Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells

European Journal of Pharmacology

Volumn 360, Issue 2-3, 1998, Pages 273-280

  Kusuhara, Hidenobu ^a   Matsuyuki, Hirofumi ^a   Matsuura, Mamoru ^a   Imayoshi, Tomonori ^a   Okumoto, Takeki ^a   Matsui, Hirofumi ^b  

^a Research Laboratories   (Japan)

^b RIKEN   (Japan)

Author keywords

Apoptosis; Caspase; Cyclooxygenase; DNA fragmentation; Nonsteroidal anti inflammatory drug; Prostaglandin

Indexed keywords

16,16 DIMETHYLPROSTAGLANDIN E2; CASPASE; CASPASE INHIBITOR; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DICLOFENAC; DNA FRAGMENT; INDOMETACIN; MESSENGER RNA; MOFEZOLAC; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CHICK EMBRYO; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; FIBROBLAST; MESSENGER RNA SYNTHESIS; MUCOSA CELL; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT; STOMACH MUCOSA;

16,16-DIMETHYLPROSTAGLANDIN E2; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CASPASES; CELL LINE; CYCLOOXYGENASE 2; DNA FRAGMENTATION; GASTRIC MUCOSA; HUMANS; ISOENZYMES; MALE; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 0032491381     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00679-7     Document Type: Article

References (37)

1. Beiche F., Scheuerer S., Brune K., Geisslinger G., Goppelt-Struebe M. Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation. FEBS Lett. 390:1996;165-169.
2. Bonfoco E., Krainc D., Ankarcrona M., Nicotera P., Lipton S.A. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. USA. 92:1995;7162-7166.
3. Carson D.A., Ribeiro J.M. Apoptosis and disease. Lancet. 341:1993;1251-1254.
4. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
5. Dubrez L., Savoy I., Hamman A., Solary E. Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways. EMBO J. 15:1996;5504-5512.
6. Funk C.D., Func L.B., Kennedy M.E., Pong A.S., Fitzgerald G.A. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J. 5:1991;2304-2312.
7. Futaki N., Yoshikawa K., Hamasaka Y., Arai I., Higuchi S., Iizuka H., Otomo S. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen. Pharmacol. 24:1993;105-110.
8. Futaki N., Takahashi S., Yokoyama M., Arai I., Higuchi S., Otomo S. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 24:1994;105-110.
9. Hanif R., Pittas A., Feng Y., Koutsos M.I., Qiao L., Staiano-Coico L., Shiff S.I., Rigas B. Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem. Pharmacol. 52:1996;237-245.
10. Hla T., Neilson K. Human cyclooxygenase-2 cDNA. Proc. Natl. Acad. Sci. USA. 89:1992;7384-7388.
11. Kinoshita Y., Nakata H., Hassan S., Asahara M., Kawanami C., Matsushima Y., Naribayashi-Inomoto Y., Ping C.Y., Min D., Nakamura A., Chiba T. Gene expression of keratinocyte and hepatocyte growth factors during the healing of rat gastric mucosal lesions. Gastroenterology. 109:1995;1068-1077.
12. Kobayashi I., Kawano S., Tsuji S., Matsui H., Nakama A., Sawaoka H., Masuda E., Takei Y., Nagano K., Fusamoto H., Ohno T., Fukutomi H., Kamada T. RGM1, a cell line derived from normal gastric mucosa of rat. In Vitro Cell. Dev. Biol. Anim. 32:1996;259-261.
13. Kujubu D.A., Fletcher B.S., Varnum B.C., Lim R.W., Herschman H.R. TIS10, a phorbol ester tumor promotor-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J. Biol. Chem. 266:1991;12866-12872.
14. Kusuhara H., Komatsu H., Hisadome M., Ikeda Y. (±)-3-[4-(2-Dimethylamino-1-methylethoxy)-phenyl]-1H-pyrazolo[3,4-b] pyridine-1-acetic acid (Y-25510) stimulates production of IL-1β and IL-6 at the level of messenger RNA expression in cultured human monocytes. Int. J. Immunopharmacol. 18:1996;719-728.
15. Kusuhara H., Fukunari A., Matsuyuki H., Okumoto T. Principal involvement of cyclooxygenase-1-derived prostaglandins in the c-fos expression of the rat hind brain following visceral stimulation with acetic acid. Mol. Brain Res. 52:1997;151-156.
16. Kusuhara H., Matsuyuki H., Okumoto T. Effects of nonsteroidal anti-inflammatory drugs on interleukin-1 receptor antagonist production in cultured human peripheral blood mononuclear cells. Prostaglandins. 54:1997;795-804.
17. Langenbach R., Morham S.G., Tiano H.F., Loftin C.D., Ghanayem B.I., Chulada P.C., Mahler J.F., Lee C.A., Goulding E.H., Kluckman K.D., Kim H.S., Smithies O. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell. 83:1995;483-492.
18. Lu X., Xie W., Reed D., Bradshaw W.S., Simmons D.L. Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts. Proc. Natl. Acad. Sci. USA. 92:1995;7961-7965.
19. Meade E.A., Smith W.L., Dewitt D.L. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 268:1993;6610-6614.
20. Merlie J.P., Fagan D., Mudd J., Needleman P. Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase). J. Biol. Chem. 263:1988;3550-3553.
21. Mitchell J.A., Akarasereenont P., Thiemermann C., Flower R.J., Vane J.R. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA. 90:1994;11693-11697.
22. Miyazaki Y., Shinomura Y., Tsutsui S., Yasunaga Y., Zushi S., Higashiyama H., Taniguchi N., Matsuzawa Y. Oxidative stress increases gene expression of heparin-binding EGF-like growth factor and amphiregurin in cultured rat gastric epithelial cells. Biochem. Biophys. Res. Commun. 226:1996;542-546.
23. O'Banion M.K., Sadowski H.B., Winn V., Young D.A. A serum-and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. J. Biol. Chem. 266:1991;23261-23267.
24. O'Neill P.O., Ford-Hutchinson A.W. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett. 330:1993;156-160.
25. Ono N., Yamamoto N., Sunami A., Yamasaki Y., Miyake H. Pharmacological profile of mofezolac, a new non-steroidal analgesic anti-inflammatory drug. Folia Pharmocol. Jpn. (Tokyo). 95:1990;63-81.
26. Pollard M., Luckert P.H. Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine. Science. 214:1981;558-559.
27. Rao C.V., Rivenson A., Simi B., Zang E., Kelloff G., Steele V., Reddy B.S. Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent. Cancer Res. 55:1995;1464-1472.
28. Reddy B., Rao C., Rivenson A., Kelloff G. Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats. Carcinogenesis. 14:1993;1493-1497.
29. Riendeau D., Percival M.D., Boyce S., Brideau C., Charleson S., Cromlish W., Ethier D., Evans J., Falgueyret J.-P., Ford-Hutchinson A.W., Gordon R., Greig G., Gresser M., Guay J., Kargman S., Léger S., Mancini J.A., O'Neill G., Ouellet M., Rodger I.W., Thérien M., Wang Z., Webb J.K., Wong E., Xu L., Young R.N., Zamboni R., Prasit P., Chan C.-C. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br. J. Pharmacol. 121:1997;105-117.
30. Rosa M.D., Persico P. Mechanism of inhibition of prostaglandin biosynthesis by hydrocortisone in rat leukocytes. Br. J. Pharmacol. 66:1979;161-163.
31. Shimura M., Ishizuka Y., Yuo A., Hatake K., Oshima M., Sasaki T., Takaku F. Characterization of room temperature induced apoptosis in HL-60. FEBS Lett. 417:1997;379-384.
32. Slomiany B.L., Piotrowski J., Slomiany A. Induction of tumor necrosis factor-α and apoptosis in gastric mucosal injury by indomethacin: effect of omeprazole and ebrotidine. Scan. J. Gastroenterol. 32:1997;638-642.
33. Vane J.R. Inhibition of prostaglandin biosynthesis as a mechanism of action for aspirin-like drugs. Nature, New Biol. 231:1971;232-235.
34. Wallace J.L. Mechanisms of nonsteroidal anti-inflammatory drugs (NSAIDs) induced gastrointestinal damage-potential for development of gastrointestinal tract safe NSAIDs. Can. J. Physiol. Pharmacol. 72:1994;1493-1498.
35. Wang A.M., Doyle M.W., Mark D.F. Quantitation of mRNA by the polymerase chain reaction. Proc. Natl. Acad. Sci. USA. 86:1991;9717-9721.
36. Williams G.T., Smith C.A. Molecular regulation of apoptosis: genetic controls on cell death. Cell. 74:1993;777-779.
37. Xie W.L., Chipman J.G., Robertson D.L., Erikson R.L., Simmons D.L. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc. Natl. Acad. Sci. USA. 88:1991;2692-2696.