Transfer of p16(inka)/CDKN2 gene in leukaemic cell lines inhibits cell proliferation

British Journal of Haematology

Volumn 95, Issue 2, 1996, Pages 291-298

  Quesnel, Bruno ^a,b   Preudhomme, Claude ^a,b   Lepelley, Pascale ^b   Hetuin, Dominique ^b   Vanrumbeke, Michael ^b   Bauters, Francis ^a   Velu, Thierry ^c   Fenaux, Pierre ^a,b  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b INSERM   (France)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

CDKN2; Cell cycle; Gene transfer; P16(ink4a); Retrovirus

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; ENZYME INHIBITOR;

ARTICLE; CONTROLLED STUDY; GENE TRANSFER; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; RETROVIRUS; ACUTE LYMPHOCYTIC LEUKEMIA; CELL CULTURE; CELL DIVISION; GENE DELETION; GENETICS; HOMOZYGOTE; PATHOLOGY; TUMOR SUPPRESSOR GENE;

CELL DIVISION; GENE DELETION; GENE TRANSFER TECHNIQUES; GENES, TUMOR SUPPRESSOR; HOMOZYGOTE; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; TUMOR CELLS, CULTURED;

EID: 0029662028     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.d01-1913.x     Document Type: Article

References (41)

1. Ando, K. & Griffin, J.D. (1995) Cdk4 integrates growth stimulatory and inhibitory signals during G1 phase of hematopoietic cells. Oncogene, 10, 751-755.
2. Arap, W., Nishikawa, R., Furnari, F.B., Cavenee, W.K. & Su-Huang, H.J. (1995) Replacement of the p16/CDKN2 gene suppresses human glioma cell growth. Cancer Research, 55, 1351-1354.
3. ink4a/MTS1) gene structure and expression in acute lymphoblastic leukemias. Leukemia. 9, 1240-1245.
4. ink4a/MTS1 gene transcript expressed in B-cell malignancies. Oncogene, 11, 21-29.
5. Fizzotti, M., Cimino, G., Pisegna, S., Alimena, G., Quartarone, C., Mandelli, F., Pellici, P.G. & Lo Coco, F. (1995) Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features. Blood, 85, 2685-2690.
6. INK4B MTS2-related CDK6 inhibitor, correlated with wild-type pRb function. Genes and Development, 8, 2939.
7. ink4b gene deletions in primary leukemias. Blood. 86, 311-315.
8. Hartwell, L.H. & Kastan, M.B. (1994) Cell cycle control and cancer. Science. 266, 1821-1827.
9. Hatta, Y., Hirama, T., Miller, C.W., Yamada, Y., Tomonaga, M. & Koeffler, P. (1995) Homozygous deletions in the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia. Blood, 85, 2699-2704.
10. INK4B) dysplay frequent humozygos deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias. Blood. 84, 4038-4044.
11. Hirama, T. & Koeffler, P. H. (1995) Role of the cyclin-dependent kinase inhibitors in the development of cancer. Blood. 86, 841-854.
12. Hunter, T. & Pines, J. (1994) Cyclins and cancer. II. Cyclin D and CDK inhibitors come of age. Cell. 79, 573-582.
13. Jamal, R., Thomas, N.S.B., Gale, R.E. & Linch, D.C. (1966) Variable expression of p16 protein in patients with acute myeloid leukemia without gross rearrangements at the DNA level. Leukemia. 10, 629-636.
14. ink4a gene mediated by an adenovirus vector. Cancer Research. 55, 3250-3253.
15. Kamb, A., Gruis, N.A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S.V., Stockert, E., Day, R.S., Johnson, B.E. & Skolnick, M.H. (1994) A cell cycle regulator potentially involved in genesis of many tumor types. Science. 264, 436-440.
16. Lepelley, P., Preudhomme, C., Vanrumbeke, M., Quesnel, B., Cosson, A. & Fenaux, P. (1994) Detection of p53 mutations in hematological malignancies: comparison between immunocytochemistry and DNA analysis. Leukemia. 8, 1342-1349.
17. 1. Cancer Research. 54, 6078-6082.
18. Lukas, J., Bartkova, J., Welcker, M., Petersen, O.W., Peters, G., Strauss. M. & Bartek, J. (1995a) Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types. Oncogene. 10, 2125-2134.
19. Lukas, J., Parry, D., Aagaard, L., Mann, D.J., Bartkova, J., Strauss. M., Peters, G. & Bartek, J. (1995b) Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature. 375, 503-506.
20. ink4a transcript. Cancer Research, 55, 2995-2998.
21. Medena, R.H., Herrera. R.H., Lam. F. & Weinberg, R. (1995) Growth suppressor by p16 requires functional retinoblastoma protein. Proceedings of the National Academy of Sciences of the United States of America, 92, 6289-6293.
22. Nakamaki, T., Kawamata, N., Schwaller, J., Tobler, A., Fey, M., Lee, Y.Y., Kim, B.K., Fukuchi, K., Tsuruoka, N., Kahan, J., Miller. C.W. & Koeffler. H.P. (1995) Structural integrity of the cyclin-dependent kinase inhibitor genes p15, p16 and p18 in myeloid leukaemias. British Journal of Haematology, 91, 139-149.
23. Nobori, T., Miura, K., Wu, D.J., Lois, A., Takabayashi, K. & Carson. D.A. (1994) Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature, 368, 753-756.
24. Ogawa, S., Hirano, N., Sato, N., Takahashi, T., Hangaishi, A., Tanaka, K., Kurokawa, M., Tanaka, T., Mitani, K., Yazaki, Y. & Hirai, H. (1994) Homozygous loss in the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias. Blood, 84, 2431-2435.
25. INK4 in human cancer. Proceedings of the National Academy of Sciences of the United States of America, 91, 11045-11049.
26. INK4b/MTS2 in pediatric acute lympho-blastic leukemia. Blood, 85, 2321-2330.
27. INK4B/MTS2 in human leukemias and lymphomas. Cancer Research. 55, 1436-1440.
28. INK4 MTS1 tumour suppressor gene product. EMBO Journal. 14, 503-511.
29. Peebles, P.T. (1975) An in vitro focus-induction assay for xenotropic murine leukemia virus, feline leukemia virus C, and the feline-primate virus RD-114/CCC/M-7. Virology, 67, 288-293.
30. Quelle, D.E., Ashum, R.A., Hannon, G., Rehenberger, P.A., Trono, D., Richter, K.H., Walker, C., Beach, D. Sheer, C.J. & Serrano, M. (1995) Cloning and characterization of murine p16 and p15 gene. Oncogene, 11, 635-645.
31. Quesnel, B., Preudhomme, C., Phillipe, N., Vanrumbeke, M., Dervite, I., Lai, J.L., Bauters, F., Wattel, E. & Fenaux, P. (1995) p16 gene homozygous deletions in acute lymphoblastic leukemia. Blood, 85, 657-663.
32. ink4 gene inactivation in acute lymphocytic leukemia. Blood, 85, 3431-3436.
33. INK4, the product of the putative tumor suppressor gene MTSl. Oncogene, 9, 3475-3482.
34. Selvey, L.A., Tindle, R.W., Geysen, H.M., Haller, C.J. & Frazer, I.H. (1994) Human papillomavirus (HPV) type 18 E7 protein is a short-lived steroid inducible phosphoprotein in HPV transformed cell lines. Journal of General Virology, 75, 1647-1653.
35. INK4. Science, 267, 249-252.
36. Serrano, M., Hannon, G.J. & Beach, D. (1995) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature, 366, 704-707.
37. Still, H., Goldman, J.M. & Cross, N.C.P. (1995) Homozygous deletions in the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia. Blood. 85, 2013-2016.
38. ink4a locus. Cancer Research, 55, 2998-3001.
39. Stranks, G., Height, S.E., Mitchell, P., Jadayel, D., Yuille, M.A.R., De Lord, C., Clutterbuck, R.D., Treleaven, J.G., Powles, R.L., Nacheva, E., Oscier, D.G., Karpas, A., Lenoir, G.M., Smith, S.D., Millar, J.L., Catovsky, D. & Dyer, M.J.S. (1995) Deletions and rearrangement of CDKN2 in lymphoid malignancy. Blood, 85, 893-901.
40. Takeuchi, S., Bartram, C.R., Seriu, T., Miller, C.W., Tobler, A., Janssen, J.W.G., Reiter, A., Ludwig, W.D., Zimmermann, M., Schwaller, J., Lee, E., Miyoshi, I. & Koeffler, P. (1995) Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A. and p18 genes in acute lymphohlastic leukemia of childhood. Blood, 86, 755-760.
41. Wattel, E., Vanrumbeke, M., Abina, M.A., Cambier, N., Preudhomme, C., Haddada, H. & Fenaux, P. (1996) Differential efficacy of adenoviral mediated gene transfer into cells from hematological cell lines and fresh hematological malignancies. Leukemia, 10, 175-177.