Electrophysiological abnormalities and arrhythmias in αMHC mutant familial hypertrophic cardiomyopathy mice

Journal of Clinical Investigation

Volumn 99, Issue 4, 1997, Pages 570-576

  Berul, Charles I ^a,c   Christe, Michael E ^b   Aronovitz, Mark J ^a   Seidman, Christine E ^b   Seidman, J G ^b   Mendelsohn, Michael E ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c TUFTS MEDICAL CENTER   (United States)

Author keywords

cardiomyopathy; disease models, animals; drug screening; electrophysiology; hereditary diseases; hypertrophy

Indexed keywords

MYOSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; FIBROSING ALVEOLITIS; HEART CONDUCTION; HEART ELECTROPHYSIOLOGY; HEART REPOLARIZATION; HEART RIGHT VENTRICLE OUTFLOW TRACT OBSTRUCTION; HEART VENTRICLE EXTRASYSTOLE; HISTOPATHOLOGY; HYPERTROPHIC CARDIOMYOPATHY; MISSENSE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031030298     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119197     Document Type: Article

References (31)

1. Paigen, K. 1995. A miracle enough: the power of mice. Nat. Med. 1:215-220.
2. Lin, M.C., R.A. Rockman, and K.R. Chien. 1995. Heart and lung disease in engineered mice. Nat. Med. 1:749-751.
3. Seidman, C.E., and J.G. Seidman. 1995. Gene mutations that cause familial hypertrophic cardiomyopathy. In Molecular Cardiovascular Medicine. E. Haber, editor. Scientific American Press, New York. 193-210.
4. Watkins, H., W. McKenna, L. Thierfelder, H.J. Suk, R. Anan, A. O'Donoghue, P. Spirito, A. Matsumori, C.S. Moravec, J.G. Seidman, and C.E. Seidman. 1995. Mutations in the genes for cardiac troponin T and α-tropomyosin in hypertrophic cardiomyopathy. N. Engl. J. Med. 332:1058-1064.
5. Geisterfer-Lowrance, A., M. Christe, D. Conner, J. Ingwall, F. Schoen, C.E. Seidman, and J.G. Seidman. 1996. A mouse model of familial hypertrophic cardiomyopathy. Science (Wash. DC). 272:731-734.
6. Berul, C.I., M. Aronovitz, P.J. Wang, and M.E. Mendelsohn. 1996. In vivo cardiac electrophysiology studies in the mouse. Circulation. 94:2641-2648.
7. Bazett, H.C. 1920. An analysis of the time relationships of the heart. Heart. 7:353-370.
8. Berul, C.I., T.L. Sweeten, A.M. Dubin, M.J. Shah, and V.L. Vetter. 1994. Use of the rate-corrected JT interval for prediction of repolarization abnormalities in children. Am. J. Cardiol. 74:1254-1257.
9. Gillette, P.C., D.S. Buckles, M. Harold, and A. Garson. 1990. Intracardiac electrophysiology studies. In Pediatric Arrhythmias: Electrophysiology and Pacing. P.C. Gillette and A. Garson, editors. W.B. Saunders. Philadelphia. 216-248.
10. Roberts, N.K., and P.C. Gillette. 1977. Electrophysiologic study of the conduction system in normal children. Pediatrics. 60:858-863.
11. Kugler, J.D. 1995. Electrophysiology studies. In Moss and Adam's Heart Disease in Infants, Children, and Adolescents, Including the Fetus and Young Adult. G.C. Emmanouilides. T.A. Reimenschneider, H.D. Allen, and H.P. Gutgesell, editors. Williams & Wilkins, Baltimore. 347-366.
12. Mandel, W., H. Hayakawa, R. Danzig, and H.S. Marcus. 1971. Evaluation of sino-atrial node function in man by overdrive suppression. Circulation. 44:59-66.
13. Randall, W.C. 1990. Sympathetic modulation of normal cardiac rhythm. In Cardiac Electrophysiology: A Textbook. M.R. Rosen, M.J. Janse, and A.L. Wit, editors. Futura, Mount Kisko, NY. 889-901.
14. Wit, A.L., M.B. Weiss, and W.D. Berkowitz. 1970. Patterns of A-V conduction in the human heart. Circ. Res. 27:345-352.
15. Zipes, D.P. 1992. Specific arrhythmias: diagnosis and treatment. In Heart Disease: A Textbook of Cardiovascular Medicine. E. Braunwald, editor. W.B. Saunders, Philadelphia. 667-725.
16. Watson, R.M., J.L. Schwartz, B.J. Maron, E. Tucker, D.R. Rosing, and M.E. Josephson. 1987. Inducible polymorphic ventricular tachycardia and ventricular fibrillation in a subgroup of patients with hypertrophic cardiomyopathy at risk for sudden death. J. Am. Coll. Cardiol. 10:761-774.
17. Vetter, V.L. 1985. The pediatric electrophysiology study. In Pediatric and Fundamental Electrocardiography. J. Liebman, R. Plonsey, and Y. Rudy, editors. Martinus Nijhoff, New York. 161-184.
18. Scheidt, S. 1984. Basic electrocardiography: abnormalities of electrocardiographic patterns. Clinical Symposia. 36:2-32.
19. Thierfelder, L., H. Watkins, C. MacRae, R. Lamas, W. McKenna, H.P. Vosberg, J.G. Seidman, and C.E. Seidman. 1994. Mutations in α-tropomyosin and in cardiac troponin T cause hypertrophic cardiomyopathy: a disease of the sarcomere. Cell. 77:701-712.
20. Watkins, H., R. Anan, D.A. Coviello, P. Spirito, J.G. Seidman, and C.E. Seidman. 1995. A de novo mutation in α-tropomyosin that causes hypertrophic cardiomyopathy. Circulation. 91:2302-2305.
21. Fananapazir, L., A.C. Chang, S.E. Epstein, and D. McAreavy. 1992. Prognostic determinants in hypertrophic cardiomyopathy: prospective evaluation of a therapeutic strategy based on clinical, holter, hemodynamic, and electrophysiological findings. Circulation. 86:730-740.
22. Epstein, N.D., G.M. Cohn, F. Cyran, and L. Fananapazir. 1992. Differences in clinical expression of hypertrophic cardiomyopathy associated with two distinct mutations in β-myosin heavy chain gene. Circulation. 86:345-352.
23. Buja, G., M. Miorelli, P. Turrini, P. Melacini, and A. Nava. 1993. Comparison of QT dispersion in hypertrophic cardiomyopathy between patients with and without ventricular arrhythmias and sudden death. Am. J. Cardiol. 72: 973-976.
24. Wigle, E.D., H. Rakowski, B.P. Kimball, and W.G. Williams. 1995. Hypertrophic cardiomyopathy: clinical spectrum and treatment. Circulation. 92: 1680-1692.
25. Fananapazir, L., and S.E. Epstein. 1991. Hemodynamic and electrophysiologic evaluation of patients with hypertrophic cardiomyopathy surviving cardiac arrest. Am. J. Cardiol. 67:280-287.
26. Maron, B.J., and L. Fananapazir. 1992. Sudden cardiac death in hypertrophic cardiomyopathy. Circulation. 85:I57-I63.
27. Solomon, S.D., S. Wolff, H. Watkins, P.M. Ridker, P. Come, W.J. McKenna, C.E. Seidman, and R.T. Lee. 1993. Left ventricular hypertrophy and morphology in familial hypertrophic cardiomyopathy associated with mutations of the beta-myosin heavy chain gene. J. Am. Coll. Cardiol. 22:498-505.
28. Watkins, H., A. Rosenzweig, D. Hwang, T. Levi, W. McKenna, C.E. Seidman, and J.G. Seidman. 1992. Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy. N. Engl. J. Med. 326:1108-1114.
29. Spirito, P., C. Rapezzi, C. Autore, P. Bruzzi, P. Bellone, P. Ortolani, P.V. Fragola, F. Chiarella, M. Zoni-Berisso, A. Branzi, et al. 1994. Prognosis of asymptomatic patients with hypertrophic cardiomyopathy and nonsustained ventricular tachycardia. Circulation. 90:2743-2747.
30. McKenna, W.J., N. Sadoul, A.K.B. Slade, and R.C. Saumarez. 1994. The prognostic significance of nonsustained ventricular tachycardia in hypertrophic cardiomyopathy. Circulation. 90:3115-3117.
31. Cannon, C.R., G.S. Reeder, K.R. Bailey, L.J. Melton III, and B.J. Gersh. 1995. Natural history of hypertrophic cardiomyopathy: a population-based study, 1976 through 1990. Circulation. 92:2488-2495.