Nitric oxide-releasing NSAIDs inhibit interleukin-1β converting enzyme-like cysteine proteases and protect endothelial cells from apoptosis induced by TNFα

Alimentary Pharmacology and Therapeutics

Volumn 13, Issue 3, 1999, Pages 421-435

  Fiorucci, S ^a,d   Santucci, L ^a   Federici, B ^a   Antonelli, E ^a   Distrutti, E ^a   Morelli, O ^a   Di Renzo, G ^a   Coata, G ^a   Cirino, G ^b   Del Soldato, P ^c   Morelli, A ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c NicOx SA   (France)

^d POLICLINICO MONTELUCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; CASPASE; CASPASE INHIBITOR; CYSTEINE PROTEINASE; DNA FRAGMENT; ENDOTOXIN; FLURBIPROFEN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NAPROXEN; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH MUCOSA; VASCULAR ENDOTHELIUM;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; ASPIRIN; CASPASE 1; CASPASES; CELL LINE; CYSTEINE PROTEINASE INHIBITORS; DNA FRAGMENTATION; ENDOTHELIUM, VASCULAR; FLURBIPROFEN; GASTRIC MUCOSA; HUMANS; IN SITU NICK-END LABELING; MALE; MICE; NAPROXEN; NITRIC OXIDE; PEROXIDASE; RATS; RATS, WISTAR;

EID: 0032999306     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1999.00442.x     Document Type: Article

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