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Smith S, de Lange T: TRF1, a mammalian telomeric protein. Trends Genet 1997, 13:21-26.
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Trends Genet
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Smith, S.1
De Lange, T.2
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Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase
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LaBranche H, Dupuis S, Ben-David Y, Bani MR, Wellinger RJ, Chabot B: Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. Nat Genet 1998, 19:199-202. The data here suggest that hnRNPA1 may bind to the G-strand overhang on vertebrate telomeres because, in addition to binding TTAGGG sequence, A1 regulates telomere length. A1 deficiency causes telomere shortening in mouse and human cells whereas expression of A1 or a fragment of A1 (UP1) causes telomere lengthening. UP1 but not A1 also co-immunoprecipitates with telomerase
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(1998)
Nat Genet
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LaBranche, H.1
Dupuis, S.2
Ben-David, Y.3
Bani, M.R.4
Wellinger, R.J.5
Chabot, B.6
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45
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84984775429
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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
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Broccoli D, Smogorzewska A, Chong L, de Lange T: Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet 1997, 17:231-235. Identification of the second vertebrate protein (TRF2) that localizes to telomeres. Although the domain structure of TRF2 and TRF2 is similar, these proteins show limited sequence identity and do not form heterodimers.
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(1997)
Nat Genet
, vol.17
, pp. 231-235
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Broccoli, D.1
Smogorzewska, A.2
Chong, L.3
De Lange, T.4
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46
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84984754548
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Telomeric localization of TRF2, a novel human telobox protein
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Bilaud T, Brun C, Ancelin K, Koering CE, Laroche T, Gilson E: Telomeric localization of TRF2, a novel human telobox protein. Nat Genet 1997, 17:236-239.
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(1997)
Nat Genet
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Bilaud, T.1
Brun, C.2
Ancelin, K.3
Koering, C.E.4
Laroche, T.5
Gilson, E.6
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47
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0032553473
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Tankyrase, a Poly(ADP ribose) polymerase at human telomeres
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Smith S, Giriat I, Schmitt A, de Lange T: Tankyrase, a Poly(ADP ribose) polymerase at human telomeres. Science 1998, 282:1484-1487. Identification of the first telomere protein that has enzymatic activity. Tankyrase interacts with TRF1 in a two-hybrid screen and co-localizes with TRF1 at telomeres. Tankyrase has ankyrin repeats, a PARP domain and can ADP-ribosylate both itself and TRF1. The ADP ribosylation activity suggests that Tankyrase plays a regulatory role at telomeres.
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(1998)
Science
, vol.282
, pp. 1484-1487
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Smith, S.1
Giriat, I.2
Schmitt, A.3
De Lange, T.4
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48
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0027059029
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hnRNP A2/B1 binds specifically to single stranded vertebrate telomeric repeat TTAGGGn
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McKay SJ, Cooke H: hnRNP A2/B1 binds specifically to single stranded vertebrate telomeric repeat TTAGGGn. Nucleic Acids Res 1992, 20:6461-6464.
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Nucleic Acids Res
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McKay, S.J.1
Cooke, H.2
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49
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Nuclear proteins that bind the pre-mRNA 3′ splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n
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Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR: Nuclear proteins that bind the pre-mRNA 3′ splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol Cell Biol 1993, 13:4301-4310.
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Ishikawa, F.1
Matunis, M.J.2
Dreyfuss, G.3
Cech, T.R.4
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50
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0027294031
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hnRNP proteins and biogenesis of mRNA
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Dreyfuss G, Manutiz M, Pinola-Roma S, Burd C: hnRNP proteins and biogenesis of mRNA. Annu Rev Biochem 1993, 62:289-321.
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Annu Rev Biochem
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Dreyfuss, G.1
Manutiz, M.2
Pinola-Roma, S.3
Burd, C.4
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51
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Telomere length regulation and telomeric chromatin require the nonsense-mediated mRNA decay pathway
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Lew JE, Enomoto S, Berman J: Telomere length regulation and telomeric chromatin require the nonsense-mediated mRNA decay pathway. Mol Cell Biol 1998, 18:6121-6130. A mutant that has defects in telomere localization is shown to be UPF2, a key protein in nonsense-mediated decay. Subsequent studies demonstrate that deletion or mutation of any of the known components of the nonsense-mediated decay pathway - UPF1, UPF2, UPF3, XRN1 - result in telomere shortening, Rap1 delocalization and lose of telomere position effect. Thus, the nonsense-mediated decay pathway probably regulates the levels of specific mRNAs that are important for telomere functions.
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(1998)
Mol Cell Biol
, vol.18
, pp. 6121-6130
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Lew, J.E.1
Enomoto, S.2
Berman, J.3
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52
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0031027618
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Control of telomere length by the human telomeric protein TRF1
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van Steensel B, de Lange T: Control of telomere length by the human telomeric protein TRF1. Nature 1997, 385:740-743.
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(1997)
Nature
, vol.385
, pp. 740-743
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Van Steensel, B.1
De Lange, T.2
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53
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TRF2 protects human telomeres from end-to-end fusions
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van Steensel B, Smogorzewska A, de Lange T: TRF2 protects human telomeres from end-to-end fusions. Cell 1998, 92:401-413. TRF2 is required to maintain the correct structure at the DNA terminus. Removal of TRF2 from the telomere by expression of a dominant negative allele results in end-to-end fusion of chromosomes and a loss of the G-strand overhang. The fusions appear to be caused by ligation of the telomeric DNA. The presence of TRF2 is also required for proper cell-cycle control because removal of TRF2 from the telomere causes a senescence phenotype.
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(1998)
Cell
, vol.92
, pp. 401-413
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Van Steensel, B.1
Smogorzewska, A.2
De Lange, T.3
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