메뉴 건너뛰기




Volumn 6, Issue 3, 2000, Pages 117-131

Molecular-targeted anticancer therapy: Challenges related to study design and choice of proper endpoints

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; FARNESYL DIPHOSPHATE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN P53; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN BINDING PROTEIN 3; TRASTUZUMAB; VASCULOTROPIN;

EID: 0033914016     PISSN: 15289117     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (41)

References (116)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0027254069 scopus 로고
    • How many mutations are required for tumorigenesis? Implications from human cancer data
    • Renan MJ. How many mutations are required for tumorigenesis? Implications from human cancer data. Mol Carcinogenesis 1993;7:139-146.
    • (1993) Mol Carcinogenesis , vol.7 , pp. 139-146
    • Renan, M.J.1
  • 3
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C, Kinzler KW, Volgestein B. Genetic instabilities in human cancers. Nature 1998;396:643-649.
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Volgestein, B.3
  • 4
    • 0034614334 scopus 로고    scopus 로고
    • A long twentieth century of the cell cycle and beyond
    • Nurse P. A long twentieth century of the cell cycle and beyond. Cell 2000;100:71-78.
    • (2000) Cell , vol.100 , pp. 71-78
    • Nurse, P.1
  • 5
    • 0033614998 scopus 로고    scopus 로고
    • Creation of human tumor cells with defined genetic elements
    • Hahn WC, Counter CM, Lundberg AS et al. Creation of human tumor cells with defined genetic elements. Nature 1999;400:464-468.
    • (1999) Nature , vol.400 , pp. 464-468
    • Hahn, W.C.1    Counter, C.M.2    Lundberg, A.S.3
  • 6
    • 0343415646 scopus 로고    scopus 로고
    • Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay
    • Bieche I, Nogues C, Paradis V et al. Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay. Clin Cancer Res 2000;6:452-459.
    • (2000) Clin Cancer Res , vol.6 , pp. 452-459
    • Bieche, I.1    Nogues, C.2    Paradis, V.3
  • 7
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC. The clonal evolution of tumor cell populations. Science 1976;194:23-28.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 8
    • 0025773554 scopus 로고
    • Mutator phenotype may be required for multistep carcinogenesis
    • Loeb LA. Mutator phenotype may be required for multistep carcinogenesis. Cancer Res 1991;51:3073-3079.
    • (1991) Cancer Res , vol.51 , pp. 3073-3079
    • Loeb, L.A.1
  • 9
    • 0032524104 scopus 로고    scopus 로고
    • Landscaping the cancer terrain
    • Kinzler KW, Volgestein B. Landscaping the cancer terrain. Science 1998;280:1036-1037.
    • (1998) Science , vol.280 , pp. 1036-1037
    • Kinzler, K.W.1    Volgestein, B.2
  • 10
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • Golub TR, Slonim DK, Tamayo P et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999;86:531-537.
    • (1999) Science , vol.86 , pp. 531-537
    • Golub, T.R.1    Slonim, D.K.2    Tamayo, P.3
  • 11
    • 0033966575 scopus 로고    scopus 로고
    • Genetic progression and clonal relationship of recurrent premalignant head and neck lesions
    • Califano J, Westra WH, Meininger G et al. Genetic progression and clonal relationship of recurrent premalignant head and neck lesions. Clin Cancer Res 2000;6:347-352.
    • (2000) Clin Cancer Res , vol.6 , pp. 347-352
    • Califano, J.1    Westra, W.H.2    Meininger, G.3
  • 12
    • 0034606645 scopus 로고    scopus 로고
    • Genetic and epigenetic factors in anticancer drug resistance
    • Shoemaker RH. Genetic and epigenetic factors in anticancer drug resistance. J Natl Cancer Inst 2000;92:4-5.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 4-5
    • Shoemaker, R.H.1
  • 13
    • 0033970086 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment
    • Denko N, Schindler C, Koong A et al. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Clin Cancer Res 2000;6:480-487.
    • (2000) Clin Cancer Res , vol.6 , pp. 480-487
    • Denko, N.1    Schindler, C.2    Koong, A.3
  • 14
    • 0027417771 scopus 로고
    • Chemotherapeutic failure: Resistance or insensitivity?
    • Braverman AS. Chemotherapeutic failure: resistance or insensitivity? Ann Intern Med 1993;118:630-632.
    • (1993) Ann Intern Med , vol.118 , pp. 630-632
    • Braverman, A.S.1
  • 15
    • 0031764330 scopus 로고    scopus 로고
    • Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance
    • Bradshaw DM, Arceci RJ. Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance. J Clin Oncol 1998;16:3674-3690.
    • (1998) J Clin Oncol , vol.16 , pp. 3674-3690
    • Bradshaw, D.M.1    Arceci, R.J.2
  • 16
    • 0032474017 scopus 로고    scopus 로고
    • Molecular assessment of cancer
    • Caldas C. Molecular assessment of cancer. BMJ 1998; 316:1360-1363.
    • (1998) BMJ , vol.316 , pp. 1360-1363
    • Caldas, C.1
  • 17
    • 0032537407 scopus 로고    scopus 로고
    • The promise of molecular oncology
    • Lane D. The promise of molecular oncology. Lancet 1998;351:17-20.
    • (1998) Lancet , vol.351 , pp. 17-20
    • Lane, D.1
  • 18
    • 0033523233 scopus 로고    scopus 로고
    • Anticancer agents targeting signaling molecules and cancer cell environment: Challenges for drug development?
    • Gelmon KA, Eisenhauer EA, Harris AL et al. Anticancer agents targeting signaling molecules and cancer cell environment: challenges for drug development? J Natl Cancer Inst 1999;91:1281-1287.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1281-1287
    • Gelmon, K.A.1    Eisenhauer, E.A.2    Harris, A.L.3
  • 19
    • 0033973067 scopus 로고    scopus 로고
    • Translational research offers individually tailored treatments for cancer patients
    • Bartelink H, Begg AC, Martin JC et al. Translational research offers individually tailored treatments for cancer patients. Cancer J Sci Am 2000;6:2-10.
    • (2000) Cancer J Sci Am , vol.6 , pp. 2-10
    • Bartelink, H.1    Begg, A.C.2    Martin, J.C.3
  • 20
    • 0033981857 scopus 로고    scopus 로고
    • Can molecular assessment improve classification of head and neck premalignancy?
    • Mao L. Can molecular assessment improve classification of head and neck premalignancy? Clin Cancer Res 2000;6: 321-322.
    • (2000) Clin Cancer Res , vol.6 , pp. 321-322
    • Mao, L.1
  • 21
    • 0033970141 scopus 로고    scopus 로고
    • Modulation of molecular targets to enhance radiation
    • Harari PM, Huang S-M. Modulation of molecular targets to enhance radiation. Clin Cancer Res 2000;6:323-325.
    • (2000) Clin Cancer Res , vol.6 , pp. 323-325
    • Harari, P.M.1    Huang, S.-M.2
  • 23
    • 0032544336 scopus 로고    scopus 로고
    • Genetic variation as a guide to drug development
    • Kleyn PW, Vesell ES. Genetic variation as a guide to drug development. Science 1998;281:1820-1821.
    • (1998) Science , vol.281 , pp. 1820-1821
    • Kleyn, P.W.1    Vesell, E.S.2
  • 24
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 25
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995;1:27-31.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 26
    • 0031406307 scopus 로고    scopus 로고
    • Antiangiogenic drugs as a novel anticancer therapeutic strategy. Which are the more promising agents? What are the clinical developments and indications?
    • Gasparini G. Antiangiogenic drugs as a novel anticancer therapeutic strategy. Which are the more promising agents? What are the clinical developments and indications? Crit Rev Oncol Hematol 1997;26:147-162.
    • (1997) Crit Rev Oncol Hematol , vol.26 , pp. 147-162
    • Gasparini, G.1
  • 27
    • 0032792360 scopus 로고    scopus 로고
    • The rationale and future potential of angiogenesis inhibitors in neoplasia
    • Gasparini G. The rationale and future potential of angiogenesis inhibitors in neoplasia. Drugs 1999;58:17-38.
    • (1999) Drugs , vol.58 , pp. 17-38
    • Gasparini, G.1
  • 28
    • 0032845684 scopus 로고    scopus 로고
    • Monitoring response to antiangiogenic agents using noninvasive imaging tests
    • Libutti SK, Choyke P, Carrasquillo JA et al. Monitoring response to antiangiogenic agents using noninvasive imaging tests. Cancer J Sci Am 1999;5:252-256.
    • (1999) Cancer J Sci Am , vol.5 , pp. 252-256
    • Libutti, S.K.1    Choyke, P.2    Carrasquillo, J.A.3
  • 29
    • 0028951043 scopus 로고
    • Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
    • Holmgren L, O'Reilly MS, Folkman J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1995;1:149-153.
    • (1995) Nat Med , vol.1 , pp. 149-153
    • Holmgren, L.1    O'Reilly, M.S.2    Folkman, J.3
  • 30
    • 0030920374 scopus 로고    scopus 로고
    • Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents
    • Kakeji Y, Teicher BA. Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents. Invest New Drugs 1997;15:39-48.
    • (1997) Invest New Drugs , vol.15 , pp. 39-48
    • Kakeji, Y.1    Teicher, B.A.2
  • 31
    • 0032127350 scopus 로고    scopus 로고
    • Recombinant humanized anti-HER2 antibody (Herceptin™) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts
    • Baselga J, Norton L, Albanell J et al. Recombinant humanized anti-HER2 antibody (Herceptin™) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Cancer Res 1998;58:2825-2831.
    • (1998) Cancer Res , vol.58 , pp. 2825-2831
    • Baselga, J.1    Norton, L.2    Albanell, J.3
  • 32
    • 0032704708 scopus 로고    scopus 로고
    • Ras protein farnesyl-transferase: A strategic target for anticancer therapeutic development
    • Rowinsky E, Windle JJ, Von Hoff DD. Ras protein farnesyl-transferase: a strategic target for anticancer therapeutic development. J Clin Oncol 1999;17:3631-3652.
    • (1999) J Clin Oncol , vol.17 , pp. 3631-3652
    • Rowinsky, E.1    Windle, J.J.2    Von Hoff, D.D.3
  • 33
    • 0032844121 scopus 로고    scopus 로고
    • Overview of the trastuzumab (Herceptin) anti-HER2 monoclonal antibody clinical program in HER2-overexpressing metastatic breast cancer
    • Shak S. Overview of the trastuzumab (Herceptin) anti-HER2 monoclonal antibody clinical program in HER2-overexpressing metastatic breast cancer. Semin Oncol 1999;26:71-77.
    • (1999) Semin Oncol , vol.26 , pp. 71-77
    • Shak, S.1
  • 34
    • 0028263197 scopus 로고
    • Does improved control of tumour growth require an anti-cancer therapy targeting both neoplastic and intratumoral endothelial cells?
    • Gasparini G, Harris AL. Does improved control of tumour growth require an anti-cancer therapy targeting both neoplastic and intratumoral endothelial cells? Eur J Cancer 1994;30A:201-206.
    • (1994) Eur J Cancer , vol.30 A , pp. 201-206
    • Gasparini, G.1    Harris, A.L.2
  • 35
    • 0032537396 scopus 로고    scopus 로고
    • Tamoxifen for early breast cancer: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group. Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet 1998;351:1451-1467.
    • (1998) Lancet , vol.351 , pp. 1451-1467
  • 36
    • 0027235762 scopus 로고
    • Evaluating the potential usefulness of new prognostic and predictive indicators in node-negative breast cancer patients
    • Gasparini G, Pozza F, Harris AL. Evaluating the potential usefulness of new prognostic and predictive indicators in node-negative breast cancer patients. J Natl Cancer Inst 1993;85:1206-1219.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1206-1219
    • Gasparini, G.1    Pozza, F.2    Harris, A.L.3
  • 37
    • 0032430698 scopus 로고    scopus 로고
    • Prognostic variables in node-negative breast cancer
    • Gasparini G. Prognostic variables in node-negative breast cancer. Breast Cancer Res Treat 1998;52:321-331.
    • (1998) Breast Cancer Res Treat , vol.52 , pp. 321-331
    • Gasparini, G.1
  • 38
    • 0033375647 scopus 로고    scopus 로고
    • Current issues in phase I trials: New study designs and informed consent procedures
    • Cavalli F, Sessa C. Current issues in phase I trials: new study designs and informed consent procedures. Ann Oncol 1999;10:147-148.
    • (1999) Ann Oncol , vol.10 , pp. 147-148
    • Cavalli, F.1    Sessa, C.2
  • 39
    • 0033973070 scopus 로고    scopus 로고
    • Phase I clinical trial design in cancer drug development
    • Eisenhauer EA, O'Dwyer PJ, Christian M et al. Phase I clinical trial design in cancer drug development. J Clin Oncol 2000;18:684-692.
    • (2000) J Clin Oncol , vol.18 , pp. 684-692
    • Eisenhauer, E.A.1    O'Dwyer, P.J.2    Christian, M.3
  • 40
    • 0033971036 scopus 로고    scopus 로고
    • Impact of quality of life on patient expectations regarding phase I clinical trials
    • Cheng JD, Hitt J, Koczwara B et al. Impact of quality of life on patient expectations regarding phase I clinical trials. J Clin Oncol 2000;18:421-428.
    • (2000) J Clin Oncol , vol.18 , pp. 421-428
    • Cheng, J.D.1    Hitt, J.2    Koczwara, B.3
  • 41
    • 0030749549 scopus 로고    scopus 로고
    • Accelerated titration designs for phase I clinical trials in oncology
    • Simon R, Freidlin B, Rubinstein L et al. Accelerated titration designs for phase I clinical trials in oncology. J Natl Cancer Inst 1997;89:1138-1147.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1138-1147
    • Simon, R.1    Freidlin, B.2    Rubinstein, L.3
  • 42
    • 0025148278 scopus 로고
    • Continual reassessment method: A practical design for phase I clinical trials in cancer
    • O'Quigley J, Pepe M, Fisher L. Continual reassessment method: a practical design for phase I clinical trials in cancer. Biometrics 1990;46:33-48.
    • (1990) Biometrics , vol.46 , pp. 33-48
    • O'Quigley, J.1    Pepe, M.2    Fisher, L.3
  • 43
    • 0026725698 scopus 로고
    • Estimating the probability of toxicity at the recommended dose following a phase I clinical trial in cancer
    • O'Quigley J. Estimating the probability of toxicity at the recommended dose following a phase I clinical trial in cancer. Biometrics 1992;48:853-862.
    • (1992) Biometrics , vol.48 , pp. 853-862
    • O'Quigley, J.1
  • 44
    • 0029027770 scopus 로고
    • Some practical improvements in the continual reassessment method for phase I studies
    • Goodman SN, Zahurak ML, Piantadosi S. Some practical improvements in the continual reassessment method for phase I studies. Stat Med 1995;14:1149-1161.
    • (1995) Stat Med , vol.14 , pp. 1149-1161
    • Goodman, S.N.1    Zahurak, M.L.2    Piantadosi, S.3
  • 46
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors
    • Therasse P, Arbuck SG, Elisenhauer FLA et al. New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 2000;92:205-216.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Elisenhauer, F.L.A.3
  • 47
    • 0034594626 scopus 로고    scopus 로고
    • Will there be resistance to the RECIST (response evaluation criteria in solid tumors)?
    • Gehan E, Tefft MC. Will there be resistance to the RECIST (response evaluation criteria in solid tumors)? J Natl Cancer Inst 2000;92:179-181.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 179-181
    • Gehan, E.1    Tefft, M.C.2
  • 48
    • 0033984551 scopus 로고    scopus 로고
    • Content and quality of currently published phase II cancer trials
    • Mariani L, Marubini E. Content and quality of currently published phase II cancer trials. J Clin Oncol 2000;18:429-436.
    • (2000) J Clin Oncol , vol.18 , pp. 429-436
    • Mariani, L.1    Marubini, E.2
  • 49
    • 0034000338 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor (VEGF) in breast cancer
    • Gasparini G. Prognostic value of vascular endothelial growth factor (VEGF) in breast cancer.The Oncologist 2000;5[suppl 1]: 37-44.
    • (2000) The Oncologist , vol.5 , Issue.1 SUPPL. , pp. 37-44
    • Gasparini, G.1
  • 50
    • 0001194118 scopus 로고
    • Tumor angiogenesis predicts clinical outcome of node-positive breast cancer patients treated with adjuvant hormone therapy or chemotherapy
    • Gasparini G, Barbareschi M, Boracchi P et al. Tumor angiogenesis predicts clinical outcome of node-positive breast cancer patients treated with adjuvant hormone therapy or chemotherapy. Cancer J Sci Am 1995;1:131-141.
    • (1995) Cancer J Sci Am , vol.1 , pp. 131-141
    • Gasparini, G.1    Barbareschi, M.2    Boracchi, P.3
  • 51
    • 0031032073 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma
    • Gasparini G, Toi M, Gion M et al. Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma. J Natl Cancer Inst 1997;9:139-147.
    • (1997) J Natl Cancer Inst , vol.9 , pp. 139-147
    • Gasparini, G.1    Toi, M.2    Gion, M.3
  • 52
    • 0032943036 scopus 로고    scopus 로고
    • Clinical relevance of vascular endothelial growth factor and thymidine phosphorylase in patients with node-positive breast cancer treated with either adjuvant chemotherapy or hormone therapy
    • Gasparini G, Toi M, Miceli R et al. Clinical relevance of vascular endothelial growth factor and thymidine phosphorylase in patients with node-positive breast cancer treated with either adjuvant chemotherapy or hormone therapy. Cancer J Sci Am 1999;5:101-111.
    • (1999) Cancer J Sci Am , vol.5 , pp. 101-111
    • Gasparini, G.1    Toi, M.2    Miceli, R.3
  • 53
    • 0032432921 scopus 로고    scopus 로고
    • Clinical significance of angiogenic factors in breast cancer
    • Locopo N, Fanelli M, Gasparini G. Clinical significance of angiogenic factors in breast cancer. Breast Cancer Res Treat 1998;52:159-173.
    • (1998) Breast Cancer Res Treat , vol.52 , pp. 159-173
    • Locopo, N.1    Fanelli, M.2    Gasparini, G.3
  • 54
    • 0026610881 scopus 로고
    • Humanization of an anti-p185HER2 antibody for human cancer therapy
    • Carter P, Presta L, Gorman CM et al. Humanization of an anti-p185HER2 antibody for human cancer therapy. Proc Natl Acad Sci USA 1992;89:4285-4289.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4285-4289
    • Carter, P.1    Presta, L.2    Gorman, C.M.3
  • 55
    • 0002350734 scopus 로고
    • Antibodies to growth factors and receptors
    • De Vita VT, Hellman S, Rosemberg SA, eds. Philadelphia: JB Lippincott
    • Mendelsohn J, Baselga J. Antibodies to growth factors and receptors. In: De Vita VT, Hellman S, Rosemberg SA, eds. Biologic Therapy of Cancer (2nd ed). Philadelphia: JB Lippincott, 1995:607-624.
    • (1995) Biologic Therapy of Cancer (2nd Ed) , pp. 607-624
    • Mendelsohn, J.1    Baselga, J.2
  • 56
    • 0031903646 scopus 로고    scopus 로고
    • HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment
    • HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J Clin Oncol 1998;16:2659-2671.
    • (1998) J Clin Oncol , vol.16 , pp. 2659-2671
    • Pegram, M.D.1    Lipton, A.2    Hayes, D.3
  • 57
    • 0029991439 scopus 로고    scopus 로고
    • HER2 monoclonal antibody in patients with HER2/neu-overxpressing metastatic breast cancer
    • HER2 monoclonal antibody in patients with HER2/neu-overxpressing metastatic breast cancer. J Clin Oncol 1996;14: 737-744.
    • (1996) J Clin Oncol , vol.14 , pp. 737-744
    • Baselga, J.1    Tripathy, D.2    Mendelsohn, J.3
  • 58
    • 19244366949 scopus 로고    scopus 로고
    • Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
    • Baselga J, Cooper MR, Cohen R et al. Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J Clin Oncol 2000;18:904-914.
    • (2000) J Clin Oncol , vol.18 , pp. 904-914
    • Baselga, J.1    Cooper, M.R.2    Cohen, R.3
  • 60
    • 0029670014 scopus 로고    scopus 로고
    • Involvement of p27kip1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody
    • Wu X, Rubin M, Fan Z et al. Involvement of p27kip1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene 1996;12:1397-1403.
    • (1996) Oncogene , vol.12 , pp. 1397-1403
    • Wu, X.1    Rubin, M.2    Fan, Z.3
  • 61
    • 0029776415 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor monoclonal antibody C225 upregulates p27kip1 and induces G1 arrest in prostatic cancer cell line DU145
    • Peng D, Fan Z, Lu Y et al. Anti-epidermal growth factor receptor monoclonal antibody C225 upregulates p27kip1 and induces G1 arrest in prostatic cancer cell line DU145. Cancer Res 1996;56:3666-3669.
    • (1996) Cancer Res , vol.56 , pp. 3666-3669
    • Peng, D.1    Fan, Z.2    Lu, Y.3
  • 62
    • 0030693984 scopus 로고    scopus 로고
    • Reciprocal changes in p27kip1 and p21cip1 in growth inhibition mediated by blockade or overexpression of epidermal growth factor receptor
    • Fan Z, Shang BY, Lu Y et al. Reciprocal changes in p27kip1 and p21cip1 in growth inhibition mediated by blockade or overexpression of epidermal growth factor receptor. Clin Cancer Res 1997;3:1943-1948.
    • (1997) Clin Cancer Res , vol.3 , pp. 1943-1948
    • Fan, Z.1    Shang, B.Y.2    Lu, Y.3
  • 63
    • 0027428571 scopus 로고
    • Antitumor effects of antiepidermal growth factor receptor monoclonal antibodies plus cisdiamminedichloroplatinum on well established A431 cell xenografts
    • Fan Z, Baselga J, Masui H et al. Antitumor effects of antiepidermal growth factor receptor monoclonal antibodies plus cisdiamminedichloroplatinum on well established A431 cell xenografts. Cancer Res 1993;53:4637-4642.
    • (1993) Cancer Res , vol.53 , pp. 4637-4642
    • Fan, Z.1    Baselga, J.2    Masui, H.3
  • 64
    • 0027290650 scopus 로고
    • Antitumor effects of doxorubicin in combination with anti-epidermal growth factors receptor monoclonal antibodies
    • Baselga J, Norton L, Masui H et al. Antitumor effects of doxorubicin in combination with anti-epidermal growth factors receptor monoclonal antibodies. J Natl Cancer Inst 1993; 85:1327-1333.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1327-1333
    • Baselga, J.1    Norton, L.2    Masui, H.3
  • 65
    • 0001687355 scopus 로고
    • Antitumor activity of paclitaxel in combination with anti-growth factor receptor monoclonal antibodies in breast cancer xenografts
    • Baselga J, Norton L, Coplan K et al. Antitumor activity of paclitaxel in combination with anti-growth factor receptor monoclonal antibodies in breast cancer xenografts. Proc Am Assoc Cancer Res 1994;35:2262.
    • (1994) Proc Am Assoc Cancer Res , vol.35 , pp. 2262
    • Baselga, J.1    Norton, L.2    Coplan, K.3
  • 66
    • 0003135037 scopus 로고    scopus 로고
    • Use of HER2 for predicting response to breast cancer therapy
    • Harris JR, Lippman ME, eds. Updates Philadelphia: Lippincott-Raven
    • Pegram MD, Konecny G, Slamon DJ. Use of HER2 for predicting response to breast cancer therapy. In: Harris JR, Lippman ME, eds. Diseases of the Breast. Updates Philadelphia: Lippincott-Raven, 1999;4:1-9.
    • (1999) Diseases of the Breast , vol.4 , pp. 1-9
    • Pegram, M.D.1    Konecny, G.2    Slamon, D.J.3
  • 67
    • 0033965962 scopus 로고    scopus 로고
    • Assessment of HER2 status in breast cancer: Why, when and how?
    • Dowsett M, Cooke T, Ellis I et al. Assessment of HER2 status in breast cancer: why, when and how? Eur J Cancer 2000;36:170-176.
    • (2000) Eur J Cancer , vol.36 , pp. 170-176
    • Dowsett, M.1    Cooke, T.2    Ellis, I.3
  • 68
    • 0024376173 scopus 로고
    • ras oncogenes in human cancer: A review
    • Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-4689.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 69
    • 0013055679 scopus 로고
    • Three human transforming genes are related to the viral oncogenes
    • Shimizu K, Goldfarb M, Suard Y et al: Three human transforming genes are related to the viral oncogenes. Proc Natl Acad Sci USA 1983;80:2112-2116.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 2112-2116
    • Shimizu, K.1    Goldfarb, M.2    Suard, Y.3
  • 70
    • 0028869067 scopus 로고
    • Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956
    • Nagasu T, Yoshimatsu K, Rowell C et al. Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956. Cancer Res 1995;55:5310-5314.
    • (1995) Cancer Res , vol.55 , pp. 5310-5314
    • Nagasu, T.1    Yoshimatsu, K.2    Rowell, C.3
  • 71
    • 0030068062 scopus 로고
    • Unfarnesylated transforming Ras mutant inhibits the Ras-signaling pathway by forming a stable Ras.Raf complex in the cytosol
    • Miyake M, Mizutani S, Koide H et al: Unfarnesylated transforming Ras mutant inhibits the Ras-signaling pathway by forming a stable Ras.Raf complex in the cytosol. FEBS Lett 1992;378:15-18.
    • (1992) FEBS Lett , vol.378 , pp. 15-18
    • Miyake, M.1    Mizutani, S.2    Koide, H.3
  • 72
    • 0029150669 scopus 로고
    • Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
    • Kohl NE, Omer CA, Conner MW et al: Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nat Med 1995;1:792-797.
    • (1995) Nat Med , vol.1 , pp. 792-797
    • Kohl, N.E.1    Omer, C.A.2    Conner, M.W.3
  • 73
    • 0031877635 scopus 로고    scopus 로고
    • Restriction endonuclease-mediated selective polymerase chain reaction: A novel assay for the detection of K-ras mutations in clinical samples
    • Ward R, Hawkins N, O' Grady R et al. Restriction endonuclease-mediated selective polymerase chain reaction: a novel assay for the detection of K-ras mutations in clinical samples. Am J Pathol 1998;153:373-379.
    • (1998) Am J Pathol , vol.153 , pp. 373-379
    • Ward, R.1    Hawkins, N.2    O' Grady, R.3
  • 74
    • 0345148793 scopus 로고    scopus 로고
    • Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas
    • Peli J, Schroter M, Rudaz C et al. Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas. Embo J 1999;18:1824-1831.
    • (1999) Embo J , vol.18 , pp. 1824-1831
    • Peli, J.1    Schroter, M.2    Rudaz, C.3
  • 75
    • 18544412314 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer
    • Zujewski J, Horak ID, Bol CJ et al. Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer. J Clin Oncol 2000;18:927-941.
    • (2000) J Clin Oncol , vol.18 , pp. 927-941
    • Zujewski, J.1    Horak, I.D.2    Bol, C.J.3
  • 76
    • 0030593681 scopus 로고    scopus 로고
    • ERβ: Identification and characterization of a novel human estrogen receptor
    • Mosselman S, Polman J, Dijkema R. ERβ: identification and characterization of a novel human estrogen receptor. FEBS Lett 1996;392:49-53.
    • (1996) FEBS Lett , vol.392 , pp. 49-53
    • Mosselman, S.1    Polman, J.2    Dijkema, R.3
  • 77
    • 0029026592 scopus 로고
    • Coexpression of multiple estrogen receptor variant messenger RNAs in normal and neoplastic breast tissues and in MCF-7 cells
    • Pfeffer U, Fecarotta E, Vidali G. Coexpression of multiple estrogen receptor variant messenger RNAs in normal and neoplastic breast tissues and in MCF-7 cells. Cancer Res 1995;55:2158-2165.
    • (1995) Cancer Res , vol.55 , pp. 2158-2165
    • Pfeffer, U.1    Fecarotta, E.2    Vidali, G.3
  • 78
    • 0029740105 scopus 로고    scopus 로고
    • Nuclear receptor coactivators and corepressor
    • Horowitz KB, Jackson TA, Bain DL et al. Nuclear receptor coactivators and corepressor. Mol Endocrinol 1996; 10:1167-1177.
    • (1996) Mol Endocrinol , vol.10 , pp. 1167-1177
    • Horowitz, K.B.1    Jackson, T.A.2    Bain, D.L.3
  • 79
    • 0028886694 scopus 로고
    • Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
    • Kato S, Endoh H, Masuhiro Y et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 1995;270:1491-1494.
    • (1995) Science , vol.270 , pp. 1491-1494
    • Kato, S.1    Endoh, H.2    Masuhiro, Y.3
  • 80
    • 0032533881 scopus 로고    scopus 로고
    • Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1
    • Zwijsen RM, Buckle RS, Hijmans EM et al. Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1. Genes Dev 1998;12:3488-3498.
    • (1998) Genes Dev , vol.12 , pp. 3488-3498
    • Zwijsen, R.M.1    Buckle, R.S.2    Hijmans, E.M.3
  • 81
    • 0033379037 scopus 로고    scopus 로고
    • Selective oestrogen receptor modulation: Molecular pharmacology for the millennium
    • Levenson AS, Jordan VC. Selective oestrogen receptor modulation: molecular pharmacology for the millennium. Eur J Cancer 1999;35:1628-1639.
    • (1999) Eur J Cancer , vol.35 , pp. 1628-1639
    • Levenson, A.S.1    Jordan, V.C.2
  • 82
    • 0028232729 scopus 로고
    • Sensitivity of HER2/neu antibodies in archival tissue samples: Potential source of error in immunohistochemical studies of oncogene expression
    • Press MF, Hung G, Godolphin W et al. Sensitivity of HER2/neu antibodies in archival tissue samples: potential source of error in immunohistochemical studies of oncogene expression. Cancer Res 1994;54:2771-2777.
    • (1994) Cancer Res , vol.54 , pp. 2771-2777
    • Press, M.F.1    Hung, G.2    Godolphin, W.3
  • 83
    • 0030992404 scopus 로고    scopus 로고
    • Detection of different estrogen receptor forms in breast cancer cytosol by enzyme immunoassay
    • Dittadi R, Meo S, Amoroso B et al. Detection of different estrogen receptor forms in breast cancer cytosol by enzyme immunoassay. Cancer Res 1997;57:1066-1072.
    • (1997) Cancer Res , vol.57 , pp. 1066-1072
    • Dittadi, R.1    Meo, S.2    Amoroso, B.3
  • 84
    • 12944329696 scopus 로고    scopus 로고
    • Commission on Laboratory Accreditation. College of American Pathologists, 325 Waukegan Rd, Northfield, IL 60093
    • Molecular Pathology Inspection Checklist, 1993 edition. Commission on Laboratory Accreditation. College of American Pathologists, 325 Waukegan Rd, Northfield, IL 60093.
    • Molecular Pathology Inspection Checklist, 1993 Edition
  • 86
    • 0031973351 scopus 로고    scopus 로고
    • Fundamentals of quality assessment of molecular amplification methods in clinical diagnostics
    • Neumaier M, Braun A, Wagener C et al. Fundamentals of quality assessment of molecular amplification methods in clinical diagnostics. Clin Chem 1998;44:12-26.
    • (1998) Clin Chem , vol.44 , pp. 12-26
    • Neumaier, M.1    Braun, A.2    Wagener, C.3
  • 87
    • 0019083094 scopus 로고
    • Revision of the standards for the assessment of hormone receptors in human breast cancer; report of the second EORTC Workshop, held on 16-17 March 1979, in the Netherlands Cancer Institute
    • EORTC Breast Cooperative Group. Revision of the standards for the assessment of hormone receptors in human breast cancer; report of the second EORTC Workshop, held on 16-17 March 1979, in the Netherlands Cancer Institute. Eur J Cancer 1980;16:1513-1535.
    • (1980) Eur J Cancer , vol.16 , pp. 1513-1535
  • 88
    • 7844236388 scopus 로고    scopus 로고
    • External quality assessment of trans-European multicentre antigen determinations (enzyme-linked immunosorbent assay) of urokinase-type plasminogen activator (uPA) and its type 1 inhibitor (PAI-1) in human breast cancer tissue extracts
    • Sweep CGJ, Geurts-Moespot J, Grebenschikov N et al. External quality assessment of trans-European multicentre antigen determinations (enzyme-linked immunosorbent assay) of urokinase-type plasminogen activator (uPA) and its type 1 inhibitor (PAI-1) in human breast cancer tissue extracts. Br J Cancer 1998;78:1434-1441.
    • (1998) Br J Cancer , vol.78 , pp. 1434-1441
    • Sweep, C.G.J.1    Geurts-Moespot, J.2    Grebenschikov, N.3
  • 89
    • 0032953135 scopus 로고    scopus 로고
    • Prognostic value of tissue-type plasminogen activator (tPA) and its complex with the type-1 inhibitor (PAI-1) in breast cancer
    • de Witte JH, Sweep CGJ, Klijn JGM et al. Prognostic value of tissue-type plasminogen activator (tPA) and its complex with the type-1 inhibitor (PAI-1) in breast cancer. Br J Cancer 1999;80:286-294.
    • (1999) Br J Cancer , vol.80 , pp. 286-294
    • De Witte, J.H.1    Sweep, C.G.J.2    Klijn, J.G.M.3
  • 90
    • 0028179558 scopus 로고
    • Dangers of using "optimal" cutpoints in the evaluation of prognostic factors
    • Altman DG, Lausen B, Sauerbrei W et al. Dangers of using "optimal" cutpoints in the evaluation of prognostic factors. J Natl Cancer Inst 1994;86:829-835.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 829-835
    • Altman, D.G.1    Lausen, B.2    Sauerbrei, W.3
  • 91
    • 0002722679 scopus 로고    scopus 로고
    • Co-determination of the angiogenic factots thymidine phosphorylase and vascular endothelial growth factor in node-negative breast cancer: Prognostic implications
    • Toi M, Gion M, Biganzoli E et al. Co-determination of the angiogenic factots thymidine phosphorylase and vascular endothelial growth factor in node-negative breast cancer: prognostic implications. Angiogenesis 1997;1:71-83.
    • (1997) Angiogenesis , vol.1 , pp. 71-83
    • Toi, M.1    Gion, M.2    Biganzoli, E.3
  • 92
    • 0031819577 scopus 로고    scopus 로고
    • Impact of steroid receptors, pS2 and cathepsin D on the outcome of N+ postmenopausal breast cancer patients treated with tamoxifen
    • Dittadi R, Biganzoli E, Boracchi P et al. Impact of steroid receptors, pS2 and cathepsin D on the outcome of N+ postmenopausal breast cancer patients treated with tamoxifen. Int J Biol Markers 1998;13:30-41.
    • (1998) Int J Biol Markers , vol.13 , pp. 30-41
    • Dittadi, R.1    Biganzoli, E.2    Boracchi, P.3
  • 93
    • 0031825176 scopus 로고    scopus 로고
    • Effect of steroid receptors, pS2 and cathepsin D on the outcome of elderly breast cancer patients: An exploratory investigation
    • Coradini D, Biganzoli E, Boracchi P et al. Effect of steroid receptors, pS2 and cathepsin D on the outcome of elderly breast cancer patients: an exploratory investigation. Int J Cancer 1998;79:305-311.
    • (1998) Int J Cancer , vol.79 , pp. 305-311
    • Coradini, D.1    Biganzoli, E.2    Boracchi, P.3
  • 94
    • 0344549142 scopus 로고    scopus 로고
    • Dissemination risk index based on plasminogen activator system components in primary breast cancer
    • Bouchet C, Hacene K, Martin PM et al. Dissemination risk index based on plasminogen activator system components in primary breast cancer. J Clin Oncol 1999; 17:3048-3057.
    • (1999) J Clin Oncol , vol.17 , pp. 3048-3057
    • Bouchet, C.1    Hacene, K.2    Martin, P.M.3
  • 95
    • 0032467834 scopus 로고    scopus 로고
    • Flexible modelling in survival analysis: Structuring biological complexity from the information provided by tumor markers
    • Biganzoli E, Boracchi P, Daidone MG et al. Flexible modelling in survival analysis: structuring biological complexity from the information provided by tumor markers. Int J Biol Markers 1998;13:107-123.
    • (1998) Int J Biol Markers , vol.13 , pp. 107-123
    • Biganzoli, E.1    Boracchi, P.2    Daidone, M.G.3
  • 96
    • 0029155613 scopus 로고
    • Review of survival analyses published in cancer journals
    • Altman DG, De Stavola BL, Love SB et al. Review of survival analyses published in cancer journals. Br J Cancer 1995;72:511-518.
    • (1995) Br J Cancer , vol.72 , pp. 511-518
    • Altman, D.G.1    De Stavola, B.L.2    Love, S.B.3
  • 97
    • 0003077113 scopus 로고
    • A regulatory authority's opinion about surrogate endpoints
    • Nimmo WS, Tucker GT, eds. New York: J Wiley
    • Temple RJ. A regulatory authority's opinion about surrogate endpoints. In: Nimmo WS, Tucker GT, eds. Clinical Measurement in Drug Evaluation. New York: J Wiley, 1995.
    • (1995) Clinical Measurement in Drug Evaluation
    • Temple, R.J.1
  • 98
    • 0030268577 scopus 로고    scopus 로고
    • Surrogate end points in clinical trials: Are we being misled?
    • Fleming TR, DeMets DL. Surrogate end points in clinical trials: are we being misled? Ann Intern Med 1996;125: 605-613.
    • (1996) Ann Intern Med , vol.125 , pp. 605-613
    • Fleming, T.R.1    DeMets, D.L.2
  • 99
    • 0024520844 scopus 로고
    • Surrogate endpoints in clinical trials: Definition and operational criteria
    • Prentice RL. Surrogate endpoints in clinical trials: definition and operational criteria. Stat Med 1989;8:431-440.
    • (1989) Stat Med , vol.8 , pp. 431-440
    • Prentice, R.L.1
  • 100
    • 0030771191 scopus 로고    scopus 로고
    • Estimating the proportion of treatment effect explained by a surrogate marker
    • Lin DY, Fleming TR, De Gruttola V. Estimating the proportion of treatment effect explained by a surrogate marker. Stat Med 1997;16:1515-1527.
    • (1997) Stat Med , vol.16 , pp. 1515-1527
    • Lin, D.Y.1    Fleming, T.R.2    De Gruttola, V.3
  • 101
    • 0032513744 scopus 로고    scopus 로고
    • CONSORT: An evolving tool to help improve the quality of reports of randomized trials
    • Moher D. CONSORT: an evolving tool to help improve the quality of reports of randomized trials. JAMA 1998; 279:1489-1491.
    • (1998) JAMA , vol.279 , pp. 1489-1491
    • Moher, D.1
  • 102
    • 0030961103 scopus 로고    scopus 로고
    • Medical editors trial amnesty: Unreported trial registration form
    • Horton R. Medical editors trial amnesty: unreported trial registration form. Lancet 1997;350:756-757.
    • (1997) Lancet , vol.350 , pp. 756-757
    • Horton, R.1
  • 103
    • 10244261646 scopus 로고    scopus 로고
    • Tumor marker utility grading system: A framework to evaluate clinical utility of tumor markers
    • Hayes DF, Bast RC, Desch CE et al. Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markers. J Natl Cancer Inst 1996;88:1456-1466.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1456-1466
    • Hayes, D.F.1    Bast, R.C.2    Desch, C.E.3
  • 104
    • 0032728231 scopus 로고    scopus 로고
    • A guide for reviewing submitted manuscripts and indications for the design of translational research studies on biomarkers
    • Gion M, Boracchi P, Biganzoli E et al. A guide for reviewing submitted manuscripts and indications for the design of translational research studies on biomarkers. Int J Biol Markers 1999;13:123-133.
    • (1999) Int J Biol Markers , vol.13 , pp. 123-133
    • Gion, M.1    Boracchi, P.2    Biganzoli, E.3
  • 105
    • 0030036156 scopus 로고    scopus 로고
    • Clinical studies with angiogenesis inhibitors: Biological rationale and challenges for their evaluation
    • Gasparini G, Presta M. Clinical studies with angiogenesis inhibitors: biological rationale and challenges for their evaluation. Ann Oncol 1996;7:441-444.
    • (1996) Ann Oncol , vol.7 , pp. 441-444
    • Gasparini, G.1    Presta, M.2
  • 106
    • 0034650627 scopus 로고    scopus 로고
    • Response of metastatic breast cancer to trastuzumab?
    • Barnes DM, Miles DW. Response of metastatic breast cancer to trastuzumab? Lancet 2000;355:160-161.
    • (2000) Lancet , vol.355 , pp. 160-161
    • Barnes, D.M.1    Miles, D.W.2
  • 107
    • 0000535592 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic trial of the farnesyltransferase inhibitor R115777 on a 21-day dosing schedule
    • Hudes G, Schol J, Baab J et al. Phase I clinical and pharmacokinetic trial of the farnesyltransferase inhibitor R115777 on a 21-day dosing schedule. Proc Am Soc Clin Oncol 1999;18:156a.
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Hudes, G.1    Schol, J.2    Baab, J.3
  • 108
    • 0033405294 scopus 로고    scopus 로고
    • The hypoxic cell: A target for selective cancer therapy: eighteenth Bruce F. Cain Memorial Award lecture
    • Brown MJ. The hypoxic cell: a target for selective cancer therapy: eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res 1999;59:5863-5870.
    • (1999) Cancer Res , vol.59 , pp. 5863-5870
    • Brown, M.J.1
  • 109
    • 0034652779 scopus 로고    scopus 로고
    • Candidate genes for the hypoxic tumor phenotype
    • Koong AC, Denko NC, Hudson KM et al. Candidate genes for the hypoxic tumor phenotype. Cancer Res 2000;60:883-887.
    • (2000) Cancer Res , vol.60 , pp. 883-887
    • Koong, A.C.1    Denko, N.C.2    Hudson, K.M.3
  • 110
    • 0033975850 scopus 로고    scopus 로고
    • Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide
    • Kimura H, Weisz A, Kurashima Y et al. Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. Blood 2000;95:189-197.
    • (2000) Blood , vol.95 , pp. 189-197
    • Kimura, H.1    Weisz, A.2    Kurashima, Y.3
  • 111
    • 0033599039 scopus 로고    scopus 로고
    • EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
    • Prenzel N, Zwick E, Daub H et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999;402:884-888.
    • (1999) Nature , vol.402 , pp. 884-888
    • Prenzel, N.1    Zwick, E.2    Daub, H.3
  • 112
    • 0033527787 scopus 로고    scopus 로고
    • Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms
    • Sanchez Y, Bachant J, Wang H et al. Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms. Science 1999;286: 1166-1171.
    • (1999) Science , vol.286 , pp. 1166-1171
    • Sanchez, Y.1    Bachant, J.2    Wang, H.3
  • 113
    • 0034629072 scopus 로고    scopus 로고
    • DNA damage-induced activation of p53 by the checkpoint kinase Chk2
    • Hirao A, Kong Y-Y, Matsuoka F et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 2000;287:1824-1827.
    • (2000) Science , vol.287 , pp. 1824-1827
    • Hirao, A.1    Kong, Y.-Y.2    Matsuoka, F.3
  • 114
    • 0034628848 scopus 로고    scopus 로고
    • Piecing together the p53 puzzle
    • Car AM. Piecing together the p53 puzzle. Science 2000; 287:1765-1766.
    • (2000) Science , vol.287 , pp. 1765-1766
    • Car, A.M.1
  • 115
    • 0033529563 scopus 로고    scopus 로고
    • For better or worse? Telomerase inhibition and cancer
    • de Lange T, Jacks T. For better or worse? Telomerase inhibition and cancer. Cell 1999;98:273-275.
    • (1999) Cell , vol.98 , pp. 273-275
    • De Lange, T.1    Jacks, T.2
  • 116
    • 0033525558 scopus 로고    scopus 로고
    • Longevity, stress response, and cancer in aging telomerase-deficient mice
    • Rudolph KL, Chang S, Lee H-W et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 1999;96:701-712.
    • (1999) Cell , vol.96 , pp. 701-712
    • Rudolph, K.L.1    Chang, S.2    Lee, H.-W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.