메뉴 건너뛰기




Volumn 11, Issue 9, 1999, Pages 3073-3081

Differential effects of Bcl-2 overexpression on fibre outgrowth and survival of "embryonic dopaminergic neurons in intracerebral transplants

Author keywords

Apoptosis; Intracerebral transplantation; Mouse; Parkinson's disease; Rat

Indexed keywords

CASPASE INHIBITOR; DNA FRAGMENT; LACTATE DEHYDROGENASE; PROTEIN BCL 2; STAUROSPORINE; TYROSINE 3 MONOOXYGENASE;

EID: 0032880090     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00727.x     Document Type: Article
Times cited : (38)

References (61)
  • 2
    • 0030932056 scopus 로고    scopus 로고
    • Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase
    • Barkats, M., Nakao, N., Grasbon-Frodl, E.M., Bilang-Bleuel, A., Revah, F., Mallet, J. & Brundin, P. (1997) Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase. Neuroscience, 78, 703-713.
    • (1997) Neuroscience , vol.78 , pp. 703-713
    • Barkats, M.1    Nakao, N.2    Grasbon-Frodl, E.M.3    Bilang-Bleuel, A.4    Revah, F.5    Mallet, J.6    Brundin, P.7
  • 3
    • 0031266085 scopus 로고    scopus 로고
    • Tirilazad mesylate increases dopaminergic neuronal survival in the in oculo grafting model
    • Björklund, L., Spenger, C. & Strömberg, I. (1997) Tirilazad mesylate increases dopaminergic neuronal survival in the in oculo grafting model. Exp. Neurol., 148, 324-333.
    • (1997) Exp. Neurol. , vol.148 , pp. 324-333
    • Björklund, L.1    Spenger, C.2    Strömberg, I.3
  • 4
    • 0022239947 scopus 로고
    • Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons
    • Brundin, P., Nilsson, O.G., Gage, F.H. & Björklund, A. (1985) Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons. Exp. Brain Res., 60, 204-208.
    • (1985) Exp. Brain Res. , vol.60 , pp. 204-208
    • Brundin, P.1    Nilsson, O.G.2    Gage, F.H.3    Björklund, A.4
  • 5
    • 0003057732 scopus 로고
    • Functional effects of mesencephalic dopamine neurons and adrenal chromaffin cells grafted to the rodent striatum
    • Dunnett, S.B. & Björklund, A. (eds), Raven Press, New York
    • Brundin, P., Duan, W.-M. & Sauer, H. (1994) Functional effects of mesencephalic dopamine neurons and adrenal chromaffin cells grafted to the rodent striatum. In Dunnett, S.B. & Björklund, A. (eds), Functional Neural Transplantation. Raven Press, New York, pp. 9-46.
    • (1994) Functional Neural Transplantation , pp. 9-46
    • Brundin, P.1    Duan, W.-M.2    Sauer, H.3
  • 6
    • 0001343810 scopus 로고    scopus 로고
    • Bcl-2 promotes regeneration of severed axons in mammalian CNS
    • Chen, D.F., Schneider, G.E., Martinou, J.C. & Tonegawa, S. (1997) Bcl-2 promotes regeneration of severed axons in mammalian CNS. Nature, 385, 434-139.
    • (1997) Nature , vol.385 , pp. 434-1139
    • Chen, D.F.1    Schneider, G.E.2    Martinou, J.C.3    Tonegawa, S.4
  • 8
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • Coyle, J.T. & Puttfarcken, P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science, 262, 689-695.
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.2
  • 9
    • 0029047361 scopus 로고
    • Temporal pattern of host responses against intrastriatal grafts of syngeneic, allogeneic or xenogeneic embryonic neuronal tissue in rats
    • Duan, W.-M., Widner, H. & Brundin, P. (1995) Temporal pattern of host responses against intrastriatal grafts of syngeneic, allogeneic or xenogeneic embryonic neuronal tissue in rats. Exp. Brain Res., 104, 227-242.
    • (1995) Exp. Brain Res. , vol.104 , pp. 227-242
    • Duan, W.-M.1    Widner, H.2    Brundin, P.3
  • 10
    • 0028343507 scopus 로고
    • Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death
    • Dubois-Dauphin, M., Frankowski, H., Tsujimoto, Y., Huarte, J. & Martinou, J.-C. (1994) Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death. Proc. Natl Acad. Sci. USA, 91, 3309-3313.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 3309-3313
    • Dubois-Dauphin, M.1    Frankowski, H.2    Tsujimoto, Y.3    Huarte, J.4    Martinou, J.-C.5
  • 12
    • 0029047946 scopus 로고
    • Bcl-2 transgene expression can protect neurons against developmental and induced cell death
    • Farlie, P.G., Dringen, R., Rees, S.M., Kannourakis, G. & Bernard, O. (1995) bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proc. Natl Acad. Sci. USA, 92, 4397-4401.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 4397-4401
    • Farlie, P.G.1    Dringen, R.2    Rees, S.M.3    Kannourakis, G.4    Bernard, O.5
  • 13
    • 0032473496 scopus 로고    scopus 로고
    • Alphaviruses induce apoptosis in Bcl-2 overexpressing cells: Evidence for a caspase-mediated, proteolytic inactivation of Bcl-2
    • Grandgirard, D., Studer, E., Monney, L., Belser, T., Fellay, I., Borner, C. & Michel, M.R. (1998) Alphaviruses induce apoptosis in Bcl-2 overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2. EMBO J., 17, 1268-1278.
    • (1998) EMBO J. , vol.17 , pp. 1268-1278
    • Grandgirard, D.1    Studer, E.2    Monney, L.3    Belser, T.4    Fellay, I.5    Borner, C.6    Michel, M.R.7
  • 15
    • 0028288277 scopus 로고
    • C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
    • Hengartner, M.O. & Horvitz, H.R. (1994) C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell, 76, 665-676.
    • (1994) Cell , vol.76 , pp. 665-676
    • Hengartner, M.O.1    Horvitz, H.R.2
  • 16
    • 0032527879 scopus 로고    scopus 로고
    • Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury
    • Herdegen, T., Claret, F.X., Kallunki, T., Martin-Villalba, A., Winter. C., Hunter, T. & Karin, M. (1998) Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J. Neurosci., 18, 5124-5135.
    • (1998) J. Neurosci. , vol.18 , pp. 5124-5135
    • Herdegen, T.1    Claret, F.X.2    Kallunki, T.3    Martin-Villalba, A.4    Winter, C.5    Hunter, T.6    Karin, M.7
  • 19
    • 0028878716 scopus 로고
    • Expression of bcl-2 inhibits necrotic neural cell death
    • Kane, D.J., Ord, T., Anton, R. & Bredesen, D.E. (1995) Expression of bcl-2 inhibits necrotic neural cell death. J. Neurosci. Res., 40, 269-275.
    • (1995) J. Neurosci. Res. , vol.40 , pp. 269-275
    • Kane, D.J.1    Ord, T.2    Anton, R.3    Bredesen, D.E.4
  • 20
    • 0344938398 scopus 로고    scopus 로고
    • Treatment with the spin-trap agent a-phenyl-tert-butyl nitrone does not enhance the survival of embryonic or adult dopamine neurons
    • Karlsson, J., Emgård, M., Rosenblad, C. & Brundin, P. (1998) Treatment with the spin-trap agent a-phenyl-tert-butyl nitrone does not enhance the survival of embryonic or adult dopamine neurons. Brain Res., 805, 155-168.
    • (1998) Brain Res. , vol.805 , pp. 155-168
    • Karlsson, J.1    Emgård, M.2    Rosenblad, C.3    Brundin, P.4
  • 21
    • 0030916669 scopus 로고    scopus 로고
    • The proto-oncogene Bcl-2 and its role in regulating apoptosis
    • Kroemer, G. (1997) The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nature Med., 3, 614-620.
    • (1997) Nature Med. , vol.3 , pp. 614-620
    • Kroemer, G.1
  • 22
    • 0030986669 scopus 로고    scopus 로고
    • Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis
    • Kruman, I., Bruce-Keller, A.J., Bredesen, D., Waeg, G. & Mattson, M.P. (1997) Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J. Neurosci., 17, 5089-5100.
    • (1997) J. Neurosci. , vol.17 , pp. 5089-5100
    • Kruman, I.1    Bruce-Keller, A.J.2    Bredesen, D.3    Waeg, G.4    Mattson, M.P.5
  • 23
    • 0030025668 scopus 로고    scopus 로고
    • Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo
    • Lawrence, M.S., Ho, D.Y., Sun, G.H., Steinberg, G.K. & Sapolsky, R.M. (1996) Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo. J. Neurosci., 16, 486-496.
    • (1996) J. Neurosci. , vol.16 , pp. 486-496
    • Lawrence, M.S.1    Ho, D.Y.2    Sun, G.H.3    Steinberg, G.K.4    Sapolsky, R.M.5
  • 24
    • 0031816414 scopus 로고    scopus 로고
    • Apoptosis, excitotoxicity, and neuropathology
    • Leist, M. & Nicotera, P. (1998) Apoptosis, excitotoxicity, and neuropathology. Exp. Cell Res., 239, 183-201.
    • (1998) Exp. Cell Res. , vol.239 , pp. 183-201
    • Leist, M.1    Nicotera, P.2
  • 25
    • 0032937879 scopus 로고    scopus 로고
    • Following withdrawal of survival factors activation of the JNK pathway in neuronal cells results in Fas ligand induction leading to cell death
    • Le-Niculescu, H., Bonfoco, E., Kasuya, Y., Claret, F.X., Green, D.R. & Karin, M. (1999) Following withdrawal of survival factors activation of the JNK pathway in neuronal cells results in Fas ligand induction leading to cell death. Mol. Cell Biol., 19, 751-763.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 751-763
    • Le-Niculescu, H.1    Bonfoco, E.2    Kasuya, Y.3    Claret, F.X.4    Green, D.R.5    Karin, M.6
  • 26
    • 0027944626 scopus 로고
    • Programmed cell death in developing grafts of fetal substantia nigra
    • Owens, G.P. (1994) Programmed cell death in developing grafts of fetal substantia nigra. Exp. Neurol., 129, 27-36.
    • (1994) Exp. Neurol. , vol.129 , pp. 27-36
    • Owens, G.P.1
  • 28
    • 0031606827 scopus 로고    scopus 로고
    • Free radicals, calcium, and the synaptic plasticity-cell death continuum: Emerging roles of the transcription factor NF kappa B
    • Mattson, M.P. (1998) Free radicals, calcium, and the synaptic plasticity-cell death continuum: emerging roles of the transcription factor NF kappa B. Int. Rev. Neurobiol., 42, 103-168.
    • (1998) Int. Rev. Neurobiol. , vol.42 , pp. 103-168
    • Mattson, M.P.1
  • 29
    • 0027236053 scopus 로고
    • Basic fibroblast growth factor promotes the survival of embryonic ventral mesencephalic dopaminergic neurons-II. Effects on nigral transplants in vivo
    • Mayer, E., Fawcett, J.W. & Dunnett, S.B. (1993) Basic fibroblast growth factor promotes the survival of embryonic ventral mesencephalic dopaminergic neurons-II. Effects on nigral transplants in vivo. Neuroscience, 56, 389-398.
    • (1993) Neuroscience , vol.56 , pp. 389-398
    • Mayer, E.1    Fawcett, J.W.2    Dunnett, S.B.3
  • 30
  • 31
    • 0028899401 scopus 로고
    • Overexpressing Cu/ZN superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease
    • Nakao, N., Frodl, E.M., Widner, H., Carlson, E., Eggerding, F.A., Epstein, C.J. & Brundin, P. (1995) Overexpressing Cu/ZN superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease. Nature Med., 1, 226-231.
    • (1995) Nature Med. , vol.1 , pp. 226-231
    • Nakao, N.1    Frodl, E.M.2    Widner, H.3    Carlson, E.4    Eggerding, F.A.5    Epstein, C.J.6    Brundin, P.7
  • 32
    • 0033083559 scopus 로고    scopus 로고
    • Neuronal cell death: A demise with different shapes
    • Nicotera, P., Leist, M. & Manzo, L. (1999) Neuronal cell death: a demise with different shapes. Trends Pharmacol. Sci., 20, 46-51.
    • (1999) Trends Pharmacol. Sci. , vol.20 , pp. 46-51
    • Nicotera, P.1    Leist, M.2    Manzo, L.3
  • 33
    • 0032510758 scopus 로고    scopus 로고
    • Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
    • Offen, D., Beart, P.M., Cheung, N.S., Pascoe, C.J., Hochman, A., Gorodin, S., Melamed, E., Bernard, R. & Bernard, O. (1998) Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Proc. Natl Acad. Sci. USA, 95, 5789-5794.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 5789-5794
    • Offen, D.1    Beart, P.M.2    Cheung, N.S.3    Pascoe, C.J.4    Hochman, A.5    Gorodin, S.6    Melamed, E.7    Bernard, R.8    Bernard, O.9
  • 34
    • 0032211304 scopus 로고    scopus 로고
    • Overexpression of HA-Bax but not Bcl-2 or Bel-XL attenuates 6-hydroxydopamine-induced neuronal apoptosis
    • Oh, J.H., Choi, W.S., Kim, J.E., Seo, J.W., O'Malley, K.L. & Oh, Y.J. (1998) Overexpression of HA-Bax but not Bcl-2 or Bel-XL attenuates 6-hydroxydopamine-induced neuronal apoptosis. Exp. Neurol., 154, 193-198.
    • (1998) Exp. Neurol. , vol.154 , pp. 193-198
    • Oh, J.H.1    Choi, W.S.2    Kim, J.E.3    Seo, J.W.4    O'Malley, K.L.5    Oh, Y.J.6
  • 35
    • 0025730221 scopus 로고
    • Local support cells promote survival of substantia nigra dopaminergic neurons in culture
    • O'Malley, E.K., Black, I.E. & Dreyfus, C.F. (1991) Local support cells promote survival of substantia nigra dopaminergic neurons in culture. Exp. Neurol., 112, 40-48.
    • (1991) Exp. Neurol. , vol.112 , pp. 40-48
    • O'Malley, E.K.1    Black, I.E.2    Dreyfus, C.F.3
  • 36
    • 0032055973 scopus 로고    scopus 로고
    • Neuronal cell death
    • Pettmann, B. & Hendersen, C.E. (1998) Neuronal cell death. Neuron, 20, 633-647.
    • (1998) Neuron , vol.20 , pp. 633-647
    • Pettmann, B.1    Hendersen, C.E.2
  • 37
    • 0030979773 scopus 로고    scopus 로고
    • Double identity for proteins of the Bcl-2 family
    • Reed, J.C. (1997) Double identity for proteins of the Bcl-2 family. Nature, 387, 773-776.
    • (1997) Nature , vol.387 , pp. 773-776
    • Reed, J.C.1
  • 38
    • 0030298512 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor increases survival, growth and function of intrastriatal fetal nigral dopaminergic grafts
    • Rosenblad, C., Martinez-Serrano, A. & Björklund, A. (1996) Glial cell line-derived neurotrophic factor increases survival, growth and function of intrastriatal fetal nigral dopaminergic grafts. Neuroscience, 75, 979-985.
    • (1996) Neuroscience , vol.75 , pp. 979-985
    • Rosenblad, C.1    Martinez-Serrano, A.2    Björklund, A.3
  • 39
    • 0031730496 scopus 로고    scopus 로고
    • Bcl-2 family members in the development and degenerative pathologies of the nervous system
    • Sadoul, R. (1998) Bcl-2 family members in the development and degenerative pathologies of the nervous system. Cell Death Differ., 5, 805-815.
    • (1998) Cell Death Differ. , vol.5 , pp. 805-815
    • Sadoul, R.1
  • 40
    • 0025846973 scopus 로고
    • Effects of cool storage on survival and function of intrastriatal ventral mesencephalic grafts
    • Sauer, H. & Brundin, P. (1991) Effects of cool storage on survival and function of intrastriatal ventral mesencephalic grafts. Restor. Neurol. Neurosci., 2, 123-135.
    • (1991) Restor. Neurol. Neurosci. , vol.2 , pp. 123-135
    • Sauer, H.1    Brundin, P.2
  • 41
    • 0031936437 scopus 로고    scopus 로고
    • Implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor improve survival, growth, and function of fetal dopaminergic grafts
    • Sautter, J., Tseng, J.L., Braguglia, D., Aebischer, P., Spenger, C., Seiler, R.W., Widmer, H.R. & Zurn, A.D. (1998) Implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor improve survival, growth, and function of fetal dopaminergic grafts. Exp. Neurol., 149, 230-236.
    • (1998) Exp. Neurol. , vol.149 , pp. 230-236
    • Sautter, J.1    Tseng, J.L.2    Braguglia, D.3    Aebischer, P.4    Spenger, C.5    Seiler, R.W.6    Widmer, H.R.7    Zurn, A.D.8
  • 43
    • 0033008216 scopus 로고    scopus 로고
    • Caspase inhibition reduces apoptosis and increases survival of nigral transplants
    • Schierle, G.S., Hansson, O., Leist, M., Nicotera, P., Widner, H. & Brundin, P. (1999) Caspase inhibition reduces apoptosis and increases survival of nigral transplants. Nature Med., 5, 97-100.
    • (1999) Nature Med. , vol.5 , pp. 97-100
    • Schierle, G.S.1    Hansson, O.2    Leist, M.3    Nicotera, P.4    Widner, H.5    Brundin, P.6
  • 44
    • 0021000670 scopus 로고
    • Intracerebral grafting of neuronal cell suspensions. III. Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism
    • Schmidt, R.H., Björklund, A., Stenevi, U., Dunnett, S.B. & Gage, F.H. (1983) Intracerebral grafting of neuronal cell suspensions. III. Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism. Acta Physiol. Scand. Suppl., 522, 19-28.
    • (1983) Acta Physiol. Scand. Suppl. , vol.522 , pp. 19-28
    • Schmidt, R.H.1    Björklund, A.2    Stenevi, U.3    Dunnett, S.B.4    Gage, F.H.5
  • 45
    • 0028001530 scopus 로고
    • Divergent signalling via Apo-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death
    • Schulze-Osthoff, K., Krammer, P.H. & Dröge, W. (1994) Divergent signalling via Apo-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. EMBO J., 13, 4587-4596.
    • (1994) EMBO J. , vol.13 , pp. 4587-4596
    • Schulze-Osthoff, K.1    Krammer, P.H.2    Dröge, W.3
  • 46
    • 0029891535 scopus 로고    scopus 로고
    • Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: Possible involvement of common mediators in apoptotic and necrotic signal transductions
    • Shimizu, S., Eguchi, Y., Kamiike, W., Waguri, S., Uchiyama, Y., Matsuda, H. & Tsujimoto, Y. (1996) Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions. Oncogene, 12, 2045-2050.
    • (1996) Oncogene , vol.12 , pp. 2045-2050
    • Shimizu, S.1    Eguchi, Y.2    Kamiike, W.3    Waguri, S.4    Uchiyama, Y.5    Matsuda, H.6    Tsujimoto, Y.7
  • 47
  • 48
    • 0032135785 scopus 로고    scopus 로고
    • Fetal tissue transplantation in Parkinson's disease
    • Tabbal, S., Fahn, S. & Frucht, S. (1998) Fetal tissue transplantation in Parkinson's disease. Curr. Opin. Neurol., 11, 341-349.
    • (1998) Curr. Opin. Neurol. , vol.11 , pp. 341-349
    • Tabbal, S.1    Fahn, S.2    Frucht, S.3
  • 49
    • 0028953328 scopus 로고
    • Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease
    • Takayama, H., Ray, J., Raymon, H.K., Baird, A., Hogg, J., Fisher, L.J. & Gage, F.H. (1995) Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease. Nature Med., 1, 53-58.
    • (1995) Nature Med. , vol.1 , pp. 53-58
    • Takayama, H.1    Ray, J.2    Raymon, H.K.3    Baird, A.4    Hogg, J.5    Fisher, L.J.6    Gage, F.H.7
  • 50
    • 0028111551 scopus 로고
    • Mesencephalic type 1 astrocytes rescue dopaminergic neurons from death induced by serum deprivation
    • Takeshima, T., Johnston, J.M. & Commissiong, J.W. (1994) Mesencephalic type 1 astrocytes rescue dopaminergic neurons from death induced by serum deprivation. J. Neurosci., 14, 4769-4779.
    • (1994) J. Neurosci. , vol.14 , pp. 4769-4779
    • Takeshima, T.1    Johnston, J.M.2    Commissiong, J.W.3
  • 51
    • 0032528139 scopus 로고    scopus 로고
    • Roles of Bcl-2 and caspases in hypoxia-induced neuronal cell death: A possible neuroprotective mechanism of peptide growth factors
    • Tamatani, M., Ogawa, S. & Tohyama, M. (1998) Roles of Bcl-2 and caspases in hypoxia-induced neuronal cell death: a possible neuroprotective mechanism of peptide growth factors. Brain Res. Mol. Brain Res., 58, 27-39.
    • (1998) Brain Res. Mol. Brain Res. , vol.58 , pp. 27-39
    • Tamatani, M.1    Ogawa, S.2    Tohyama, M.3
  • 52
    • 0030888097 scopus 로고    scopus 로고
    • Susceptibility of cerebellar granule neurons derived from Bcl-2 deficient and transgenic mice to cell death
    • Tanabe, H., Eguchi, Y., Kamada, S., Martinou, J.-C. & Tsujimoto, Y. (1997) Susceptibility of cerebellar granule neurons derived from Bcl-2 deficient and transgenic mice to cell death. Eur. J. Neurosci., 9, 848-856.
    • (1997) Eur. J. Neurosci. , vol.9 , pp. 848-856
    • Tanabe, H.1    Eguchi, Y.2    Kamada, S.3    Martinou, J.-C.4    Tsujimoto, Y.5
  • 54
    • 0345498292 scopus 로고    scopus 로고
    • Bcl-2 targets the protein kinase Raf-1 to mitochondria
    • Wang, H.G., Rapp, U.R. & Reed, J.C. (1996) Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell, 87, 629-638.
    • (1996) Cell , vol.87 , pp. 629-638
    • Wang, H.G.1    Rapp, U.R.2    Reed, J.C.3
  • 55
    • 0031981143 scopus 로고    scopus 로고
    • Mechanisms of Bcl-2 function
    • Wang, H.G. & Reed, J.C. (1998) Mechanisms of Bcl-2 function. Histol. Histopathol., 13, 521-530.
    • (1998) Histol. Histopathol. , vol.13 , pp. 521-530
    • Wang, H.G.1    Reed, J.C.2
  • 56
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
    • West, M.J., Slomianka, L. & Gundersen, H.J. (1991) Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat. Rec., 231, 482-497.
    • (1991) Anat. Rec. , vol.231 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.3
  • 58
    • 0030053470 scopus 로고    scopus 로고
    • BDNF enhances the functional reinnervation of the striatum by grafted fetal dopamine neurons
    • Yurek, D.M., Lu, W., Hipkens, S. & Wiegand, S.J. (1996) BDNF enhances the functional reinnervation of the striatum by grafted fetal dopamine neurons. Exp. Neurol., 137, 105-118.
    • (1996) Exp. Neurol. , vol.137 , pp. 105-118
    • Yurek, D.M.1    Lu, W.2    Hipkens, S.3    Wiegand, S.J.4
  • 59
    • 0032498835 scopus 로고    scopus 로고
    • Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats
    • Zawada, W.M., Zastrow, D.J., Clarkson, E.D., Adams, F.S., Bell, K.P. & Freed, C.R. (1998) Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats. Brain Res., 786, 96-103.
    • (1998) Brain Res. , vol.786 , pp. 96-103
    • Zawada, W.M.1    Zastrow, D.J.2    Clarkson, E.D.3    Adams, F.S.4    Bell, K.P.5    Freed, C.R.6
  • 61
    • 0030158340 scopus 로고    scopus 로고
    • Altered motor function and graft survival produced by basic fibroblast growth factor in rats with 6-OHDA lesions and fetal ventral mesencephalic grafts are associated with glial proliferation
    • Zeng, B.Y., Jenner, P. & Marsden, C.D. (1996) Altered motor function and graft survival produced by basic fibroblast growth factor in rats with 6-OHDA lesions and fetal ventral mesencephalic grafts are associated with glial proliferation. Exp. Neurol., 139, 214-226.
    • (1996) Exp. Neurol. , vol.139 , pp. 214-226
    • Zeng, B.Y.1    Jenner, P.2    Marsden, C.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.