Cytosine arabinoside is neurotoxic to chick embryo spinal cord motoneurons in culture

Neuroscience Letters

Volumn 223, Issue 3, 1997, Pages 141-144

  Sanz Rodriguez, Cesar ^a   Boix, Jacint ^a   Comella, Joan X ^a  

^a Dept Ciencies Mediques Basiques F   (Spain)

Author keywords

2' deoxycytidine; apoptosis; cell death; cytosine arabinoside; motoneurons; muscle extract; nitrobenzylthioinosine

Indexed keywords

CYTARABINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHICKEN; CONTROLLED STUDY; DNA SYNTHESIS; EMBRYO; MOTONEURON; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELLS, CULTURED; CHICK EMBRYO; CYTARABINE; DEOXYCYTIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; MOTOR NEURONS; NEUROTOXINS; OSMOLAR CONCENTRATION; SPINAL CORD;

EID: 0031047094     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)13412-7     Document Type: Article

References (16)

1. Bustos M., Alcain F.J., Padilla F. Survival of chick embryo ciliary ganglia neurons in cellular cultures. Collagen, polylysine, and cytosine-arabinoside effects. Trab. Inst. Cajal. 71:1980;63-70.
2. Comella J.X., Sanz-Rodriguez C., Aldea M., Esquerda J.E. Skeletal muscle-derived trophic factors prevent motoneurons from entering an active cell death program in vitro. J. Neurosci. 14:1994;2674-2686.
3. Dessi F., Pollard H., Moreau J., Ben-Ari Y., Charriaut-Marlangue C. Cytosine arabinoside induces apoptosis in cerebellar neurons in culture. J. Neurochem. 64:1995;1980-1987.
4. Fram R.J., Kufe D.W. Inhibition of DNA excision repair and the repair of x-ray-induced DNA damage by cytosine arabinoside and hydroxyurea. Pharmacol. Ther. 31:1985;165-176.
5. Gorczyca W., Bigman K., Mittelman A., Ahmed T., Gong J., Melamed M., Darzynkiewicz Z. Induction of DNA strand breaks associated with apoptosis during treatment of leukemias. Leukemia. 7:1993;659-670.
6. Hwang T.L., Yung W.K.A., Estey E.H., Fields W.S. Central nervous system toxicity with high doses Ara-C. Neurology. 35:1985;1475-1479.
7. Kufe D.W., Major P.P. Studies on the mechanism of action of cytosine arabinoside. Med. Pediatr. Oncol. 1:1982;49-67.
8. Martin D.P., Wallace T.L., Johnson E.M. Jr. Cytosine arabinoside kills postmitotic neurons in a fashion resembling trophic factor deprivation: evidence that a deoxycytidine-dependent process may be required for nerve growth factor signal transduction. J. Neurosci. 10:1990;184-193.
9. Masuck T.M., Taylor A.R., Lough J. Arabinosylcytosine-induced accumulation of DNA nicks in myotube nuclei detected by in situ nick translation. J. Cell Physiol. 144:1990;12-17.
10. Russell J.A., Powles R.L. Neuropathy due to cytosine arabinoside. Br. Med. J. 4:1974;652-653.
11. Smith R.A., Orr D.J. The survival of adult mouse sensory neurons in vitro is enhanced by natural and synthetic substrata, particularly fibronectin. J. Neurosci. 17:1987;265-270.
12. Tomkins C.E., Edwards S.N., Tolkovsky A.M. Apoptosis is induced in post-mitotic rat sympathetic neurons by arabinosides and topoisomerase II inhibitors in the presence of NGF. J. Cell Sci. 107:1994;1499-1507.
13. Villa P., Miehe M., Sensenbrenner M., Pettmann B. Synthesis of specific proteins in trophic-deprived neurons undergoing apoptosis. J. Neurochem. 62:1994;1468-1475.
14. Wakade A.R., Przywara D.A., Palmer K.C., Kulkarni J.S., Wakade T.D. Deoxynucleoside induces neuronal apoptosis independent of neurotrophic factors. J. Biol. Chem. 270:1995;17986-17992.
15. Wallace T.L., Johnson E.M. Jr. Cytosine arabinoside kills postmitotic neurons: evidence that deoxycytidine may have a role in neuronal survival that is independent of DNA synthesis. J. Neurosci. 9:1989;115-124.
16. Young J.D., Jarvis S.M. Nucleoside transport in animal cells. Biosci. Rep. 3:1983;309-322.