Members only encodes a Drosophila nucleoporin required for Rel protein import and immune response activation

Genes and Development

Volumn 14, Issue 15, 2000, Pages 1945-1957

  Uv, Anne E ^a   Roth, Peggy ^a   Xylourgidis, Nikos ^a   Wickberg, Anna ^a   Cantera, Rafael ^b   Samakovlis, Christos ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Innate immunity; Nuclear import; Nup88; Rel family; Tracheal branch fusion

Indexed keywords

ISOPROTEIN; MESSENGER RNA; NUCLEAR PROTEIN; NUCLEOPORIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR REL; UNCLASSIFIED DRUG;

ARTICLE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; DROSOPHILA; GENE CONTROL; GENE EXPRESSION; IMMUNE RESPONSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT; CELL NUCLEUS; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LARVA; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PORE COMPLEX PROTEINS; NUCLEAR PROTEINS; PHOSPHOPROTEINS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

EID: 0033900370     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase
2. Nucleocytoplasmic localisation of extradenticle protein is spatially regulated throughout development in Drosophila
3. Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex
4. Developmental function of Elf-1: An essential transcription factor during embryogenesis in Drosophila
5. 312) enhances dorsal nuclear import through facilitating nuclear localization sequence/importin interaction
6. Dif and Cactus are colocalized in the larval nervous system of Drosophila melanogaster
7. Mutual exclusivity of DNA binding and nuclear localization signal recognition by the yeast transcription factor GAL4: Implications for nonviral DNA delivery
8. 1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras
9. Generation of anti-Antennapedia monoclonal antibodies and Antennapedia protein expression in imaginal discs
10. Genetic approaches to nuclear pore structure and function
11. Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation
12. An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators
13. Adrift, a novel bnl-induced Drosophila gene, required for tracheal pathfinding into the CNS
14. Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides
15. Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1
16. The human homolgue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88
17. In situ activation pattern of Drosophila EGF receptor pathway during development
18. Nup154, a new Drosophila gene essential for male and female gametogenesis is related to the nup155 vertebrate nucleoporin gene
19. Dorsal, a Drosophila rel-like protein, is phosphorylated upon activation of the transmembrane protein toll
20. Regulated nuclear import of the Drosophila rel protein dorsal: Structure-function analysis
21. Transport between the cell nucleus and the cytoplasm
22. Relish, a central factor in the control of humoral but not cellular immunity in Drosophila
23. Phylogenetic perspectives in innate immunity
24. Dif, a dorsal-related gene that mediates an immune response in Drosophila
25. Germ cell-less encodes a cell type-specific nuclear pore-associated protein and functions early in the germ-cell specification pathway of Drosophila
26. Regulation of nuclear localization: A key to a door
27. The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm
28. In situ hybridization to RNA
29. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
30. A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
31. Nuclear import of the homeodomain protein extradenticle in response to Wg and Dpp signalling
32. Development of the Drosophila tracheal system
33. Toll receptor-mediated Drosophila immune response requires Dif, an NF-κB factor
34. Multiple signals converging on NF-kappaB
35. Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo
36. In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila
37. Sequential binding of import ligands to distinct nucleopore regions during their nuclear import
38. Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes
39. The dorsal-related immunity factor, Dif, is a sequence specific trans-activator of Drosophila Cecropin gene expression
40. A gradient of cactus protein degradation establises dorsoventral polarity in the Drosophila embryo
41. A stable genomic source of P element transposase in Drosophila melanogaster
42. The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila
43. Yeast heat shock mRNAs are exported through a distinct pathway defined by Rip1p
44. Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events
45. Genetic control of epithelial tube fusion during Drosophila tracheal development
46. Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo
47. Separate nuclear import pathways converge on the nucleoporin Nup153 and can be dissected with dominant-negative inhibitors
48. A nuclear GFP/ beta-galactosidase fusion protein as a marker for morphogenesis in living Drosophila
49. Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization
50. P element-mediated transformation
51. The nuclear pore complex: From molecular architecture to functional dynamics
52. G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214
53. Headcase, an imaginal specific gene requred for adult morphogenesis in Drosophila melanogaster
54. Protein products of the Bithorax complex in Drosophila
55. Insect immunity. Characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides
56. Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1
57. Ectopic expression and function of the Antp and Scr homeotic genes: The N terminus of the homeodomain is critical to functional specificity