QT dispersion in α-myosin heavy-chain familial hypertrophic cardiomyopathy mice

Pediatric Research

Volumn 45, Issue 5, 1999, Pages 643-647

  Bevilacqua, Laura M ^a,c   Maguire, Colin T ^a,c   Seidman, Jonathan G ^b,c   Seidman, Christine E ^b,c   Berul, Charles I ^a,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b Howard Hughes Med I Harvard M S   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; FAMILIAL DISEASE; FEMALE; GENDER; HEART VENTRICLE ARRHYTHMIA; HYPERTROPHIC CARDIOMYOPATHY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; RISK ASSESSMENT; RISK FACTOR;

AMINO ACID SUBSTITUTION; ANIMALS; BODY SURFACE POTENTIAL MAPPING; CARDIOMYOPATHY, HYPERTROPHIC; FEMALE; HEART; HEART RATE; LONG QT SYNDROME; MALE; MICE; MICE, MUTANT STRAINS; MYOSIN HEAVY CHAINS; PHENOTYPE; REFERENCE VALUES; RISK FACTORS; SEX CHARACTERISTICS; TACHYCARDIA, VENTRICULAR;

EID: 0032907451     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/00006450-199905010-00005     Document Type: Article

References (18)

1. Watkins H, Rosenzweig A, Hwang D, Levi T, McKenna W, Seidman CE, Seidman JG 1992 Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy. N Engl J Med 326:1108-1114.
2. Epstein ND, Cohn GM, Cyran F, Fananapazir L 1992 Differences in clinical expression of hypertrophic cardiomyopathy associated with two distinct mutations in the β-myosin heavy chain gene. Circulation 86:345-352
3. Ryan MP, Cleland JGF, French JA, Joshi J, Choudhury L, Chojnowska L, Michalak E, al-Mahdawi S, Nihoynnopoulos P, Oakley CM 1995 The standard electrocardiogram as a screening tool for hypertrophic cardiomyopathy. Am J Cardiol 76:689-694
4. Buja G, Miorelli M, Turrini P, Melacini P, Nava A 1993 Comparison of QT dispersion in hypertrophic cardiomyopathy between patients with and without ventricular arrhythmias and sudden death. Am J Cardiol 72:973-976
5. Miorelli M, Buja G, Melacini P, Fasoli G, Nava A 1994 QT-interval variability in hypertrophic cardiomyopathy patients with cardiac arrest. Int J Cardiol 45:121-127
6. Berul CI, Christe ME, Aronovitz MJ, Maguire CT, Seidman CE, Seidman JG, Mendelsohn ME 1998 Familial hypertrophic cardiomyopathy mice display gender differences in electrophysiologic abnormalities. J Interv Card Electrophysiol 2:7-14
7. Geisterfer-Lowrance AAT, Christe M, Conner DA, Ingwall JS, Schoen FJ, Seidman CE, Seidman JG 1996 A mouse model of familial hypertrophic cardiomyopathy. Science 272:731-734
8. Berul CI, Christe ME, Aronovitz MJ, Seidman CE, Seidman JG, Mendelsohn ME 1997 Electrophysiologic abnormalities and arrhythmias in α-MHC mutant familial hypertrophic cardiomyopathy mice. J Clin Invest 99:570-576
9. Berul CI, Aronovitz MJ, Wang PJ, Mendelsohn ME 1996 In vitro electrophysiology studies in mice. Circulation 94:2641-2648
10. Mitchell GF, Jeron A, Koren G 1998 Measurement of heart rate and QT interval in the conscious mouse. Am J Physiol 274:H747-H751
11. Priori SG, Napolitano C, Diehl L, Schwartz PJ 1989 Dispersion of the QT interval: a marker of therapeutic efficacy in the idiopathic long QT syndrome. Circulation 4:1681-1689
12. Molnar J, Rosenthal JE, Weiss JS, Somberg JC 1997 QT interval dispersion in healthy subjects and survivors of sudden cardiac death: circadian variation in a twenty-four-hour assessment. Am J Cardiol 79:1190-1193
13. Day CP, McComb JM, Campbell RWF 1990 QT dispersion: an indication of arrhythmic risk in patients with long QT intervals. Br Heart J 63:342-344
14. Zareba W, Moss AJ, Cessie SL 1994 Dispersion of ventricular repolarization and arrhythmic cardiac death in coronary artery disease. Am J Cardiol 74:550-553
15. Cin VG, Celik M, Ulucan S 1997 QT dispersion ratio in patients with unstable angina pectoris (a new risk factor). Clin Cardiol 20:533-535
16. Hii JTY, Wyse DG, Gillis AM, Duff HJ, Solylo MA, Mitchell LB 1992 Torsades de pointes; disparate effects of class Ia antiarrhythmic drugs and amiodarone. Circulation 86:1376-1382
17. Linker NJ, Colonna P, Kekwick CA, Till J, Camm AJ, Ward DE 1992 Assessment of QT dispersion in symptomatic patients with congenital long QT syndrome. Am J Cardiol 69:634-638
18. Shah MJ, Wieand TS, Rhodes LA, Berul CI, Vetter VL 1997 QT and JT dispersion in children with long QT syndrome. J Cardiovasc Electrophysiol 8:642-648