IVIG-bound IgG and IgM cloned by phage display from a healthy individual reveal the same restricted germ-line gene origin as in autoimmune thrombocytopenia

Clinical and Experimental Immunology

Volumn 121, Issue 1, 2000, Pages 37-46

  Hoffmann, M ^a   Uttenreuther Fischer, M M ^a   Lerch, H ^a   Gaedicke, G ^a   Fischer, Peter ^a,b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Anti idiotype germ line; CDR; Immunoglobulin gene; Phage display

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

AMINO ACID SEQUENCE; ARTICLE; AUTOIMMUNITY; BINDING SITE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOGLOBULIN BLOOD LEVEL; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTOPENIA;

ADULT; AMINO ACID SEQUENCE; BLOOD PLATELETS; CLONING, MOLECULAR; FEMALE; GERM CELLS; HEALTH STATUS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOGLOBULINS, INTRAVENOUS; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE LIBRARY; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC;

EID: 0033947302     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2000.01229.x     Document Type: Article

References (45)

1. Imbach P, Wagner HP, Berchtold W et al. Intravenous immunoglobulin versus oral corticosteroids in acute immune thrombocytopenic purpura in childhood. Lancet 1985; 2:464-8.
2. Fischer P, Uttenreuther-Fischer MM, Naoe S, Gaedicke G. Kawasaki disease: update on diagnosis, treatment and a still controversial etiology. Pediatr Hematol Oncol 1996; 13:487-501.
3. Debre M, Bonnet MC, Fridman WH et al. Infusion of Fc gamma fragments for treatment of children with acute immune thrombocytopenic purpura. Lancet 1993; 342:945-9.
4. Bjorkholm M. Intravenous immunoglobulin treatment in cytopenic haematological disorders. J Intern Med 1993; 234:119-26.
5. Levy Y, Sherer Y, George J et al. Serologic and clinical response to treatment of systemic vasculitis and associated autoimmune disease with intravenous immunoglobulin. Int Arch Allergy Immunol 1999; 119:231-8.
6. Lacroix-Desmazes S, Mouthon L, Spalter SH, Kaveri S, Kazatchkine MD. Immunoglobulins and the regulation of autoimmunity through the immune network. Clin Exp Rheumatol 1996; 14:S9-S15.
7. Jerne NK. Towards a network theory of the immune system. Ann Immunol (Paris) 1974; 125C:373-89.
8. Imholz B, Imbach P, Baumgartner C et al. Intravenous immunoglobulin (i.v. IgG) for previously treated acute or for chronic idiopathic thrombocytopenic purpura (ITP) in childhood: a prospective multicenter study. Blut 1988; 56:63-68.
9. Abu-Shakra M, Buskila D, Shoenfeld Y. Idiotypes and anti-idiotypic antibodies. In: Peter JB, Shoenfeld Y, eds. Autoantibodies. Amsterdam: Elsevier, 1996.
10. Barbas CFI, Kang AS, Lerner RA, Benkovic SJ. Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc Natl Acad Sci USA 1991; 88:7978-82.
11. Breitling F, Dübel S, Seehaus T, Klewinghaus I, Little M. A surface expression vector for antibody screening. Gene 1991; 104:147-53.
12. Duchosal MA, Eming SA, Fischer P et al. Immunization of hu-PBL- SCID mice and the rescue of human monoclonal Fab fragments through combinatorial libraries. Nature 1992; 355:258-62.
13. Yang YY, Fischer P, Leu SJ, Zhu M, Woods VI Jr, Chen PP. Possible presence of enhancing antibodies in idiopathic thrombocytopenic purpura. Br J Haematol 1999; 104:69-80.
14. Jendreyko N, Uttenreuther-Fischer MM, Lerch H, Gaedicke G, Fischer P. Genetic origin of IgG antibodies cloned by phage display and antiidiotypic panning from three patients with autoimmune thrombocytopenia. Eur J Immunol 1998; 28:4236-47.
15. Fischer P, Jendreyko N, Hoffmann M, Lerch H, Uttenreuther-Fischer MM, Chen PP, Gaedicke G. Platelet reactive IgG antibodies cloned by phage display and panning with IVIG from three patients with autoimmune thrombocytopenia. Br J Haematol 1999; 105:626-40.
16. Barbas CFI, Burton DR. 1993 Cold Spring Harbor Laboratory course on: monoclonal antibodies from combinatorial libraries. La Jolla: The Scripps Research Inst., 1993.
17. Barbas CFI, Lerner RA. Combinatorial immunoglobulin libraries on the surface of phage (Phabs): rapid selection of antigen-specific Fabs. Methods Companion Methods Enzymol 1991; 2:119-24.
18. Fischer P, Leu SJC, Yang YY, Chen PP. Rapid simultaneous screening for DNA integrity and antigen specificity of clones selected by phage display. Biotechniques 1994; 16:828-30.
19. Graus YF, Debaets MH, Parren PWHI, Berrihaknin S, Wokke J, Vriesman PJV, Burton DR. Human anti-nicotinic acetylcholine receptor recombinant Fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies. J Immunol 1997; 158:1919-29.
20. Tomlinson IM, Williams SC, Ignatovich O, Corbett SJ, Winter G. V BASE sequence directory. Cambridge: MRC Centre for Protein Engineering, 1998.
21. Kabat EA, Wu TT, Perry HM, Gottesmann KS, Foeller C. Sequences of proteins of immunological interest, 5 edn. Bethesda: NIH, 1991.
22. Lefranc MP, Giudicelli V, Ginestoux C et al. IMGT, the international ImMunoGeneTics database. Nucl Acids Res 1999; 27:209-12.
23. Knappik A, Plückthun A. Engineered turns of a recombinant antibody improve its in vivo folding. Protein Eng 1995; 8:81-89.
24. Stewart AK, Huang C, Stollar BD, Schwartz RS. High-frequency representation of a single VH gene in the expressed human B cell repertoire. J Exp Med 1993; 177:409-18.
25. Kraj P, Rao SP, Glas AM, Hardy RR, Milner ECB, Silberstein LE. The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells. J Immunol 1997; 158:5824-32.
26. Hoet RMA, Raats JMH, de Wildt R, Dumortier H, Muller S, Van den Hoogen F, van Venrooij WJ. Human monoclonal autoantibody fragments from combinatorial antibody libraries directed to the U1snRNP associated U1C protein; epitope mapping, immunolocalization and V-gene usage. Mol Immunol 1998; 35:1045-55.
27. Rubinstein DB, Leblanc P, Wright DG, Guillaume T, Strotchevoi A, Boosalis M. Anti-CD34 (+) fabs generated against hematopoietic stem cells in HIV-derived combinatorial immunoglobulin library suggest antigen-selected autoantibodies. Mol Immunol 1998; 35:955-64.
28. Guo J, Mcintosh RS, Czarnocka B, Weetman AP, Rapoport B, McLachlan SM. Relationship between autoantibody epitopic recognition and immunoglobulin gene usage. Clin Exp Immunol 1998; 111:408-14.
29. Ikematsu W, Kobarg J, Ikematsu H, Ichiyoshi Y, Casali P. Clonal analysis of a human antibody response. III. Nucleotide sequences of monoclonal IgM, IgG, and IgA to rabies virus reveal restricted VK gene utilization, junctional V kappa J kappa and V lambda J lambda diversity, and somatic hypermutation. J Immunol 1998; 161:2895-905.
30. Stott DI, Hiepe F, Hummel M, Steinhauser G, Berek C. Antigen-driven clonal proliferation of a cells within the target tissue of an autoimmune disease - the salivary glands of patients with Sjögren's syndrome. J Clin Invest 1998; 102:938-46.
31. Matsuda F, Shin EK, Nagaoka H et al. Structure and physical map of 64 variable segments in the 3′0.8-megabase region of the human immunoglobulin heavy-chain locus. Nat Genet 1993; 3:88-94.
32. Adderson EE, Shikhman AR, Ward KE, Cunningham MW. Molecular analysis of polyreactive monoclonal antibodies from rheumatic carditis: human anti-N-acetylglucosamine anti-myosin antibody V region genes. J Immunol 1998; 161:2020-31.
33. Noronha EJ, Wang XH, Desai SA, Kageshita T, Ferrone S. Limited diversity of human scFv fragments isolated by panning a synthetic phage-display scFv library with cultured human melanoma cells. J Immunol 1998; 161:2968-76.
34. Schier R, Bye J, Apell G, Mccall A, Adams GP, Malmqvist M, Weiner LM, Marks JD. Isolation of high-affinity monomeric human Anti-c- erbB-2 single chain Fv using affinity-driven selection. J Mol Biol 1996; 255:28-43.
35. Dewildt RMT, Hoet RMA, Vanvenrooij WJ, Tomlinson IM, Winter G. Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire. J Mol Biol 1999; 285:895-901.
36. Huang SC, Jiang RH, Glas AM, Milner ECB. Non-stochastic utilization of Ig V region genes in unselected human peripheral B cells. Mol Immunol 1996; 33:553-60.
37. Huang C, Stollar BD. A majority of Ig H chain cDNA of normal human adult blood lymphocytes resembles cDNA for fetal Ig and natural autoantibodies. J Immunol 1993; 151:5290-300.
38. Pascual V, Victor K, Randen I et al. Nucleotide sequence analysis of rheumatoid factors and polyreactive antibodies derived from patients with rheumatoid arthritis reveals diverse use of VH and VL gene segments and extensive variability in CDR- 3. Scand J Immunol 1992; 36:349-62.
39. Sanz I, Casali P, Thomas JW, Notkins AL, Capra JD. Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families. J Immunol 1989; 142:4054-61.
40. Schroeder Hw Jr, Hillson JL, Perlmutter RM. Early restriction of the human antibody repertoire. Science 1987; 238:791-3.
41. Mo L, Leu SJC, Berry C et al. The frequency of homozygous deletion of a developmentally regulated Vh gene (Humhv3005) is increased in patients with chronic idiopathic thrombocytopenic purpura. Autoimmunity 1996; 24:257-63.
42. Coutinho A. The network theory: 21 years later. Scand J Immunol 1995; 42:3-8.
43. Chen PP, Carson DA, Fischer P et al. Molecular genetics of human autoantibodies. Pathol Biol 1994; 42:798-800.
44. Rao SP, Riggs JM, Friedman DF, Scully MS, Lebien TW, Silberstein LE. Biased V-H gene usage in early lineage human B cells: evidence for preferential Ig gene rearrangement in the absence of selection. J Immunol 1999; 163:2732-40.
45. Tighe H, Warnatz K, Brinson D, Corr M, Weigle WO, Baird SM, Carson DA. Peripheral deletion of rheumatoid factor B cells after abortive activation by IgG. Proc Natl Acad Sci USA 1997; 94:646-51.