Expression of a mutant (Arg92Gln) human cardiac troponin T, known to cause hypertrophic cardiomyopathy, impairs adult cardiac myocyte contractility

Circulation Research

Volumn 81, Issue 1, 1997, Pages 76-85

  Marian, Ali J ^a,b   Zhao, Guiling ^a   Seta, Yukihiro ^a   Roberts, Robert ^a   Yu, Qun Tao ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Section of Cardiology   (United States)

Author keywords

Contractility; Gene transfer; Hypertrophic cardiomyopathy; Sarcomere; Troponin T

Indexed keywords

ARGININE; GLUTAMINE; MUTANT PROTEIN; TROPONIN T; BIOLOGICAL MARKER; TROPONIN;

ANIMAL CELL; ARTICLE; CAT; CONTROLLED STUDY; GENE TRANSFER; HYPERTROPHIC CARDIOMYOPATHY; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN ISOLATION; SARCOMERE; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; ADULT; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; ELECTRON MICROSCOPY; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC RECOMBINATION; GENETIC TRANSDUCTION; GENETICS; HEART CONTRACTION; HEART MUSCLE; HUMAN; IMMUNOHISTOCHEMISTRY; MUSCLE FIBRIL; MUTATION; TIME; WESTERN BLOTTING;

ADULT; ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CARDIOMYOPATHY, HYPERTROPHIC; CATS; CELLS, CULTURED; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE TRANSFER TECHNIQUES; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, ELECTRON; MUTATION; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOFIBRILS; RECOMBINATION, GENETIC; SARCOMERES; TIME FACTORS; TRANSDUCTION, GENETIC; TROPONIN; TROPONIN T;

EID: 0030611676     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.81.1.76     Document Type: Article

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