 154: 5590-5600, 1995
    • (1995) J Immunol , vol.154 , pp. 5590-5600
    • Zheng, X.X.1    Steele, A.W.2    Nickerson, P.W.3    Steurer, W.4    Steiger, J.5    Strom, T.B.6
  • 58
    • 0031000670 scopus 로고    scopus 로고
    • Molecular analyses of human renal allografts: Differential intragraft gene expression during rejection
    • Suthanthiran M: Molecular analyses of human renal allografts: Differential intragraft gene expression during rejection. Kidney Im Suppl 58: S15-S21, 1997
    • (1997) Kidney Im Suppl , vol.58
    • Suthanthiran, M.1
  • 59
    • 0031567892 scopus 로고    scopus 로고
    • Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells
    • Picotti JR, Chan SY, Li K, Eichwald EJ, Bishop DK: Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells. J Immunol 158: 643-648, 1997
    • (1997) J Immunol , vol.158 , pp. 643-648
    • Picotti, J.R.1    Chan, S.Y.2    Li, K.3    Eichwald, E.J.4    Bishop, D.K.5
  • 61
    • 0023907493 scopus 로고
    • Interleukin-2: Inception, impact, and implications
    • Smith KA: Interleukin-2: Inception, impact, and implications. Science 240: 1169-1176, 1988
    • (1988) Science , vol.240 , pp. 1169-1176
    • Smith, K.A.1
  • 63
    • 0031569514 scopus 로고    scopus 로고
    • Functional responses and apoptosis of CD25 (IL-2Rα)-deficient T cells expressing a transgenic antigen receptor
    • Van-Parijs L, Biuckians A, Ibragimov A, Alt FW, Willerford DM, Abbas AK: Functional responses and apoptosis of CD25 (IL-2Rα)-deficient T cells expressing a transgenic antigen receptor. J Immunol 158: 3738-3745, 1997
    • (1997) J Immunol , vol.158 , pp. 3738-3745
    • Van-Parijs, L.1    Biuckians, A.2    Ibragimov, A.3    Alt, F.W.4    Willerford, D.M.5    Abbas, A.K.6
  • 64
    • 0029118133 scopus 로고
    • Normal clonal expansion but impaired Fas-mediated cell death and anergy in IL-2 deficient mice
    • Kneitz B, Herman T, Yonehara S, Schimpl A: Normal clonal expansion but impaired Fas-mediated cell death and anergy in IL-2 deficient mice. Eur J Immunol 25: 2572-2577, 1995
    • (1995) Eur J Immunol , vol.25 , pp. 2572-2577
    • Kneitz, B.1    Herman, T.2    Yonehara, S.3    Schimpl, A.4
  • 68
    • 0030587910 scopus 로고    scopus 로고
    • IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    • Willenborg DO, Fordham S, Bernard CCA, Cowden WB, Ramshaw IA: IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J Immunol 157: 3223-3227, 1996
    • (1996) J Immunol , vol.157 , pp. 3223-3227
    • Willenborg, D.O.1    Fordham, S.2    Bernard, C.C.A.3    Cowden, W.B.4    Ramshaw, I.A.5
  • 69
    • 0028984182 scopus 로고
    • IFN-γ receptor-deficient mice are hypersensitive to the anti-CD3-induced cytokine release syndrome and thymocyte apoptosis: Protective role of endogenous nitric oxide
    • Matthys P, Froyen G, Verdot L, Huang S, Sobis H: Van Damme J, Vray B, Aguet M, Billiau A: IFN-γ receptor-deficient mice are hypersensitive to the anti-CD3-induced cytokine release syndrome and thymocyte apoptosis: Protective role of endogenous nitric oxide. J Immunol 155: 3823-3829, 1995
    • (1995) J Immunol , vol.155 , pp. 3823-3829
    • Matthys, P.1    Froyen, G.2    Verdot, L.3    Huang, S.4    Sobis, H.5    Van Damme, J.6    Vray, B.7    Aguet, M.8    Billiau, A.9
  • 71
    • 0029414785 scopus 로고
    • Interleukin-2 deficient mice: A new model to study autoimmunity and self-tolerance
    • Horak I, Lohler J, Ma A, Smith KA: Interleukin-2 deficient mice: A new model to study autoimmunity and self-tolerance. Immunol Rev 148: 35-44, 1995
    • (1995) Immunol Rev , vol.148 , pp. 35-44
    • Horak, I.1    Lohler, J.2    Ma, A.3    Smith, K.A.4
  • 72
    • 0030272248 scopus 로고    scopus 로고
    • Interleukin 2 and its receptors: Recent advances and new immunological functions
    • Theze J, Alzari PM, Bertoglio J: Interleukin 2 and its receptors: Recent advances and new immunological functions. Immunol Today 17: 481-486, 1996
    • (1996) Immunol Today , vol.17 , pp. 481-486
    • Theze, J.1    Alzari, P.M.2    Bertoglio, J.3
  • 73
    • 0028783963 scopus 로고
    • Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells
    • Sadlack B, Lohler J, Schorle H, Klebb G, Haber H, Sickel E, Noelle RJ, Horak I: Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur J Immunol 25: 3053-3059, 1995
    • (1995) Eur J Immunol , vol.25 , pp. 3053-3059
    • Sadlack, B.1    Lohler, J.2    Schorle, H.3    Klebb, G.4    Haber, H.5    Sickel, E.6    Noelle, R.J.7    Horak, I.8
  • 74
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I: Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-261, 1993
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 76
    • 0028784289 scopus 로고
    • Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW: Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3: 521-530, 1995
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 77
    • 0026017971 scopus 로고
    • Interleukin-2 programs mouse alpha/beta T lymphocytes for apoptosis
    • Lenardo MJ: Interleukin-2 programs mouse alpha/beta T lymphocytes for apoptosis. Nature 353: 858-861, 1991
    • (1991) Nature , vol.353 , pp. 858-861
    • Lenardo, M.J.1
  • 78
    • 0027182225 scopus 로고
    • Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle
    • Boehme SA, Lenardo MJ: Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle. Eur J Immunol 23: 1552-1560, 1993
    • (1993) Eur J Immunol , vol.23 , pp. 1552-1560
    • Boehme, S.A.1    Lenardo, M.J.2
  • 81
    • 0029899783 scopus 로고    scopus 로고
    • CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
    • Krummel MF, Allison JP: CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med 183: 2533-2540, 1996
    • (1996) J Exp Med , vol.183 , pp. 2533-2540
    • Krummel, M.F.1    Allison, J.P.2
  • 82
    • 0029953858 scopus 로고    scopus 로고
    • CTLA-4 ligation blocks CD28-dependent T cell activation
    • Walunas TL, Bakker CY, Bluestone JA: CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med 183: 2541-2550, 1996
    • (1996) J Exp Med , vol.183 , pp. 2541-2550
    • Walunas, T.L.1    Bakker, C.Y.2    Bluestone, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.