FK506 and cyclosporin A enhance the survival of cultured and grafted rat embryonic dopamine neurons

Experimental Neurology

Volumn 164, Issue 1, 2000, Pages 94-101

  Castilho, Roger F ^a,b   Hansson, Oskar ^a   Brundin, Patrik ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Cell death; Cyclosporin A; Dopamine; FK506; Immunophilin ligand; Intracerebral transplantation; Parkinson's disease

Indexed keywords

CYCLOSPORIN A; DOPAMINE; TACROLIMUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DEATH; CELL SURVIVAL; CELL SUSPENSION; CELL TRANSPLANTATION; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DRUG EFFECT; DRUG EFFICACY; EMBRYO; GRAFT SURVIVAL; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; TISSUE PREPARATION; TISSUE PRESERVATION;

EID: 0033913626     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7405     Document Type: Article

References (45)

1. Ankarcrona M., Dypbukt J. M., Orrenius S., Nicotera P. Calcineurin and mitochondrial function in glutamate-induced neuronal cell death. FEBS Lett. 394:1996;321-324.
2. Armstrong R. C., Aja T. J., Hoang K. D., Gaur S., Bai X., Alnemri E. S., Litwack G., Karanewsky D. S., Fritz L. C., Tomaselli K. J. Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis. J. Neurosci. 17:1997;553-562.
3. Borlongan C. V., Stahl C. E., Fujisaki T., Sanberg P. R., Watanabe S. Cyclosporine A-induced hyperactivity in rats: Is it mediated by immunosuppression, neurotrophism, or both? Cell Transplant. 8:1999;153-159.
4. Brundin P., Strecker R. E. Preparation and intracerebral grafting of dissociated fetal brain tissue in rats. Conn P. M. Methods in Neurosciences. 1991;305-326 Academic Press, San Diego.
5. Brundin P., Karlsson J., Emgard M., Schierle G. S. K., Hansson O., Petersen A., Castilho R. F. Improving the survival of grafted dopaminergic neurons: A review over current approaches. Cell Transplant. 9:2000;179-195.
6. Butcher S. P., Henshall D. C., Teramura Y., Iwasaki K., Sharkey J. Neuroprotective actions of FK506 in experimental stroke: In vivo evidence against an antiexcitotoxic mechanism. J. Neurosci. 17:1997;6939-6946.
7. Costantini L. C., Chaturvedi P., Armistead D. M., McCaffrey P. G., Deacon T. W., Isacson O. A novel immunophilin ligand: Distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease. Neurobiol. Dis. 5:1998;97-106.
8. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem. J. 341:1999;233-249.
9. Dawson T. M., Steiner J. P., Dawson V. L., Dinerman J. L., Uhl G. R., Snyder S. H. Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc. Natl. Acad. Sci. USA. 90:1993;9808-9812.
10. Doucet G., Brundin P., Descarries L., Bjorklund A. Effect of prior dopamine denervation on survival and fiber outgrowth from intrastriatal fetal mesencephalic grafts. Eur. J. Neurosci. 2:1990;279-290.
11. Duan W. M., Widner H., Brundin P. Temporal pattern of host responses against intrastriatal grafts of syngeneic, allogeneic or xenogeneic embryonic neuronal tissue in rats. Exp. Brain Res. 104:1995;227-242.
12. Emgard M., Karlsson J., Hansson O., Brundin P. Patterns of cell death and dopaminergic neuron survival in intrastriatal nigral grafts. Exp. Neurol. 160:1999;279-288.
13. Fawcett J. W., Barker R. A., Dunnett S. B. Dopaminergic neuronal survival and the effects of bFGF inexplant, three dimensional and monolayer cultures of embryonic rat ventral mesencephalon. Exp. Brain Res. 106:1995;275-282.
14. Friberg H., Ferrand-Drake M., Bengtsson F., Halestrap A. P., Wieloch T. Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death. J. Neurosci. 18:1998;5151-5159.
15. Gold B. G., Katoh K., Storm-Dickerson T. The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve. J. Neurosci. 15:1995;7509-7516.
16. Grasbon-Frodl E. M., Brundin P. Mesencephalic neuron death induced by congeners of nitrogen monoxide is prevented by the lazaroid U-83836E. Exp. Brain Res. 113:1997;138-143.
17. Grasbon-Frodl E. M., Nakao N., Brundin P. The lazaroid U-83836E improves the survival of rat embryonic mesencephalic tissue stored at 4 degrees C and subsequently used for cultures or intracerebral transplantation. Brain Res. Bull. 39:1996;341-347.
18. Griffiths E. J., Halestrap A. P. Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin. Biochem. J. 274:1991;611-614.
19. Hansson O., Castilho R. F., Kaminski G. S., Karlsson J., Nicotera P., Leist M., Brundin P. Additive effects of caspase inhibitor and lazaroid on the survival of transplanted rat and human embryonic dopamine neurons. Exp. Neurol. 164:2000;102-111.
20. Kaminski Schierle G. S., Hansson O., Brundin P. Flunarizine improves the survival of grafted dopaminergic neurons. Neuroscience. 94:1999;17-20.
21. Karlsson J., Emgard M., Rosenblad C., Brundin P. Treatment with the spin-trap agent alpha-phenyl-N-tert-butyl nitrone does not enhance the survival of embryonic or adult dopamine neurons. Brain Res. 805:1998;155-168.
22. Kitamura Y., Itano Y., Kubo T., Nomura Y. Suppressive effect of FK-506, a novel immunosuppressant, against MPTP-induced dopamine depletion in the striatum of young C57BL/6 mice. J. Neuroimmunol. 50:1994;221-224.
23. Kroemer G., Dallaporta B., Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu. Rev. Physiol. 60:1998;619-642.
24. Kuroda S., Janelidze S., Siesjo B. K. The immunosuppressants cyclosporin A and FK506 equally ameliorate brain damage due to 30-min middle cerebral artery occlusion in hyperglycemic rats. Brain Res. 835:1999;148-153.
25. Mahalik T. J., Hahn W. E., Clayton G. H., Owens G. P. Programmed cell death in developing grafts of fetal substantia nigra. Exp. Neurol. 129:1994;27-36.
26. Matsumoto S., Friberg H., Ferrand-Drake M., Wieloch T. Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 19:1999;736-741.
27. Matsuura K., Makino H., Ogawa N. Cyclosporin A attenuates the decrease in tyrosine hydroxylase immunoreactivity in nigrostriatal dopaminergic neurons and in striatal dopamine content in rats with intrastriatal injection of 6-hydroxydopamine. Exp. Neurol. 146:1997;526-535.
28. Morioka M., Hamada J., Ushio Y., Miyamoto E. Potential role of calcineurin for brain ischemia and traumatic injury. Prog. Neurobiol. 58:1999;1-30.
29. Nakao N., Frodl E. M., Duan W. M., Widner H., Brundin P. Lazaroids improve the survival of grafted rat embryonic dopamine neurons. Proc. Natl. Acad. Sci. USA. 91:1994;12408-12412.
30. Nikkhah G., Olsson M., Eberhard J., Bentlage C., Cunningham M. G., Bjorklund A. A microtransplantation approach for cell suspension grafting in the rat Parkinson model: A detailed account of the methodology. Neuroscience. 63:1994;57-72.
31. Pincus M. R., Abraham N. Z. Toxicology and therapeutic drug monitoring. Henry J. B. Clinical Diagnosis and Management by Laboratory Methods. 1996;374-407 Saunders, Philadelphia.
32. Sauer H., Brundin P. Effects of cool storage on survival and function of intrastriatal ventral mesencephalic grafts. Rest. Neurol. Neurosci. 2:1991;1783-1787.
33. Schierle G. S., Hansson O., Leist M., Nicotera P., Widner H., Brundin P. Caspase inhibition reduces apoptosis and increases survival of nigral transplants. Nature Med. 5:1999;97-100.
34. Schierle G. S., Leist M., Martinou J. C., Widner H., Nicotera P., Brundin P. Differential effects of Bcl-2 overexpression on fibre outgrowth and survival of embryonic dopaminergic neurons in intracerebral transplants. Eur. J. Neurosci. 11:1999;3073-3081.
35. Snyder S. H., Lai M. M., Burnett P. E. Immunophilins in the nervous system. Neuron. 21:1998;283-294.
36. Steiner J. P., Connolly M. A., Valentine H. L., Hamilton G. S., Dawson T. M., Hester L., Snyder S. H. Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. Nature Med. 3:1997;421-428.
37. Tocci M. J., Matkovich D. A., Collier K. A., Kwok P., Dumont F., Lin S., Degudicibus S., Siekierka J. J., Chin J., Hutchinson N. I. The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J. Immunol. 143:1989;718-726.
38. Uchino H., Elmer E., Uchino K., Li P. A., He Q. P., Smith M. L., Siesjo B. K. Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat. Brain Res. 812:1998;216-226.
39. Van Muiswinkel F. L., Drukarch B., Steinbusch H. W., De Vente J. Sustained pharmacological inhibition of nitric oxide synthase does not affect the survival of intrastriatal rat fetal mesencephalic transplants. Brain Res. 792:1998;48-58.
40. Venkataramanan R., Swaminathan A., Prasad T., Jain A., Zuckerman S., Warty V., McMichael J., Lever J., Burckart G., Starzl T. Clinical pharmacokinetics of tacrolimus. Clin. Pharmacokinet. 29:1995;404-430.
41. 2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science. 284:1999;339-343.
42. Wang M. S., Zeleny-Pooley M., Gold B. G. Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in the rat sciatic nerve. J. Pharmacol. Exp. Ther. 282:1997;1084-1093.
43. West M. J., Slomianka L., Gundersen H. J. Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 231:1991;482-497.
44. Yardin C., Terro F., Lesort M., Esclaire F., Hugon J. FK506 antagonizes apoptosis and c-jun protein expression in neuronal cultures. NeuroReport. 9:1998;2077-2080.
45. Zawada W. M., Zastrow D. J., Clarkson E. D., Adams F. S., Bell K. P., Freed C. R. Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats. Brain Res. 786:1998;96-103.