Hedgehog activates the EGF receptor pathway during Drosophila head development

Development

Volumn 126, Issue 12, 1999, Pages 2623-2630

  Amin, Amr ^b   Li, Yuebing ^a,b   Finkelstein, Robert ^b  

^a CHRIST HOSPITAL   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Drosophila; Epidermal growth factor receptor; Head development; Hedgehog; Vein

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; SONIC HEDGEHOG PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; CELL PROLIFERATION; DROSOPHILA MELANOGASTER; EMBRYO DEVELOPMENT; GENE EXPRESSION; HEAD; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEAD; INSECT PROTEINS; MUTATION; NEUREGULINS; PROTO-ONCOGENE PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

ANIMALIA; CUBITUS; CUBITUS INTERRUPTUS; DROSOPHILA MELANOGASTER; ERINACEIDAE; HEXAPODA; INVERTEBRATA; MELANOGASTER; VERTEBRATA;

EID: 0032810839     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Alexandre, C., Jacinto, A. and Ingham, P. W. (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev. 10, 2003-2013.
2. Altaba, A. R. (1997). Catching a Gli-mpse of hedgehog. Cell 90, 193-196.
3. Aza-Blanc, P., Ramirez-Weber, F.-A., Laget, M.-P., Schwartz, C. and Kornberg, T. B. (1997). Proteolysis that is inhibited by Hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053.
4. Baker, N. E. (1988a). Embryonic and imaginai requirements for wingless, a segment polarity gene in Drosophila. Dev. Biol. 125, 96-108.
5. Baker, N. E. (1988b). Localization of transcripts from the wingless gene in whole Drosophila embryos. Development 103, 289-298.
6. Bejsovec, A. and Martinez-Arias, A. (1991). Roles of wingless in patterning the larval epidermis of Drosophila. Development 113, 471-485.
7. Blackman, R. K., Sanicola, M., Raftery, L. A., Gillevet, T. and Gelbart, W. M. (1991). An extensive 3'cis-regulatory region directs the imaginai disk expression of decapentaplegic, a menber of the TGF-b family in Drosophila. Development 111, 657-665.
8. Brand, A. and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
9. Buff, E., Carmena, A., Gisselbrecht, S., Jimenez, F. and Michelson, A. M. (1998). Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors. Development 125, 2075-2086.
10. Clifford, R. and Schupbach, T. (1992). The torpedo (DER) receptor tyrosine kinase is required at multiple times during Drosophila embryogenesis. Development 115, 853-872.
11. Clifford, R. J. and Schupbach, T. (1989). Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene. Genetics 123, 771-87.
12. Dominguez, M., Wasserman, J. D. and Freeman, M. (1998). Multiple functions of the EGF receptor in Drosophila eye development. Current Biol. 8, 1039-1048.
13. Eaton, S. and Kornberg, T. B. (1990). Repression of ci-D in posterior compartments of Drosophila by engrailed. Genes Dev. 4, 1068-77.
14. Freeman, M. (1994). The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor. Mech Dev. 48, 25-33.
15. Freeman, M. (1997). Cell determination strategies in the Drosophila eye. Development 124, 261-70.
16. Freeman, M., Klambt, C., Goodman, C. S. and Rubin, G. M. (1992). The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye. Cell 69, 963-975.
17. Gabay, L., Seger, R. and Shilo, B.-Z. (1997). In situ activation pattern of Drosophila EGF Receptor pathway during development. Science 277, 1103-1106.
18. Gao, Q., Wang, Y. and Finkelstein, R. (1996). Orthodenticle regulation during embryonic head development in Drosophila. Mech. Dev. 56, 3-15.
19. Golembo, M., Raz, E. and Shilo, B. Z. (1996a). The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm. Development 122, 3363-70.
20. Golembo, M., Schweitzer, R., Freeman, M. and Shilo, B. Z. (1996b). Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop. Development 122, 223-30.
21. Gonzalez, F., Swales, L., Bejsovec, A., Skaer, H. and Martinez Arias, A. (1991). Secretion and movement of the wingless protein in the Drosophila embryo. Mech. Dev. 35, 43-54.
22. Haynie, J. L. and Bryant, P. J. (1986). Development of the eye-antenna imaginai disc and morphogenesis of the adult head in Drosophila melanogaster. J. Exp. Zool. 237, 293-308.
23. Hepker, J., Wang, Q. T., Motzny, C. K., Holmgren, R. and Orenic, T. V. (1997). Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes. Development 124, 549-58.
24. Ingham, P. W. (1995). Signalling by hedgehog family proteins in Drosophila and vertebrate development. Curr. Opin. Genet. Dev. 5, 492-498.
25. Kassis, J., Noll, E., VanSickle, E. P., Odenwald, W. F. and Perrimon, N. (1992). Altering the insertional specificity of a Drosophila transposable element. Proc. Natl. Acad. Sci. 89, 1919-1923.
26. Kumar, J. P., Tin, M., Hsiung, F., Akopyan, S., Gabay, L., Seger, R., Shilo, B. Z. and Moses, K. (1998). Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development 125, 3875-3885.
27. Lee, J. J., von Kessler, D. P., Parks, S. and Beachy, P. A. (1992). Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 71, 33-50.
28. Lindsley, D. L. and Zimm, G. G. (1992). The Genome of Drosophila melanogaster. New York: Academic Press.
29. Ma, C. and Moses, K. (1995). Wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye. Development 121, 2279-89.
30. Ma, C., Zhou, Y., Beachy, P. A. and Moses, K. (1993). The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. Cell 75, 927-38.
31. Motzny, C. K. and Holmgren, R. (1995). The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech. Dev. 52, 137-50.
32. Neuman-Silberberg, F. and Schupbach, T. (1993). The Drosophila gene gurken produces a dorsally localized RNA and encodes aTGF-a like protein. Cell 75, 165-174.
33. O'Keefe, L., Dougan, S. T., Gabay, L., Raz, E., Shilo, B.-Z. and DiNardo, S. (1997). Spitz, and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis. Development 124, 4837-4845.
34. Perrimon, N. (1995). Hedgehog and beyond. Cell 80, 517-520.
35. Perrimon, N. and Perkins, L. A. (1997). There must be 50 ways to rule the signal: the case of the Drosophila EGF receptor. Cell 89, 13-16.
36. Raz, E. and Shilo, B.-Z. (1992). Dissection of the faint little ball (flb) phenotype: determination of the development of the Drosophila central nervous system by early interactions in the ectoderm. Development 114. 113-123.
37. Royet, J. and Finkelstein, R. (1996). hedgehog, wingless and orthodenticle specify adult head development in Drosophila. Development 122, 1849-58.
38. Royet, J. and Finkelstein, R. (1997). Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog. Development 124, 4793-800.
39. Rutledge, B. J., Zhang, K., Bier, E., Jan, Y. N. and Perrimon, N. (1992). The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes Dev. 6, 1503-1517.
40. Schnepp, B., Grumbling, G., Donaldson, T. and Simcox, A. (1996). Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes Dev. 10, 2302-13.
41. Schweitzer, R., Howes, R., Smith, R., Shilo, B. Z. and Freeman, M. (1995). Inhibition of Drosophila EGF receptor activation by the secreted protein Argos. Nature 376, 699-702.
42. Schweitzer, R., Shaharabany, M., Seger, R. and Shilo, B. Z. (1995). Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev. 9, 1518-29.
43. Schweitzer, R. and Shilo, B.-Z. (1997). A thousand and one roles for the Drosophila EGF receptor. Trends Genet. 13, 191-196.
44. Simcox, A. (1997). Differential requirement for EGF-like ligands in Drosophila wing development. Mech. Dev. 62, 41-50.
45. Simcox, A. A., Roberts, I.J., Hersperger, E., Gribbin, M.C., Shearn, A., Whittle, J.R.S. (1989). Imaginal discs can be recovered from cultured embryos mutant for the segment polarity genes engrailed, naked, and patched but not from wingless. Development 107,
46. Simcox, A. A., Grumbling, G., Schnepp, B., Bennington-Mathias, C., Hersperger, E. and Shearn, A. (1996). Molecular, phenotypic, and expression analysis of vein, a gene required for growth of the Drosophila wing disc. Dev. Biol. 177, 475-489.
47. Spencer, S. A., Powell, P. A., Miller, D. T. and Cagan, R. L. (1998). Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina. Development 125, 4777-4790.
48. Staehling-Hampton, K., Jackson, P. D., Clark, M. J., Brand, A. H. and Hoffmann, F. M. (1994). Specificity of bone morphogenesis protein (BMP) related factors: cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic out not 60A. Cell Growth Diff. 5, 585-593.
49. Struhl, G. and Basler, K. (1993). Organizing activity of wingless protein in Drosophila. Cell 72, 527-540.
50. Su, M.-T., Golden, K. and Bodmer, R. (1998). X-gal staining of Drosophila embryos compatible with antibody staining or in situ hybridization. Biotechniques 24, 918-922.
51. Szuts, D., Eresh, S. and Bienz, M. (1998). Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction. Genes Dev. 12, 2022-2035.
52. Szuts, D., Freeman, M. and Bienz, M. (1997). Antagonism between EGFR and Wingless signalling in the larval cuticle of Drosophila. Development 124, 3209-3219.
53. Tautz, D. and Pfeifle, C. (1989). A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals a translational control of the segmentation gene hunchback. Chromosoma 98, 81-85.
54. Treisman, J. E. and Rubin, G. M. (1995). wingless inhibits morphogenetic furrow movement in the Drosophila eye disc. Development 121, 3519-27.
55. Wappner, P., Gabay, L. and Shilo, B.-Z. (1997). Interactions between the EGF receptor and DPP pathways establish distinct cell fates in the tracheal placodes. Development 124, 4707-4716.
56. Wurst, G., Hersperger, E. and Shearn, A. (1984). Genetic analysis of transdetermination in Drosophila II. Transdetermination to wing and leg discs from a mutant which lacks wing discs. Dev. Biol. 106, 147-155.
57. Xu, T. and Rubin, G. M. (1993). Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237.
58. Yarnitzky, T., Min, L. and Volk., T. (1997). The Drosophila neuroregulin homolog Vein mediates inductive interactions between myotubes and their epidermal attachment cells. Genes Dev. 11, 2691-2700.