-
1
-
-
0029118518
-
Hypertrophic cardiomyopathy. Clinical spectrum and treatment
-
1 Wigle ED, Rakowski H, Kimball BP, Williams WG: Hypertrophic cardiomyopathy. Clinical spectrum and treatment. Circulation 1995, 92:1680-1692.
-
(1995)
Circulation
, vol.92
, pp. 1680-1692
-
-
Wigle, E.D.1
Rakowski, H.2
Kimball, B.P.3
Williams, W.G.4
-
2
-
-
0030761751
-
Hypertrophic cardiomyopathy
-
2 Maron BJ: Hypertrophic cardiomyopathy. Lancet 1997, 350:127-133.
-
(1997)
Lancet
, vol.350
, pp. 127-133
-
-
Maron, B.J.1
-
3
-
-
0029083650
-
Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA study. Coronary artery risk development in (young) adults
-
3 Maron BJ, Gardin JM, Flack JM, Gidding SS, Kurosaki TT, Bild DE: Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA study. Coronary artery risk development in (young) adults. Circulation 1995, 92:785-789.
-
(1995)
Circulation
, vol.92
, pp. 785-789
-
-
Maron, B.J.1
Gardin, J.M.2
Flack, J.M.3
Gidding, S.S.4
Kurosaki, T.T.5
Bild, D.E.6
-
4
-
-
0033540007
-
Late-onset hypertrophic cardiomyopathy caused by a mutation in the cardiac troponin T gene
-
4 Elliott PM, D'Cruz L, McKenna WJ: Late-onset hypertrophic cardiomyopathy caused by a mutation in the cardiac troponin T gene. Lancet 1999, 341:1855-1856.
-
(1999)
Lancet
, vol.341
, pp. 1855-1856
-
-
Elliott, P.M.1
D'Cruz, L.2
McKenna, W.J.3
-
5
-
-
0032580520
-
Mutations in the gene for cardiac myosin binding protein C and late-onset familial hypertrophic cardiomyopathy
-
5 Nimura H, Bachinski LL, Sangwatanaroj S, Watkins H, Chudley AE, McKenna W, et al.: Mutations in the gene for cardiac myosin binding protein C and late-onset familial hypertrophic cardiomyopathy. N Engl J Med 1998, 338:1248-1257.
-
(1998)
N Engl J Med
, vol.338
, pp. 1248-1257
-
-
Nimura, H.1
Bachinski, L.L.2
Sangwatanaroj, S.3
Watkins, H.4
Chudley, A.E.5
McKenna, W.6
-
6
-
-
0030057106
-
Sudden death in young competitive athletes. Clinical, demographic, and pathological profiles
-
6 Maron BJ, Shirani J, Poliac LC, Mathenge R, Roberts WC, Mueller FO: Sudden death in young competitive athletes. Clinical, demographic, and pathological profiles. JAMA 1996, 276:199-204.
-
(1996)
Jama
, vol.276
, pp. 199-204
-
-
Maron, B.J.1
Shirani, J.2
Poliac, L.C.3
Mathenge, R.4
Roberts, W.C.5
Mueller, F.O.6
-
7
-
-
0025040392
-
A molecular basis for familial hypertrophic cardiomyopathy: A beta-cardiac myosin heavy chain gene missense mutation
-
7 Geisterfer-Lowrance AA, Kass S, Tanigawa G, Vosberg HP, McKenna W, Seidman CE, Seidman JG: A molecular basis for familial hypertrophic cardiomyopathy: a beta-cardiac myosin heavy chain gene missense mutation. Cell 1990, 62:999-1006.
-
(1990)
Cell
, vol.62
, pp. 999-1006
-
-
Geisterfer-Lowrance, A.A.1
Kass, S.2
Tanigawa, G.3
Vosberg, H.P.4
McKenna, W.5
Seidman, C.E.6
Seidman, J.G.7
-
8
-
-
18744433901
-
α-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy
-
8 Mogensen J, Klausen IC, Pedersen AK, Egeblad H, Bross P, Kruse TA, et al.: α-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy. J Clin Invest 1999, 103:R39-R43.
-
(1999)
J Clin Invest
, vol.103
-
-
Mogensen, J.1
Klausen, I.C.2
Pedersen, A.K.3
Egeblad, H.4
Bross, P.5
Kruse, T.A.6
-
9
-
-
0032555955
-
Familial hypertrophic cardiomyopathy - From mutations to functional defects
-
9 Bonne G, Carrier L, Richard P, Hainque B, Schwartz K: Familial hypertrophic cardiomyopathy - from mutations to functional defects. Circ Res 1998, 83:580-593.
-
(1998)
Circ Res
, vol.83
, pp. 580-593
-
-
Bonne, G.1
Carrier, L.2
Richard, P.3
Hainque, B.4
Schwartz, K.5
-
10
-
-
0028849972
-
Phenotypic spectrum and patterns of left ventricular hypertrophy in hypertrophic cardiomyopathy: Morphologic observations and significance as assessed by two-dimensional echocardiography in 600 patients
-
10 Klues HG, Schiffers A, Maron BJ: Phenotypic spectrum and patterns of left ventricular hypertrophy in hypertrophic cardiomyopathy: morphologic observations and significance as assessed by two-dimensional echocardiography in 600 patients. J Am Coll Cardiol 1995, 26:1699-1708.
-
(1995)
J Am Coll Cardiol
, vol.26
, pp. 1699-1708
-
-
Klues, H.G.1
Schiffers, A.2
Maron, B.J.3
-
11
-
-
0028140230
-
Genotype-phenotype correlations in hypertrophic cardiomyopathy: Insights provided by comparisons of kindreds with distinct and identical β-myosin heavy chain mutations
-
11 Fananapazir L, Epstein ND: Genotype-phenotype correlations in hypertrophic cardiomyopathy: insights provided by comparisons of kindreds with distinct and identical β-myosin heavy chain mutations. Circulation 1994, 89:22-32.
-
(1994)
Circulation
, vol.89
, pp. 22-32
-
-
Fananapazir, L.1
Epstein, N.D.2
-
12
-
-
8544283018
-
Penetrance of familial hypertrophic cardiomyopathy
-
12 Charron P, Carrier L, Dubourg O, Tesson F, Desnos M, Richard P, et al.: Penetrance of familial hypertrophic cardiomyopathy. Genet Couns 1997, 8:107-114.
-
(1997)
Genet Couns
, vol.8
, pp. 107-114
-
-
Charron, P.1
Carrier, L.2
Dubourg, O.3
Tesson, F.4
Desnos, M.5
Richard, P.6
-
13
-
-
0001597277
-
Impact of gender on the clinical and morphologic expression of hypertrophic cardiomyopathy
-
13 Maron BJ, Casey SA, Gohmann TE, Aeppli DM: Impact of gender on the clinical and morphologic expression of hypertrophic cardiomyopathy. Circulation 1999, 100:1-212.
-
(1999)
Circulation
, vol.100
, pp. 1-212
-
-
Maron, B.J.1
Casey, S.A.2
Gohmann, T.E.3
Aeppli, D.M.4
-
14
-
-
0032498785
-
Cardiac physiology in transgenic mice
-
14 James JF, Hewett TE, Robbins J: Cardiac physiology in transgenic mice. Circ Res 1998, 82:407-415.
-
(1998)
Circ Res
, vol.82
, pp. 407-415
-
-
James, J.F.1
Hewett, T.E.2
Robbins, J.3
-
15
-
-
0030976860
-
The in vitro activity of beta-cardiac myosin depends on the nature of the beta-myosin heavy chain gene mutation in hypertrophic cardiomyopathy
-
15 Cuda G, Fananapazir L, Epstein ND, Sellers JR: The in vitro activity of beta-cardiac myosin depends on the nature of the beta-myosin heavy chain gene mutation in hypertrophic cardiomyopathy. J Muscle Res Cell Motil 1997, 18:275-283.
-
(1997)
J Muscle Res Cell Motil
, vol.18
, pp. 275-283
-
-
Cuda, G.1
Fananapazir, L.2
Epstein, N.D.3
Sellers, J.R.4
-
16
-
-
0028967729
-
Abnormal contractile properties of muscle fibers expressing beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy
-
16 Lankford EB, Epstein ND, Fananapazir L, Sweeney HL: Abnormal contractile properties of muscle fibers expressing beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy. J Clin Invest 1995, 95:1409-1414.
-
(1995)
J Clin Invest
, vol.95
, pp. 1409-1414
-
-
Lankford, E.B.1
Epstein, N.D.2
Fananapazir, L.3
Sweeney, H.L.4
-
17
-
-
0034614419
-
Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy
-
17 Szczesna D, Zhang R, Zhao J, Jones M, Guzman G, Potter JD: Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy. J Biol Chem 2000, 275:624-630.
-
(2000)
J Biol Chem
, vol.275
, pp. 624-630
-
-
Szczesna, D.1
Zhang, R.2
Zhao, J.3
Jones, M.4
Guzman, G.5
Potter, J.D.6
-
18
-
-
0031873371
-
Ca2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy
-
18 Morimoto S, Yanaga F, Minakami R, Ohtsuki I: Ca2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy. Am J Physiol 1998, 275(Cell Physiol44):C200-C207.
-
(1998)
Am J Physiol
, vol.275
, Issue.CELL PHYSIOL44
-
-
Morimoto, S.1
Yanaga, F.2
Minakami, R.3
Ohtsuki, I.4
-
19
-
-
0032564354
-
Functional analysis of troponin T mutations that cause hypertrophic cardiomyopathy: Insights into disease pathogenesis and troponin function
-
19 Sweeney HL, Feng HS, Yang Z, Watkins H: Functional analysis of troponin T mutations that cause hypertrophic cardiomyopathy: insights into disease pathogenesis and troponin function. Proc Natl Acad Sci USA 1998, 95:14406-14410.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 14406-14410
-
-
Sweeney, H.L.1
Feng, H.S.2
Yang, Z.3
Watkins, H.4
-
20
-
-
0032724289
-
Identification of a contractile deficit in adult cardiac myocytes expressing hypertrophic cardiomyopathy-associated mutant troponin T proteins
-
20 Rust EM, Albayya FP, Metzger JM: Identification of a contractile deficit in adult cardiac myocytes expressing hypertrophic cardiomyopathy-associated mutant troponin T proteins. J Clin Invest 1999, 103:1459-1467.
-
(1999)
J Clin Invest
, vol.103
, pp. 1459-1467
-
-
Rust, E.M.1
Albayya, F.P.2
Metzger, J.M.3
-
21
-
-
0030611676
-
Expression of a mutant (Arg92Gln) human cardiac troponin T, known to cause hypertrophic cardiornyopathy, impairs adult cardiac myocyte contractility
-
21 Marian AJ, Zhao G, Seta Y, Roberts R, Yu Q-Y: Expression of a mutant (Arg92Gln) human cardiac troponin T, known to cause hypertrophic cardiornyopathy, impairs adult cardiac myocyte contractility. Circ Res 1997, 81:76-85.
-
(1997)
Circ Res
, vol.81
, pp. 76-85
-
-
Marian, A.J.1
Zhao, G.2
Seta, Y.3
Roberts, R.4
Yu, Q.-Y.5
-
22
-
-
0032824580
-
Effects of missense mutations Phe110Ile and Glu244Asp in human cardiac troponin T on force generation in skinned cardiac muscle fibers
-
22 Nakaura H, Yanaga F, Ohtsuki I, Morimoto S: Effects of missense mutations Phe110Ile and Glu244Asp in human cardiac troponin T on force generation in skinned cardiac muscle fibers. J Biochem 1998, 126:457-460.
-
(1998)
J Biochem
, vol.126
, pp. 457-460
-
-
Nakaura, H.1
Yanaga, F.2
Ohtsuki, I.3
Morimoto, S.4
-
23
-
-
0033214054
-
Functional consequences of troponin T mutations found in hypertrophic cardiomyopathy
-
23 Tobacman LS, Lin D, Butters C, Landis C, Back N, Pavlov D, Homsher E: Functional consequences of troponin T mutations found in hypertrophic cardiomyopathy. J Biol Chem 1999, 274:28363-28370.
-
(1999)
J Biol Chem
, vol.274
, pp. 28363-28370
-
-
Tobacman, L.S.1
Lin, D.2
Butters, C.3
Landis, C.4
Back, N.5
Pavlov, D.6
Homsher, E.7
-
24
-
-
0033595110
-
Functional consequences of a carboxyl terminal missense mutation Arg278Cys in human cardiac troponin T
-
24 Morimoto S, Nakaura H, Yanaga F, Ohtsuki I: Functional consequences of a carboxyl terminal missense mutation Arg278Cys in human cardiac troponin T. Biochem Biophys Res Comm 1999, 261:79-82.
-
(1999)
Biochem Biophys Res Comm
, vol.261
, pp. 79-82
-
-
Morimoto, S.1
Nakaura, H.2
Yanaga, F.3
Ohtsuki, I.4
-
25
-
-
0032864309
-
Functional changes in troponin T by a splice donor site mutation that causes hypertrophic cardiomyopathy
-
25 Nakaura H, Morimoto S, Yanaga F, Nakata M, Nishi H, Imaizumi T, Ohtsuki I: Functional changes in troponin T by a splice donor site mutation that causes hypertrophic cardiomyopathy. Am J Physiol 1999, 277 (Cell Physiol 46):C225-C232.
-
(1999)
Am J Physiol
, vol.277
, Issue.CELL PHYSIOL 46
-
-
Nakaura, H.1
Morimoto, S.2
Yanaga, F.3
Nakata, M.4
Nishi, H.5
Imaizumi, T.6
Ohtsuki, I.7
-
26
-
-
0032751723
-
Direct, convergent hypersensitivity of calcium-activated force generation produced by hypertrophic cardiomyopathy mutant α-tropomyosins in adult cardiac myocytes
-
26 Michele DE, Albayya FP, Metzger JM: Direct, convergent hypersensitivity of calcium-activated force generation produced by hypertrophic cardiomyopathy mutant α-tropomyosins in adult cardiac myocytes. Nat Med 1999, 5:1413-1417.
-
(1999)
Nat Med
, vol.5
, pp. 1413-1417
-
-
Michele, D.E.1
Albayya, F.P.2
Metzger, J.M.3
-
27
-
-
0031883848
-
A mutant tropomyosin that causes hypertrophic cardiomyopathy is expressed in vivo and associated with an increased calcium sensitivity
-
27 Bottinelli R, Coviello DA, Redwood CS, Pellegrino MA, Maron BJ, Spirito P, et al.: A mutant tropomyosin that causes hypertrophic cardiomyopathy is expressed in vivo and associated with an increased calcium sensitivity. Circ Res 1998, 82:106-115.
-
(1998)
Circ Res
, vol.82
, pp. 106-115
-
-
Bottinelli, R.1
Coviello, D.A.2
Redwood, C.S.3
Pellegrino, M.A.4
Maron, B.J.5
Spirito, P.6
-
28
-
-
0030067394
-
A mouse model of familial hypertrophic cardiomyopathy
-
28 Geisterfer-Lowrance AAT, Christe ME, Conner DA, Ingwall JS, Schoen FJ, Seidman CE, Seidman JG: A mouse model of familial hypertrophic cardiomyopathy. Science 1996, 272:731-734.
-
(1996)
Science
, vol.272
, pp. 731-734
-
-
Geisterfer-Lowrance, A.A.T.1
Christe, M.E.2
Conner, D.A.3
Ingwall, J.S.4
Schoen, F.J.5
Seidman, C.E.6
Seidman, J.G.7
-
29
-
-
0029807438
-
Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy
-
29 Vikstrom KL, Factor SM, Leinwand LA: Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy. Mol Med 1996, 2:556-567.
-
(1996)
Mol Med
, vol.2
, pp. 556-567
-
-
Vikstrom, K.L.1
Factor, S.M.2
Leinwand, L.A.3
-
30
-
-
0032943836
-
Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the α cardiac myosin heavy chain gene
-
30 Fatkin D, Christe ME, Aristazabal O, McConnell BK, Srinivasan S, Schoen FJ, et al.: Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the α cardiac myosin heavy chain gene. J Clin Invest 1999, 103:147-153.
-
(1999)
J Clin Invest
, vol.103
, pp. 147-153
-
-
Fatkin, D.1
Christe, M.E.2
Aristazabal, O.3
McConnell, B.K.4
Srinivasan, S.5
Schoen, F.J.6
-
31
-
-
0033017175
-
The pathogenesis of familial hypertrophic cardiomyopathy: Early and evolving effects from an alpha-cardiac myosin heavy chain missense mutation
-
31 Georgakopoulos D, Christe ME, Giewat M, Seidman CE, Seidman JG, Kass DA: The pathogenesis of familial hypertrophic cardiomyopathy: early and evolving effects from an alpha-cardiac myosin heavy chain missense mutation. Nat Med 1999, 5:327-330. In this study, contraction kinetics of hearts from 6-week-and 20-week-old α-MyHC-R403Q mice showed temporal evolution of changes similar to human disease.
-
(1999)
Nat Med
, vol.5
, pp. 327-330
-
-
Georgakopoulos, D.1
Christe, M.E.2
Giewat, M.3
Seidman, C.E.4
Seidman, J.G.5
Kass, D.A.6
-
32
-
-
0039813929
-
Altered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathy
-
32 Gao WD, Perez NG, Seidman CE, Seidman JG, Marban E: Altered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathy. J Clin Invest 1999, 103:661-666.
-
(1999)
J Clin Invest
, vol.103
, pp. 661-666
-
-
Gao, W.D.1
Perez, N.G.2
Seidman, C.E.3
Seidman, J.G.4
Marban, E.5
-
33
-
-
0032523194
-
Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy
-
33 Spindler M, Saupe KW, Christe ME, Sweeney HL, Seidman CE, Seidman JG, Ingwall JS: Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy. J Clin Invest 1998, 101:1775-1783.
-
(1998)
J Clin Invest
, vol.101
, pp. 1775-1783
-
-
Spindler, M.1
Saupe, K.W.2
Christe, M.E.3
Sweeney, H.L.4
Seidman, C.E.5
Seidman, J.G.6
Ingwall, J.S.7
-
34
-
-
0031030298
-
Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice
-
34 Berul CI, Christe ME, Aronovitz MJ, Seidman CE, Seidman JG, Mendelsohn ME: Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice. J Clin Invest 1997, 99:570-576.
-
(1997)
J Clin Invest
, vol.99
, pp. 570-576
-
-
Berul, C.I.1
Christe, M.E.2
Aronovitz, M.J.3
Seidman, C.E.4
Seidman, J.G.5
Mendelsohn, M.E.6
-
35
-
-
0032907451
-
QT dispersion in alpha-myosin heavy-chain familial hypertrophic cardiomyopathy mice
-
35 Bevilacqua LM, Maguire CT, Seidman JG, Seidman CE, Berul CI: QT dispersion in alpha-myosin heavy-chain familial hypertrophic cardiomyopathy mice. Pediatr Res 1999, 45:643-647.
-
(1999)
Pediatr Res
, vol.45
, pp. 643-647
-
-
Bevilacqua, L.M.1
Maguire, C.T.2
Seidman, J.G.3
Seidman, C.E.4
Berul, C.I.5
-
36
-
-
0032550267
-
Hypertrophy, pathology, and molecular markers of cardiac pathogenesis
-
36 Vikstrom KL, Bohlmeyer T, Factor SM, Leinwand LA: Hypertrophy, pathology, and molecular markers of cardiac pathogenesis. Circ Res 1998, 82:773-778.
-
(1998)
Circ Res
, vol.82
, pp. 773-778
-
-
Vikstrom, K.L.1
Bohlmeyer, T.2
Factor, S.M.3
Leinwand, L.A.4
-
37
-
-
0033386313
-
A transgenic rabbit model for human hypertrophic cardiomyopathy
-
37 Marian AJ, Wu Y, Lim D-S, McCluggage M, Youker K, Yu Q, et al.: A transgenic rabbit model for human hypertrophic cardiomyopathy. J Clin Invest 1999, 104:1683-1692. The transgenic rabbit model with the β-MyHC-R403Q mutation described in this article is the first rabbit model of the disease. It showed the typical histologic features of FHC and premature death. Contrary to small rodents, rabbits show the same myosin isoform composition as humans and are therefore well suited for the investigation of myosin mutations.
-
(1999)
J Clin Invest
, vol.104
, pp. 1683-1692
-
-
Marian, A.J.1
Wu, Y.2
Lim, D.-S.3
McCluggage, M.4
Youker, K.5
Yu, Q.6
-
38
-
-
0033003018
-
Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice
-
HEART CIRC PHYSIOL 45
-
38 Welikson RE, Buck SH, Patel JR, Moss RL, Vikstrom KL, Factor SM, et al.: Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice. Am J Physiol 1999, 276 (Heart Circ Physiol 45):H2148-H2158. This mouse model with a deletion of the MLC binding domain in MyHC showed the typical FHC histopathology in addition to severe valvular pathology, being the first animal model with valve alterations.
-
(1999)
Am J Physiol
, vol.276
-
-
Welikson, R.E.1
Buck, S.H.2
Patel, J.R.3
Moss, R.L.4
Vikstrom, K.L.5
Factor, S.M.6
-
39
-
-
10244221064
-
Ablation of the murine α myosin heavy chain gene leads to dosage effects and functional deficits in the heart
-
39 Jones WK, Grupp IL, Doetschmann T, Grupp G, Osinska H, Hewett TE, et al.: Ablation of the murine α myosin heavy chain gene leads to dosage effects and functional deficits in the heart. J Clin Invest 1996, 98:1906-1917.
-
(1996)
J Clin Invest
, vol.98
, pp. 1906-1917
-
-
Jones, W.K.1
Grupp, I.L.2
Doetschmann, T.3
Grupp, G.4
Osinska, H.5
Hewett, T.E.6
-
40
-
-
0033597848
-
Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2
-
40 Sanbe A, Fewell JG, Gulick J, Osinska H, Lorenz J, Hall DG, et al.: Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2. J Biol Chem 1999, 274:21085-21094.
-
(1999)
J Biol Chem
, vol.274
, pp. 21085-21094
-
-
Sanbe, A.1
Fewell, J.G.2
Gulick, J.3
Osinska, H.4
Lorenz, J.5
Hall, D.G.6
-
41
-
-
0032526155
-
A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy
-
41 Tardiff JC, Factor SM, Tompkins BD, Hewett TE, Palmer BM, Moore RL, et al.: A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy. J Clin Invest 1998, 101:2800-2811.
-
(1998)
J Clin Invest
, vol.101
, pp. 2800-2811
-
-
Tardiff, J.C.1
Factor, S.M.2
Tompkins, B.D.3
Hewett, T.E.4
Palmer, B.M.5
Moore, R.L.6
-
42
-
-
0032716486
-
Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy
-
42 Tardiff JC, Hewett TE, Palmer BM, Olsson C, Factor SM, Moore RL, et al.: Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy. J Clin Invest 1999, 104:469-481. Mice expressing high levels of their TnT as a missense mutation (R92Q) showed histopathologic features of FHC and induction of hypertrophic markers, but no LV hypertrophy, but rather smaller size of LV caused by smaller myocytes. Functional analyses of these hearts showed hypercontractility with impaired relaxation.
-
(1999)
J Clin Invest
, vol.104
, pp. 469-481
-
-
Tardiff, J.C.1
Hewett, T.E.2
Palmer, B.M.3
Olsson, C.4
Factor, S.M.5
Moore, R.L.6
-
43
-
-
0032532087
-
Dominant-negative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice
-
43 Oberst L, Zhao G, Park JT, Brugada R, Michael LH, Entmann ML, et al.: Dominant-negative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice. J Clin Invest 1998, 102:1498-1505.
-
(1998)
J Clin Invest
, vol.102
, pp. 1498-1505
-
-
Oberst, L.1
Zhao, G.2
Park, J.T.3
Brugada, R.4
Michael, L.H.5
Entmann, M.L.6
-
44
-
-
0013687927
-
Transgenic rats overexpressing a human cardiac troponin T deletion exhibit diastolic dysfunction in the "working heart model."
-
44 Frey N, Degenhardt M, Lorenzen H-P, Katus HA, Franz WM: Transgenic rats overexpressing a human cardiac troponin T deletion exhibit diastolic dysfunction in the "working heart model." Circulation 1998, 100:1-626.
-
(1998)
Circulation
, vol.100
, pp. 1-626
-
-
Frey, N.1
Degenhardt, M.2
Lorenzen, H.-P.3
Katus, H.A.4
Franz, W.M.5
-
45
-
-
0013667153
-
Transgenic rats overexpressing wild-type human troponin T show improved contractile performance in the "working heart."
-
45 Frey N, Franz WM, Degenhardt M, Lorenzen H-P, Katus HA: Transgenic rats overexpressing wild-type human troponin T show improved contractile performance in the "working heart." Circulation 1999, 100:1-762.
-
(1999)
Circulation
, vol.100
, pp. 1-762
-
-
Frey, N.1
Franz, W.M.2
Degenhardt, M.3
Lorenzen, H.-P.4
Katus, H.A.5
-
46
-
-
0032189352
-
A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy
-
46 Yang Q, Sanbe A, Osinska H, Hewett TE, Klevitsky R, Robbins J: A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy. J Clin Invest 1998, 102:1292-1300.
-
(1998)
J Clin Invest
, vol.102
, pp. 1292-1300
-
-
Yang, Q.1
Sanbe, A.2
Osinska, H.3
Hewett, T.E.4
Klevitsky, R.5
Robbins, J.6
-
47
-
-
0032749319
-
In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy
-
47 Yang Q, Sanbe A, Osinska H, Hewett TE, Klevitsky R, Robbins J: In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy. Circ Res 1999, 85:841-847. This report describes a mouse model expressing MyBP-C lacking the myosin-binding domain. Hearts of these mice showed only modest levels of mutant protein. Despite normal levels of wild-type MyBP-C, hearts showed mild hypertrophy, histopathologic changes, and animals had impaired exercise tolerance.
-
(1999)
Circ Res
, vol.85
, pp. 841-847
-
-
Yang, Q.1
Sanbe, A.2
Osinska, H.3
Hewett, T.E.4
Klevitsky, R.5
Robbins, J.6
-
48
-
-
0032741970
-
Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice
-
48 McConnell BK, Jones KA, Fatkin D, Arroyo LH, Lee RT, Aristizabal O, et al.: Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice. J Clin Invest 1999, 104:1235-1244. This description of a mouse model mimicking a human MyBP-C mutation causing FHC showed that homozygous mice develop histopathologic features of FHC but develop progressive ventricular dilation.
-
(1999)
J Clin Invest
, vol.104
, pp. 1235-1244
-
-
McConnell, B.K.1
Jones, K.A.2
Fatkin, D.3
Arroyo, L.H.4
Lee, R.T.5
Aristizabal, O.6
-
49
-
-
0033538612
-
Mouse model of a familial hypertrophic cardiomyopathy mutation in α-tropomyosin manifests cardiac dysfunction
-
49 Muthuchamy M, Pieples K, Rethinasamy P, Hoit B, Grupp IL, Boivin GP, et al.: Mouse model of a familial hypertrophic cardiomyopathy mutation in α-tropomyosin manifests cardiac dysfunction. Circ Res 1999, 85:47-56. The mouse model with α-TM-D175N mutation described here showed typical FHC histopathology. In vivo physiologic analyses showed severe impairment of both contractility and relaxation.
-
(1999)
Circ Res
, vol.85
, pp. 47-56
-
-
Muthuchamy, M.1
Pieples, K.2
Rethinasamy, P.3
Hoit, B.4
Grupp, I.L.5
Boivin, G.P.6
-
50
-
-
0030732231
-
Targeted ablation of the murine α-tropomyosin gene
-
50 Blanchard E, Iizuka K, Christe M, Conner D, Geisterfer-Lowrance A, Schoen F, et al.: Targeted ablation of the murine α-tropomyosin gene. Circ Res 1997, 81:1005-1010.
-
(1997)
Circ Res
, vol.81
, pp. 1005-1010
-
-
Blanchard, E.1
Iizuka, K.2
Christe, M.3
Conner, D.4
Geisterfer-Lowrance, A.5
Schoen, F.6
-
51
-
-
0031908697
-
Molecular and physiological effects of α-tropomyosin ablation in the mouse
-
51 Rethinasamy OP, Muthachamy M, Hewett T, Boivin G, Wolska B, Evans C, et al.: Molecular and physiological effects of α-tropomyosin ablation in the mouse. Circ Res 1998, 82:116-123.
-
(1998)
Circ Res
, vol.82
, pp. 116-123
-
-
Rethinasamy, O.P.1
Muthachamy, M.2
Hewett, T.3
Boivin, G.4
Wolska, B.5
Evans, C.6
-
52
-
-
0013666847
-
Characterization of a transgenic rat model of familial hypertrophic cardiomyopathy with missense mutations Asp175Asn or Glu180Gly in α-tropomyosin
-
52 Wernicke D, Thiel C, Isac C, Plehm R, Hammes A, Ganten U, et al.: Characterization of a transgenic rat model of familial hypertrophic cardiomyopathy with missense mutations Asp175Asn or Glu180Gly in α-tropomyosin. Circulation 1999, 100:1-268.
-
(1999)
Circulation
, vol.100
, pp. 1-268
-
-
Wernicke, D.1
Thiel, C.2
Isac, C.3
Plehm, R.4
Hammes, A.5
Ganten, U.6
-
53
-
-
0031471956
-
Both hypertrophic and dilated cardiomyopathies are caused by mutation of the same gene, delta-sarcoglycan, in hamster: An animal model of disrupted dystrophin-associated glycoprotein complex
-
53 Sakamoto A, Ono K, Abe M, Jasmin G, Eki T, Murakami Y, et al.: Both hypertrophic and dilated cardiomyopathies are caused by mutation of the same gene, delta-sarcoglycan, in hamster: an animal model of disrupted dystrophin-associated glycoprotein complex. Proc Natl Acad Sci USA 1997, 94:13873-13878.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13873-13878
-
-
Sakamoto, A.1
Ono, K.2
Abe, M.3
Jasmin, G.4
Eki, T.5
Murakami, Y.6
-
54
-
-
0033594889
-
Familial hypertrophic cardiomyopathy in Maine Coon cats - An animal model of human disease
-
54 Kittleson MD, Meurs KM, Munro MJ, Kittleson JA, Liu S-K, Pion PD, Towbin JA: Familial hypertrophic cardiomyopathy in Maine Coon cats - An animal model of human disease. Circulation 1999, 99:3172-3180. In this article, a naturally occurring form of FHC in cats is described. This strain of cats showed all the important features of human FHC, including sudden cardiac death.
-
(1999)
Circulation
, vol.99
, pp. 3172-3180
-
-
Kittleson, M.D.1
Meurs, K.M.2
Munro, M.J.3
Kittleson, J.A.4
Liu, S.-K.5
Pion, P.D.6
Towbin, J.A.7
-
55
-
-
0025855389
-
Transgenic animals as a tool for studying the effect of the c-myc proto-oncogene on cardiac development
-
55 Jackson T, Allard MF, Sreenan CM, Doss LK, Bishop SP, Swain JL: Transgenic animals as a tool for studying the effect of the c-myc proto-oncogene on cardiac development. Mol Cell Biochem 1991, 104:15-19.
-
(1991)
Mol Cell Biochem
, vol.104
, pp. 15-19
-
-
Jackson, T.1
Allard, M.F.2
Sreenan, C.M.3
Doss, L.K.4
Bishop, S.P.5
Swain, J.L.6
-
56
-
-
0029091356
-
Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice
-
56 Hunter JJ, Tanaka N, Rockman HA, Ross Jr J, Chien KR: Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice. J Biol Chem 1996, 270:23173-23178.
-
(1996)
J Biol Chem
, vol.270
, pp. 23173-23178
-
-
Hunter, J.J.1
Tanaka, N.2
Rockman, H.A.3
Ross J., Jr.4
Chien, K.R.5
-
57
-
-
0027234582
-
Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice
-
57 Gruver CL, DeMayo F, Goldstein MA, Means AR: Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice. Endocrinology 1993, 133:376-388.
-
(1993)
Endocrinology
, vol.133
, pp. 376-388
-
-
Gruver, C.L.1
DeMayo, F.2
Goldstein, M.A.3
Means, A.R.4
-
58
-
-
0032555959
-
Expression of proto-oncogenes and gene mutation of sarcomeric proteins in patients with hypertrophic cardiomyopathy
-
58 Kai H, Muraishi A, Sugiu Y, Nishi H, Seki Y, Kuwahara F, et al.: Expression of proto-oncogenes and gene mutation of sarcomeric proteins in patients with hypertrophic cardiomyopathy. Circ Res 1998, 83:594-601.
-
(1998)
Circ Res
, vol.83
, pp. 594-601
-
-
Kai, H.1
Muraishi, A.2
Sugiu, Y.3
Nishi, H.4
Seki, Y.5
Kuwahara, F.6
-
59
-
-
0032540267
-
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
-
59 Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, et al.: A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 1998, 93:215-228.
-
(1998)
Cell
, vol.93
, pp. 215-228
-
-
Molkentin, J.D.1
Lu, J.R.2
Antos, C.L.3
Markham, B.4
Richardson, J.5
Robbins, J.6
-
60
-
-
0032508640
-
Prevention of cardiac hypertrophy in mice by calcineurin inhibition
-
60 Sussmann MA, Lim HW, Gude N, Taigen T, Olson EN, Robbins J, et al.: Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science 1998, 281:1690-1693.
-
(1998)
Science
, vol.281
, pp. 1690-1693
-
-
Sussmann, M.A.1
Lim, H.W.2
Gude, N.3
Taigen, T.4
Olson, E.N.5
Robbins, J.6
-
61
-
-
0033592754
-
Signaling pathways for cardiac hypertrophy and failure
-
61 Hunter JJ, Chien KR: Signaling pathways for cardiac hypertrophy and failure. N Engl J Med 1999, 341:1276-1283. This comprehensive review describes the signaling pathways that are involved in cardiac hypertrophy, some of which may be operational in the pathogenesis of FHC.
-
(1999)
N Engl J Med
, vol.341
, pp. 1276-1283
-
-
Hunter, J.J.1
Chien, K.R.2
-
62
-
-
0033979552
-
Pathogenesis of diverse clinical and pathological phenotypes in hypertrophic cardiomyopathy
-
62 Marian AJ: Pathogenesis of diverse clinical and pathological phenotypes in hypertrophic cardiomyopathy. Lancet 2000, 355:58-60. This article hypothesizes a model for the pathogenesis of FHC and describes the experimental approach to be used.
-
(2000)
Lancet
, vol.355
, pp. 58-60
-
-
Marian, A.J.1
-
63
-
-
0030877545
-
Overexpression of transforming growth factor-β1 and insulin-like growth factor-1 in patients with idiopathic hypertrophic cardiomyopathy
-
63 Li RK, Li G, Mickle DA, Weisel RD, Merante F, Luss H, et al.: Overexpression of transforming growth factor-β1 and insulin-like growth factor-1 in patients with idiopathic hypertrophic cardiomyopathy. Circulation 1997, 96:874-881.
-
(1997)
Circulation
, vol.96
, pp. 874-881
-
-
Li, R.K.1
Li, G.2
Mickle, D.A.3
Weisel, R.D.4
Merante, F.5
Luss, H.6
-
64
-
-
9044230117
-
Endothelin-1 and its receptor in hypertrophic cardiomyopathy
-
64 Hasegawa K, Fujiwara H, Koshiji M, Inada T, Ohtani S, Doyama K, et al.: Endothelin-1 and its receptor in hypertrophic cardiomyopathy. Hypertension 1996, 27:259-264.
-
(1996)
Hypertension
, vol.27
, pp. 259-264
-
-
Hasegawa, K.1
Fujiwara, H.2
Koshiji, M.3
Inada, T.4
Ohtani, S.5
Doyama, K.6
-
65
-
-
0030783729
-
Cardiac myocytes and fibroblasts contain functional estrogen receptors
-
65 Grohas C, Kahlert S, Loebbert K, Stimpel M, Karas RH, Vetter H, Neyses L: Cardiac myocytes and fibroblasts contain functional estrogen receptors. FEBS Lett 1997, 416:107-112.
-
(1997)
FEBS Lett
, vol.416
, pp. 107-112
-
-
Grohas, C.1
Kahlert, S.2
Loebbert, K.3
Stimpel, M.4
Karas, R.H.5
Vetter, H.6
Neyses, L.7
-
66
-
-
0033165785
-
Gender differences in molecular remodeling in pressure overload hypertrophy
-
66 Weinberg EO, Thienelt CD, Katz SE, Bartunek J, Tajima M, Rohrbach S, et al.: Gender differences in molecular remodeling in pressure overload hypertrophy. J Am Coll Cardiol 1999, 34:264-273.
-
(1999)
J Am Coll Cardiol
, vol.34
, pp. 264-273
-
-
Weinberg, E.O.1
Thienelt, C.D.2
Katz, S.E.3
Bartunek, J.4
Tajima, M.5
Rohrbach, S.6
|