Role of suppressors of cytokine signaling (Socs) in leukemia inhibitory factor (LIF) -dependent embryonic stem cell survival

FASEB Journal

Volumn 14, Issue 11, 2000, Pages 1577-1584

  Duval, D ^a   Reinhardt, B ^a   Kedinger, C ^a   Boeuf, H ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Apoptosis; Early response genes; Pluripotency; Transcription

Indexed keywords

CYTOKINE; LEUKEMIA INHIBITORY FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C FOS; PROTEIN C JUN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CELL VIABILITY; EARLY RESPONSE GENE; EMBRYO CELL; ENZYME ACTIVATION; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0033886322     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.99-0810com     Document Type: Article

References (67)

1. Reflections on the biology of embryonic stem (ES) cells
2. Beyond 'knock-out' mice: New perspectives for the programmed modification of the mammalian genome
3. Signaling mechanisms through gp130: A model of the cytokine system
4. Leukemia inhibitory factor: Part of a large in-gathering family
5. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
6. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders
7. Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death
8. Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIF
9. STATs and MAPKs: Obligate or opportunistic partners in signaling
10. STATs and gene regulation
11. The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs)
12. The Jak-STAT pathway: Cytokine signalling from the receptor to the nucleus
13. STAT structure and function in signaling
14. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
15. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase
16. Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals
17. Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells
18. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line
19. A central role for Stat3 in II-6-induced regulation of growth and differentiation in M1 leukemia cells
20. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
21. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
22. The CIS family: Negative regulators of JAK-STAT signaling
23. Negative regulation of the JAK/STAT pathway
24. The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families
25. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
26. Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling
27. CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells
28. Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation
29. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
30. Structure and function of a new STAT-induced STAT inhibitor
31. Embryo-derived stem cell lines
32. Cell-free activation of a DNA binding protein by epidermal growth factor
33. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter
34. The mouse homologue of the human acidic ribosomal phosphoprotein PO: A highly conserved polypeptide that is under translational control
35. Complementary tissue-specific expression of LIF and LIF-receptor mRNAs in early mouse embryogenesis
36. Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter
37. The biochemistry of programmed cell death
38. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
39. Apoptosis: The germs of death
40. The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac, blood islands and myocardium
41. Caspases: Killer proteases
42. Cell signalling and the control of gene transcription
43. Transcriptional regulation of the junB promoter: Analysis of STAT-mediated signal transduction
44. Cloning and characterization of novel CIS family genes
45. Identification of a developmentally regulated protein tyrosine phosphatase in embryonic stem cells that is a marker of pluripotential epiblast and early mesoderm
46. Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation
47. The CIS/JAB family: Novel negative regulators of JAK signaling pathways
48. Twenty proteins containing a C-terminal SOCS box form five structural classes
49. PML induces a novel caspase-independent death process
50. Caspase-independent programmed cell death with necrotic morphology
51. Stem cell factor and leukemia inhibitory factor promote primordial germ cell survival by suppressing programmed cell death (apoptosis)
52. Angiotensin II interferes with leukemia inhibitory factor-induced STAT3 activation in cardiac myocytes
53. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
54. Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis: Lesson from an uncleavable mutant
55. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: Involvement of STAT3 in anti-apoptosis
56. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice
57. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
58. Essential role of STAT3 for embryonic stem cell pluripotency
59. The carboxyl-terminal domains of gp130-related cytokine receptors are necessary for suppressing embryonic stem cell differentiation. Involvement of STAT3
60. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
61. Fos and bone cell development: Lessons from a nuclear oncogene
62. Functions of c-Jun in Liver and Heart Development
63. Role of leukemia inhibitory factor during mammalian development
64. Autoregulation of pituitary corticotroph SOCS-3 expression: Characterization of the murine SOCS-3 promoter
65. Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins
66. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice
67. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1