-
1
-
-
0000092254
-
Prevalence of Alzheimer disease in a community population higher than previously reported
-
Evans DA, Funkenstein HH, Albert MS, et al. Prevalence of Alzheimer disease in a community population higher than previously reported. JAMA. 1989;262:2251-2256.
-
(1989)
JAMA
, vol.262
, pp. 2251-2256
-
-
Evans, D.A.1
Funkenstein, H.H.2
Albert, M.S.3
-
2
-
-
13044309464
-
Opposite roles of apolipoprotein e in normal brains and in Alzheimer's disease
-
Russo C, Angelini G, Dapino D, et al. Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease. Proc Natl Acad Sci USA. 1998;95:15598-155602.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15598-155602
-
-
Russo, C.1
Angelini, G.2
Dapino, D.3
-
3
-
-
0033051445
-
Intracellular accumulation of detergent-soluble amyloidogenic a beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice
-
Li QX, Maynard C, Cappai R, et al. Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice. J Neurochem. 1999;72:2479-87.
-
(1999)
J Neurochem
, vol.72
, pp. 2479-2487
-
-
Li, Q.X.1
Maynard, C.2
Cappai, R.3
-
4
-
-
0032150877
-
Genetic dissection of Alzheimer's disease and related dementias
-
Hardy J, Duff K, Gwinn-Hardy K, Perez-Tur J, Hutton M. Genetic dissection of Alzheimer's disease and related dementias. Nat Neurosci. 1998;1:355-358.
-
(1998)
Nat Neurosci
, vol.1
, pp. 355-358
-
-
Hardy, J.1
Duff, K.2
Gwinn-Hardy, K.3
Perez-Tur, J.4
Hutton, M.5
-
5
-
-
0031325129
-
The APP and PS1/2 mutations linked to early onset Alzheimer's disease increase the extracellular concentration of alpha/beta 1-42(43)
-
Younkim SG. The APP and PS1/2 mutations linked to early onset Alzheimer's disease increase the extracellular concentration of alpha/beta 1-42(43). Clin Neurol. 1994;37:1099.
-
(1994)
Clin Neurol
, vol.37
, pp. 1099
-
-
Younkim, S.G.1
-
6
-
-
17344362232
-
Alpha-2 macroglobulin is genetically associated with Alzheimer's disease
-
Blacker D, Wilcox MA, Laird NM, et al. Alpha-2 macroglobulin is genetically associated with Alzheimer's disease. Nat Genet. 1998;19:357-360
-
(1998)
Nat Genet
, vol.19
, pp. 357-360
-
-
Blacker, D.1
Wilcox, M.A.2
Laird, N.M.3
-
7
-
-
0031057837
-
Exploring the etiology of Alzheimer disease using molecular genetics
-
Lenden CL, Ashall F, Goate AM. Exploring the etiology of Alzheimer disease using molecular genetics JAMA. 1997;277:825-831.
-
(1997)
JAMA
, vol.277
, pp. 825-831
-
-
Lenden, C.L.1
Ashall, F.2
Goate, A.M.3
-
8
-
-
0032981558
-
Mechanism of the cleavage specificity of Alzheimer's disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein
-
Lichtenthaler SF, Wang R, Grimm H, Uljon SN, Masters CL, Beyreuther K. Mechanism of the cleavage specificity of Alzheimer's disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein. Proc Natl Acad Sci U S A. 1999;96:3053-3058.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 3053-3058
-
-
Lichtenthaler, S.F.1
Wang, R.2
Grimm, H.3
Uljon, S.N.4
Masters, C.L.5
Beyreuther, K.6
-
9
-
-
0029795254
-
Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain
-
Pedersen WA, Kloczewiak MA, Blusztajn JK. Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain. Proc Natl Acad Sci U S A. 1996;93:8068-8071.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 8068-8071
-
-
Pedersen, W.A.1
Kloczewiak, M.A.2
Blusztajn, J.K.3
-
10
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R, Rogaev EI, Liang Y, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 1995;375:754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
-
11
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med. 1996;2:864-870.
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
-
12
-
-
0028172930
-
Apolipoprotein e in animal models of CNS injury and in Alzheimer's disease
-
Poirier J. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci. 1994;17:525-530.
-
(1994)
Trends Neurosci
, vol.17
, pp. 525-530
-
-
Poirier, J.1
-
13
-
-
0027407565
-
Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
-
Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA. 1993;90:1977-1981.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 1977-1981
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schmechel, D.3
-
14
-
-
0032543684
-
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
-
Hutton M, Lendon CL, Rizzu P, et al. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature. 1998;393:702-705.
-
(1998)
Nature
, vol.393
, pp. 702-705
-
-
Hutton, M.1
Lendon, C.L.2
Rizzu, P.3
-
15
-
-
0030704680
-
Zinc-induced Alzheimer's a beta 1-40 aggregation is mediated by conformational factors
-
Huang X, Atwood CS, Moir RD, et al. Zinc-induced Alzheimer's A beta 1-40 aggregation is mediated by conformational factors. J Biol Chem. 1997;272:26464-70.
-
(1997)
J Biol Chem
, vol.272
, pp. 26464-26470
-
-
Huang, X.1
Atwood, C.S.2
Moir, R.D.3
-
16
-
-
0032890439
-
Alzheimer's disease and oxidative stress: Implications for novel therapeutic approaches
-
Behl C. Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches. Prog Neurobiol. 1999;57:301-323.
-
(1999)
Prog Neurobiol
, vol.57
, pp. 301-323
-
-
Behl, C.1
-
17
-
-
0013079948
-
An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease
-
Yan SD, Fu J, Soto C, et al. An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease. Nature. 1997;389:589-695.
-
(1997)
Nature
, vol.389
, pp. 589-695
-
-
Yan, S.D.1
Fu, J.2
Soto, C.3
-
18
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
-
Games D, Adams D, Alessandrini R, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature. 1995; 373:523-527.
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
-
19
-
-
0029742199
-
Correlative memory deficits, a beta elevation, and amyloid plaques in transgenic mice
-
Hsiao K, Chapman P, Nilsen S, et al. Correlative memory deficits, A beta elevation, and amyloid plaques in transgenic mice. Science. 1996;274:99-102.
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
-
20
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
-
Sturchler-Pierrat C, Abramowski D, Duke M, et al. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci USA. 1997;94:13287-13292.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abramowski, D.2
Duke, M.3
-
21
-
-
0029862137
-
Age-dependent neuronal and synaptic degeneration in mice transgenic for the C-terminus of the amyloid precursor protein
-
Oster-Granite ML, Mcphie DL, Greenan J, Neve RL. Age-dependent neuronal and synaptic degeneration in mice transgenic for the C-terminus of the amyloid precursor protein. J Neurosci. 1996;16:6732-6741.
-
(1996)
J Neurosci
, vol.16
, pp. 6732-6741
-
-
Oster-Granite, M.L.1
Mcphie, D.L.2
Greenan, J.3
Neve, R.L.4
-
22
-
-
0033051445
-
Intracellular accumulation of detergent-soluble amyloidogenic a beta fragment of Alzheimer's disease precursor protein in hippocampus of aged transgenic mice
-
LiQ-X, Maynard C, Cappai R, et al. Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in hippocampus of aged transgenic mice. J Neurochem. 1999;72:2479-2487.
-
(1999)
J Neurochem
, vol.72
, pp. 2479-2487
-
-
Li, Q.-X.1
Maynard, C.2
Cappai, R.3
-
23
-
-
16044366039
-
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
-
Duff K, Eckman C, Zehr C, et al. Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature. 1996;383:710-713
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
-
24
-
-
0030833055
-
Accelerated amyloid deposition in the brains of transgenic mice coexpressiing mutant presenilin 1 and amyloid precursor proteins
-
Borchelt DR, Ratovitski T, Van Lare J, et al. Accelerated amyloid deposition in the brains of transgenic mice coexpressiing mutant presenilin 1 and amyloid precursor proteins. Neuron. 1997;19:939-945.
-
(1997)
Neuron
, vol.19
, pp. 939-945
-
-
Borchelt, D.R.1
Ratovitski, T.2
Van Lare, J.3
-
25
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
Holcomb L, Gordon MN, McGowan E, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med. 1998;4:97-100.
-
(1998)
Nat Med
, vol.4
, pp. 97-100
-
-
Holcomb, L.1
Gordon, M.N.2
McGowan, E.3
-
26
-
-
0031278270
-
Lack of apolipoprotein e dramatically reduces amyloid β-peptide deposition
-
Bales KR, Verina T, Dodel RC, et al. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nat Genet. 1997;17:263-264.
-
(1997)
Nat Genet
, vol.17
, pp. 263-264
-
-
Bales, K.R.1
Verina, T.2
Dodel, R.C.3
-
27
-
-
0028988801
-
β-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
-
Zheng H, Jiang M-H, Trumbauer ME, et al. β-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell. 1995; 81:525-531.
-
(1995)
Cell
, vol.81
, pp. 525-531
-
-
Zheng, H.1
Jiang, M.-H.2
Trumbauer, M.E.3
-
28
-
-
0030779784
-
Skeletal and CNS defects in presenilin-1-deficient mice
-
Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in presenilin-1-deficient mice. Cell. 1997;89:629-639.
-
(1997)
Cell
, vol.89
, pp. 629-639
-
-
Shen, J.1
Bronson, R.T.2
Chen, D.F.3
Xia, W.4
Selkoe, D.J.5
Tonegawa, S.6
-
29
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper B, Saftig P, Craessaerts K, et al. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 1998;391:387-390.
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
-
30
-
-
0031981072
-
Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress
-
Smith MA, Hirai K, Hsiao K, et al. Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress. J Neurochem. 1998;70:2212-2215.
-
(1998)
J Neurochem
, vol.70
, pp. 2212-2215
-
-
Smith, M.A.1
Hirai, K.2
Hsiao, K.3
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