Mesencephalic neuron death induced by congeners of nitrogen monoxide is prevented by the lazaroid U-83836E

Experimental Brain Research

Volumn 113, Issue 1, 1997, Pages 138-143

  Grasbon Frodl, Eva M ^a   Brundin, Patrik ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Cell death; Dopamine; Free radicals; Lazaroid; Neural transplantation; Parkinson's disease; Rat

Indexed keywords

2 [[4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]METHYL] 3,4 DIHYDRO 2,5,7,8 TETRAMETHYL 2H 1 BENZOPYRAN 6 OL; ASCORBIC ACID; LAZAROID; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; LIPID PEROXIDATION; MESENCEPHALON; NERVE CELL NECROSIS; NONHUMAN; OXIDATION REDUCTION STATE; PARKINSON DISEASE; PRIORITY JOURNAL; RAT;

ANIMALS; CELL DEATH; CELLS, CULTURED; CHROMANS; EMBRYONIC AND FETAL DEVELOPMENT; FREE RADICAL SCAVENGERS; MESENCEPHALON; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; NITROPRUSSIDE; OXIDATION-REDUCTION; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031026026     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02454149     Document Type: Article

References (45)

1. Althaus JS, Oien TT, Fici GJ, Scherch HM, Strautmann AF, Sethy VH, Von Voigtlander PF (1993) Peroxynitrite (POX) scavengers: possible neuroprotectants against nitric oxide (NO)-dependent toxicity. Soc Neurosci Abstr 609.2
2. Bates JN, Baker MT, Guerra R, Harrison DG (1991) Nitric oxide generation from nitroprusside by vascular tissue. Biochem Pharmacol [Suppl] 42: S157-S165
3. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87: 1620-1624
4. Beckman JS, Ischiropoulos H, Zhu L, Woerd M van der, Smith C, Chen J, Harrison J, Martin JC, Tasi M (1992) Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite. Arch Biochem Biophys 298: 438-445
5. Beckman JS, Carson M, Smith CS, Koppenol WH (1993) ALS, SOD and peroxynitrite. Nature 364: 584
6. Dawson TM, Snyder SH (1994) Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J Neurosci 14: 5147-5159
7. Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH (1991) Nitric oxide mediates glutamate neuotoxicity in primary cortical cultures. Proc Natl Acad Sci USA 88: 6368-6371
8. Dawson TM, Dawson VL, Snyder SH (1992) A novel neuronal messenger molecule in brain: the free radical nitric oxide. Ann Neurol 32: 297-311
9. Dawson VL, Dawson TM, Bartley DA, Uhl GR, Snyder SH (1993) Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J Neurosci 13: 2651-2661
10. Dawson TM, Zhang J, Dawson VL, Snyder SH (1994) Nitric oxide: cellular regulation and neuronal injury. Prog Brain Res 103: 365-369
11. Dexter DT, Carter CJ, Wells FR, Javoy-Agid F, Agid Y, Lees AJ, Jenner P, Marsden CD (1989) Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease. J Neurochem 52: 381-389
12. Dexter DT, Holley AE, Flitter WD, Slator TF, Wells FR, Daniel SE, Lees AJ, Jenner P, Marsden CD (1994) Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study. Mov Disorders 9: 92-97
13. DiFiglia M (1990) Excitotoxic injury of the neostriatum: a model for Huntington's disease. Trends Neurosci 13(7): 286-289
14. Ferrante RJ, Kowall NW, Beal MF, Richardson EP, Bird ED, Martin JB (1985) Selective sparing of a class of striatal neurons in Huntington's disease. Science 230: 561-563
15. Fici GJ, Althaus JS, Zhang ED, Hall ED, Von Voigtlander PF (1994) Peroxynitrite toxicity in cerebellar granule cells: reversal by tirilazad mesylate (U-74006F). Soc Neurosci Abstr 675.7
16. Fornstedt B (1990) Cysteinyl adducts as putative indices of catechol autooxidation in dopaminergic brain regions. Thesis of the Department of Pharmacology, University of Göteborg, Sweden
17. Frodl EM, Nakao N, Brundin P (1994) Lazaroids improve the survival of cultured rat embryonic mesencephalic neurons. Neuroreport 5: 2393-2396
18. Grasbon-Frodl EM, Andersson A, Brundin P (1996) Lazaroid treatment prevents death of cultured rat embryonic mesencephalic neurons following glutathione depletion. J Neurochem (in press)
19. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA (1994) Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265: 1883-1885
20. Hunot S, Boissiere F, Faucheux B, Brugg B, Mouatt-Prigent A, Agid Y, Hirsch EC (1996) Nitric oxide synthase and neuronal vulnerability in Parkinson's disease. Neuroscience 72: 355-341
21. Hyman BT, Marloff K, Wenniger JJ, Dawson TM, Bredt DS, Snyder SH (1992) Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease. Ann Neurol 32(6): 818-820
22. Izumi Y, Benz AM, Clifford DB, Zorumski CF (1992) Nitric oxide inhibitors attenuate N-methyl-D-aspartate excitotoxicity in rat hippocampal slices. Neurosci Lett 135: 227-230
23. Koh JY, Choi DW (1988) Cultured striatal neurons containing NADPH-diaphorase or acetylcholinesterase are selectively resistant to injury by NMDA receptor agonists. Brain Res 446(2): 374-378
24. Kollegger H, McBean GJ, Tipton KF (1993) Reduction of striatal N-methyl-D-aspartate toxicity by inhibition of nitric oxide synthase. Biochem Pharmacol 45(1): 260-264
25. Lei SZ, Pan ZH, Aggarwal SK, Chen HSV, Hartman J, Sucher NJ, Lipton SA (1992) Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex. Neuron 8: 1087-1099
26. Lipton SA, Choi YB, Pan ZH, Li SZ, Chen HSV, Sucher NJ, Loscalzo J, Singel DJ, Stamler JS (1993) A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364: 626-632
27. Lustig HS, von Brauchitsch KL, Chan J, Greenberg DA (1992) Cyclic GMP modulators and excitotoxic injury in cerebral cortical cultures. Brain Res 577: 343-346
28. McGeer PL, McGeer EG (1995) The inflammatory response system of brain: implications for the therapy of Alzheimer and other neurodegenerative diseases. Brain Res Rev 21: 195-218
29. Mizuno Y, Ikebe S, Hattori N, Nakagawa-Hattori Y, Mochizuki H, Tanaka M, Ozawa T (1995) Role of mitochondria in the etiology and pathogenesis of Parkinson's disease. Biochim Biophys Acta 1271: 265-274
30. Moncada C, Lekieffre D, Arvin B, Meldrum B (1992) Effect of NO synthase inhibition on NMDA- and ischemia-induced hippocampal lesions. Neuroreport 3: 530-532
31. Nakao N, Frodl EM, Duan WM, Widner H, Brundin P (1994) Lazaroids improve the survival of grafted rat embryonic dopamine neurons. Proc Natl Acad Sci USA 91: 12408-12412
32. Olanow CW (1993) A radical hypothesis for neurodegeneration. Trends Neurosci 16: 439-444
33. Perry TL, Godin DV, Hansen S (1982) Parkinson's disease: a disorder due to nigral glutathione deficiency? Neurosci Lett 33: 305-310
34. Radi R, Beckman JS, Bush KM, Feeman BA (1991a) Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys 288: 481-487
35. Radi R, Beckman JS, Bush KM, Freeman BA (1991b) Peroxynitrite oxidation of sulfhydryls - the cytotoxic potential of superoxide and nitric oxide. J Biol Chem 266: 4244-4250
36. Riederer P, Sofic E, Rausch WD, Schmidt B, Reynolds GP. Jellinger K, Youdim MBH (1989) Tansition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. J Neurochem 52: 515-520
37. Schulz JB, Beal MF (1994) Mitochondrial dysfunction in movement disorders. Curr Opin Neurol 7: 333-339
38. Schulz JB, Matthews RT, Muqit MMK, Browne SA, Beal MF (1995) Inhibition of nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. J Neurochem 64: 936-939
39. Schapira AHV (1995) Oxidative stress in Parkinson's disease. Neuropathol Appl Neurobiol 21: 3-9
40. Sian J, Dexter DT, Lees AJ, Daniel S, Agid Y, Javoy-Agid F, Jenner P, Marsden CD (1994a) Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann Neurol 36: 348-355
41. Sian J, Dexter DT, Lees AJ, Daniel S, Jenner P, Marsden CD (1994b) Glutathione-related enzymes in Parkinson's disease. Ann Neurol 36: 356-361
42. Stamler JS, Singel DJ, Loscalzo J (1992) Biochemistry of nitric oxide and its redox-activated forms. Science 258: 1898-1902
43. Uemura Y, Kowall NW, Beal MF (1990) Selective sparing of NADPH-diaphorase-somatostatin-neuropeptide Y neurons in ischemic gerbil striatum. Ann Neurol 27(6): 620-625
44. Van Muiswinkel FL, Steinbusch HWM, Drukarch B, DeVente J (1994) Identification of NO-producing and -receptive cells in mesencephalic transplants in a rat model of Parkinson's disease: a study using NADPH-d enzyme and NOSc/cGMP immunocytochemistry. Ann NY Acad Sci 738: 289-304
45. Wallis RA, Panizzon K, Wasterlain CG (1992) Inhibition of nitric oxide synthase protects against hypoxic neuronal injury. Neuroreport 3: 645-648