Apoptosis in the gastric mucosa: Molecular mechanisms, basic and clinical implications

Journal of Physiology and Pharmacology

Volumn 51, Issue 1, 2000, Pages 3-15

  Szabo I ^a   Tarnawski, Andrzej S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

Apoptosis; Caspases; Gastric mucosa; Helicobacter priori; NSAIDs

Indexed keywords

CASPASE; CYCLOOXYGENASE 2 INHIBITOR; CYTOTOXIN; DICLOFENAC; INDOMETACIN; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT;

APOPTOSIS; HELICOBACTER PYLORI; HUMAN; NONHUMAN; REVIEW; STOMACH MUCOSA INJURY; STOMACH ULCER; ULCER HEALING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; GASTRIC MUCOSA; HELICOBACTER PYLORI; HUMANS;

EID: 0034035591     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (71)

1. Stachura J, Tarnawski A, Dabros W. Apoptosis: genetically programmed physiologic cell loss in normal gastric oxyntic mucosa and in mucosa of grossly healed gastric ulcer. J Clin Gastroenterol 1993; 17: S70-7.
2. Bursch W, Obermammer F, Schulte-Herman R. Cell death by apoptosis and its protective role against disease. Trends Pharmacol Sci 1992; 13: 245-51.
3. Evans VG. Multiple pathways of apoptosis. Cell Biol Int 1993; 17: 461-75.
4. Nagata S. Apoptosis by death factor. Cell 1997; 88: 355-65.
5. Alnemri ES, Livingston DJ, Nicholson DW et al. Human ICE/CED-3 protease nomenclature. Cell 1996; 87: 171.
6. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998; 281: 1312-6.
7. Schwartzman RA, Cidlowski JA. Apoptosis the biochemistry and molecular biology of programmed cell death. Endocr Rev 1993; 14: 133-51.
8. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 1994; 371: 346-7.
9. Kothakota S, Azuma T, Reinhard C et al. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science 1997; 278: 294-8.
10. Mashima T, Naito M, Noguchi K, Miller DK, Nicholson DW, Tsuruo T. Actin cleavage by CPP-32/apopain during the development of apoptosis. Oncogene 1997; 14: 1007-12.
11. Martin SJ, O'Brien GA, Nishioka WK et al. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J Biol Chem 1995; 270: 6425-28.
12. Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998; 281: 1305-8.
13. Tartaglia LA, Ayres TM, Wong GH, Goeddel DV. A novel domain within the 55 kd TNF receptor signals cell death. Cell 1993; 74: 845-53.
14. Derijard B, Hibi M, Wu IH et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994; 76: 1025-37.
15. Kyriakis JM, Avruch J. pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine. J Biol Chem 1990; 265: 17355-63.
16. Kyriakis JM, Banerjee P, Nikolakaki E et al. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 1994; 369: 156-60.
17. Han J, Lee JD, Jiang Y, Li Z, Feng L, Ulevitch RJ. Characterisation of the structure and function of a novel MAP kinase kinase (MKK6). J Biol Chem 1996; 271: 2886-91.
18. Lee JC, Laydon JT, McDonnell PC et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994; 372: 739-46.
19. Chinnaiyan AM, Tepper CG, Seldin MF et al. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem 1996; 271: 4961-65.
20. Lynch DH, Ramsdell F, Alderson MR. Fas and FasL in the homeostatic regulation of immune responses. Immunol Today 1995; 16: 569-74.
21. Moriguchi T, Toyoshima F, Masuyama N, Hanafusa H, Gotoh Y, Nishida E. A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses. EMBO J 1997; 16: 7045-53.
22. Nagata S. Apoptosis mediated by Fas and its related diseases. Nippon Ika Daigaku Zasshi 1997; 64: 459-62.
23. French LE, Hahne M, Viard I et al. Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterised by apoptotic cell turnover. J Cell Biol 1996; 133: 335-43.
24. Houghton J, Korah RM, Condon MR, Kim KH. Apoptosis in Helicobacter pylori-associated gastric and duodenal ulcer disease is mediated via the Fas antigen pathway. Dig Dis Sci 1999; 44: 465-78.
25. Chinnaiyan AM, O'Rourke K, Yu GL et al. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 1996; 274: 990-2.
26. Griffith TS, Lynch DH. TRAIL: a molecule with multiple receptors and control mechanisms. Curr Opin Immunol 1998; 10: 559-63.
27. Ashkenazi A, Dixit VM. Apoptosis control by death and decoy receptors. Curr Opin Cell Biol 1999; 11: 255-60.
28. Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome C. Cell 1996; 86: 147-157.
29. Korsmeyer SJ. Regulators of cell death. Trends Genet 1995; 11: 101-5.
30. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome C-dependent activation of caspase-3. Cell 1997; 90: 405-13.
31. Moss SF, Calam J, Agarwal B, Wang S, Holt PR. Induction of gastric epithelial apoptosis by Helicobacter pylori. Gut 1996; 38: 498-501.
32. Piotrowski J, Slomiany A, Slomiany BL. Activation of apoptotic caspase-3 and nitric oxide synthase-2 in gastric mucosal injury induced by indomethacin. Scand J Gastroenterol 1999; 34: 129-34.
33. Slomiany BL, Piotrowski J, Slomiany A. Role of basic fibroblast growth factor in the suppression of apoptotic caspase-3 during chronic gastric ulcer healing. J Physiol Pharmacol 1998; 49: 489-500.
34. M Shimada, K Ina, T Ando et al. Fas/Fas Ligand pathway is associated with epithelial apoptosis in gastric ulceration. Gastroenterology 1999; 116: A310.
35. Knipp U, Birkholz S, Kaup W, Opferkuch W. Partial characterisation of cell proliferation-inhibiting protein produced by Helicobacter pylori. Infect Immun 1996; 64: 3491-96.
36. Ricci V, Ciacci C, Zarrilli R et al. Effect of Helicobacter pylori on gastric epithelial cell migration and proliferation in vitro: role of VacA and CagA. Infect Immun 1996; 64: 2829-33.
37. Chang K, Fujiwara Y, Wyle F, Tarnawski A. Helicobacter pylori toxin inhibits growth and proliferation of cultured gastric cells-KATO III. J Physiol Pharmacol 1993; 44: 17-22.
38. Tsuji S, Kawano S, Takei Y, Tsuji M, Kobayashi I, Nagano K. Ammonia induces gastric cell apoptosis: possible implication to Helicobacter-related gastric mucosal atrophy. Gastroenterology 1995; 108: A244.
39. Wagner S, Beil W, Westermann J et al. Regulation of gastric epithelial cell growth by Helicobacter pylori: evidence for a major role of apoptosis. Gastroenterology 1997; 113: 1836-47.
40. Minohara Y, Fan X, Ernst PB, Crowe SE, Patel JA. The effects of clarithromycin on Helicobacter pylori adherence and induction of apoptosis in gastric epithelial cells. Gastroenterology 1999; 116: A254.
41. Brenes F, Ruiz B, Correa P, Hunter F, Rhamakrishnan T, Fontham E, Shi TY. Helicobacter pylori cause hyperproliferation of the gastric epithelium: pre- and post-eradication indices of proliferating cell nuclear antigen. Am J Gastroenterol 1993; 88: 1870-75.
42. Fraser AG, Sim R, Sankey EA, Dhillon AP, Pounder RE. Effect of eradication of Helicobacter pylori on gastric epithelial cell proliferation. Aliment Pharmacol Ther 1994; 8: 167-73.
43. Lynch DA, Mapstone NP, Clarke AM et al. Cell proliferation in Helicobacter pylori associated gastritis and the effect of eradication therapy. Gut 1995; 36: 346-350.
44. Cahill RJ, Xia H, Kilgallen C, Beattie S, Hamilton H, O'Morain C. Effect of eradication of Helicobacter pylori infection on gastric epithelial cell proliferation. Dig Dis Sci 1995; 40: 1627-1631.
45. Cahill RJ, O'Morain CA. Gastric epithelial cell proliferation. Eur J Cancer Prev 1994; 3 (Suppl 2): 55-60.
46. Piotrowski J, Skrodzka D, Slomiany A, Slomiany BL. Helicobacter pylori lipopolysaccharide induces gastric epithelial apoptosis. Biochem Mol Biol Int 1996; 40: 597-602.
47. Peek RM Jr, Blaser MJ. Pathophysiology of Helicobacter pylori-induced gastritis and peptic ulcer disease. Am J Med 1997; 102: 200-7.
48. Sharma SA, Tummuru MK, Miller GG, Blaser MJ. Interleukin-8 response of gastric epithelial cell lines to Helicobacter pylori stimulation in vitro. Infect Immun 1995; 63: 1681-87.
49. Yamaoka Y, Kita M, Kodama T, Sawai N, Kashima K, Imanishi J. Expression of cytokine mRNA in gastric mucosa with Helicobacter pylori infection. Scand J Gastroenterol 1995; 30: 1153-59.
50. + T cells from human immunodeficiency virus-infected persons: differential in vitro preventive effect of cytokines and protease antagonists. Blood 1996; 87: 4959-66.
51. Rudi J, Kuck D, Strand S et al. Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J Clin Invest 1998; 102: 1506-14.
52. Censini S, Lange C, Xiang Z et al. CagA pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci USA 1996; 93: 14648-53.
53. Tummuru MK, Sharma SA, Blaser MJ. Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol Microbiol 1995; 18: 867-76.
54. Peek RM Jr, Miller GG, Tham KT et al. Heightened inflammatory response and cytokine expression in vivo to CagA+ Helicobacter pylori strains. Lab Invest 1995; 73: 760-70.
55. Yamaoka Y, Kita M, Kodama T, Sawai N, Imanishi J. Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa. Gastroenterology 1996; 110: 1744-52
56. Papini E, Gottardi E, Satin B et al. The vacuolar ATPase proton pump is present on intracellular vacuoles induced by Helicobacter pylori. J Med Microbiol 1996; 45: 84-89.
57. Konturek P, Faller G, Marilcz K et al. Antigastric autoantibodies in Helicobacter pylori infected patients with Gastric carcinoma: implication of plasma gastrin release and gastric secretory functions. Gastroenterology 1999; 116: A218.
58. Takagi A, Watanabe S, Igarashi M, Koike J, Miwa T. Helicobacter pylori induced cell Death is associated with expression of Bcl-xs in gastric epithelial cells. Gastroenterology 1999; 116: A326.
59. Kusuhara H, Matsuyuki H, Matsuura M, Imayoshi T, Okumoto T, Matsui H. Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells. Eur J Pharmacol 1998; 360: 273-80.
60. Slomiany BL, Piotrowski J, Slomiany A. Role of caspase-3 and nitric oxide synthase-2 in gastric mucosal injury induced by indomethacin: effect of sucralfate. J Physiol Pharmacol 1999; 50: 3-16.
61. Zhu GH, Wong BC, Ching CK, Lai KC, Lam SK. Differential apoptosis by indomethacin in gastric epithelial cells through the constitutive expression of wild-type p53 and/or up-regulation of c-myc. Biochem Pharmacol 1999; 58: 193-200.
62. Bortuzzo C, Hanif R, Kashfi K, Staiano-Coico L, Shiff SJ, Rigas B. The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells. Biochim Biophys Acta 1996; 1300: 240-46.
63. Shiff SJ, Koutsos MI, Qiao L, Rigas B. Nonsteroidal anti-inflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. Exp Cell Res 1996; 222: 179-88.
64. Kuwayama H, Nakajima N, Matsuo Y, Eastwood GL. Effects of single parenteral indomethacin injection in rat fundic and antral epithelial proliferation. J Clin Gastroenterol 1990; 12 (Suppl 1): S72-75.
65. Ahnen DJ. Colon cancer prevention by NSAIDs: what is the mechanism of action? Eur J Surg Suppl 1998; 582: 111-14.
66. Fiorucci S, Santucci L, Federici B et al. Nitric oxide-releasing NSAIDs inhibit interleukin-lbeta converting enzyme-like cysteine proteases and protect endothelial cells from apoptosis induced by TNFalpha. Aliment Pharmacol Ther 1999; 13: 421-35.
67. Fiorucci S, Antonelli E, Migliorati G et al. TNFalpha processing enzyme inhibitors prevents aspirin-induced TNFalpha release and protection against gastric mucosal injury in rats. Aliment Pharmacol Ther 1998; 12: 1139-53.
68. Hong SP, Ha SH, Park IS, Kim WH. Induction of apoptosis in colon cancer cells by nonsteroidal anti-inflammatory drugs. Yonsei Med J 1998; 39: 287-95.
69. Zhu GH, Wong BC, Eggo MC et al. Nonsteroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. Br J Cancer 1999; 79: 393-400.
70. Alderman BM, Cook GA, Yeomans ND. Resistance to apoptosis is a likely mechanism of gastric mucosal adaptation to aspirin. Gastroenterology 1999; 116: A110.
71. Zhu GH, Yang XL, Lai KC et al. Nonsteroidal anti-inflammatory drugs could reverse Helicobacter pylori-induced apoptosis and proliferation in gastric epithelial cells. Dig Dis Sci 1998; 43: 1957-63.